{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:26:39Z","timestamp":1791156399430,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2002,5,25]],"date-time":"2002-05-25T00:00:00Z","timestamp":1022284800000},"content-version":"vor","delay-in-days":1666,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology and Immunopathology"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1006\/clin.1997.4428","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:27:27Z","timestamp":1033928847000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cloning and Characterization of Murine Thyroglobulin cDNA"],"prefix":"10.1006","volume":"85","author":[{"given":"Patrizio","family":"Caturegli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre O.","family":"Vidalain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murtaza","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Aguilera-Galaviz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel R.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/clin.1997.4428_II974428C1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.1957.02980130015004","article-title":"Chronic thyroiditis and autoimmunization","volume":"164","author":"Witebsky","year":"1957","journal-title":"J. Am. Med. Assoc."},{"key":"10.1006\/clin.1997.4428_II974428C2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.174.4014.1137","article-title":"Autoimmune murine thyroiditis: Relation to histocompatibility (H-2) type","volume":"174","author":"Vladutiu","year":"1971","journal-title":"Science"},{"key":"10.1006\/clin.1997.4428_II974428C3","series-title":"Autoimmune Endocrine Disease","article-title":"Genetics of autoimmune endocrinopathies: Animal Models","author":"Beisel","year":"1983"},{"key":"10.1006\/clin.1997.4428_II974428C4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0008-8749(85)90394-6","article-title":"Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells","volume":"93","author":"Braley-Mullen","year":"1985","journal-title":"Cell. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C5","first-page":"63","article-title":"Autoimmune murine thyroiditis. VIII. Role of different thyroid antigens in the induction of experimental autoimmune thyroiditis","volume":"30","author":"Tomazic","year":"1976","journal-title":"Immunology"},{"key":"10.1006\/clin.1997.4428_II974428C6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0090-1229(86)90098-X","article-title":"Activation of cytotoxic T cells and effector cells in experimental autoimmune thyroiditis by shared determinants of mouse and human thyroglobulins","volume":"39","author":"Simon","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1006\/clin.1997.4428_II974428C7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0008-8749(90)90241-I","article-title":"Suppression in experimental autoimmune thyroiditis: The role of unique and shared determinants on mouse thyroglobulin in self-tolerance","volume":"131","author":"Nabozny","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/eji.1830141005","article-title":"T cell competence to heterologous and homologous thyroglobulin during the induction of experimental autoimmune thyroiditis","volume":"14","author":"Romball","year":"1984","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.139.3.643","article-title":"Roles of T and B lymphocytes in the termination of unresponsiveness to autologous thyroglobulin in mice","volume":"139","author":"Clagett","year":"1974","journal-title":"J. Exp. Med."},{"key":"10.1006\/clin.1997.4428_II974428C10","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.4049\/jimmunol.131.5.2316","article-title":"T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice","volume":"131","author":"Maron","year":"1983","journal-title":"J. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C11","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.4049\/jimmunol.145.6.1768","article-title":"Autoantibodies to thyroglobulin are encoded by diverse V-gene segments and recognize restricted epitopes","volume":"145","author":"Gleason","year":"1990","journal-title":"J. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C12","series-title":"Molecular Immunobiology of Self-Reactivity","first-page":"247","article-title":"Immunodominant determinants of thyroglobulin associated with autoimmune thyroiditis","author":"Kuppers","year":"1992"},{"key":"10.1006\/clin.1997.4428_II974428C13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/08916939608995341","article-title":"Mouse thyroglobulin: Conservation of sequence homology in C-terminal immunogenic regions of thyroglobulin","volume":"23","author":"Kuppers","year":"1996","journal-title":"Autoimmunity"},{"key":"10.1006\/clin.1997.4428_II974428C14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/316647a0","article-title":"Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA","volume":"316","author":"Mercken","year":"1985","journal-title":"Nature"},{"key":"10.1006\/clin.1997.4428_II974428C15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1432-1033.1987.tb11466.x","article-title":"Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA","volume":"165","author":"Malthi\u00e9ry","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/clin.1997.4428_II974428C16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1073\/pnas.83.2.323","article-title":"The complete sequence of the rat thyroglobulin gene","volume":"83","author":"Musti","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/clin.1997.4428_II974428C17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1432-1033.1985.tb08799.x","article-title":"The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin","volume":"148","author":"Di Lauro","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/clin.1997.4428_II974428C18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0300-9084(89)90058-8","article-title":"Studies on the structure of the normal and abnormal goat thyroglobulin genes","volume":"71","author":"Van Ommen","year":"1989","journal-title":"Biochimie"},{"key":"10.1006\/clin.1997.4428_II974428C19","first-page":"258","article-title":"L'extremite C-terminale de la thyroglobuline ovine present de fortes homologies interspecifiques","volume":"181","author":"Durand","year":"1987","journal-title":"C. R. Soc. Biol. (Paris)"},{"key":"10.1006\/clin.1997.4428_II974428C20","doi-asserted-by":"crossref","first-page":"16948","DOI":"10.1016\/S0021-9258(18)45475-0","article-title":"The sites of thyroid hormone formation in rabbit thyroglobulin","volume":"262","author":"Dunn","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1006\/clin.1997.4428_II974428C21","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1210\/endo-124-3-1327","article-title":"The hormonogenic sites of turtle thyroglobulin and their homology with those of mammals","volume":"124","author":"Roe","year":"1989","journal-title":"Endocrinology"},{"key":"10.1006\/clin.1997.4428_II974428C22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1006\/clin.1997.4428_II974428C23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2144\/96211bm06","article-title":"Improved ligation-anchored PCR strategy for identification of 5\u2032 ends of transcripts","volume":"21","author":"Ansari-Lari","year":"1996","journal-title":"Biotechniques"},{"key":"10.1006\/clin.1997.4428_II974428C24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0264-410X(94)00014-E","article-title":"Two novel T cell epitope prediction algorithms based on MHC-binding motifs; Comparison of predicted and published epitopes fromMycobacterium tuberculosis","volume":"13","author":"Meister","year":"1995","journal-title":"Vaccine"},{"key":"10.1006\/clin.1997.4428_II974428C25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s003359900171","article-title":"Interpreting cDNA sequences: Some insights from studies on translation","volume":"7","author":"Kozak","year":"1996","journal-title":"Mammalian Genome"},{"key":"10.1006\/clin.1997.4428_II974428C26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","article-title":"Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"10.1006\/clin.1997.4428_II974428C27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/319407a0","article-title":"Primary structure ofTorpedo californica","volume":"319","author":"Schumacher","year":"1986","journal-title":"Nature"},{"key":"10.1006\/clin.1997.4428_II974428C28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(86)92515-8","article-title":"Homology between thyroglobulin and acetylcholinesterase: An explanation for the pathogenesis of Graves' ophthalmopathy?","volume":"11","author":"Ludgate","year":"1986","journal-title":"Lancet"},{"key":"10.1006\/clin.1997.4428_II974428C29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/pro.5560020309","article-title":"Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases and related proteins","volume":"2","author":"Cygler","year":"1993","journal-title":"Protein Sci."},{"key":"10.1006\/clin.1997.4428_II974428C30","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.4049\/jimmunol.151.11.6175","article-title":"Mapping the major human T helper epitopes of Tetanus toxin","volume":"151","author":"Reece","year":"1993","journal-title":"J. Immunol."},{"key":"10.1006\/clin.1997.4428_II974428C31","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1126\/science.3194755","article-title":"Autologous peptides constitutively occupy the antigen binding site on Ia","volume":"242","author":"Buus","year":"1988","journal-title":"Science"},{"key":"10.1006\/clin.1997.4428_II974428C32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/351290a0","article-title":"Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules","volume":"351","author":"Falk","year":"1991","journal-title":"Nature"},{"key":"10.1006\/clin.1997.4428_II974428C33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1084\/jem.176.4.1007","article-title":"Identification of a motif for HLA-DR1 binding peptides using M13 display libraries","volume":"176","author":"Hammer","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1006\/clin.1997.4428_II974428C34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/aid.1996.12.593","article-title":"Prediction of HIV peptide epitopes by a novel algorithm","volume":"12","author":"Roberts","year":"1996","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1006\/clin.1997.4428_II974428C35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF00364266","article-title":"Regulation of experimental autoimmune thyroiditis: Mapping of susceptibility to the I-A subregion of the mouse H-2","volume":"15","author":"Beisel","year":"1982","journal-title":"Immunogenetics"}],"container-title":["Clinical Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090122997944287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090122997944287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:10:36Z","timestamp":1758762636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090122997944287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["S0090122997944287"],"URL":"https:\/\/doi.org\/10.1006\/clin.1997.4428","relation":{},"ISSN":["0090-1229"],"issn-type":[{"value":"0090-1229","type":"print"}],"subject":[],"published":{"date-parts":[[1997,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cloning and Characterization of Murine Thyroglobulin cDNA","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/clin.1997.4428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}