{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:20Z","timestamp":1790794760483,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1006\/cyto.1999.0501","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T22:36:01Z","timestamp":1033943761000},"page":"822-830","source":"Crossref","is-referenced-by-count":112,"title":["SYNERGISTIC PROLIFERATION AND ACTIVATION OF NATURAL KILLER CELLS BY INTERLEUKIN 12 AND INTERLEUKIN 18"],"prefix":"10.1006","volume":"11","author":[{"given":"Bernard R","family":"Lauwerys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Renauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9D\u00e9Ric A","family":"Houssiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/cyto.1999.0501_RF1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.16.1.495","article-title":"The interleukin-12\/interleukin-12-receptor system; role in normal and pathologic immunes responses","volume":"16","author":"Gately","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1006\/cyto.1999.0501_RF2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","article-title":"Cloning of a new cytokine that induces IFN-\u03b3 production by T cells","volume":"378","author":"Okamura","year":"1995","journal-title":"Nature"},{"key":"10.1006\/cyto.1999.0501_RF3","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.4049\/jimmunol.156.11.4274","article-title":"Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein","volume":"156","author":"Ushio","year":"1996","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF4","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/eji.1830260736","article-title":"Interferon-\u03b3-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-\u03b3 production","volume":"26","author":"Micallef","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1074-7613(00)80378-7","article-title":"IGIF does not drive Th1 development but synergizes with IL-12 for interferon-\u03b3 production and activates IRAK and NF-\u03baB","volume":"7","author":"Robinson","year":"1997","journal-title":"Immunity"},{"key":"10.1006\/cyto.1999.0501_RF6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0952-7915(98)80163-5","article-title":"Regulation of interferon-\u03b3 production by IL-12 and IL-18","volume":"10","author":"Okamura","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1006\/cyto.1999.0501_RF7","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1073\/pnas.94.8.3948","article-title":"Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-\u03b3 production from activated B cells","volume":"94","author":"Yoshimoto","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1006\/cyto.1999.0501_RF8","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2017::AID-IMMU2017>3.0.CO;2-2","article-title":"Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft- vs.-host disease; synergism with IL-18","volume":"28","author":"Lauwerys","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF9","doi-asserted-by":"crossref","first-page":"25737","DOI":"10.1074\/jbc.272.41.25737","article-title":"Purification and characterization of human interleukin-18 receptor","volume":"272","author":"Torigoe","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1006\/cyto.1999.0501_RF10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.immunol.14.1.619","article-title":"Receptors for HLA class-I molecules in human natural killer cells","volume":"14","author":"Moretta","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1006\/cyto.1999.0501_RF11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","article-title":"NK cell receptors","volume":"16","author":"Lanier","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1006\/cyto.1999.0501_RF12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.3116668","article-title":"The IL-2 receptor \u03b2 chain (p70): role in mediating signals for LAK, NK, and proliferative activities","volume":"238","author":"Siegel","year":"1987","journal-title":"Science"},{"key":"10.1006\/cyto.1999.0501_RF13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.170.3.827","article-title":"Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes","volume":"170","author":"Kobayashi","year":"1989","journal-title":"J Exp Med"},{"key":"10.1006\/cyto.1999.0501_RF14","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.4049\/jimmunol.148.11.3433","article-title":"Cloning and expression of murine IL-12","volume":"148","author":"Schoenhaut","year":"1992","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF15","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/eji.1830270612","article-title":"Interleukin-15-induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94\/NKG2-A as the only HLA class I-specific inhibitory receptor","volume":"27","author":"Mingari","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1172\/JCI119258","article-title":"A potential role for interleukin-15 in the regulation of human natural killer cell survival","volume":"99","author":"Carson","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1006\/cyto.1999.0501_RF17","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.4049\/jimmunol.157.9.3967","article-title":"IFN-\u03b3-inducing factor up-regulates fas ligand-mediated cytotoxic activity or murine natural killer cell clones","volume":"157","author":"Tsutsui","year":"1996","journal-title":"J. Immunol"},{"key":"10.1006\/cyto.1999.0501_RF18","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/eji.1830271107","article-title":"Comparison of the effects of interleukin-1\u03b1, interleukin-1\u03b2 and interferon-\u03b3-inducing factor on the production of interferon-\u03b3 by natural killer cells","volume":"27","author":"Hunter","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF19","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.4049\/jimmunol.160.10.4738","article-title":"A critical role for IL-18 in the proliferation and activation of NK1.1+CD3\u2212cells","volume":"160","author":"Tomura","year":"1998","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.145.1.1","article-title":"Identification of a cell-surface antigen selectively expressed on the natural killer cell","volume":"145","author":"Glimcher","year":"1977","journal-title":"J Exp Med"},{"key":"10.1006\/cyto.1999.0501_RF21","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4049\/jimmunol.145.4.1039","article-title":"NK1.1+thymocytes. Adult murine CD4\u2212, CD8\u2212thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+subset","volume":"145","author":"Ballas","year":"1990","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF22","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.4049\/jimmunol.149.6.1957","article-title":"Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1","volume":"149","author":"Giorda","year":"1992","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF23","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.4049\/jimmunol.154.4.1624","article-title":"The NK1.1 antigen in NK-mediated F1 antiparent killing in vitro","volume":"154","author":"Kung","year":"1995","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0167-5699(96)80582-2","article-title":"Mouse NK1.1+T cells: a new family of T cells","volume":"17","author":"Vicari","year":"1996","journal-title":"Immunol Today"},{"key":"10.1006\/cyto.1999.0501_RF25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.179.4.1285","article-title":"CD4+, NK1.1+T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3","volume":"179","author":"Yoshimoto","year":"1994","journal-title":"J Exp Med"},{"key":"10.1006\/cyto.1999.0501_RF26","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.4049\/jimmunol.159.5.2125","article-title":"A mechanism underlying synergy between IL-12 and IFN-\u03b3 inducing factor in enhanced production of IFN-\u03b3","volume":"159","author":"Ahn","year":"1997","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF27","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.160.8.3642","article-title":"Cutting edge: IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-\u03b3 promoter in primary CD4+T lymphocytes","volume":"160","author":"Barbulescu","year":"1998","journal-title":"J Immunol"},{"key":"10.1006\/cyto.1999.0501_RF28","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0167-5699(97)01149-3","article-title":"The immunoregulatory effects of NK cells: the role of TGF-\u03b2 and implications for autoimmunity","volume":"18","author":"Horwitz","year":"1997","journal-title":"Immunol Today"},{"key":"10.1006\/cyto.1999.0501_RF29","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-\u03b3 receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"10.1006\/cyto.1999.0501_RF30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0076-6879(81)74008-4","article-title":"Particle counting immunoassay (PACIA)","volume":"74","author":"Masson","year":"1981","journal-title":"Methods Enzymol"},{"key":"10.1006\/cyto.1999.0501_RF31","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1073\/pnas.83.24.9679","article-title":"Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas","volume":"83","author":"Van Snick","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1006\/cyto.1999.0501_RF32","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1073\/pnas.85.18.6934","article-title":"Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity","volume":"85","author":"Uyttenhove","year":"1988","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346669990501X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104346669990501X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T10:14:44Z","timestamp":1680603284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104346669990501X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S104346669990501X"],"URL":"https:\/\/doi.org\/10.1006\/cyto.1999.0501","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}