{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:41:22Z","timestamp":1789184482878,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/cyto.2000.0822","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"220-226","source":"Crossref","is-referenced-by-count":35,"title":["ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN B CELL LINE FROM THE LUNG TISSUE OF A PATIENT WITH SCLERODERMA; EXTRAORDINARY HIGH LEVEL OF IL-6 SECRETION BY STIMULATED FIBROBLASTS"],"prefix":"10.1006","volume":"13","author":[{"given":"Kazuo","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Date","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Sugie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/cyto.2000.0822_RF1","series-title":"Current Topics in Rheumatology: Systemic Sclerosis (Scleroderma)","first-page":"7","article-title":"Classification of systemic sclerosis (scleroderma)","author":"Masi","year":"1985"},{"key":"10.1006\/cyto.2000.0822_RF2","first-page":"601","article-title":"Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis","volume":"88","author":"Stuart","year":"1976","journal-title":"J Lab Clin Med"},{"key":"10.1006\/cyto.2000.0822_RF3","first-page":"342","article-title":"Subpopulations of human T lymphocytes: IX. imbalance of T cell subpopulations in patients with progressive systemic sclerosis","volume":"38","author":"Gupta","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"10.1006\/cyto.2000.0822_RF4","first-page":"43","article-title":"Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis","volume":"48","author":"Bernstein","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"10.1006\/cyto.2000.0822_RF5","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0140-6736(63)92920-9","article-title":"Antinuclear and precipitating autoantibodies in progressive systemic sclerosis","volume":"ii","author":"Beck","year":"1963","journal-title":"Lancet"},{"key":"10.1006\/cyto.2000.0822_RF6","series-title":"Immunology of Rheumatic Diseases","first-page":"167","article-title":"Rheumatoid factor","author":"Fong","year":"1985"},{"key":"10.1006\/cyto.2000.0822_RF7","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1172\/JCI108594","article-title":"Cutaneous antigen-stimulating lymphokine production by lymphocytes of patients with progressive systemic sclerosis (scleroderma)","volume":"58","author":"Kondo","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1006\/cyto.2000.0822_RF8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archderm.1981.01650020022017","article-title":"Abnormalities of immunoregulation in progressive systemic sclerosis: Evidence for excess helper-cell function and altered B-cell function","volume":"117","author":"Krakauer","year":"1981","journal-title":"Arch Dermatol"},{"key":"10.1006\/cyto.2000.0822_RF9","first-page":"264","article-title":"Abnormalities of T lymphocyte subsets in patients with progressive systemic sclerosis (PSS, scleroderma)","volume":"97","author":"Inoshita","year":"1981","journal-title":"J Lab Clin Med"},{"key":"10.1006\/cyto.2000.0822_RF10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.iy.08.040190.001345","article-title":"Interleukin-6: an overview","volume":"8","author":"Van Snick","year":"1990","journal-title":"Annu Rev Immunol"},{"key":"10.1006\/cyto.2000.0822_RF11","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/0090-1229(92)90042-M","article-title":"Interleukin-6 and its relation to inflammation and disease","volume":"62","author":"Hirano","year":"1992","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1006\/cyto.2000.0822_RF12","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/art.1780340912","article-title":"Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis","volume":"34","author":"De Benedetti","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1006\/cyto.2000.0822_RF13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1172\/JCI113921","article-title":"Synovium as a source of interleukin 6 in vivo. Contribution to local and systemic manifestations of arthritis","volume":"83","author":"Guerne","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1006\/cyto.2000.0822_RF14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/art.1780350111","article-title":"Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor \u03b1, and interferon-\u03b3 levels in sera from patients with scleroderma","volume":"35","author":"Needleman","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1006\/cyto.2000.0822_RF15","first-page":"17","article-title":"Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders","volume":"13","author":"Stuart","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"10.1006\/cyto.2000.0822_RF16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/08916939409010671","article-title":"Control of IL-6 expression and response in fibroblasts from patients with systemic sclerosis","volume":"17","author":"Feghali","year":"1994","journal-title":"Autoimmunity"},{"key":"10.1006\/cyto.2000.0822_RF17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.187.4.461","article-title":"Interleukin 6 is required for the development of collagen-induced arthritis","volume":"187","author":"Alonzi","year":"1998","journal-title":"J Exp Med"},{"key":"10.1006\/cyto.2000.0822_RF18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1411569","article-title":"Interleukin-6 and its receptor: a paradigm for cytokines","volume":"258","author":"Kishimoto","year":"1992","journal-title":"Science"},{"key":"10.1006\/cyto.2000.0822_RF19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1172\/JCI117206","article-title":"Serum soluble interleukin 6 (IL-6) receptor and IL-6\/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis","volume":"93","author":"De Benedetti","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1006\/cyto.2000.0822_RF20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1074-7613(00)80334-9","article-title":"Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment","volume":"6","author":"Romano","year":"1997","journal-title":"Immunity"},{"key":"10.1006\/cyto.2000.0822_RF21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/1523-1747.ep12483971","article-title":"Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6","volume":"97","author":"Duncan","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1006\/cyto.2000.0822_RF22","first-page":"107","article-title":"Interleukin 1 and tumor necrosis factor-\u03b1 synergistically increase the production of Interleukin 6 in human synovial fibroblast","volume":"34","author":"Harigai","year":"1991","journal-title":"J Clin Lab Immunol"},{"key":"10.1006\/cyto.2000.0822_RF23","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1084\/jem.169.6.2191","article-title":"Detection of Epstein\u2013Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome","volume":"169","author":"Saito","year":"1989","journal-title":"J Exp Med"},{"key":"10.1006\/cyto.2000.0822_RF24","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1172\/JCI111388","article-title":"Abnormally elevated frequency of Epstein\u2013Barr virus-infected B cells in the blood of patients with rheumatoid arthritis","volume":"73","author":"Tosato","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1006\/cyto.2000.0822_RF25","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1182\/blood.V84.8.2489.2489","article-title":"Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+\/Fc\u03f5RI\u2212cell population","volume":"84","author":"Rottem","year":"1994","journal-title":"Blood"},{"key":"10.1006\/cyto.2000.0822_RF26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/cyto.990200207","article-title":"Cell cycle progression and phenotypic modification of Ki67 antigen-negative G1- and G2phase cells in phorbol ester-treated Molt-4 human leukemia cells","volume":"20","author":"Tsurusawa","year":"1995","journal-title":"Cytometry"},{"key":"10.1006\/cyto.2000.0822_RF27","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1093\/nar\/12.23.9179","article-title":"The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species","volume":"12","author":"Arcari","year":"1984","journal-title":"Nucleic Acids Res"},{"key":"10.1006\/cyto.2000.0822_RF28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/310207a0","article-title":"DNA sequence and expression of the B95-8 Epstein\u2013Barr virus genome","volume":"310","author":"Baer","year":"1984","journal-title":"Nature"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466600908226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466600908226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T03:15:39Z","timestamp":1576552539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466600908226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S1043466600908226"],"URL":"https:\/\/doi.org\/10.1006\/cyto.2000.0822","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}