{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:35:35Z","timestamp":1790940935206,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytokine"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1006\/cyto.2001.0959","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:32:46Z","timestamp":1033929166000},"page":"210-219","source":"Crossref","is-referenced-by-count":90,"title":["OVER-EXPRESSION OF HSP-70 INHIBITS BACTERIAL LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF CYTOKINES IN HUMAN MONOCYTE-DERIVED MACROPHAGES"],"prefix":"10.1006","volume":"16","author":[{"given":"Xuan Z.","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Fernandez-Prada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurba K.","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Hoover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/cyto.2001.0959_RF1","series-title":"Bacterial endotoxins: pathophysiological effects, clinical significance, and pharmacological control","first-page":"247","article-title":"Increased plasma levels of endotoxin and corresponding changes in circulatory performance in a porcine sepsis model: the effect of antibiotic administration","author":"Rokke","year":"1988"},{"key":"10.1006\/cyto.2001.0959_RF2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","article-title":"Bacterial endotoxin: molecular relationships of structure to activity and function","volume":"8","author":"Rietschel","year":"1994","journal-title":"FASEB J"},{"key":"10.1006\/cyto.2001.0959_RF3","series-title":"Tumor necrosis factors: the molecules and their emerging role in medicine","first-page":"485","article-title":"The LPS gene: insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation","author":"Vogel","year":"1992"},{"key":"10.1006\/cyto.2001.0959_RF4","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1093\/clinids\/21.Supplement_2.S190","article-title":"Knowledge of cellular receptors for bacterial endotoxin","volume":"2","author":"Viriyakosol","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1006\/cyto.2001.0959_RF5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2249.1995.tb03801.x","article-title":"Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumor necrosis factor (TNF) and IL-1 beta","volume":"102","author":"Herbein","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1006\/cyto.2001.0959_RF6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0171-2985(11)80349-9","article-title":"Mechanisms of endotoxin shock and endotoxin hypersensitivity","volume":"187","author":"Galanos","year":"1993","journal-title":"Immunobiology"},{"key":"10.1006\/cyto.2001.0959_RF7","first-page":"40","article-title":"The role of cytokines in endotoxic shock and in endotoxin hypersensitivity","volume":"21","author":"Freudenberg","year":"1993","journal-title":"Immun Infect"},{"key":"10.1006\/cyto.2001.0959_RF8","series-title":"Cellular and Molecular Immunology","author":"Abbas","year":"1994"},{"key":"10.1006\/cyto.2001.0959_RF9","first-page":"72","article-title":"The role of cytokines in host responses to endotoxin","volume":"3","author":"Manthey","year":"1992","journal-title":"Rev Med Microbiol"},{"key":"10.1006\/cyto.2001.0959_RF10","series-title":"Immunophysiology","first-page":"238","article-title":"Role of cytokines in endotoxin-mediated host response","author":"Vogel","year":"1990"},{"key":"10.1006\/cyto.2001.0959_RF11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1182\/blood.V77.3.579.579","article-title":"Expression of a heat-inducible gene of the HSP-70 family in human myelomonocytic cells: regulation by bacterial products and cytokines","volume":"77","author":"Fincato","year":"1991","journal-title":"Blood"},{"key":"10.1006\/cyto.2001.0959_RF12","first-page":"375","article-title":"Stress proteins in inflammation","volume":"77","author":"Polla","year":"1996","journal-title":"EXS"},{"key":"10.1006\/cyto.2001.0959_RF13","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/IAI.61.3.868-875.1993","article-title":"Murine peritoneal macrophages activated by the mycobacterial 65-kilodalton heat shock protein express enhanced microbicidal activity in vitro","volume":"61","author":"Peetermans","year":"1993","journal-title":"Infect Immun"},{"key":"10.1006\/cyto.2001.0959_RF14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/bj3150497","article-title":"Induction of heat shock proteins and their possible roles in macrophages during activation by macrophage colony-stimulating factor","volume":"315","author":"Shigetada","year":"1996","journal-title":"Biochem J"},{"key":"10.1006\/cyto.2001.0959_RF15","series-title":"The Biology of Heat Shock Proteins and Molecular Chaperones","first-page":"1","article-title":"Progress and perspectives on the biology of heat shock proteins and molecular chaperones","author":"Morimoto","year":"1994"},{"key":"10.1006\/cyto.2001.0959_RF16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0016-5085(91)90473-X","article-title":"Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells","volume":"101","author":"Nakamura","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1006\/cyto.2001.0959_RF17","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/00003246-199406000-00007","article-title":"Induction of heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model","volume":"22","author":"Villar","year":"1994","journal-title":"Crit Care Med"},{"key":"10.1006\/cyto.2001.0959_RF18","first-page":"460","article-title":"Heat shock protects pig kidneys against warm ischemic injury","volume":"22","author":"Perdrizet","year":"1990","journal-title":"Transplant Proc"},{"key":"10.1006\/cyto.2001.0959_RF19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.RES.63.3.543","article-title":"Heat shock response is associated with enhanced post-ischemic ventricular recovery","volume":"63","author":"Currie","year":"1988","journal-title":"Circ Res"},{"key":"10.1006\/cyto.2001.0959_RF20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0016-5085(95)90339-9","article-title":"Induction of heat shock protein-72 protects against ischemia\/reperfusion injury in rat small intestine","volume":"109","author":"Stojadinovic","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1006\/cyto.2001.0959_RF21","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1126\/science.3175623","article-title":"Hyperthermia protects against light damage in the rat retina","volume":"241","author":"Barbe","year":"1988","journal-title":"Science"},{"key":"10.1006\/cyto.2001.0959_RF22","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1073\/pnas.93.13.6458","article-title":"Mitochondria are selective targets for the protective effects of heat shock against oxidative injury","volume":"93","author":"Polla","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/cyto.2001.0959_RF23","doi-asserted-by":"crossref","first-page":"C640","DOI":"10.1152\/ajpcell.1987.252.6.C640","article-title":"Hormone 1, 25-dihydroxyvitamin D3, modulates heat shock response in monocytes","volume":"252","author":"Polla","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1006\/cyto.2001.0959_RF24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/taap.1997.8364","article-title":"Overexpression of HSP-70 attenuates increases in [Ca2+]i and protects human epidermoid A-431 cells after chemical hypoxia","volume":"149","author":"Kiang","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1006\/cyto.2001.0959_RF25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jlb.51.2.181","article-title":"Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritoneal macrophages","volume":"51","author":"Snyder","year":"1992","journal-title":"J Leukoc Biol"},{"key":"10.1006\/cyto.2001.0959_RF26","doi-asserted-by":"crossref","first-page":"C967","DOI":"10.1152\/ajpcell.1994.266.4.C967","article-title":"Differential effects of hyperthermia on macrophage interleukin-6 and tumor necrosis factor-alpha expression","volume":"266","author":"Ensor","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1006\/cyto.2001.0959_RF27","first-page":"144","article-title":"Increase in HSF1 translocation and synthesis in human epidermoid A431 cells: role of protein kinase C and [Ca2+]i","volume":"44","author":"Ding","year":"1996","journal-title":"J Inv Med"},{"key":"10.1006\/cyto.2001.0959_RF28","first-page":"460","article-title":"Heat shock protects pig kidneys against warm ischemic injury","volume":"22","author":"Perdrizet","year":"1990","journal-title":"Transplant Proc"},{"key":"10.1006\/cyto.2001.0959_RF29","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/00003246-199406000-00007","article-title":"Induction of heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model","volume":"22","author":"Villar","year":"1994","journal-title":"Crit Care Med"},{"key":"10.1006\/cyto.2001.0959_RF30","series-title":"Stress Proteins in Biology and Medicine","first-page":"131","article-title":"Stress protein and infectious diseases","author":"Yong","year":"1990"},{"key":"10.1006\/cyto.2001.0959_RF31","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1073\/pnas.87.2.846","article-title":"Decreased expression of heat shock protein 70mRNA and protein after heat treatment in cells of aged rats","volume":"87","author":"Fargnoli","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/cyto.2001.0959_RF32","series-title":"Heat shock protein gene expression in response to physiologic stress and aging","first-page":"577","author":"Holbrook","year":"1994"},{"key":"10.1006\/cyto.2001.0959_RF33","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1073\/pnas.88.21.9873","article-title":"stress-induced heat shock protein 70 expression in adrenal cortex: An adrenocorticotropic hormone-sensitive, age-dependent response","volume":"88","author":"Blake","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/cyto.2001.0959_RF34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0169-328X(95)00131-B","article-title":"Transcriptional activation of Alzheimer's B-amyloid precursor protein gene by stress","volume":"33","author":"Dewji","year":"1995","journal-title":"Mol Brain Res"},{"key":"10.1006\/cyto.2001.0959_RF35","first-page":"6001","article-title":"Suppression of stress protein GRP78 induction in tumor B\/C10ME eliminates resistance to cell mediated cytotoxicity","volume":"40","author":"Sugawara","year":"1993","journal-title":"Cancer Res"},{"key":"10.1006\/cyto.2001.0959_RF36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0167-5699(90)90050-J","article-title":"Heat shock proteins and the immune response","volume":"11","author":"Kaufmann","year":"1990","journal-title":"Immunol Today"},{"key":"10.1006\/cyto.2001.0959_RF37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/thy.1996.6.475","article-title":"Heat shock inhibits the hypoxia-induced effects in rat thyroid FRTL-5 cells","volume":"6","author":"Kiang","year":"1996","journal-title":"Thyroid"},{"key":"10.1006\/cyto.2001.0959_RF38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj2980561","article-title":"Isolation of a novel inducible rat heat shock protein (HSP70) gene and its expression during ischemia\/hypoxia and heat shock","volume":"298","author":"Mestril","year":"1994","journal-title":"Biochem J"},{"key":"10.1006\/cyto.2001.0959_RF39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0016-5085(91)90473-X","article-title":"Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells","volume":"101","author":"Nakamura","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1006\/cyto.2001.0959_RF40","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1126\/science.3175623","article-title":"Hyperthermia protects against light damage in the rat retina","volume":"241","author":"Barbe","year":"1988","journal-title":"Science"},{"key":"10.1006\/cyto.2001.0959_RF41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2165\/00003495-199957020-00001","article-title":"Treatment of sepsis: past and future avenues","volume":"57","author":"Baumgartner","year":"1999","journal-title":"Drugs"},{"key":"10.1006\/cyto.2001.0959_RF42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0898-6568(97)00042-9","article-title":"Stress-activated protein kinases: activation, regulation and function","volume":"9","author":"Paul","year":"1997","journal-title":"Cell Signal"},{"key":"10.1006\/cyto.2001.0959_RF43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0163-7258(98)00028-X","article-title":"Heat shock protein 70kDa: molecular biology, biochemistry, and physiology","volume":"80","author":"Kiang","year":"1998","journal-title":"Pharmacol Ther"},{"key":"10.1006\/cyto.2001.0959_RF44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF01520287","article-title":"Inhibition of proliferation and induction of apoptosis by abrogation of heat shock protein (HSP) 70 expression in tumor cells","volume":"40","author":"Wei","year":"1997","journal-title":"Cancer Immunol Immunother"},{"key":"10.1006\/cyto.2001.0959_RF45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0167-5699(97)01103-1","article-title":"IL-6 and APPs: anti-inflammatory and immunosuppressive mediators","volume":"18","author":"Tilg","year":"1997","journal-title":"Immunol Today"},{"key":"10.1006\/cyto.2001.0959_RF46","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.4049\/jimmunol.159.5.2375","article-title":"Heat shock protein 65 induced by gamma, delta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii","volume":"159","author":"Hisaeda","year":"1997","journal-title":"J Immunol"},{"key":"10.1006\/cyto.2001.0959_RF47","first-page":"341","article-title":"Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat shock protein 65","volume":"83","author":"Silva","year":"1994","journal-title":"Immunology"},{"key":"10.1006\/cyto.2001.0959_RF48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1379\/1466-1268(1997)002<0050:HPMIWS>2.3.CO;2","article-title":"Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-\u03b1-induced cell death","volume":"2","author":"Nishimura","year":"1997","journal-title":"Stress Chaperones"},{"key":"10.1006\/cyto.2001.0959_RF49","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.4049\/jimmunol.145.9.2925","article-title":"Induction of heat shock response protects cells from lysis by tumor necrosis factor","volume":"145","author":"Kusher","year":"1990","journal-title":"J Immunol"},{"key":"10.1006\/cyto.2001.0959_RF50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4049\/jimmunol.154.1.363","article-title":"Constitutive expression of human HSP 27, Drosiphola HSP 27, or human alpha B-crystalline confer resistance to TNF-and oxidative stress-induced cytotoxicity in stably transfected murin L292 fibroblasts","volume":"154","author":"Mehlen","year":"1995","journal-title":"J Immunol"},{"key":"10.1006\/cyto.2001.0959_RF51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00002371-199601000-00002","article-title":"Murine cells transfected with human HSP 27 cDNA resist TNF-induced cytotoxicity","volume":"19","author":"Wang","year":"1996","journal-title":"J Immunother"},{"key":"10.1006\/cyto.2001.0959_RF52","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1164\/ajrccm.154.6.8970379","article-title":"Effects of the stress response in septic rats and LPS-stimulated alveolar macrophages: evidence for TNF-alpha posttranslational regulation","volume":"154","author":"Ribeiro","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1006\/cyto.2001.0959_RF53","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.62.10.4432-4439.1994","article-title":"Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP","volume":"62","author":"Hoover","year":"1994","journal-title":"Infect Immun"},{"key":"10.1006\/cyto.2001.0959_RF54","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0016-5085(95)90339-9","article-title":"Induction of heat shock protein-72 protects against ischemia\/reperfusion injury in rat small intestine","volume":"109","author":"Stojadinovic","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1006\/cyto.2001.0959_RF55","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1021\/bi00400a034","article-title":"Structural elucidation of the Brucella melitensis M antigen by high-resolution NMR at 500MHz","volume":"26","author":"Bundle","year":"1987","journal-title":"Biochemistry"},{"key":"10.1006\/cyto.2001.0959_RF56","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0003-2697(78)90260-9","article-title":"A new and improved microassay to determine 2-keto-3-deoxyoctonate in lipopolysaccharide of Gram-negative bacteria","volume":"85","author":"Karkhanis","year":"1978","journal-title":"Anal Biochem"},{"key":"10.1006\/cyto.2001.0959_RF57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"10.1006\/cyto.2001.0959_RF58","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.1073\/pnas.82.19.6455","article-title":"Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70","volume":"82","author":"Hunt","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/cyto.2001.0959_RF59","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF00225845","article-title":"Rapid assay of HSF1 and HSF2 gene expression by RT-PCR","volume":"158","author":"Ding","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"10.1006\/cyto.2001.0959_RF60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(97)00190-7","article-title":"A flash-type bioluminescent immunoassay that is more sensitive than radioimaging: quantitative detection of cytokine cDNA in activated and resting human cells","volume":"211","author":"Actor","year":"1998","journal-title":"J Immunol Methods"},{"key":"10.1006\/cyto.2001.0959_RF61","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/nar\/12.3.1687","article-title":"Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of human beta-actin cDNA","volume":"12","author":"Ponte","year":"1984","journal-title":"Nucleic Acids Res"},{"key":"10.1006\/cyto.2001.0959_RF62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1006833522418","article-title":"Heat shock gene-expression in HSP-70 and HSF1 gene-transfected human epidermoid A-431 cells","volume":"167","author":"Ding","year":"1997","journal-title":"Mol Cell Biochem"}],"container-title":["Cytokine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466601909597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043466601909597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T07:08:33Z","timestamp":1680592113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043466601909597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S1043466601909597"],"URL":"https:\/\/doi.org\/10.1006\/cyto.2001.0959","relation":{},"ISSN":["1043-4666"],"issn-type":[{"value":"1043-4666","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}