{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:40:52Z","timestamp":1772898052080,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6010,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1006\/dbio.1996.8474","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"162-171","source":"Crossref","is-referenced-by-count":77,"title":["Retinoic Acid Directs Cardiac Laterality and the Expression of Early Markers of Precardiac Asymmetry"],"prefix":"10.1016","volume":"182","author":[{"given":"Susan M.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen D.","family":"Dickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan R.","family":"Sinning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Wunsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger R.","family":"Markwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.1996.8474_DB968474C1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.1084576","article-title":"A human syndrome caused by immotile cilia","volume":"193","author":"Afzelius","year":"1976","journal-title":"Science"},{"key":"10.1006\/dbio.1996.8474_DB968474C2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jez.1400980202","article-title":"Self-differentiation and induction in the heart of Amblystoma","volume":"98","author":"Bacon","year":"1945","journal-title":"J. Exp. Zool."},{"key":"10.1006\/dbio.1996.8474_DB968474C3","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1073\/pnas.93.7.3110","article-title":"Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis","volume":"93","author":"Bavik","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.1996.8474_DB968474C4","unstructured":"J. K. Butler, 1952, An Experimental Analysis of Cardiac Loop Formation in the Chick, University of Texas, Austin, Texas"},{"key":"10.1006\/dbio.1996.8474_DB968474C5","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/hrt.28.4.472","article-title":"Dextrocardia and isolated laevocardia. II. Situs inversus and isolated dextrocardia","volume":"28","author":"Campbell","year":"1966","journal-title":"Br. Heart J."},{"key":"10.1006\/dbio.1996.8474_DB968474C6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/dbio.1996.0021","article-title":"Hensen's node from vitamin A-deficient quail embryo induces chick limb bud duplication and retains its normal asymmetric expression ofSonic hedgehogShh","volume":"173","author":"Chen","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C7","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1073\/pnas.89.21.10056","article-title":"Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chick embryo","volume":"89","author":"Chen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.1996.8474_DB968474C8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lackingSonic hedgehog","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/dbio.1996.0161","article-title":"The fate diversity of mesodermal cells within the heart field during chicken embryogenesis","volume":"177","author":"Cohen-Gould","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/381155a0","article-title":"Relationship between asymmetric nodal expression and the direction of embryonic turning","volume":"381","author":"Collignon","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/374681a0","article-title":"Vertebrate embryo handedness","volume":"374","author":"Cooke","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/dbio.1996.0148","article-title":"Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus","volume":"177","author":"Danos","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/dbio.1993.1318","article-title":"Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids","volume":"160","author":"Dersch","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0177(199605)206:1<39::AID-AJA4>3.0.CO;2-1","article-title":"Selective regulation of cardiomyocyte gene expression and cardiac morphogenesis by retinoic acid","volume":"206","author":"Dickman","year":"1996","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.1996.8474_DB968474C15","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1006\/bbrc.1995.2872","article-title":"Endogenous retinoids in the early avian embryo","volume":"217","author":"Dong","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/dbio.1996.8474_DB968474C16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF00957902","article-title":"The mechanism of cervical flexure formation in the chick","volume":"184","author":"Flynn","year":"1991","journal-title":"Anat. Embryol."},{"key":"10.1006\/dbio.1996.8474_DB968474C17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/dbio.1993.1276","article-title":"Primitive-streak origin of the cardiovascular system in avian embryos","volume":"159","author":"Garcia-Martinez","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(92)90465-O","article-title":"The generation of diversity and pattern in animal development","volume":"68","author":"Gurdon","year":"1992","journal-title":"Cell"},{"key":"10.1006\/dbio.1996.8474_DB968474C19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/359237a0","article-title":"Evidence that Hensen's node is a site of retinoic acid synthesis","volume":"359","author":"Hogan","year":"1992","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J. Morphol."},{"key":"10.1006\/dbio.1996.8474_DB968474C21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02889897","article-title":"Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo","volume":"50","author":"Heine","year":"1985","journal-title":"Virchows Arch. [Cell. Pathol.]"},{"key":"10.1006\/dbio.1996.8474_DB968474C22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/tera.1420220104","article-title":"Teratological and radiocephalometric analysis of craniofacial malformations induced with retinoic acid in rhesus monkeys (Macaca mulatta","volume":"22","author":"Hendrickx","year":"1980","journal-title":"Teratology"},{"key":"10.1006\/dbio.1996.8474_DB968474C23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1242\/dev.115.4.1071","article-title":"Development of left\/right handedness in the chick heart","volume":"115","author":"Hoyle","year":"1992","journal-title":"Development"},{"key":"10.1006\/dbio.1996.8474_DB968474C24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/oxfordjournals.jhered.a106870","article-title":"Visceral inversion and associated anomalies in the mouse","volume":"50","author":"Hummel","year":"1959","journal-title":"J. Hered."},{"key":"10.1006\/dbio.1996.8474_DB968474C25","series-title":"Embryonic Origins of Defective Heart Development","author":"Irie","year":"1990"},{"key":"10.1006\/dbio.1996.8474_DB968474C26","series-title":"Cardiac Morphogenesis","first-page":"134","article-title":"The biology of asymmetry and the development of the cardiac loop","author":"Layton","year":"1985"},{"key":"10.1006\/dbio.1996.8474_DB968474C27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(95)90477-8","article-title":"A molecular pathway determining left-right asymmetry in chick embryogenesis","volume":"82","author":"Levin","year":"1995","journal-title":"Cell"},{"key":"10.1006\/dbio.1996.8474_DB968474C28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/381158a0","article-title":"Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus","volume":"381","author":"Lowe","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/374354a0","article-title":"Functional analysis of activins during mammalian development","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C30","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/374356a0","article-title":"Different phenotypes for mice deficient in either activins or activin receptor type II","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00215298","article-title":"The role of extracardiac factors in normal and abnormal development of the chick embryo heart: Cranial flexure and ventral thoracic wall","volume":"191","author":"Manner","year":"1995","journal-title":"Anat. Embryol."},{"key":"10.1006\/dbio.1996.8474_DB968474C32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/381151a0","article-title":"Left-right asymmetric expression of the TGFJ-family memberlefty","volume":"381","author":"Meno","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C33","unstructured":"S. Miura, S. Miyagawa, M. Morishima, M. Ando, A. Takao, 1990, Retinoic acid-induced visceroatrial heterotaxy syndrome in rat embryos, Developmental Cardiology: Morphogenesis and Function, E. B. ClarkA. Takao, 467, 484, Future, Mount Kisco, NY"},{"key":"10.1006\/dbio.1996.8474_DB968474C34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF00713791","article-title":"A causal analysis of the heart curvatures in the chicken embryo","volume":"158","author":"Orts Llorca","year":"1967","journal-title":"Roux Arch. Entwicklungsmech. Organ."},{"key":"10.1006\/dbio.1996.8474_DB968474C35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/aja.1000300304","article-title":"The formation of the cardiac loop in the chick","volume":"30","author":"Patten","year":"1922","journal-title":"Am. J. Anat."},{"key":"10.1006\/dbio.1996.8474_DB968474C36","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.1996.8474_DB968474C37","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1242\/dev.121.12.4203","article-title":"Induction of avian cardiac myogenesis by anterior endoderm","volume":"121","author":"Schultheiss","year":"1995","journal-title":"Development"},{"key":"10.1006\/dbio.1996.8474_DB968474C38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/tera.1420050115","article-title":"Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment","volume":"5","author":"Shenefelt","year":"1971","journal-title":"Teratology"},{"key":"10.1006\/dbio.1996.8474_DB968474C39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000147810","article-title":"Identification of hLAMP-1: A 283 kDa protein component of the particulate matrix associated with cardiac mesenchyme formation","volume":"155","author":"Sinning","year":"1996","journal-title":"Acta Anat."},{"key":"10.1006\/dbio.1996.8474_DB968474C40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/aja.1002000103","article-title":"Retinoic acid receptor isoform-J2 is an early marker for alimentary tract and central nervous system positional specification in the chicken","volume":"200","author":"Smith","year":"1994","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.1996.8474_DB968474C41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0012-1606(69)90051-7","article-title":"The origin of heart asymmetry: Right and left contributions to the early chick embryo heart","volume":"19","author":"Stalsberg","year":"1969","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C42","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/dbio.1995.0015","article-title":"Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo","volume":"172","author":"Stern","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C43","series-title":"Developmental Mechanisms of Congenital Heart Disease","first-page":"269","article-title":"Organization and function of early specialized myocardium","author":"Thompson","year":"1995"},{"key":"10.1006\/dbio.1996.8474_DB968474C44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/dbio.1996.0005","article-title":"Left-right asymmetric localization of flectin in the extracellular matrix during heart looping","volume":"173","author":"Tsuda","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/dbio.1995.1075","article-title":"Anti-retinoic acid monoclonal antibody localizes all-trans","volume":"168","author":"Twal","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mrd.1080290208","article-title":"Situs inversus in the developing mouse: Proteins affected by the iv mutation (genocopy) and the teratogen retinoic acid (phenocopy)","volume":"29","author":"VanKeuren","year":"1991","journal-title":"Mol. Reprod. Dev."},{"key":"10.1006\/dbio.1996.8474_DB968474C47","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/pd.1970120812","article-title":"Morphological features of a case of retinoic acid embryopathy","volume":"12","author":"Van Maldergem","year":"1992","journal-title":"Prenatal Diagnosis"},{"key":"10.1006\/dbio.1996.8474_DB968474C48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1006\/dbio.1994.1278","article-title":"Cardiac endothelial heterogeneity defines valvular development as demonstrated by the diverse expression of JB3, an antigen of the endocardial cushion tissue","volume":"165","author":"Wunsch","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1996.8474_DB968474C49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.8480178","article-title":"Reversal of left-right asymmetry: A situs inversus mutation","volume":"260","author":"Yokoyama","year":"1993","journal-title":"Science"},{"key":"10.1006\/dbio.1996.8474_DB968474C50","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/357158a0","article-title":"Regulation of vertebrate left-right asymmetries by extracellular matrix","volume":"357","author":"Yost","year":"1992","journal-title":"Nature"},{"key":"10.1006\/dbio.1996.8474_DB968474C51","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0092-8674(95)90464-6","article-title":"Vertebrate left-right development","volume":"82","author":"Yost","year":"1995","journal-title":"Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160696984742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160696984742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:35:39Z","timestamp":1620009339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160696984742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0012160696984742"],"URL":"https:\/\/doi.org\/10.1006\/dbio.1996.8474","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}