{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:52:48Z","timestamp":1790938368960,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5068,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1006\/dbio.1999.9382","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"418-431","source":"Crossref","is-referenced-by-count":148,"title":["Roles for the Winged Helix Transcription Factors MF1 and MFH1 in Cardiovascular Development Revealed by Nonallelic Noncomplementation of Null Alleles"],"prefix":"10.1016","volume":"213","author":[{"given":"Glenn E.","family":"Winnier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Bundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Raines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid L.M.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.1999.9382_RF1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/BF00187468","article-title":"Onset of elastogenesis and downregulation of smooth muscle actin as distinguishing phenomena in artery differentiation in the chick embryo","volume":"194","author":"Bergwerff","year":"1996","journal-title":"Anat. Embryol."},{"key":"10.1006\/dbio.1999.9382_RF2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1101\/gad.8.9.1019","article-title":"Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues","volume":"8","author":"Brannan","year":"1994","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.1999.9382_RF3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/dev.125.5.813","article-title":"Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice","volume":"125","author":"Clouthier","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.124.2.505","article-title":"Pax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant","volume":"124","author":"Conway","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0008-6363(97)00172-7","article-title":"Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse","volume":"36","author":"Conway","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1006\/dbio.1999.9382_RF6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.physiol.60.1.267","article-title":"Role of cardiac neural crest cells in cardiovascular development","volume":"60","author":"Creazzo","year":"1998","journal-title":"Annu. Rev. Physiol."},{"key":"10.1006\/dbio.1999.9382_RF7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/dbio.1995.1245","article-title":"Expression of the novel basic\u2013helix\u2013loop\u2013helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development","volume":"170","author":"Cserjesi","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9382_RF8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/jmg.30.10.813","article-title":"Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndrome: Implications for genetic counseling and prenatal diagnosis","volume":"30","author":"Driscoll","year":"1993","journal-title":"J. Med. Genet."},{"key":"10.1006\/dbio.1999.9382_RF9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.77.1.1","article-title":"Molecular regulation of atrioventricular vavuloseptal morphogenesis","volume":"77","author":"Eisenberg","year":"1995","journal-title":"Circ. Res."},{"key":"10.1006\/dbio.1999.9382_RF10","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1242\/dev.124.11.2099","article-title":"Fashioning the vertebrate heart: Earliest embryonic decisions","volume":"124","author":"Fishman","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI4143","article-title":"Fallen arches, or how the vertebrate got its head","volume":"102","author":"Fishman","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1006\/dbio.1999.9382_RF12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0012-1606(70)90142-9","article-title":"The developmental effects of congenital hydrocephalus (ch) in the mouse","volume":"23","author":"Green","year":"1970","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9382_RF13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02982770","article-title":"Congenital hydrocephalus in the mouse: a case of spurious pleitropism","volume":"45","author":"Gruneberg","year":"1943","journal-title":"J. Genetics"},{"key":"10.1006\/dbio.1999.9382_RF14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0925-4773(98)00039-2","article-title":"Expression of the mouse Fkh1\/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives","volume":"73","author":"Hiemisch","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.1999.9382_RF15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/hmg\/8.4.625","article-title":"Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch\/Mf1) arise from a winged helix\/forkhead transcription factor gene","volume":"8","author":"Hong","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/dbio.1999.9382_RF16","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1242\/dev.124.22.4627","article-title":"Essential roles of the winged helix transcription factor MFH-1 in aortic patterning and skeletogenesis","volume":"124","author":"Iida","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1","volume":"7","author":"Jacks","year":"1994","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9382_RF18","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1242\/dev.122.6.1751","article-title":"Clustered arrangement of winged helix genes fkh-6 and MFH-1: Possible implications for mesoderm development","volume":"122","author":"Kaestner","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00539-4","article-title":"Five years on the wings of fork head","volume":"57","author":"Kaufmann","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.1999.9382_RF20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/dbio.1999.9314","article-title":"The forkhead\/winged helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye","volume":"211","author":"Kidson","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9382_RF21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/01.RES.77.2.211","article-title":"Neural crest and cardiovascular patterning","volume":"77","author":"Kirby","year":"1995","journal-title":"Circ. Res."},{"key":"10.1006\/dbio.1999.9382_RF22","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1242\/dev.121.6.1927","article-title":"Dorsal\u2013ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm","volume":"121","author":"Knecht","year":"1995","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0092-8674(00)81204-0","article-title":"The forkhead\/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus","volume":"93","author":"Kume","year":"1998","journal-title":"Cell"},{"key":"10.1006\/dbio.1999.9382_RF24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1172\/JCI118033","article-title":"Aortic arch malformations and ventricualr septal defect in mice deficient in endothelin-1","volume":"96","author":"Kurihara","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1006\/dbio.1999.9382_RF25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ajmg.1320250615","article-title":"The DiGeorge anomaly as a developmental field defect","volume":"29","author":"Lammer","year":"1986","journal-title":"Am. J. Med. Genet."},{"key":"10.1006\/dbio.1999.9382_RF26","first-page":"125","article-title":"Mesenchymal derivatives of the nerual crest: Analysis of chimeric quail and chick embryos","volume":"34","author":"Le Lievre","year":"1975","journal-title":"J. Embrol. Exp. Morphol."},{"key":"10.1006\/dbio.1999.9382_RF27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0959-437X(96)80067-0","article-title":"Vertebrate heart development","volume":"6","author":"Lyons","year":"1996","journal-title":"Curr. Opinion Genet. Dev."},{"key":"10.1006\/dbio.1999.9382_RF28","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1086\/302109","article-title":"Mutations of the forkhead\/winged helix gene, FREAC3, in patients with galucoma and anterior segment dysgenesis","volume":"63","author":"Mears","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1006\/dbio.1999.9382_RF29","first-page":"1321","article-title":"Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25","volume":"59","author":"Mears","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1006\/dbio.1999.9382_RF30","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants","volume":"120","author":"Mendelsohn","year":"1994","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1006\/geno.1997.4695","article-title":"Isolation of the mouse (MFH-1) and Human (FKHL14) mesenchyme fork head-1 genes reveals conservation of ther gene and protein structures","volume":"41","author":"Miura","year":"1997","journal-title":"Genomics"},{"key":"10.1006\/dbio.1999.9382_RF32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0014-5793(93)81785-X","article-title":"MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme","volume":"326","author":"Miura","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1006\/dbio.1999.9382_RF33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/493","article-title":"The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25","volume":"19","author":"Nishimura","year":"1998","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9382_RF34","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/dev.111.4.867","article-title":"Origins and patterning of avian outflow tract endocardium","volume":"111","author":"Noden","year":"1991","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.272.5262.671","article-title":"Molecular pathways controling heart development","volume":"272","author":"Olson","year":"1996","journal-title":"Science"},{"key":"10.1006\/dbio.1999.9382_RF36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ajmg.1320390208","article-title":"Patial deletion of chromsome 6p: Delination of the syndrome","volume":"39","author":"Palmer","year":"1991","journal-title":"Am. J. Med. Genet."},{"key":"10.1006\/dbio.1999.9382_RF37","first-page":"56","article-title":"A new syndrome involving cleft palate, cardiac anormalies, typical facies, and learning disabilities: Velo-cardio-facial syndrome","volume":"15","author":"Shprintzen","year":"1978","journal-title":"Cleft Palate J."},{"key":"10.1006\/dbio.1999.9382_RF38","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1126\/science.270.5244.1995","article-title":"A Subclass of bHLH proteins required for cardiac morphogenesis","volume":"270","author":"Srivastava","year":"1995","journal-title":"Science"},{"key":"10.1006\/dbio.1999.9382_RF39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF00185997","article-title":"Spatial and temporal pattern of smooth muscle cell differentiation during development of the vascular system in the mouse embryo","volume":"194","author":"Takahashi","year":"1996","journal-title":"Anat. Embryol."},{"key":"10.1006\/dbio.1999.9382_RF40","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1242\/dev.125.16.3005","article-title":"A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme","volume":"125","author":"Thomas","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF41","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0002-9149(84)80215-5","article-title":"Interruption of the aortic arch and coarctation of the aorta: Pathogenetic relations","volume":"54","author":"Van Mierop","year":"1984","journal-title":"Am. J. Cardiol."},{"key":"10.1006\/dbio.1999.9382_RF42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-0177(199603)205:3<281::AID-AJA8>3.0.CO;2-E","article-title":"Cardiac neural crest is essential for the persistence rather than the formation of an arch artery","volume":"205","author":"Waldo","year":"1996","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.1999.9382_RF43","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nm1195-1143","article-title":"Gridlock, a localized heritable vascular patterning defect in the zebrafish","volume":"1","author":"Weinstein","year":"1995","journal-title":"Nat. Med."},{"key":"10.1006\/dbio.1999.9382_RF44","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jmg.30.10.852","article-title":"DiGeorge syndrome: Part of CATCH22","volume":"30","author":"Wilson","year":"1993","journal-title":"J. Med. Genet."},{"key":"10.1006\/dbio.1999.9382_RF45","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1101\/gad.11.7.926","article-title":"The winged helix transcription factor, MFH1, is required for proliferation and patterning of the paraxial mesoderm in the mose embryo","volume":"11","author":"Winnier","year":"1997","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.1999.9382_RF46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI2698","article-title":"Role of endothelin-1\/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice","volume":"102","author":"Yanagisawa","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1006\/dbio.1999.9382_RF47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1242\/dev.125.5.825","article-title":"Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene","volume":"125","author":"Yanagisawa","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9382_RF48","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.1073\/pnas.90.18.8633","article-title":"Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes","volume":"90","author":"Zhao","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216069999382X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216069999382X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:50:28Z","timestamp":1620010228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216069999382X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["S001216069999382X"],"URL":"https:\/\/doi.org\/10.1006\/dbio.1999.9382","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}