{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:56:10Z","timestamp":1791327370279,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4946,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1006\/dbio.1999.9534","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T17:18:44Z","timestamp":1034011124000},"page":"42-53","source":"Crossref","is-referenced-by-count":386,"title":["Endoglin, an Ancillary TGF\u03b2 Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development"],"prefix":"10.1016","volume":"217","author":[{"given":"Helen M.","family":"Arthur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Ure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Renforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Torsney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinah V.","family":"Parums","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Jowett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Marchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin G.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.1999.9534_RF1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/bbrc.1998.8734","article-title":"Expression of endoglin mRNA and protein in human vascular smooth muscle cells","volume":"247","author":"Adam","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/dbio.1999.9534_RF2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1074\/jbc.274.2.584","article-title":"Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members transforming growth factor-\u03b2 superfamily","volume":"274","author":"Barbara","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/dbio.1999.9534_RF3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng0297-207","article-title":"Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice","volume":"15","author":"Bonyadi","year":"1997","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9534_RF4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/dbio.1996.0070","article-title":"Antibodies to the type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart","volume":"174","author":"Brown","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9534_RF5","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1126\/science.283.5410.2080","article-title":"Requirement of type III TGF-\u03b2 receptor for endocardial cell transformation in the heart","volume":"283","author":"Brown","year":"1999","journal-title":"Science"},{"key":"10.1006\/dbio.1999.9534_RF6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/dbio.1998.8905","article-title":"A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice","volume":"199","author":"Charng","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9534_RF7","doi-asserted-by":"crossref","first-page":"19027","DOI":"10.1016\/S0021-9258(18)41732-2","article-title":"Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells","volume":"267","author":"Cheifetz","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1006\/dbio.1999.9534_RF8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0012-1606(91)90316-U","article-title":"Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo","volume":"148","author":"Coffin","year":"1991","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9534_RF9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.121.6.1845","article-title":"Defective hematopoiesis and vasculogenesis in transforming growth- factor-beta-1 knock out mice","volume":"121","author":"Dickson","year":"1995","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9534_RF10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0168-9525(00)89107-6","article-title":"Mouse embryonic hematopoiesis","volume":"11","author":"Dzierzak","year":"1995","journal-title":"Trends Genet."},{"key":"10.1006\/dbio.1999.9534_RF11","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0092-8674(00)81810-3","article-title":"Blood vessel formation: What is its molecular basis","volume":"87","author":"Folkman","year":"1996","journal-title":"Cell"},{"key":"10.1006\/dbio.1999.9534_RF12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<286::AID-HUMU6>3.0.CO;2-B","article-title":"Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles","volume":"11","author":"Gallione","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1006\/dbio.1999.9534_RF13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0378-1119(94)90808-7","article-title":"Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand","volume":"138","author":"Ge","year":"1994","journal-title":"Gene"},{"key":"10.1006\/dbio.1999.9534_RF14","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary haemorrhagic telangiectasia","volume":"333","author":"Guttmacher","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/dbio.1999.9534_RF15","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1083\/jcb.105.6.2861","article-title":"Role of transforming growth factor-beta in the development of the mouse embryo","volume":"105","author":"Heine","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1006\/dbio.1999.9534_RF16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-beta signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1006\/dbio.1999.9534_RF17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","article-title":"Mutations in the activin receptor-like kinase-1 gene in hereditary hemorrhagic telangiectasia type-2","volume":"13","author":"Johnson","year":"1996","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9534_RF18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","article-title":"Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction","volume":"11","author":"Kaartinen","year":"1995","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9534_RF19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","article-title":"Transforming growth factor beta1 null mutation in mice causes excessive inflammmatory response and early death","volume":"90","author":"Kulkarni","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.1999.9534_RF20","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1093\/nar\/19.15.4293","article-title":"Simplified mammalian DNA isolation procedure","volume":"19","author":"Laird","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/dbio.1999.9534_RF21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.133.5.1109","article-title":"Endoglin modulates cellular-responses to TGF-beta-1","volume":"133","author":"Lastres","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1006\/dbio.1999.9534_RF22","doi-asserted-by":"crossref","first-page":"33011","DOI":"10.1074\/jbc.273.49.33011","article-title":"Role of endoglin in cellular responses to transforming growth factor\u03b2\u2014A comparative study with betaglycan","volume":"273","author":"Letamend\u0131&#x0301;a","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/dbio.1999.9534_RF23","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.8009224","article-title":"Maternal rescue of transforming growth factor-beta 1 null mice","volume":"264","author":"Letterio","year":"1994","journal-title":"Science"},{"key":"10.1006\/dbio.1999.9534_RF24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0092-8674(91)90073-8","article-title":"Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system","volume":"67","author":"Lopez-Casillas","year":"1991","journal-title":"Cell"},{"key":"10.1006\/dbio.1999.9534_RF25","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0092-8674(93)90368-Z","article-title":"Betaglycan presents ligand to the TGF-\u03b2 signalling receptor","volume":"73","author":"Lopez-Casillas","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.1999.9534_RF26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1006\/dbio.1999.9534_RF27","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1093\/hmg\/4.10.1983","article-title":"Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function","volume":"4","author":"McAllister","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/dbio.1999.9534_RF28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","article-title":"Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1","volume":"8","author":"McAllister","year":"1994","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9534_RF29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/dbio.1996.0259","article-title":"TGF-beta receptor-type-II deficiency results in defects of yolk-sac hematopoiesis and vasculogenesis","volume":"179","author":"Oshima","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.1999.9534_RF30","doi-asserted-by":"crossref","first-page":"L 547","DOI":"10.1152\/ajplung.1996.270.4.L547","article-title":"Type-I receptor serine threonine kinase preferentially expressed in pulmonary blood-vessels","volume":"14","author":"Panchenko","year":"1996","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1006\/dbio.1999.9534_RF31","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1172\/JCI119800","article-title":"Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative","volume":"100","author":"Pece","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1006\/dbio.1999.9534_RF32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1359-6101(96)00048-2","article-title":"Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity","volume":"8","author":"Pepper","year":"1997","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1006\/dbio.1999.9534_RF33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng1295-409","article-title":"Transforming growth factor-beta 3 is required for secondary palate fusion","volume":"11","author":"Proetzel","year":"1995","journal-title":"Nature Genet."},{"key":"10.1006\/dbio.1999.9534_RF34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s004410051064","article-title":"Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation","volume":"292","author":"Qu","year":"1998","journal-title":"Cell Tissue Res."},{"key":"10.1006\/dbio.1999.9534_RF35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1097-0177(199708)209:4<418::AID-AJA9>3.0.CO;2-L","article-title":"Expression of ALK-1, a type 1 serine\/threonine kinase receptor, coincide with sites of vasculogenesis and angiogenesis in early mouse development","volume":"209","author":"Roelen","year":"1997","journal-title":"Dev. Dynam."},{"key":"10.1006\/dbio.1999.9534_RF36","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.4049\/jimmunol.154.9.4456","article-title":"Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow","volume":"154","author":"Rokhlin","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/dbio.1999.9534_RF37","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes","volume":"124","author":"Sanford","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.1999.9534_RF38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/376062a0","article-title":"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice","volume":"376","author":"Shalaby","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.1999.9534_RF39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1086\/513906","article-title":"Characterization of endoglin and identification of novel mutations in Hereditary Hemorrhagic Telangiectasia","volume":"61","author":"Shovlin","year":"1997","journal-title":"Am. J. Human Genet."},{"key":"10.1006\/dbio.1999.9534_RF40","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-beta1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1006\/dbio.1999.9534_RF41","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1210\/endo.134.6.8194490","article-title":"Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells","volume":"134","author":"St-Jacques","year":"1994","journal-title":"Endocrinology"},{"key":"10.1006\/dbio.1999.9534_RF42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1097-0177(199811)213:3<237::AID-AJA1>3.0.CO;2-M","article-title":"Production of the transforming growth factor-beta binding protein endoglin is regulated during chick heart development","volume":"213","author":"Vincent","year":"1998","journal-title":"Dev. Dynam."},{"key":"10.1006\/dbio.1999.9534_RF43","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1182\/blood.V92.8.2791","article-title":"Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo","volume":"92","author":"Yamamoto","year":"1998","journal-title":"Blood"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160699995349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160699995349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T16:11:03Z","timestamp":1680624663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160699995349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0012160699995349"],"URL":"https:\/\/doi.org\/10.1006\/dbio.1999.9534","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}