{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:57:52Z","timestamp":1778612272329,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4702,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1006\/dbio.2000.9852","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"447-458","source":"Crossref","is-referenced-by-count":43,"title":["csal1 Is Controlled by a Combination of FGF and Wnt Signals in Developing Limb Buds"],"prefix":"10.1016","volume":"225","author":[{"given":"Elizabeth R","family":"Farrell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E","family":"M\u00fcnsterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2000.9852_RF1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0925-4773(96)00606-5","article-title":"The ectodermal control in chick limb development: Wnt7a, Shh, BMP2 and BMP4 expression, and the effect of FGF4 on gene expression","volume":"60","author":"Akita","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2000.9852_RF2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1097-2765(00)80393-7","article-title":"Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin","volume":"4","author":"Capdevila","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2000.9852_RF3","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1242\/dev.120.11.3339","article-title":"Products, genetic linkage and limb patterning activity of a murine hedgehog gene","volume":"120","author":"Chang","year":"1994","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF4","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1242\/dev.125.24.4959","article-title":"The transcription factors KNIRPS and KNIRPS related control cell migration and branch morphogenesis during Drosophila tracheal development","volume":"125","author":"Chen","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0092-8674(00)80999-X","article-title":"Roles for FGF8 in the induction, initiation, and maintenance of chick limb development","volume":"84","author":"Crossley","year":"1996","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/381421a0","article-title":"A gene complex acting downstream of dpp in Drosophila wing morphogenesis","volume":"381","author":"de Celis","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF7","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1242\/dev.126.12.2653","article-title":"Regulation of the spalt\/spalt-related gene complex and its function during sensory organ development in the Drosophila thorax","volume":"126","author":"de Celis","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0925-4773(93)90034-U","article-title":"Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern-formation along the proximodistal and dorsoventral axes","volume":"43","author":"Dealy","year":"1993","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2000.9852_RF9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/342767a0","article-title":"Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation","volume":"342","author":"Doll\u00e9","year":"1989","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF10","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1242\/dev.127.7.1337","article-title":"A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling","volume":"127","author":"Drossopoulou","year":"2000","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic-hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF12","doi-asserted-by":"crossref","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J. Morphol."},{"key":"10.1006\/dbio.2000.9852_RF13","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/375787a0","article-title":"Expression of a Delta-homolog in prospective neurons in the chick","volume":"375","author":"Henrique","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF14","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/dev.124.22.4605","article-title":"Noggin acts downstream of Wnt and Sonic hedgehog to antagonize BMP4 in avian somite patterning","volume":"124","author":"Hirsinger","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0925-4773(95)00485-8","article-title":"Xenopus Xsal-1, a vertebrate homolog of the region specific homeotic gene spalt of Drosophila","volume":"55","author":"Hollemann","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2000.9852_RF16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/350585a0","article-title":"Expression of the homeobox Hox-4 genes and the specification of position in chick wing development","volume":"350","author":"Izpis\u00faa-Belmonte","year":"1991","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF17","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)80364-5","article-title":"Molecular models for vertebrate limb development","volume":"90","author":"Johnson","year":"1997","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/j.1460-2075.1988.tb02799.x","article-title":"Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene","volume":"7","author":"J\u00fcrgens","year":"1988","journal-title":"EMBO J."},{"key":"10.1006\/dbio.2000.9852_RF19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1126\/science.280.5367.1274","article-title":"Distinct Wnt pathways regulating AER formation and dorsoventral polarity in the chick limb bud","volume":"280","author":"Kengaku","year":"1998","journal-title":"Science"},{"key":"10.1006\/dbio.2000.9852_RF20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1086\/302238","article-title":"Molecular analysis of SALL1 mutations in Townes\u2013Brocks syndrome","volume":"64","author":"Kohlhase","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1006\/dbio.2000.9852_RF21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ng0198-81","article-title":"Mutations in the SALL1 putative transcription factor gene cause Townes\u2013Brocks syndrome","volume":"18","author":"Kohlhase","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1006\/dbio.2000.9852_RF22","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1242\/dev.124.16.3147","article-title":"Medaka spalt acts as a target gene of hedgehog signaling","volume":"124","author":"Koster","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF23","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0092-8674(93)90628-4","article-title":"A functionally conserved homology of the Drosophila segment polarity gene-Hh is expressed in tissues with polarizing activity in zebrafish embryos","volume":"75","author":"Krauss","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/j.1460-2075.1994.tb06246.x","article-title":"spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo","volume":"13","author":"K\u00fchnlein","year":"1994","journal-title":"EMBO J."},{"key":"10.1006\/dbio.2000.9852_RF25","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1242\/dev.122.7.2215","article-title":"Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development","volume":"122","author":"K\u00fchnlein","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1126\/science.8235591","article-title":"Neural induction by the secreted polypeptide noggin","volume":"262","author":"Lamb","year":"1993","journal-title":"Science"},{"key":"10.1006\/dbio.2000.9852_RF27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(94)90030-2","article-title":"Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud","volume":"79","author":"Laufer","year":"1994","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/381387a0","article-title":"Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing","volume":"381","author":"Lecuit","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF29","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0960-9822(95)00156-4","article-title":"Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage","volume":"5","author":"Lopezmartinez","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1006\/dbio.2000.9852_RF30","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1101\/gad.12.11.1571","article-title":"The roles of FGFs in the early development of vertebrate limb","volume":"12","author":"Martin","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9852_RF31","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1101\/gad.9.23.2911","article-title":"Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite","volume":"9","author":"M\u00fcnsterberg","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9852_RF32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(00)81114-9","article-title":"Direct and long-range action of a Dpp morphogen gradient","volume":"85","author":"Nellen","year":"1996","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/371609a0","article-title":"A positive feedback loop coordinates growth and patterning in the vertebrate limb","volume":"371","author":"Niswander","year":"1994","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(93)90391-3","article-title":"FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb","volume":"75","author":"Niswander","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0925-4773(96)00516-3","article-title":"The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures","volume":"56","author":"Ott","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2000.9852_RF36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/374350a0","article-title":"Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb","volume":"374","author":"Parr","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(95)90103-5","article-title":"Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb","volume":"83","author":"Riddle","year":"1995","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF38","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9852_RF39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0168-9525(98)01477-2","article-title":"Limbs are moving: Where are they going?","volume":"14","author":"Schwabe","year":"1998","journal-title":"Trends Genet."},{"key":"10.1006\/dbio.2000.9852_RF40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/381367a0","article-title":"How to tell a cell where it is","volume":"381","author":"Smith","year":"1996","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dev.124.1.21","article-title":"The spalt gene links the A\/P compartment boundary to a linear adult structure in the Drosophila wing","volume":"124","author":"Sturtevant","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF42","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/244492a0","article-title":"Positional information in chick limb morphogenesis","volume":"224","author":"Summerbell","year":"1973","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF43","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1242\/dev.125.22.4417","article-title":"The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development","volume":"125","author":"Takahashi","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF44","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0959-437X(95)90052-I","article-title":"Vertebrate limb development","volume":"5","author":"Tickle","year":"1995","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2000.9852_RF45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/254199a0","article-title":"Positional signalling and specification of digits in chick limb morphogenesis","volume":"254","author":"Tickle","year":"1975","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/378716a0","article-title":"Dorsal cell fate specified by chick Lmx1 during vertebrate limb development","volume":"378","author":"Vogel","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9852_RF47","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1101\/gad.5.12b.2467","article-title":"Identification of target genes of the homeotic gene Antennapedia by enhancer detection","volume":"5","author":"Wagner-Bernholz","year":"1991","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9852_RF48","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1242\/dev.124.21.4393","article-title":"Relationship between dose, distance and time in Sonic hedgehog-mediated regulation of anteroposterior polarity in the chick limb","volume":"124","author":"Yang","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9852_RF49","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.272.5262.738","article-title":"Requirement for BMP signaling in interdigital apoptosis and scale formation","volume":"272","author":"Zou","year":"1996","journal-title":"Science"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216060099852X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216060099852X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T01:41:53Z","timestamp":1620006113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216060099852X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S001216060099852X"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2000.9852","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}