{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:28:12Z","timestamp":1791088092134,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4641,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1006\/dbio.2000.9902","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T11:45:48Z","timestamp":1032176748000},"page":"432-449","source":"Crossref","is-referenced-by-count":184,"title":["The Murine Otp Homeobox Gene Plays an Essential Role in the Specification of Neuronal Cell Lineages in the Developing Hypothalamus"],"prefix":"10.1016","volume":"227","author":[{"given":"Weidong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lufkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2000.9902_RF1","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1101\/gad.13.21.2787","article-title":"Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene","volume":"13","author":"Acampora","year":"1999","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9902_RF2","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1242\/dev.126.10.2171","article-title":"Spatially restricted expression of P1Otp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos","volume":"126","author":"Di Bernardo","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9902_RF3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mcne.1996.0001","article-title":"Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of down syndrome","volume":"7","author":"Fan","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1006\/dbio.2000.9902_RF4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1242\/dev.121.4.957","article-title":"Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila","volume":"121","author":"Frasch","year":"1995","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9902_RF5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0306-4522(92)90024-V","article-title":"Expression of provasopressin gene during ontogeny in the hypothalamus of developing mice","volume":"46","author":"Hyodo","year":"1992","journal-title":"Neuroscience"},{"key":"10.1006\/dbio.2000.9902_RF6","first-page":"341","article-title":"Histogenesis of the supraoptic and paraventricular neurosecretory cells of the mouse hypothalamus","volume":"130","author":"Karim","year":"1980","journal-title":"J. Anat."},{"key":"10.1006\/dbio.2000.9902_RF7","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1210\/endo.134.6.8194481","article-title":"Differential expression of corticotropin-releasing hormone in developing mouse embryos and adult brain","volume":"134","author":"Keegan","year":"1994","journal-title":"Endocrinology"},{"key":"10.1006\/dbio.2000.9902_RF8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/j.1460-2075.1996.tb00407.x","article-title":"Gsh-1, an orphan Hox gene, is required for normal pituitary development","volume":"15","author":"Li","year":"1996","journal-title":"EMBO J."},{"key":"10.1006\/dbio.2000.9902_RF9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/347528a0","article-title":"Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1","volume":"347","author":"Li","year":"1990","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9902_RF10","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2144\/97235st03","article-title":"Dicistronic lacZ and alkaline phosphatase reporter constructs permit simultaneous histological analysis of expression from multiple transgenes","volume":"23","author":"Li","year":"1997","journal-title":"BioTechniques"},{"key":"10.1006\/dbio.2000.9902_RF11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/geno.1999.5882","article-title":"Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)","volume":"60","author":"Lin","year":"1999","journal-title":"Genomics"},{"key":"10.1006\/dbio.2000.9902_RF12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/359835a0","article-title":"Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene","volume":"359","author":"Lufkin","year":"1992","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9902_RF13","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1101\/gad.12.20.3264","article-title":"Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1","volume":"12","author":"Michaud","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9902_RF14","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1101\/gad.9.24.3109","article-title":"The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse","volume":"9","author":"Nakai","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9902_RF15","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1242\/dev.121.12.4045","article-title":"Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development","volume":"121","author":"Oliver","year":"1995","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9902_RF16","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1523\/JNEUROSCI.19-14-05980.1999","article-title":"Targeted mutagenesis of the POU-domain gene Brn4\/Pou3f4 causes developmental defects in the inner ear","volume":"19","author":"Phippard","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/dbio.2000.9902_RF17","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1101\/gad.9.24.3122","article-title":"Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2","volume":"9","author":"Schonemann","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9902_RF18","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.272.5264.1004","article-title":"Specification of pituitary cell lineages by the LIM homeobox gene Lhx3","volume":"272","author":"Sheng","year":"1996","journal-title":"Science"},{"key":"10.1006\/dbio.2000.9902_RF19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-4886(73)90187-8","article-title":"Time of neuron origin in mouse hypothalamic nuclei","volume":"41","author":"Shimada","year":"1973","journal-title":"Exp. Neurol."},{"key":"10.1006\/dbio.2000.9902_RF20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0896-6273(94)90461-8","article-title":"Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila","volume":"13","author":"Simeone","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/dbio.2000.9902_RF21","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1073\/pnas.89.23.11579","article-title":"Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4","volume":"89","author":"Stadler","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2000.9902_RF22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.ne.06.030183.001413","article-title":"Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei","volume":"6","author":"Swanson","year":"1983","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1006\/dbio.2000.9902_RF23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1101\/gad.13.4.484","article-title":"Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development","volume":"13","author":"Szeto","year":"1999","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9902_RF24","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1073\/pnas.93.15.7706","article-title":"P-OTX: A PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development","volume":"93","author":"Szeto","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2000.9902_RF25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0378-1119(97)00520-9","article-title":"Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe","volume":"203","author":"Tribioli","year":"1997","journal-title":"Gene"},{"key":"10.1006\/dbio.2000.9902_RF26","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1242\/dev.126.24.5699","article-title":"The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen","volume":"126","author":"Tribioli","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9902_RF27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1046\/j.1440-169X.1997.t01-5-00008.x","article-title":"A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain","volume":"39","author":"Umesono","year":"1997","journal-title":"Dev. Growth Differen."},{"key":"10.1006\/dbio.2000.9902_RF28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s003359900494","article-title":"Otp maps to mouse Chromosome 13","volume":"8","author":"Wang","year":"1997","journal-title":"Mammal. Genome"},{"key":"10.1006\/dbio.2000.9902_RF29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dev.125.4.621","article-title":"Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene","volume":"125","author":"Wang","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9902_RF30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/aja.1002020405","article-title":"Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues","volume":"202","author":"Zhadanov","year":"1995","journal-title":"Dev. Dynam."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160600999020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160600999020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T22:32:05Z","timestamp":1619994725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160600999020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0012160600999020"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2000.9902","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}