{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:03:19Z","timestamp":1772794999827,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4580,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1006\/dbio.2000.9978","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"480-493","source":"Crossref","is-referenced-by-count":29,"title":["The Caenorhabditis elegans peb-1 Gene Encodes a Novel DNA-Binding Protein Involved in Morphogenesis of the Pharynx, Vulva, and Hindgut"],"prefix":"10.1016","volume":"229","author":[{"given":"Jack D.","family":"Thatcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony P.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Beaster-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Haun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Okkema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2000.9978_RF1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0012-1606(88)90138-8","article-title":"Mutants of Caenorhabditis elegans that form dauer-like larvae","volume":"126","author":"Albert","year":"1988","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1098\/rstb.1976.0085","article-title":"The pharynx of Caenorhabditis elegans","volume":"275","author":"Albertson","year":"1976","journal-title":"Philos. Trans. R. Soc. London B Biol. Sci."},{"key":"10.1006\/dbio.2000.9978_RF3","series-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"1990"},{"key":"10.1006\/dbio.2000.9978_RF4","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1101\/gad.10.15.1953","article-title":"The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein","volume":"10","author":"Basson","year":"1996","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9978_RF5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1242\/dev.116.3.755","article-title":"Characterization of a germ-line proliferation mutation in C. elegans","volume":"116","author":"Beanan","year":"1992","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF6","series-title":"C. elegans II","article-title":"RNA processing and gene structure","author":"Blumenthal","year":"1997"},{"key":"10.1006\/dbio.2000.9978_RF7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0070-2153(08)60453-6","article-title":"Maternal control of pattern formation in early Caenorhabditis elegans embryos","volume":"39","author":"Bowerman","year":"1998","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/genetics\/155.1.141","article-title":"Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila","volume":"155","author":"Buchner","year":"2000","journal-title":"Genetics"},{"key":"10.1006\/dbio.2000.9978_RF9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/genetics\/153.2.731","article-title":"Characterization of seven genes affecting Caenorhabditis elegans hindgut development","volume":"153","author":"Chamberlin","year":"1999","journal-title":"Genetics"},{"key":"10.1006\/dbio.2000.9978_RF10","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1242\/dev.124.20.3919","article-title":"The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans","volume":"124","author":"Chamberlin","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1242\/dev.127.4.713","article-title":"The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans","volume":"127","author":"Chamberlin","year":"2000","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.61.070192.004341","article-title":"Zinc proteins: Enzymes, storage proteins, transcription factors, and replication proteins","volume":"61","author":"Coleman","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1006\/dbio.2000.9978_RF13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0959-437X(99)00015-5","article-title":"Combinatorial codes in signaling and synergy: Lessons from pituitary development","volume":"9","author":"Dasen","year":"1999","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2000.9978_RF14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/1050-3862(92)90042-4","article-title":"Histochemical techniques for locating Escherichia coli beta-galactosidase activity in transgenic organisms","volume":"9","author":"Fire","year":"1992","journal-title":"Genet. Anal. Tech. Appl."},{"key":"10.1006\/dbio.2000.9978_RF15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-1119(90)90224-F","article-title":"A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans","volume":"93","author":"Fire","year":"1990","journal-title":"Gene"},{"key":"10.1006\/dbio.2000.9978_RF16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1006\/dbio.2000.9978_RF17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0092-8674(00)80944-7","article-title":"Polycomb and trithorax group proteins mediate the function of a chromatin insulator","volume":"92","author":"Gerasimova","year":"1998","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9978_RF18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(95)90031-4","article-title":"A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation","volume":"82","author":"Gerasimova","year":"1995","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9978_RF19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1006\/dbio.2000.9774","article-title":"sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox","volume":"224","author":"Grant","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF20","series-title":"Antibodies: A Laboratory Manual","author":"Harlow","year":"1988"},{"key":"10.1006\/dbio.2000.9978_RF21","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/MCB.17.5.2835","article-title":"Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins","volume":"17","author":"Harvey","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/dbio.2000.9978_RF22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/scdb.1998.0277","article-title":"Seeking a regulatory roadmap for heart morphogenesis","volume":"10","author":"Harvey","year":"1999","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF23","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/nbt1188-1321","article-title":"Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent","volume":"6","author":"Hochuli","year":"1990","journal-title":"Bio\/Technology"},{"key":"10.1006\/dbio.2000.9978_RF24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0092-8674(00)80562-0","article-title":"Morphogenesis","volume":"96","author":"Hogan","year":"1999","journal-title":"Cell"},{"key":"10.1006\/dbio.2000.9978_RF25","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1101\/gad.12.13.1947","article-title":"pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans","volume":"12","author":"Horner","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9978_RF26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1242\/dev.125.12.2171","article-title":"pha-4 is Ce-fkh-1, a fork head\/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx","volume":"125","author":"Kalb","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF27","series-title":"Caenorhabditis elegans: Modern Biological Analysis of an Organism","first-page":"4","article-title":"Basic culture methods","author":"Lewis","year":"1995"},{"key":"10.1006\/dbio.2000.9978_RF28","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1242\/dev.120.10.3019","article-title":"The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans","volume":"120","author":"Mango","year":"1994","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF29","series-title":"Caenorhabditis elegans: Modern Biological Analysis of an Organism","first-page":"451","article-title":"DNA transformation","author":"Mello","year":"1995"},{"key":"10.1006\/dbio.2000.9978_RF30","series-title":"Caenorhabditis elegans: Modern Biological Analysis of an Organism","first-page":"365","article-title":"Immunofluorescence microscopy","author":"Miller","year":"1995"},{"key":"10.1006\/dbio.2000.9978_RF31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0888-7543(05)80111-9","article-title":"A knowledge base for predicting protein localization sites in eukaryotic cells","volume":"14","author":"Nakai","year":"1992","journal-title":"Genomics"},{"key":"10.1006\/dbio.2000.9978_RF32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2443.1999.00264.x","article-title":"kel-1, a novel Kelch-related gene in Caenorhabditis elegans, is expressed in pharyngeal gland cells and is required for the feeding process","volume":"4","author":"Ohmachi","year":"1999","journal-title":"Genes Cells"},{"key":"10.1006\/dbio.2000.9978_RF33","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1242\/dev.120.8.2175","article-title":"The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle","volume":"120","author":"Okkema","year":"1994","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF34","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1242\/dev.124.20.3965","article-title":"The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development","volume":"124","author":"Okkema","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/genetics\/135.2.385","article-title":"Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans","volume":"135","author":"Okkema","year":"1993","journal-title":"Genetics"},{"key":"10.1006\/dbio.2000.9978_RF36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-9525(99)01916-2","article-title":"TGF beta-related pathways. Roles in Caenorhabditis elegans development","volume":"16","author":"Patterson","year":"2000","journal-title":"Trends Genet."},{"key":"10.1006\/dbio.2000.9978_RF37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(96)10031-1","article-title":"PEST sequences and regulation by proteolysis","volume":"21","author":"Rechsteiner","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1006\/dbio.2000.9978_RF38","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1101\/gad.2.5.606","article-title":"Molecular cloning and transcript analysis of fem-3, a sex-determination gene in Caenorhabditis elegans","volume":"2","author":"Rosenquist","year":"1988","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2000.9978_RF39","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1093\/nar\/20.14.3783","article-title":"Caenorhabditis cDNA encodes an eIF-4A-like protein","volume":"20","author":"Roussell","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/dbio.2000.9978_RF40","series-title":"Caenorhabditis elegans: Modern Biological Analysis of an Organism","first-page":"323","article-title":"Whole mount in situ hybridization for the detection of RNA in Caenorhabditis elegans embryos","author":"Seydoux","year":"1995"},{"key":"10.1006\/dbio.2000.9978_RF41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(83)90201-4","article-title":"The embryonic cell lineage of the nematode Caenorhabditis elegans","volume":"100","author":"Sulston","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2000.9978_RF43","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/72850","article-title":"Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes","volume":"24","author":"Tavernarakis","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1006\/dbio.2000.9978_RF44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1242\/dev.126.1.97","article-title":"The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx","volume":"126","author":"Thatcher","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2000.9978_RF45","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/dna.1995.14.869","article-title":"Promoter binding factors regulating cyclin B transcription in the sea urchin embryo","volume":"14","author":"Thatcher","year":"1995","journal-title":"DNA Cell Biol."},{"key":"10.1006\/dbio.2000.9978_RF46","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0959-437X(95)80007-7","article-title":"Structure and function of transcriptional activation domains","volume":"5","author":"Triezenberg","year":"1995","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2000.9978_RF47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biophys.29.1.183","article-title":"DNA recognition by Cys2His2 zinc finger proteins","volume":"29","author":"Wolfe","year":"2000","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1006\/dbio.2000.9978_RF48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0959-437X(98)80006-3","article-title":"Early liver differentiation: Genetic potentiation and multilevel growth control","volume":"8","author":"Zaret","year":"1998","journal-title":"Curr. Opin. Genet. Dev."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160600999780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160600999780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T04:19:44Z","timestamp":1620015584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160600999780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0012160600999780"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2000.9978","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}