{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:47:34Z","timestamp":1790246854800,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4429,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1006\/dbio.2001.0249","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"188-203","source":"Crossref","is-referenced-by-count":51,"title":["Functions of the Growth Arrest Specific 1 Gene in the Development of the Mouse Embryo"],"prefix":"10.1016","volume":"234","author":[{"given":"K.K.H.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.Q.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brancolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2001.0249_RF1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000134649","article-title":"Fine mapping of the hereditary sensory neuropathy type I locus on chromosome 8q22.1 \u2192 q22.3: Exclusion of GAS1 and XPA","volume":"78","author":"Blair","year":"1997","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1006\/dbio.2001.0249_RF2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0962-8924(98)01251-3","article-title":"Control of cell proliferation by Myc","volume":"8","author":"Bouchard","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1006\/dbio.2001.0249_RF3","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1083\/jcb.117.6.1251","article-title":"Gas2, a growth arrest-specific protein, is a component of microfilament network system","volume":"117","author":"Brancolini","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1006\/dbio.2001.0249_RF4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.124.5.743","article-title":"Phosphorylation of the growth arrest-specific protein Gas2 is coupled to actin rearrangements during G0 \u2192 G1 transition in NIH 3T3 cells","volume":"124","author":"Brancolini","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1006\/dbio.2001.0249_RF5","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1002\/j.1460-2075.1995.tb00202.x","article-title":"Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases","volume":"14","author":"Brancolini","year":"1995","journal-title":"EMBO J."},{"key":"10.1006\/dbio.2001.0249_RF6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0012-1606(91)90477-K","article-title":"Gap junctional communication during limb cartilage differentiation","volume":"144","author":"Caroline","year":"1991","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/excr.1994.1078","article-title":"Expression of growth arrest-specific (gas) genes in senescent murine cells","volume":"211","author":"Cowled","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1006\/dbio.2001.0249_RF8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0091-679X(08)60631-7","article-title":"Micromass cultures of limb and other mesenchyme","volume":"51","author":"Daniels","year":"1996","journal-title":"Methods Cell Biol."},{"key":"10.1006\/dbio.2001.0249_RF9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0092-8674(92)90429-G","article-title":"The growth arrest specific gene gas 1 is involved in growth suppression","volume":"70","author":"Del Sal","year":"1992","journal-title":"Cell"},{"key":"10.1006\/dbio.2001.0249_RF10","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1073\/pnas.91.5.1848","article-title":"Structure, function, and chromsome mapping of the growth-suppressing human homologue of the murine gas1 gene","volume":"91","author":"Del Sal","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2001.0249_RF11","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1128\/MCB.15.12.7152","article-title":"Gas1-induced growth suppression requires a transactivation-independent p53 function","volume":"15","author":"Del Sal","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1006\/dbio.2001.0249_RF12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF01002714","article-title":"Golgi orientation and cell behaviour in the developing pattern of chondrogenic condensations in chick limb bud mesenchyme","volume":"13","author":"Ede","year":"1981","journal-title":"Histochem. J."},{"key":"10.1006\/dbio.2001.0249_RF13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/excr.1998.4011","article-title":"Growth-regulatory activity of the growth arrest-specific gene gas1, in NIH3T3 fibroblasts","volume":"240","author":"Evdokiou","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1006\/dbio.2001.0249_RF14","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/(SICI)1097-0215(19980209)75:4<568::AID-IJC13>3.0.CO;2-5","article-title":"Tumor-suppressive activity of the growth arrest-specific gene, gas1 in human tumor cell lines","volume":"75","author":"Evdokiou","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1006\/dbio.2001.0249_RF15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0168-9525(99)01719-9","article-title":"NF-kappaB to the rescue: RELs, apoptosis and cellular transformation","volume":"15","author":"Foo","year":"1999","journal-title":"Trends Genet."},{"key":"10.1006\/dbio.2001.0249_RF16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0012-1606(89)90133-4","article-title":"The mechanism of precartilage mesenchymal condensation: A major role for interaction of the cell surface with the amino-terminal heparin-binding domain of fibronectin","volume":"136","author":"Frenz","year":"1989","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF17","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/emboj\/16.6.1381","article-title":"Transgenic mouse model for studying the transcriptional activity of the p53 protein: Age- and tissue-dependent changes in radiation-induced activation during embryogenesis","volume":"16","author":"Gottlieb","year":"1997","journal-title":"EMBO J."},{"key":"10.1006\/dbio.2001.0249_RF18","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/sj.onc.1202090","article-title":"Role of gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src","volume":"17","author":"Grossi","year":"1998","journal-title":"Oncogene"},{"key":"10.1006\/dbio.2001.0249_RF19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0959-437X(96)90011-8","article-title":"Cdk inhibitors in development and cancer","volume":"6","author":"Harper","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2001.0249_RF20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/33429","article-title":"Role of Rel\/NF-kappaB transcription factors during the outgrowth of the vertebrate limb","volume":"392","author":"Kanegae","year":"1998","journal-title":"Nature"},{"key":"10.1006\/dbio.2001.0249_RF21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/aja.1002010402","article-title":"Influence of digits, ectoderm, and retinoic acid on chondrogenesis by mouse interdigital mesoderm in culture","volume":"201","author":"Lee","year":"1994","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.2001.0249_RF22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/dbio.1998.9086","article-title":"Gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb","volume":"207","author":"Lee","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF23","doi-asserted-by":"crossref","first-page":"12886","DOI":"10.1073\/pnas.94.24.12886","article-title":"Myc represses transcription of the growth arrest gene gas1","volume":"94","author":"Lee","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2001.0249_RF24","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1523\/JNEUROSCI.16-06-02012.1996","article-title":"Identification of gas6 as a growth factor for human schwann cells","volume":"16","author":"Li","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/dbio.2001.0249_RF25","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/art.1780400814","article-title":"Human chondrocytes expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: Potential role in autocrine signaling in cartilage","volume":"40","author":"Loeser","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1006\/dbio.2001.0249_RF26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/dbio.1997.8666","article-title":"Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development","volume":"189","author":"Louvi","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00187925","article-title":"In vivo inhibition of programmed cell death by local administration of FGF-2 and FGF-4 in the interdigital areas of the embryonic chick leg bud","volume":"193","author":"Macias","year":"1996","journal-title":"Anat. Embryol."},{"key":"10.1006\/dbio.2001.0249_RF28","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/dev.124.6.1109","article-title":"Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development","volume":"124","author":"Macias","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2001.0249_RF29","first-page":"1213","article-title":"Protein kinase A and AP-1 (c-Fos\/JunD) are induced during apoptosis of mouse mammary epithelial cells","volume":"9","author":"Marti","year":"1994","journal-title":"Oncogene"},{"key":"10.1006\/dbio.2001.0249_RF30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/dbio.1998.8946","article-title":"Morphogenesis of digits in the avian limb is controlled by FGFs, TGF\u03b2s, and noggin through BMP signaling","volume":"200","author":"Merino","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/bj3230387","article-title":"Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: Contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells","volume":"323","author":"Nakano","year":"1997","journal-title":"Biochem. J."},{"key":"10.1006\/dbio.2001.0249_RF32","doi-asserted-by":"crossref","first-page":"5672","DOI":"10.1073\/pnas.95.10.5672","article-title":"Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2","volume":"95","author":"Ortega","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2001.0249_RF33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.122.1.1","article-title":"Programmed cell death in the absence of c-Fos and c-Jun","volume":"122","author":"Roffler-Tarlov","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2001.0249_RF34","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1073\/pnas.94.9.4675","article-title":"A proline-rich motif in p53 is required for transactivation-dependent growth arrest as induced by Gas1","volume":"94","author":"Ruaro","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2001.0249_RF35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.cellbio.12.1.697","article-title":"RDG and recognition sequences for integrins","volume":"12","author":"Ruoslahi","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF36","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(88)91065-3","article-title":"Genes specifically expressed at growth arrest of mammalian cells","volume":"54","author":"Schneider","year":"1988","journal-title":"Cell"},{"key":"10.1006\/dbio.2001.0249_RF37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1126\/science.284.5412.313","article-title":"Limb and skin abnormalities in mice lacking IKKalpha","volume":"284","author":"Takeda","year":"1999","journal-title":"Science"},{"key":"10.1006\/dbio.2001.0249_RF38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/dbio.1999.9578","article-title":"Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues","volume":"218","author":"Tang","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/6350","article-title":"Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis","volume":"2","author":"Vaccarino","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1006\/dbio.2001.0249_RF40","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0888-7543(05)80267-8","article-title":"Assignment, by in situ hybridization, of the growth arrest-specific gene, Gas-1, to mouse chromosome 13 and bands B3\u2013C2","volume":"14","author":"Webb","year":"1992","journal-title":"Genomics"},{"key":"10.1006\/dbio.2001.0249_RF41","first-page":"597","article-title":"Effect of platelet-derived growth factor isoforms on the migration of mouse embryo limb myogenic cells","volume":"41","author":"Webb","year":"1997","journal-title":"Int. J. Dev. Biol."},{"key":"10.1006\/dbio.2001.0249_RF42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-0177(199706)209:2<206::AID-AJA6>3.0.CO;2-M","article-title":"Fibroblast growth factor 2 and 4 stimulate migration of mouse embryonic limb myogenic cells","volume":"209","author":"Webb","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.2001.0249_RF43","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1242\/dev.122.12.3725","article-title":"BMP-2\/-4 mediate programmed cell death in chicken limb buds","volume":"122","author":"Yokouchi","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2001.0249_RF44","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.272.5262.738","article-title":"Requirement for BMP signaling in interdigital apoptosis and scale formation","volume":"272","author":"Zou","year":"1996","journal-title":"Science"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160601902490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160601902490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T04:40:44Z","timestamp":1620016844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160601902490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S0012160601902490"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2001.0249","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}