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Chem."},{"key":"10.1006\/dbio.2001.0500_RF82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/350081a0","article-title":"Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud","volume":"350","author":"Wanek","year":"1991","journal-title":"Nature"},{"key":"10.1006\/dbio.2001.0500_RF83","series-title":"In Situ Hybridization: A Practical Approach","first-page":"75","article-title":"Whole-mount in situ hybridization of vertebrate embryos","author":"Wilkinson","year":"1992"},{"key":"10.1006\/dbio.2001.0500_RF84","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1242\/dev.124.21.4393","article-title":"Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb","volume":"124","author":"Yang","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2001.0500_RF85","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(91)90512-W","article-title":"Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor","volume":"64","author":"Yayon","year":"1991","journal-title":"Cell"},{"key":"10.1006\/dbio.2001.0500_RF86","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s004410051262","article-title":"Hox genes in digit development and evolution","volume":"296","author":"Zakany","year":"1999","journal-title":"Cell Tissue Res."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160601905007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160601905007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T23:30:27Z","timestamp":1619998227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160601905007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0012160601905007"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2001.0500","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1004546.50454","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}