{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:47:05Z","timestamp":1791902825281,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4125,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1006\/dbio.2002.0606","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"226-242","source":"Crossref","is-referenced-by-count":135,"title":["Reciprocal Regulatory Interactions between the Notch and Ras Signaling Pathways in the Drosophila Embryonic Mesoderm"],"prefix":"10.1016","volume":"244","author":[{"given":"Ana","family":"Carmena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Buff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Halfon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Gisselbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Baylies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Michelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2002.0606_RF1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: Cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0606_RF2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1242\/dev.122.2.617","article-title":"Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila","volume":"122","author":"Baker","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1242\/dev.119.Supplement.149","article-title":"A dual requirement for neurogenic genes in Drosophila myogenesis","author":"Bate","year":"1993","journal-title":"Dev."},{"key":"10.1006\/dbio.2002.0606_RF4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0959-437X(00)00214-8","article-title":"Invertebrate myogenesis: Looking back to the future of muscle development","volume":"11","author":"Baylies","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2002.0606_RF5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1055642","article-title":"Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development","volume":"291","author":"Berset","year":"2001","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0606_RF6","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1101\/gad.14.12.1498","article-title":"Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion","volume":"14","author":"Bour","year":"2000","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0606_RF7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0960-9822(99)80313-3","article-title":"Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila","volume":"9","author":"Brennan","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1006\/dbio.2002.0606_RF9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/370386a0","article-title":"The Ets domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway","volume":"370","author":"Brunner","year":"1994","journal-title":"Nature"},{"key":"10.1006\/dbio.2002.0606_RF10","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1242\/dev.125.11.2075","article-title":"Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors","volume":"125","author":"Buff","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF11","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1101\/gad.9.19.2373","article-title":"lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis","volume":"9","author":"Carmena","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0606_RF12","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1101\/gad.12.24.3910","article-title":"Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm","volume":"12","author":"Carmena","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0606_RF13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1101\/gad.12.3.304","article-title":"inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis","volume":"12","author":"Carmena","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0606_RF14","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0960-9822(00)00826-5","article-title":"R7 photoreceptor specification requires Notch activity","volume":"10","author":"Cooper","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1006\/dbio.2002.0606_RF15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0092-8674(91)90183-Y","article-title":"A role for the Drosophila neurogenic genes in mesoderm differentiation","volume":"67","author":"Corbin","year":"1991","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1242\/dev.128.2.299","article-title":"The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning","volume":"128","author":"Cul\u0131&#x0301;","year":"2001","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF17","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1242\/dev.124.10.1919","article-title":"Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing","volume":"124","author":"de Celis","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF18","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/dev.127.6.1291","article-title":"The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe","volume":"127","author":"de Celis","year":"2000","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF19","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1038\/sj.onc.1203766","article-title":"Ras pathway signals are required for notch-mediated oncogenesis","volume":"19","author":"Fitzgerald","year":"2000","journal-title":"Oncogene"},{"key":"10.1006\/dbio.2002.0606_RF20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0959-437X(99)00014-3","article-title":"Controls in patterning and diversification of somatic muscle during Drosophila embryogenesis","volume":"9","author":"Frasch","year":"1999","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2002.0606_RF21","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/dev.120.8.2297","article-title":"Misexpression of the Drosophila argos gene, a secreted regulator of cell determination","volume":"120","author":"Freeman","year":"1994","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/35042500","article-title":"Feedback control of intercellular signalling in development","volume":"408","author":"Freeman","year":"2000","journal-title":"Nature"},{"key":"10.1006\/dbio.2002.0606_RF23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0092-8674(92)90615-J","article-title":"The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye","volume":"69","author":"Freeman","year":"1992","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/dbio.1998.8944","article-title":"Multiple roles for Notch in Drosophila myogenesis","volume":"201","author":"Fuerstenberg","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0606_RF25","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1242\/dev.124.18.3535","article-title":"MAP kinase in situ activation atlas during Drosophila embryogenesis","volume":"124","author":"Gabay","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1242\/dev.122.1.223","article-title":"argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop","volume":"122","author":"Golembo","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF27","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.12.12.1751","article-title":"LIN-12\/Notch signaling: Lessons from worms and flies","volume":"12","author":"Greenwald","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0606_RF28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0092-8674(00)00105-7","article-title":"Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors","volume":"103","author":"Halfon","year":"2000","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.122.1.161","article-title":"Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila","volume":"122","author":"Heitzler","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0092-8674(91)90263-X","article-title":"The choice of cell fate in the epidermis of Drosophila","volume":"64","author":"Heitzler","year":"1991","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF31","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.124.17.3283","article-title":"Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis","volume":"124","author":"Huppert","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF32","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1242\/dev.126.20.4455","article-title":"Interplay of Notch anf FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea","volume":"126","author":"Ikeya","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/genetics\/152.1.307","article-title":"stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells","volume":"152","author":"Imam","year":"1999","journal-title":"Genetics"},{"key":"10.1006\/dbio.2002.0606_RF34","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1242\/dev.125.22.4531","article-title":"Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila","volume":"125","author":"Jacobsen","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0092-8674(00)00112-4","article-title":"Signaling networks: The origins of cellular multitasking","volume":"103","author":"Jordan","year":"2000","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF36","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1091\/mbc.9.7.1709","article-title":"Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development","volume":"9","author":"Klueg","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1006\/dbio.2002.0606_RF37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0092-8674(01)00265-3","article-title":"EGF receptor and Notch signaling act upstream of Eyeless\/Pax6 to control eye specification","volume":"104","author":"Kumar","year":"2001","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF38","doi-asserted-by":"crossref","first-page":"10139","DOI":"10.1073\/pnas.91.21.10139","article-title":"Lateral inhibition mediated by the Drosophila neurogenic gene Delta is enhanced by proneural proteins","volume":"91","author":"Kunisch","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/dbio.2002.0606_RF39","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1242\/dev.125.16.3101","article-title":"LIN-12 protein expression and localization during vulval development in C. elegans","volume":"125","author":"Levitan","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF40","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1242\/dev.125.22.4379","article-title":"Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila","volume":"125","author":"Michelson","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<212::AID-DVG4>3.0.CO;2-9","article-title":"Dual functions of the Heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm","volume":"22","author":"Michelson","year":"1998","journal-title":"Dev. Genet."},{"key":"10.1006\/dbio.2002.0606_RF42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0092-8674(94)90580-0","article-title":"The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras\/MAPK pathway","volume":"78","author":"O'Neill","year":"1994","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<201::AID-DVG3>3.0.CO;2-A","article-title":"Dual role for the zeste-white3\/shaggy-encoded kinase in mesoderm and heart development of Drosophila","volume":"22","author":"Park","year":"1998","journal-title":"Dev. Genet."},{"key":"10.1006\/dbio.2002.0606_RF44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0925-4773(98)00098-7","article-title":"Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch and sanpodo","volume":"75","author":"Park","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2002.0606_RF45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0925-4773(97)00675-8","article-title":"The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster","volume":"63","author":"Parks","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2002.0606_RF46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)80710-2","article-title":"Negative feedback mechanisms and their roles during pattern formation","volume":"97","author":"Perrimon","year":"1999","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF47","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/genetics\/147.3.1139","article-title":"Dominant enhancers of Egfr in Drosophila melanogaster: Genetic links between Notch and Egfr signaling pathways","volume":"147","author":"Price","year":"1997","journal-title":"Genetics"},{"key":"10.1006\/dbio.2002.0606_RF48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.283.5398.91","article-title":"Processing of the Notch ligand Delta by the metalloprotease Kuzbanian","volume":"283","author":"Qi","year":"1999","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0606_RF49","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1242\/dev.124.23.4857","article-title":"Segregation of myogenic lineages in Drosophila requires Numb","volume":"124","author":"Ruiz Gomez","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0092-8674(00)00024-6","article-title":"Drosophila Dumbfounded: A myoblast attractant essential for fusion","volume":"102","author":"Ruiz Gomez","year":"2000","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/376699a0","article-title":"Inhibition of Drosophila EGF receptor activation by the secreted protein Argos","volume":"376","author":"Schweitzer","year":"1995","journal-title":"Nature"},{"key":"10.1006\/dbio.2002.0606_RF52","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1242\/dev.125.23.4777","article-title":"Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina","volume":"125","author":"Spencer","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0606_RF53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00291041","article-title":"A nonradioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals a translational control of the segmentation gene hunchback","volume":"98","author":"Tautz","year":"1989","journal-title":"Chromosoma"},{"key":"10.1006\/dbio.2002.0606_RF54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/dbio.1996.0157","article-title":"Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila","volume":"177","author":"Tepass","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0606_RF55","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1097-2765(01)00196-4","article-title":"Delta\/Notch and Boss\/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor","volume":"7","author":"Tomlinson","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2002.0606_RF56","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/genetics\/144.3.1127","article-title":"Analysis of dominant enhancers and suppressors of activated Notch in Drosophila","volume":"144","author":"Verheyen","year":"1996","journal-title":"Genetics"},{"key":"10.1006\/dbio.2002.0606_RF57","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1097-2765(00)80151-3","article-title":"The Drosophila protein Dof is specifically required for FGF signaling","volume":"2","author":"Vincent","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2002.0606_RF58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0070-2153(01)51006-6","article-title":"Pattern formation during C. elegans vulval induction","volume":"51","author":"Wang","year":"2001","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1006\/dbio.2002.0606_RF59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81767-5","article-title":"An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg","volume":"95","author":"Wasserman","year":"1998","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF60","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0092-8674(94)90010-8","article-title":"Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision","volume":"79","author":"Wilkinson","year":"1994","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0606_RF61","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1242\/dev.126.14.3149","article-title":"Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors","volume":"126","author":"zur Lage","year":"1999","journal-title":"Development"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160602906068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160602906068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T06:26:11Z","timestamp":1680589571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160602906068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0012160602906068"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2002.0606","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}