{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:55:47Z","timestamp":1791158147678,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3972,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1006\/dbio.2002.0752","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:48Z","timestamp":1032191148000},"page":"108-120","source":"Crossref","is-referenced-by-count":129,"title":["In Vivo Evidence That BMP Signaling Is Necessary for Apoptosis in the Mouse Limb"],"prefix":"10.1016","volume":"249","author":[{"given":"Udayan","family":"Guha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Pestell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/dbio.2002.0752_RF1","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1242\/dev.128.22.4449","article-title":"BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb","volume":"128","author":"Ahn","year":"2001","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/5.7.945","article-title":"Genomic structure of HOXD 13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families","volume":"5","author":"Akarsu","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/dbio.2002.0752_RF3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/dev.127.3.605","article-title":"Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity","volume":"127","author":"Baur","year":"2000","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF4","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.280.5368.1455","article-title":"Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton","volume":"280","author":"Brunet","year":"1998","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0752_RF5","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1128\/MCB.13.6.3176","article-title":"Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice","volume":"13","author":"Byrne","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/dbio.2002.0752_RF6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/dbio.1997.8824","article-title":"Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning","volume":"197","author":"Capdevila","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1097-2765(00)80393-7","article-title":"Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin","volume":"4","author":"Capdevila","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2002.0752_RF8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(00)81732-8","article-title":"Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development","volume":"94","author":"Cecconi","year":"1998","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0752_RF9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S","article-title":"Shaping limbs by apoptosis","volume":"282","author":"Chen","year":"1998","journal-title":"J. Exp. Zool."},{"key":"10.1006\/dbio.2002.0752_RF10","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1101\/gad.6.8.1444","article-title":"Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice","volume":"6","author":"Cheng","year":"1992","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.289.5478.438","article-title":"Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling","volume":"289","author":"Dahn","year":"2000","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0752_RF12","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.122.4.1175","article-title":"A mutational analysis of the 5\u2032 HoxD genes: Dissection of genetic interactions during limb development in the mouse","volume":"122","author":"Davis","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF13","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1210\/endo.136.6.7750489","article-title":"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis","volume":"136","author":"Dewulf","year":"1995","journal-title":"Endocrinology"},{"key":"10.1006\/dbio.2002.0752_RF14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(93)90378-4","article-title":"Disruption of the HoxD13 gene induces localized heterochrony leading to mice with neotenic limbs","volume":"75","author":"Dolle","year":"1993","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0752_RF15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0959-437X(00)00101-5","article-title":"Constructive antagonism in limb development","volume":"10","author":"Dudley","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2002.0752_RF16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/dbio.1998.9176","article-title":"Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods","volume":"208","author":"Dupe","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0925-4773(96)00540-0","article-title":"Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb","volume":"57","author":"Duprez","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2002.0752_RF18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/dbio.1998.8880","article-title":"Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis","volume":"197","author":"Ferrari","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s004410051272","article-title":"BMP\/GDF-signalling interactions during synovial joint development","volume":"296","author":"Francis-West","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1006\/dbio.2002.0752_RF20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/dbio.1997.8843","article-title":"Morphological diversity of the avian foot is related with the pattern of msx gene expression in the developing autopod","volume":"196","author":"Ganan","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/dbio.2001.0344","article-title":"Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts","volume":"237","author":"Gomes","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/372684a0","article-title":"The signaling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest","volume":"372","author":"Graham","year":"1994","journal-title":"Nature"},{"key":"10.1006\/dbio.2002.0752_RF23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0959-437X(96)80064-5","article-title":"Bone morphogenetic proteins in development","volume":"6","author":"Hogan","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1006\/dbio.2002.0752_RF24","series-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Hogan","year":"1994"},{"key":"10.1006\/dbio.2002.0752_RF25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.125.2.161","article-title":"The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot","volume":"125","author":"Jernvall","year":"1998","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF26","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1242\/dev.122.11.3557","article-title":"BMP signaling during bone pattern determination in the developing limb","volume":"122","author":"Kawakami","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF27","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1242\/dev.122.9.2651","article-title":"Function of posterior HoxD genes in the morphogenesis of the anal sphinctor","volume":"122","author":"Kondo","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1097-2765(00)80029-5","article-title":"Control of colinearity in AbdB genes of the mouse HoxD complex","volume":"1","author":"Kondo","year":"1997","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2002.0752_RF29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/aja.1001940107","article-title":"Talpid2 limb bud mesoderm does not express Ghox-8 and has analteredexpression pattern of GHox-7","volume":"194","author":"Krabbenhoft","year":"1992","journal-title":"Dev. Dyn."},{"key":"10.1006\/dbio.2002.0752_RF30","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(94)90030-2","article-title":"Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud","volume":"79","author":"Laufer","year":"1994","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0752_RF31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1126\/science.278.5336.305","article-title":"BMP expression in duck interdigital webbing: A reanalysis","volume":"278","author":"Laufer","year":"1997","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0752_RF32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(95)90276-7","article-title":"Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm","volume":"82","author":"Liem","year":"1995","journal-title":"Cell"},{"key":"10.1006\/dbio.2002.0752_RF33","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S1097-2765(00)00136-2","article-title":"The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues","volume":"6","author":"Lindsten","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1006\/dbio.2002.0752_RF34","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1101\/gad.9.22.2808","article-title":"BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning","volume":"9","author":"Luo","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF35","first-page":"555","article-title":"Interdigital soft tissue seperation induced by retinoic acid in mouse limbs cultured in vitro","volume":"37","author":"Lussier","year":"1993","journal-title":"Int. J. Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0925-4773(94)00326-I","article-title":"Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development","volume":"50","author":"Lyons","year":"1995","journal-title":"Mech. Dev."},{"key":"10.1006\/dbio.2002.0752_RF37","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/dev.124.6.1109","article-title":"Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development","volume":"124","author":"Macias","year":"1997","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/dbio.1997.8576","article-title":"Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway","volume":"186","author":"Marazzi","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF39","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1101\/gad.12.11.1571","article-title":"The role of FGFs in the early development of vertebrate limbs","volume":"12","author":"Martin","year":"1998","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/dbio.1998.8946","article-title":"Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling","volume":"200","author":"Merino","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF41","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.126.10.2161","article-title":"Control of digit formation by activin signalling","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF42","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1242\/dev.126.23.5515","article-title":"The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF43","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1101\/gad.9.24.3027","article-title":"Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis","volume":"9","author":"Mishina","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/82601","article-title":"Fgf8 is required for outgrowth and patterning of the limbs","volume":"26","author":"Moon","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1006\/dbio.2002.0752_RF45","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.272.5261.548","article-title":"Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13","volume":"272","author":"Muragaki","year":"1996","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0752_RF46","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/371609a0","article-title":"A positive feedback loop coordinates growth and patterning in the vertebrate limb","volume":"371","author":"Niswander","year":"1994","journal-title":"Nature"},{"key":"10.1006\/dbio.2002.0752_RF47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/dbio.1999.9240","article-title":"A mouse cerberus\/Dan-related gene family","volume":"209","author":"Pearce","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/dev.126.5.883","article-title":"BMPs negatively regulate structure and function of the limb apical ectodermal ridge","volume":"126","author":"Pizette","year":"1999","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/dbio.2000.9610","article-title":"BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes","volume":"219","author":"Pizette","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/0470846658.ch3","article-title":"Early steps in limb patterning and chondrogenesis","volume":"232","author":"Pizette","year":"2001","journal-title":"Novartis Found. Symp."},{"key":"10.1006\/dbio.2002.0752_RF51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/10098","article-title":"Retinoic acid regulates programmed cell death through BMP signalling","volume":"1","author":"Rodriguez-Leon","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1006\/dbio.2002.0752_RF52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/dbio.1999.9578","article-title":"Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues","volume":"218","author":"Tang","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF53","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1440-169X.1983.00381.x","article-title":"The inhibitory effect of 5-bromodeoxyuridine on the programmed cell death in the chick limb","volume":"25","author":"Tone","year":"1983","journal-title":"Dev. Growth Differ."},{"key":"10.1006\/dbio.2002.0752_RF54","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1101\/gad.5.5.714","article-title":"Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation","volume":"5","author":"Vassar","year":"1991","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF55","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1101\/gad.9.17.2105","article-title":"Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse","volume":"9","author":"Winnier","year":"1995","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF56","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dev.127.3.621","article-title":"The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb","volume":"127","author":"Yi","year":"2000","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF57","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1242\/dev.122.12.3725","article-title":"BMP-2\/-4 mediate programmed cell death in chicken limb buds","volume":"122","author":"Yokouchi","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF58","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/dbio.1994.1255","article-title":"Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant","volume":"165","author":"Zakeri","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1006\/dbio.2002.0752_RF59","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP2 are nonviable and have defects in amnion\/chorion and cardiac development","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"},{"key":"10.1006\/dbio.2002.0752_RF60","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.272.5262.738","article-title":"Requirement for BMP signaling in interdigital apoptosis and scale formation","volume":"272","author":"Zou","year":"1996","journal-title":"Science"},{"key":"10.1006\/dbio.2002.0752_RF61","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1101\/gad.11.17.2191","article-title":"Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage","volume":"11","author":"Zou","year":"1997","journal-title":"Genes Dev."},{"key":"10.1006\/dbio.2002.0752_RF62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/44157","article-title":"Signal relay by BMP antagonism controls the SHH\/FGF4 feedback loop in vertebrate limb buds","volume":"401","author":"Zuniga","year":"1999","journal-title":"Nature"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160602907529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160602907529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T04:56:01Z","timestamp":1622091361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160602907529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0012160602907529"],"URL":"https:\/\/doi.org\/10.1006\/dbio.2002.0752","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}