{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:21:02Z","timestamp":1759530062169},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1006\/eesa.1999.1774","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T16:47:53Z","timestamp":1034009273000},"page":"98-102","source":"Crossref","is-referenced-by-count":4,"title":["Nonsynergic Effect of Ethanol and Lead on Heme Metabolism in Rats"],"prefix":"10.1006","volume":"43","author":[{"given":"J.L.","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fontanellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Enr\u0237quez de Salamanca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/eesa.1999.1774_RF1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0009-8981(92)90140-L","article-title":"An acquired acute hepatic porphyria: A novel type of 5-aminolevulinate dehydratase inhibition","volume":"212","author":"Akagi","year":"1992","journal-title":"Clin. Chim. Acta"},{"key":"10.1006\/eesa.1999.1774_RF2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000459098","article-title":"Prophobilinogen deaminase: Methods and principles of the enzymatic assay","volume":"28","author":"Anderson","year":"1982","journal-title":"Enzyme"},{"key":"10.1006\/eesa.1999.1774_RF3","first-page":"49","article-title":"Determinaci\u00f3n anal\u0131́tica conjunta de plomo y cadmio en viales de resistoceles","volume":"36","author":"Arroyo","year":"1989","journal-title":"Med. Segur. Trab. (Madrid)"},{"key":"10.1006\/eesa.1999.1774_RF4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJM199210293271805","article-title":"Environmental exposure to lead and children's intelligence at the age of seven years","volume":"327","author":"Baghurst","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/eesa.1999.1774_RF5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0024-3205(94)00918-X","article-title":"Hepatic glutathione determination after ethanol administration in rat: Evidence of the first-pass metabolism of ethanol","volume":"56","author":"Battiston","year":"1995","journal-title":"Life Sci."},{"key":"10.1006\/eesa.1999.1774_RF6","first-page":"389","article-title":"European standardized method for the determination of aminolevulinic acid dehydratase activity in blood","volume":"12","author":"Berlin","year":"1974","journal-title":"Z. Klin. Chem. Klin. Biochem."},{"key":"10.1006\/eesa.1999.1774_RF7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0006-2952(87)90363-7","article-title":"Effect of combined exposure to lead and ethanol on some biochemical indices in the rat","volume":"36","author":"Flora","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/eesa.1999.1774_RF8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0304-4165(81)90045-3","article-title":"Evidence of increased synthesis of 5-aminolevulinic acid dehydratase in experimental lead poisoned rats","volume":"678","author":"Fujita","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/eesa.1999.1774_RF9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/bj2450339","article-title":"Metal constitution of metal-lothionein influences inhibition of 5-aminlevuinic acid dehydratase (porphobilinogen synthesis) by lead","volume":"245","author":"G\u00f6ering","year":"1987","journal-title":"Biochem. J."},{"key":"10.1006\/eesa.1999.1774_RF10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1289\/ehp.720273","article-title":"Susceptibility to lead toxicity","volume":"4","author":"Goyer","year":"1972","journal-title":"Environ. Health Perspet."},{"key":"10.1006\/eesa.1999.1774_RF11","first-page":"557","article-title":"Studies of porphyrin synthesis in fibroblasts of patients with congenital erythropoietic porphyria and one patient wit homo-zygous coproporphyria","volume":"629","author":"Grandchamp","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/eesa.1999.1774_RF12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1006\/eesa.1999.1774_RF13","author":"Hollander","year":"1973"},{"key":"10.1006\/eesa.1999.1774_RF14","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM198812223192505","article-title":"Biochemical and molecular basis of alcohol-induced injury to liver and other tissues","volume":"319","author":"Lieber","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/eesa.1999.1774_RF15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-8981(96)06434-0","article-title":"Ethanol metabolism, cirrhosis and alcoholism","volume":"257","author":"Lieber","year":"1997","journal-title":"Clin. Chim. Acta"},{"key":"10.1006\/eesa.1999.1774_RF16","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.1840100417","article-title":"Experimental methods of ethanol administration","volume":"10","author":"Lieber","year":"1989","journal-title":"Hepatology"},{"key":"10.1006\/eesa.1999.1774_RF17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1006\/eesa.1999.1774_RF18","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/S0021-9258(18)96535-X","article-title":"Aminolevulinic acid synthetase: Studies in liver homogenates","volume":"241","author":"Marver","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1006\/eesa.1999.1774_RF19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2362.1976.tb00531.x","article-title":"Effect of lead on hepatic 5-aminolevulinic acid synthase activity in the rat: A model for drug sensitivity in intermittent acute porphyria","volume":"6","author":"Maxwell","year":"1976","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1006\/eesa.1999.1774_RF20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2362.1980.tb02068.x","article-title":"Acute ethanol ingestion and haem biosynthesis in healthy subjects","volume":"10","author":"McColl","year":"1980","journal-title":"Eur. J. Invest."},{"key":"10.1006\/eesa.1999.1774_RF21","first-page":"169","article-title":"Lead posoning","volume":"5","author":"Moore","year":"1986","journal-title":"Semin. Dermatol."},{"key":"10.1006\/eesa.1999.1774_RF22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/clinchem\/23.2.264","article-title":"Free erythrocyte porphyrins in the detection of undue absorption of Pb and of Fe deficiency","volume":"23","author":"Piomelli","year":"1977","journal-title":"Clin. Chem."},{"key":"10.1006\/eesa.1999.1774_RF23","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1093\/clinchem\/36.11.1980","article-title":"Effect of occupational lead exposure on lymphocyte enzymes involved in heme biosynthesis","volume":"36","author":"Rossi","year":"1990","journal-title":"Clin. Chem."},{"key":"10.1006\/eesa.1999.1774_RF24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0741-8329(95)02013-6","article-title":"Alcohol-induced changes in urinary aminolevulinic acid and porphyrins unrelated to liver disease","volume":"13","author":"Schoenfeld","year":"1996","journal-title":"Alcohol"},{"key":"10.1006\/eesa.1999.1774_RF25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0009-8981(91)90051-D","article-title":"Effect of alcohol on delta-aminolevulinic acid dehydratase and porphyrin metabolism in man","volume":"202","author":"Sieg","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1006\/eesa.1999.1774_RF26","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1136\/gut.35.11.1644","article-title":"Lipid peroxidation in rats chronically fed ethanol","volume":"35","author":"Teare","year":"1994","journal-title":"Gut"},{"key":"10.1006\/eesa.1999.1774_RF27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5271\/sjweh.2335","article-title":"In vivo study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man","volume":"10","author":"Telisman","year":"1984","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1006\/eesa.1999.1774_RF28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bj1880549","article-title":"Effect of ethanol on glutathione concentration in isolated hepatocytes","volume":"188","author":"Vi\u00f1a","year":"1980","journal-title":"Biochem. J."},{"key":"10.1006\/eesa.1999.1774_RF29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/clinchem\/34.2.345","article-title":"A rapid and accurate spectrofluorometric method for quantification and screening of urinary porphyrins","volume":"34","author":"Westerlund","year":"1988","journal-title":"Clin. Chem."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651399917748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651399917748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T08:27:11Z","timestamp":1620030431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651399917748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0147651399917748"],"URL":"https:\/\/doi.org\/10.1006\/eesa.1999.1774","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}