{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:10:38Z","timestamp":1791263438559,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1006\/excr.2001.5444","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T15:02:41Z","timestamp":1033916561000},"page":"187-196","source":"Crossref","is-referenced-by-count":149,"title":["Characterization of ThOX Proteins as Components of the Thyroid H2O2-Generating System"],"prefix":"10.1006","volume":"273","author":[{"given":"Xavier","family":"De Deken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dantong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques E.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Miot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/excr.2001.5444_RF1","series-title":"Werner and Ingbars's The Thyroid","first-page":"47","author":"Taurog","year":"1996"},{"key":"10.1006\/excr.2001.5444_RF2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/379458a0","article-title":"Cloning and characterization of the thyroid iodide transporter","volume":"379","author":"Dai","year":"1996","journal-title":"Nature"},{"key":"10.1006\/excr.2001.5444_RF3","doi-asserted-by":"crossref","first-page":"27230","DOI":"10.1074\/jbc.272.43.27230","article-title":"Thyroid Na+\/I\u2212 symporter. Mechanism, stoichiometry, and specificity","volume":"272","author":"Eskandari","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0303-7207(97)00108-1","article-title":"Moderate doses of iodide in vivo inhibit cell proliferation and expression of thyroperoxidase and Na+\/I\u2212 symporter mRNAs in dog thyroid","volume":"131","author":"Uyttersprot","year":"1997","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1006\/excr.2001.5444_RF5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng0496-424","article-title":"Pendred syndrome maps to chromosome 7q21\u201334 and is caused by an intrinsic defect in thyroid iodine organification","volume":"12","author":"Sheffield","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1006\/excr.2001.5444_RF6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/7783","article-title":"The Pendred syndrome gene encodes a chloride\u2013iodide transport protein","volume":"21","author":"Scott","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1006\/excr.2001.5444_RF7","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1210\/endo-100-6-1610","article-title":"Purification of bovine thyroid peroxidase","volume":"100","author":"Alexander","year":"1977","journal-title":"Endocrinology"},{"key":"10.1006\/excr.2001.5444_RF8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/endo-128-2-779","article-title":"The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid","volume":"128","author":"Corvilain","year":"1991","journal-title":"Endocrinology"},{"key":"10.1006\/excr.2001.5444_RF9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1210\/endo.136.3.7867606","article-title":"Tonic modulation of dog thyrocyte H2O2 generation and I\u2212 uptake by thyrotropin through the cyclic adenosine 3\u2032,5\u2032-monophosphate cascade","volume":"136","author":"Rasp\u00e9","year":"1995","journal-title":"Endocrinology"},{"key":"10.1006\/excr.2001.5444_RF10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1432-1033.1996.0807h.x","article-title":"Solubilization and characterization of a thyroid Ca2+-dependent and NADPH-dependent K3Fe(CN)6 reductase. Relationship with the NADPH-dependent H2O2-generating system","volume":"240","author":"Gorin","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/excr.2001.5444_RF11","doi-asserted-by":"crossref","first-page":"37265","DOI":"10.1074\/jbc.274.52.37265","article-title":"Purification of a novel flavoprotein involved in the thyroid NADPH oxidase","volume":"274","author":"Dupuy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF12","doi-asserted-by":"crossref","first-page":"23227","DOI":"10.1074\/jbc.M000916200","article-title":"Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family","volume":"275","author":"De Deken","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF13","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.200103132","article-title":"Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase\/peroxidase with homology to the phagocyte oxidase subunit gp91phox","volume":"154","author":"Edens","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1006\/excr.2001.5444_RF14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/bbrc.2000.3671","article-title":"Thyroid oxidase (ThOX2) gene expression in the rat thyroid cell line FRTL-5","volume":"277","author":"Dupuy","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/excr.2001.5444_RF15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0303-7207(82)90014-4","article-title":"Stimulation by thyrotropin, cholera toxin and dibutyryl cAMP of the multiplication of differentiated thyroid cells in vitro","volume":"26","author":"Roger","year":"1982","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1006\/excr.2001.5444_RF16","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1210\/jcem-66-6-1158","article-title":"Mitogenic effects of thyrotropin and adenosine 3\u2032,5\u2032-monophosphate in differentiated normal human thyroid cells in vitro","volume":"66","author":"Roger","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/excr.2001.5444_RF17","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/MCB.7.9.3365","article-title":"One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes","volume":"7","author":"Fusco","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/excr.2001.5444_RF18","doi-asserted-by":"crossref","first-page":"9832","DOI":"10.1073\/pnas.90.21.9832","article-title":"Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox","volume":"90","author":"Zhen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/excr.2001.5444_RF19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0003-2697(90)90134-U","article-title":"A filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents","volume":"190","author":"Minamide","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1006\/excr.2001.5444_RF20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1210\/jcem-73-4-919","article-title":"Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease","volume":"73","author":"Finke","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/excr.2001.5444_RF21","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1182\/blood.V73.6.1686.1686","article-title":"Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils","volume":"73","author":"Verhoeven","year":"1989","journal-title":"Blood"},{"key":"10.1006\/excr.2001.5444_RF22","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","article-title":"Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease","volume":"18","author":"Chirgwin","year":"1979","journal-title":"Biochemistry"},{"key":"10.1006\/excr.2001.5444_RF23","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1016\/S0021-9258(19)50686-X","article-title":"In vitro and in vivo regulation of thyrotropin receptor mRNA levels in dog and human thyroid cells","volume":"267","author":"Maenhaut","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF24","first-page":"701","article-title":"Production de peroxyde dans la thyro\u0131&#x0308;de","volume":"100","author":"B\u00e9nart","year":"1971","journal-title":"Union M\u00e9d. Can."},{"key":"10.1006\/excr.2001.5444_RF25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1006\/excr.2001.5444_RF26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0014-5793(98)01177-6","article-title":"Production of bioactive amino-terminal domain of the thyrotropin receptor via insertion in the plasma membrane by a glycosylphosphatidylinositol anchor","volume":"436","author":"Costagliola","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1006\/excr.2001.5444_RF27","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1182\/blood.V84.8.2767.2767","article-title":"p22-phox-deficient chronic granulomatous disease: Reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox","volume":"84","author":"Porter","year":"1994","journal-title":"Blood"},{"key":"10.1006\/excr.2001.5444_RF28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/bj2900041","article-title":"Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase","volume":"290","author":"O'Donnel","year":"1993","journal-title":"Biochem. J."},{"key":"10.1006\/excr.2001.5444_RF29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/bj3010075","article-title":"The Ca2+\/NADPH-dependent H2O2 generator in thyroid plasma membrane: Inhibition by diphenyleneiodonium","volume":"301","author":"D\u00e8me","year":"1994","journal-title":"Biochem. J."},{"key":"10.1006\/excr.2001.5444_RF30","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.130.4.1910","article-title":"Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation","volume":"130","author":"Bass","year":"1983","journal-title":"J. Immunol."},{"key":"10.1006\/excr.2001.5444_RF31","first-page":"3351","article-title":"Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues","volume":"86","author":"Caillou","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/excr.2001.5444_RF32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/geno.2001.6586","article-title":"Cloning of tissue-specific genes using serial analysis of gene expression and a novel computational subtraction approach","volume":"75","author":"Moreno","year":"2001","journal-title":"Genomics"},{"key":"10.1006\/excr.2001.5444_RF33","first-page":"107","article-title":"Mutations in the ThOX2 gene in patients with congenital hypothyroidism due to iodide organification defects","volume":"47","author":"Moreno","year":"2000","journal-title":"Endocr. J."},{"key":"10.1006\/excr.2001.5444_RF34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcp.1041460208","volume":"146","author":"Rasp\u00e9","year":"1991","journal-title":"J. Cell. Physiol."},{"key":"10.1006\/excr.2001.5444_RF35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1677\/joe.0.1200503","article-title":"Generation of hydrogen peroxide in cultured porcine thyroid cells: Synergistic regulation by cytoplasmic free calcium and protein kinase C","volume":"120","author":"Takasu","year":"1988","journal-title":"J. Endocrinol."},{"key":"10.1006\/excr.2001.5444_RF36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0955-0674(00)00113-7","article-title":"Understanding the insertion of transporters and other membrane proteins","volume":"12","author":"Dalbey","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/excr.2001.5444_RF37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(95)90380-1","article-title":"The role of N-glycans in the secretory pathway","volume":"81","author":"Fiedler","year":"1995","journal-title":"Cell"},{"key":"10.1006\/excr.2001.5444_RF38","series-title":"Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text","author":"Braverman","year":"2000"},{"key":"10.1006\/excr.2001.5444_RF39","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1074\/jbc.270.6.2478","article-title":"Polarized distribution and delivery of plasma membrane proteins in thyroid follicular epithelial cells","volume":"270","author":"Kuliawat","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF40","doi-asserted-by":"crossref","first-page":"31946","DOI":"10.1074\/jbc.M003559200","article-title":"Cell type-dependent differences in thyroid peroxidase cell surface expression","volume":"275","author":"Zhang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF41","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1210\/endo.139.10.6265","article-title":"Human thyroperoxidase is largely retained and rapidly degraded in the endoplasmic reticulum: Its N-glycans are required for folding and intracellular trafficking","volume":"139","author":"Fayadat","year":"1998","journal-title":"Endocrinology"},{"key":"10.1006\/excr.2001.5444_RF42","doi-asserted-by":"crossref","first-page":"15947","DOI":"10.1074\/jbc.M905763199","article-title":"Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein","volume":"275","author":"Fayadat","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF43","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V93.5.1464","article-title":"NADPH oxidase: An update","volume":"93","author":"Babior","year":"1999","journal-title":"Blood"},{"key":"10.1006\/excr.2001.5444_RF44","doi-asserted-by":"crossref","first-page":"27288","DOI":"10.1074\/jbc.272.43.27288","article-title":"Biosynthesis of the phagocyte NADPH oxidase cytochrome b558","volume":"272","author":"Yu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF45","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.95.14.7993","article-title":"Gp91phox is the heme binding subunit of the superoxidegenerating NADPH oxidase","volume":"95","author":"Yu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/excr.2001.5444_RF46","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1074\/jbc.274.7.4364","article-title":"Biosynthesis of flavocytochrome b558. gp91phox is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum","volume":"274","author":"Yu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF47","doi-asserted-by":"crossref","first-page":"13986","DOI":"10.1074\/jbc.275.18.13986","article-title":"Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly","volume":"275","author":"DeLeo","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/excr.2001.5444_RF48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/43459","article-title":"Cell transformation by superoxide-generating oxidase Mox1","volume":"401","author":"Suh","year":"1999","journal-title":"Nature"},{"key":"10.1006\/excr.2001.5444_RF49","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1073\/pnas.130135897","article-title":"Identification of renox, an NAD(P)H oxidase in kidney","volume":"97","author":"Geiszt","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/excr.2001.5444_RF50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1530\/eje.0.1370579","article-title":"The dog thyroid primary culture system: A model of the regulation of function, growth and differentiation expression by cAMP and other well-defined signaling cascades","volume":"137","author":"Roger","year":"1997","journal-title":"Eur. J. Endocrinol."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482701954448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482701954448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T17:03:12Z","timestamp":1682269392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482701954448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S0014482701954448"],"URL":"https:\/\/doi.org\/10.1006\/excr.2001.5444","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}