{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:29:07Z","timestamp":1762147747813,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1006\/exer.1997.0408","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:31:24Z","timestamp":1033932684000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nitric Oxide Relaxes Bovine Ciliary Muscle contracted by Carbachol Through Elevation of Cyclic GMP"],"prefix":"10.1006","volume":"66","author":[{"given":"SOICHIRO","family":"KAMIKAWATOKO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKASHI","family":"TOKORO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AKIMASA","family":"ISHIDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"MASUDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEHISA","family":"HAMASAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUN","family":"SATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"AZUMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.1997.0408_EY970408RF1","doi-asserted-by":"crossref","unstructured":"Akaike, T. Yoshida, M. Miyamoto, Y. Sato, K. Kohno, M. Sakamoto, K. Miyazaki, K. Ueda, S. Maeda, H. 1993, Antagonistic action of imidazolineoxylN, Biochemistry, 32, 827, 32","DOI":"10.1021\/bi00054a013"},{"key":"10.1006\/exer.1997.0408_EY970408RF2","doi-asserted-by":"crossref","unstructured":"Azuma, H. Masuda, H. Sato, J. Niwa, K. Tokoro, T. 1997, A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle. Exp. Eye Res. 64, 823, 30","DOI":"10.1006\/exer.1997.0279"},{"key":"10.1006\/exer.1997.0408_EY970408RF3","doi-asserted-by":"crossref","unstructured":"Azuma, H. Sato, J. Hamasaki, H. Sugimoto, A. Isotani, E. Obayashi, S. 1995, Accumulation of endogenous inhibitor for nitric oxide synthesis and decreased content ofl, Br. J. Pharmacol. 115, 1001, 4","DOI":"10.1111\/j.1476-5381.1995.tb15910.x"},{"key":"10.1006\/exer.1997.0408_EY970408RF4","unstructured":"Becker, B. 1990, Topical 8-bromo cyclic GMP lowers intraocular pressure in rabbits. Invest. Ophthalmol. Vis. Sci. 31, 1647, 9"},{"key":"10.1006\/exer.1997.0408_EY970408RF5","unstructured":"Chen, Z., Gu, Q., Kaufmann, P. L. and Cynader, M. S. (1996). The localization of nitric oxide synthase (NOS) in human and monkey eye. Invest. Ophthalmol. Vis. Sci. 37 (Abstract), 329."},{"key":"10.1006\/exer.1997.0408_EY970408RF6","unstructured":"Geyer, O. Podos, S. M. Mittag, T. W. 1993, Nitric oxide synthase: Distribution and biochemical properties of the enzyme in the bovine eye. Invest. Ophthalmol. Vis. Sci. 34, 826, 32"},{"key":"10.1006\/exer.1997.0408_EY970408RF7","unstructured":"Goh, Y. Hoteyama, Y. Mishima, H. K. 1995, Characterization of ciliary muscle relaxation induced by various agents in cats. Invest. Ophthalmol. Vis. Sci. 36, 1188, 92"},{"key":"10.1006\/exer.1997.0408_EY970408RF8","doi-asserted-by":"crossref","unstructured":"Griffith, T. M. Edwards, D. H. Lewis, M. J. Henderson, A. H. 1985, Evidence that cGMP mediates endothelium-dependent relaxation. Eur. J. Pharmacol. 112, 195, 202","DOI":"10.1016\/0014-2999(85)90496-0"},{"key":"10.1006\/exer.1997.0408_EY970408RF9","doi-asserted-by":"crossref","unstructured":"Gryglewski, R. J. Palmer, R. M. J. Moncada, S. 1986, Superoxide anion is involved in the breakdown of endothelium derived vascular relaxing factor. Nature, 320, 454, 6","DOI":"10.1038\/320454a0"},{"key":"10.1006\/exer.1997.0408_EY970408RF10","doi-asserted-by":"crossref","unstructured":"Gryglewski, R. J. Zembowicz, A. Salvemini, D. Teylor, G. W. Vane, J. R. 1992, Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocianin. Br. J. Pharmacol. 106, 838, 45","DOI":"10.1111\/j.1476-5381.1992.tb14422.x"},{"key":"10.1006\/exer.1997.0408_EY970408RF11","unstructured":"Haefliger, I. O. Zshauer, A. Anderson, D. R. 1994, Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest. Ophthalmol. Vis. Sci. 35, 991, 7"},{"key":"10.1006\/exer.1997.0408_EY970408RF12","doi-asserted-by":"crossref","unstructured":"Honma, M. Satoh, T. Takezawa, J. Ui, M. 1977, An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small volume samples from blood and tissues. Biochem. Med. 18, 257, 73","DOI":"10.1016\/0006-2944(77)90060-6"},{"key":"10.1006\/exer.1997.0408_EY970408RF13","doi-asserted-by":"crossref","unstructured":"Ignarro, L. J. 1990, Biosynthesis and metabolism of endothelium-derived nitric oxide. Ann. Rev. Pharmacol. Toxicol. 30, 535, 60","DOI":"10.1146\/annurev.pa.30.040190.002535"},{"key":"10.1006\/exer.1997.0408_EY970408RF14","doi-asserted-by":"crossref","unstructured":"Ignarro, L. J. Kadowitz, P. J. 1985, The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Ann. Rev. Pharmacol. Toxicol. 25, 171, 91","DOI":"10.1146\/annurev.pa.25.040185.001131"},{"key":"10.1006\/exer.1997.0408_EY970408RF15","unstructured":"Kamikawatoko, S., Tokoro, T., Azuma, H., Hamasaki, H. and Ishida, A. (1994). Characteristics of contractile force of bovine ciliary muscles caused by a cholinergic agent. J. Jpn. Ophthalmol. Soc. 98, 733\u20137 (Abstract in English)."},{"key":"10.1006\/exer.1997.0408_EY970408RF16","doi-asserted-by":"crossref","unstructured":"Kamikawatoko, S. Tokoro, T. Azuma, H. Hamasaki, H. Ishida, A. 1995, Effects of endothelin-1 on isolated bovine ciliary muscles. Exp. Eye Res. 61, 559, 64","DOI":"10.1016\/S0014-4835(05)80049-1"},{"key":"10.1006\/exer.1997.0408_EY970408RF17","doi-asserted-by":"crossref","unstructured":"Koesling, D. Bohme, E. Schultz, G. 1991, Guanylate cyclase, a growing family of single-transducing enzymes. FASEB J. 5, 2785, 91","DOI":"10.1096\/fasebj.5.13.1680765"},{"key":"10.1006\/exer.1997.0408_EY970408RF18","doi-asserted-by":"crossref","unstructured":"Kowulak, E. A. Seth, P. Fung, H. 1992, Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J. Pharmacol. Exp. Ther. 262, 916, 22","DOI":"10.1016\/S0022-3565(25)10935-X"},{"key":"10.1006\/exer.1997.0408_EY970408RF19","doi-asserted-by":"crossref","unstructured":"Levi, R. C. Alloatti, G. Penna, C. Gallo, M. P. 1994, Guanylate cyclase-mediated inhibition of cardiac ICa by carbachol and sodium nitroprusside. Pflugers Arch. 426, 419, 26","DOI":"10.1007\/BF00388305"},{"key":"10.1006\/exer.1997.0408_EY970408RF20","doi-asserted-by":"crossref","unstructured":"Marczin, N. Ryan, U. S. Catravas, J. D. 1992, Methylene blue inhibits nitrodilator and endothelium-derived relaxing factor-induced cGMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J. Pharmacol. Exp. Ther. 263, 170, 9","DOI":"10.1016\/S0022-3565(25)10320-0"},{"key":"10.1006\/exer.1997.0408_EY970408RF21","doi-asserted-by":"crossref","unstructured":"Moncada, S. Palmer, R. M. J. Higgs, E. A. 1991, Nitric oxide: Physiology, pathology and pharmacology. Pharmacol. Rev. 43, 109, 42","DOI":"10.1016\/S0031-6997(25)06663-3"},{"key":"10.1006\/exer.1997.0408_EY970408RF22","doi-asserted-by":"crossref","unstructured":"Nathanson, J. A. 1988a, Direct application of guanylate cyclase activator lowers intraocular pressure. Eur. J. Pharmacol. 147, 156, 7","DOI":"10.1016\/0014-2999(88)90648-6"},{"key":"10.1006\/exer.1997.0408_EY970408RF23","unstructured":"Nathanson, J. A. 1988b, Guanylyl cyclase activators: effects on ciliary process cyclic GMP metabolism and intraocular pressure. Invest. Ophthalmol. Vis. Sci. 29, 323, 5"},{"key":"10.1006\/exer.1997.0408_EY970408RF24","unstructured":"Nathanson, J. A. McKee, M. 1995a, Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye. Invest. Ophthalmol. Vis. Sci. 36, 1765, 73"},{"key":"10.1006\/exer.1997.0408_EY970408RF25","unstructured":"Nathanson, J. A. McKee, M. 1995b, Alternations of ocular nitric oxide synthase in human glaucoma. Invest. Ophthalmol. Vis. Sci. 36, 1774, 84"},{"key":"10.1006\/exer.1997.0408_EY970408RF26","doi-asserted-by":"crossref","unstructured":"Rapoport, R. M. Murad, F. 1983, Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 52, 352, 7","DOI":"10.1161\/01.RES.52.3.352"},{"key":"10.1006\/exer.1997.0408_EY970408RF27","doi-asserted-by":"crossref","unstructured":"Schuman, J. S. Erickson, K. Nathanson, J. A. 1993, Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys. Exp. Eye Res. 58, 99, 105","DOI":"10.1006\/exer.1994.1199"},{"key":"10.1006\/exer.1997.0408_EY970408RF28","unstructured":"Tamm, E. R. Fluger-Koch, C. Mayer, B. Lutjen-Drecoll, E. 1995, Nerve cells in the human ciliary muscle: ultrastructural and immunocytochemical characterization. Invest. Ophthalmol. Vis. Sci. 36, 414, 26"},{"key":"10.1006\/exer.1997.0408_EY970408RF29","doi-asserted-by":"crossref","unstructured":"Veriac, S. Tissie, G. Bonne, C. 1993, Oxygen free radicals adversely affect the regulation of vascular tone by nitric oxide in the rabbit retina under high intraocular pressure. Exp. Eye Res. 56, 85, 8","DOI":"10.1006\/exer.1993.1012"},{"key":"10.1006\/exer.1997.0408_EY970408RF30","unstructured":"Wiederholt, W. Sturm, A. Lepple-Wienhues, A. 1994, Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide. Invest. Ophthalmol. Vis. Sci. 35, 2512, 20"},{"key":"10.1006\/exer.1997.0408_EY970408RF31","unstructured":"Wiencke, A. K. Nielsen, P. J. and Nyborg, C. B. 1994, Nonadrenergic noncholinergic vasodilation in bovine ciliary artery involves CGRP and neurogenic nitric oxide. Invest. Ophthalmol. Vis. Sci. 35, 3268, 77"},{"key":"10.1006\/exer.1997.0408_EY970408RF32","doi-asserted-by":"crossref","unstructured":"Yamamoto, R. Bredt, D. S. Snyder, S. H. Stone, R. A. 1993, The localization of nitric oxide synthase in the rat eye and related retinal ganglia. Neuroscience, 54, 189, 200","DOI":"10.1016\/0306-4522(93)90393-T"},{"key":"10.1006\/exer.1997.0408_EY970408RF33","unstructured":"Yao, K. Tsuchida, M. Flammer, J. L\u00fcscher, T. F. 1991, Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest. Ophthalmol. Vis. Sci. 32, 1791, 8"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483597904085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483597904085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:24:50Z","timestamp":1762147490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483597904085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["S0014483597904085"],"URL":"https:\/\/doi.org\/10.1006\/exer.1997.0408","relation":{},"ISSN":["0014-4835"],"issn-type":[{"type":"print","value":"0014-4835"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric Oxide Relaxes Bovine Ciliary Muscle contracted by Carbachol Through Elevation of Cyclic GMP","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/exer.1997.0408","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}