{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:11:38Z","timestamp":1775927498946,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1006\/exer.1999.0737","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T23:31:24Z","timestamp":1033947084000},"page":"467-474","source":"Crossref","is-referenced-by-count":18,"title":["Ocular Effects of Adrenomedullin"],"prefix":"10.1006","volume":"69","author":[{"given":"TORU","family":"TANIGUCHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUHIDE","family":"KAWASE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHAO-BIN","family":"GU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASASHI","family":"KIMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUKIO","family":"OKANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEAKI","family":"KAWAKAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AKIRA","family":"TSUJI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIAKI","family":"KITAZAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.1999.0737_RF1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/jop.1998.14.263","article-title":"Evaluation of soluble Bioadhesive Ophthalmic Drug Inserts (BODI\u00ae) for prolonged release of gentamicin: lachrymal pharmacokinetics and ocular tolerance","volume":"14","author":"Baeyens","year":"1998","journal-title":"J. Ocul, Pharmacol. Ther."},{"key":"10.1006\/exer.1999.0737_RF2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/jcbfm.1995.103","article-title":"Effects of adrenomedullin, calcitonin-gene-related peptide, and amylin on cerebral circulation in dogs","volume":"15","author":"Baskaya","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1006\/exer.1999.0737_RF3","first-page":"123","article-title":"hCGRP8-37, calcitonon gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery","volume":"254","author":"Dennis","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.1999.0737_RF4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-2999(94)90143-0","article-title":"Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pulmonary vascular bed of the cat","volume":"257","author":"DeWitt","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exer.1999.0737_RF5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0014-5793(94)80143-6","article-title":"Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells","volume":"340","author":"Eguchi","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1006\/exer.1999.0737_RF6","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/endo.135.6.7988431","article-title":"Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells","volume":"135","author":"Eguchi","year":"1994","journal-title":"Endocrinology."},{"key":"10.1006\/exer.1999.0737_RF7","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0042-6989(90)90004-5","article-title":"Immunoreactive atrial natriuretic factor in aqueous humor: Its concentration is increased with high intraocular pressure in rabbit eyes","volume":"30","author":"Fernandez-Durango","year":"1990","journal-title":"Vision Res."},{"key":"10.1006\/exer.1999.0737_RF8","doi-asserted-by":"crossref","first-page":"R1289","DOI":"10.1152\/ajpregu.1995.269.5.R1289","article-title":"Cardiovascular and neurohormonal effects of intravenous adrenomedullin in conscious rabbits","volume":"38","author":"Fukuhara","year":"1995","journal-title":"Am. J. Physiol. 269 (Regulatory Integrative Comp Physiol."},{"key":"10.1006\/exer.1999.0737_RF9","first-page":"S1136","article-title":"Adrenomedullin-induced relaxation of isolated porcine ciliary arteries. ARVO Abstracts","volume":"38","author":"Haefliger","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.1999.0737_RF10","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/01.HYP.25.4.790","article-title":"Mechanisms of adrenomedullin-induced vasodilatation in the rat kidney","volume":"25 (part 2)","author":"Hirata","year":"1995","journal-title":"Hypertension."},{"key":"10.1006\/exer.1999.0737_RF11","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1172\/JCI117573","article-title":"Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure","volume":"94","author":"Ishimitsu","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1006\/exer.1999.0737_RF12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: A novel hypotensive peptide isolated from human phechromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/exer.1999.0737_RF13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-5793(94)80289-0","article-title":"Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor","volume":"338","author":"Kitamura","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1006\/exer.1999.0737_RF14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-4835(88)90013-9","article-title":"CGRP in relation to neurogenic inflammation and cAMP in the rabbit eye","volume":"47","author":"Krootila","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.1999.0737_RF15","first-page":"3084","article-title":"Intraocular and cardiovascular effects of calcitonin gene-related peptide (CGRP)-I and -II in the rabbit","volume":"32","author":"Krootila","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.1999.0737_RF16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3109\/02713689209015075","article-title":"Endothelin-like immunoreactivity in the aqueous humor and in conditioned medium from cultured ciliary epithelial cells","volume":"11","author":"Lepple-Wienhues","year":"1992","journal-title":"Curr. Eye Res."},{"key":"10.1006\/exer.1999.0737_RF17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.1999.0737_RF18","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1073\/pnas.86.18.7285","article-title":"Endothelin: Visualization of mRNAs by in situ hybridization provides evidence for local action","volume":"86","author":"MacCumber","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1006\/exer.1999.0737_RF19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archopht.1991.01080050121041","article-title":"Ocular effects of endothelin: Abundant peptides in the eye","volume":"109","author":"MacCumber","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1006\/exer.1999.0737_RF20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/01.HYP.24.5.600","article-title":"Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects","volume":"24","author":"Nishikimi","year":"1994","journal-title":"Hypertension"},{"key":"10.1006\/exer.1999.0737_RF21","first-page":"56","article-title":"Mechanism of adrenomedullin-induced relaxation is isolated canine retinal arteries","volume":"38","author":"Okamura","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.1999.0737_RF22","first-page":"1006","article-title":"Effects of calcitonin gene-related peptide in the eye: A study in rabbits and cats","volume":"29","author":"Oksala","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.1999.0737_RF23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/exer.1998.0532","article-title":"Effect of intracameral and intravitreal injection of calcitonin gene-related peptide on the intraocular pressure and outflow facility of aqueous humor in the rabbit","volume":"67","author":"Oksala","year":"1998","journal-title":"Exp. Eye. Res."},{"key":"10.1006\/exer.1999.0737_RF24","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1210\/endo.136.5.7720662","article-title":"An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat","volume":"136","author":"Owji","year":"1995","journal-title":"Endocrinology."},{"key":"10.1006\/exer.1999.0737_RF25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1006\/bbrc.1993.2132","article-title":"Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide","volume":"195","author":"Sakata","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/exer.1999.0737_RF26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-5793(94)00928-7","article-title":"Distribution and characterization of immunoreactive rat adrenomedullin in tissues and plasma","volume":"352","author":"Sakata","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1006\/exer.1999.0737_RF27","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1074\/jbc.270.9.4412","article-title":"Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+mobilization, in bovine aortic endothelialcells","volume":"270","author":"Shimekake","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.1999.0737_RF28","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0006-291X(86)80523-X","article-title":"Immunoactive atrial natriuretic peptide in the rat eye: Molecular forms in anterior uvea and retina","volume":"134","author":"Stone","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/exer.1999.0737_RF29","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1210\/endo.133.6.8243333","article-title":"Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells\u2014evidence for CNP as a novel autocrine\/paracrine regulator from endothelial cells","volume":"133","author":"Suga","year":"1993","journal-title":"Endocrinology."},{"key":"10.1006\/exer.1999.0737_RF30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0014-2999(86)90292-X","article-title":"Synthetic atrial natriuretic factor lowers rabbit intraocular pressure","volume":"130","author":"Sugrue","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exer.1999.0737_RF31","first-page":"2671","article-title":"Ocular hypotensive mechanism of intravitreally injected brain natriuretic peptide in rabbit","volume":"37","author":"Takashima","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.1999.0737_RF32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3109\/02713689408999874","article-title":"Effects of endothelin-1 on intraocular pressure and aqueous humor dynamics in the rabbit eye","volume":"13","author":"Taniguchi","year":"1994","journal-title":"Curr. Eye Res."},{"key":"10.1006\/exer.1999.0737_RF33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/jop.1996.12.123","article-title":"Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye","volume":"12","author":"Taniguchi","year":"1996","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1006\/exer.1999.0737_RF34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.902330410","article-title":"Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye","volume":"233","author":"Terenghi","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exer.1999.0737_RF35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nature New Biology"},{"key":"10.1006\/exer.1999.0737_RF36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0167-0115(86)90054-6","article-title":"Calcitonin gene-related peptide in the eye: Release by sensory nerve stimulation and effects associated with neurogenic inflammation","volume":"16","author":"Wahlestedt","year":"1986","journal-title":"Regul. Pept."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483599907376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483599907376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T08:20:36Z","timestamp":1620030036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483599907376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0014483599907376"],"URL":"https:\/\/doi.org\/10.1006\/exer.1999.0737","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}