{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:06:42Z","timestamp":1769087202403,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1006\/exer.2000.0832","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:46:56Z","timestamp":1032191216000},"page":"675-682","source":"Crossref","is-referenced-by-count":24,"title":["Modulation of Ocular Hydrodynamics and Iris Function by Bremazocine, a Kappa Opioid Receptor Agonist"],"prefix":"10.1006","volume":"70","author":[{"given":"Karen R.M","family":"Russell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.2000.0832_RF1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0014-4835(84)90006-X","article-title":"Diurnal and seasonal variations in intraocular pressure in the rabbit","volume":"39","author":"Bar-Ilan","year":"1984","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0832_RF2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/neu.1998.15.117","article-title":"Effects of niravoline (RU 51599), a selective kappa-opioid receptor agonist on intracranial pressure in gradually expanding extradural mass lesion","volume":"15","author":"Bemana","year":"1998","journal-title":"J. Neurotrauma"},{"key":"10.1006\/exer.2000.0832_RF3","series-title":"Clinical Ophthalmology","first-page":"1","article-title":"Clinical evaluation of the circulation of aqueous humor","author":"Brubaker","year":"1986"},{"key":"10.1006\/exer.2000.0832_RF4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0143-4179(86)90030-2","article-title":"Reassessment of opioid binding sites in the rat brain","volume":"7","author":"Castanas","year":"1986","journal-title":"Neuropeptides"},{"key":"10.1006\/exer.2000.0832_RF5","first-page":"8","article-title":"Molecular cloning and functional expression of a \u03bc -opioid receptor from rat brain","volume":"44","author":"Chen","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF6","first-page":"194","article-title":"Effects of topical epinephrine on rabbit aqueous humor dynamics","volume":"19","author":"Chubak","year":"1980","journal-title":"Invest. Ophthalmol. Suppl."},{"key":"10.1006\/exer.2000.0832_RF7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00504223","article-title":"Opiate receptors in the rabbit iris","volume":"315","author":"Drago","year":"1980","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1440-1681.1985.tb02312.x","article-title":"Effects of opiates and opioids on intraocular pressure of rabbits and humans","volume":"12","author":"Drago","year":"1985","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1006\/exer.2000.0832_RF9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00005344-198605000-00005","article-title":"Bremazocine causes sympatho-inhibition and hypotension in rabbits by activating peripheral \u03ba-receptors","volume":"8","author":"Ensinger","year":"1986","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF10","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1126\/science.1335167","article-title":"Cloning of a delta opioid receptor by functional expression","volume":"258","author":"Evans","year":"1992","journal-title":"Science"},{"key":"10.1006\/exer.2000.0832_RF11","first-page":"109","article-title":"Search for opiate receptors in human pupil","volume":"1","author":"Fanciullacci","year":"1980","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"10.1006\/exer.2000.0832_RF12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-2999(80)90136-3","article-title":"The naloxone conjunctival test in morphine addiction","volume":"61","author":"Fanciullacci","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF13","first-page":"1331","article-title":"Measurement of aqueous flow in rabbits with corneal and vitreous depots of fluorescent dye","volume":"27","author":"Gaul","year":"1986","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0832_RF14","first-page":"91","article-title":"Morphine-induced mydriasis and fluctuation in the rat: time and dose relationships","volume":"208","author":"Klemfuss","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1476-5381.1981.tb08732.x","article-title":"Antagonism of opiate mydriasis in mice","volume":"73","author":"Korczyn","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0091-3057(82)90468-3","article-title":"Central and peripheral components of morphine mydriasis in mice","volume":"17","author":"Korczyn","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1006\/exer.2000.0832_RF17","first-page":"415","article-title":"Mechanism of morphine-induced miosis in the dog","volume":"192","author":"Lee","year":"1975","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archopht.1948.00900030291006","article-title":"Effect of intramuscular administration of morphine, atropine, scopolamine and neostigmine on the human eye","volume":"40","author":"Leopold","year":"1948","journal-title":"Arch. Ophthalmol."},{"key":"10.1006\/exer.2000.0832_RF19","first-page":"517","article-title":"The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog","volume":"197","author":"Martin","year":"1976","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0024-3205(83)90123-6","article-title":"Minireview. The pupillary effects of opioids","volume":"33","author":"Murray","year":"1983","journal-title":"Life Sci."},{"key":"10.1006\/exer.2000.0832_RF21","first-page":"95","article-title":"Ocular tension","volume":"15","author":"Myashita","year":"1913","journal-title":"Zentralblatt fur Biochemie und Biophysik"},{"key":"10.1006\/exer.2000.0832_RF22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-2999(88)90359-7","article-title":"Autoradiography of [3H]U-69593 binding sites in rat brain: evidence for kappa opioid receptor subtypes","volume":"154","author":"Nock","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/cpt196893358","article-title":"The local effect of morphine, nalorphine, and codeine on the diameter of the pupil of the eye","volume":"9","author":"Nomof","year":"1968","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1006\/exer.2000.0832_RF24","first-page":"897","article-title":"Ocular actions of moxonidine: a possible role for imidazoline receptors","volume":"269","author":"Ogidigben","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF25","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.178.4064.984","article-title":"Blood\u2013brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid artery injection","volume":"178","author":"Oldendorf","year":"1972","journal-title":"Science"},{"key":"10.1006\/exer.2000.0832_RF26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF00498739","article-title":"Blockade of alpha 2-adrenoceptors permits the operation of otherwise silent opioid kappa receptors at the sympathetic axons of rabbit jejunal arteries","volume":"334","author":"Ramme","year":"1986","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-4835(81)90003-8","article-title":"The effect of colchicine on aqueous humor dynamics","volume":"32","author":"Ritch","year":"1981","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0832_RF28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0024-3205(80)90107-1","article-title":"Bremazocine: a potent, long-acting opiate kappa-agonist","volume":"27","author":"Romer","year":"1980","journal-title":"Life Sci."},{"key":"10.1006\/exer.2000.0832_RF29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/02713688109001822","article-title":"Circadian rhythm in intraocular pressure: a rabbit model","volume":"1","author":"Rowland","year":"1981","journal-title":"Curr. Eye Res."},{"key":"10.1006\/exer.2000.0832_RF30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/02713688609020044","article-title":"Studies on the circadian rhythm of IOP in rabbits: correlation with aqueous inflow and cAMP content","volume":"5","author":"Rowland","year":"1986","journal-title":"Curr. Eye Res."},{"key":"10.1006\/exer.2000.0832_RF31","first-page":"992","article-title":"Diuretic effect of bremazocine, a kappa-opioid with central and peripheral sites of action","volume":"250","author":"Salas","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF32","first-page":"979","article-title":"[ N -Mehyl-Tyr, N -Methyl-Arg- D -Leu]-Dynorphin- A -(1-8)Ethylamide, a stable dynorphin analog, produces diuresis by kappa-opiate receptor activation in the rat","volume":"262","author":"Salas","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF33","first-page":"775","article-title":"A circadian rhythm of aqueous flow underlies the circadian rhythm of IOP in NZW rabbits","volume":"30","author":"Smith","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0832_RF34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/BF01945357","article-title":"Regulatory peptides in the eye","volume":"43","author":"Stone","year":"1987","journal-title":"Experimentia"},{"key":"10.1006\/exer.2000.0832_RF35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF00633196","article-title":"Opioid peptides decrease noradrenalin release and blood pressure in the rabbit at peripheral receptors","volume":"332","author":"Szabo","year":"1986","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0165-6147(89)90074-6","article-title":"Subtypes of the \u03ba-opioid receptor: fact or fiction?","volume":"10","author":"Traynor","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1006\/exer.2000.0832_RF37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1748-1716.1972.tb05329.x","article-title":"The action of neostigmine, morphine, cyclopentolate and homatropine on the secretion and outflow of aqueous humor in the rabbit eye","volume":"86","author":"Uusitalo","year":"1972","journal-title":"Acta Physiol. Scand."},{"key":"10.1006\/exer.2000.0832_RF38","first-page":"244","article-title":"Contribution of alpha-2 adrenoceptors to kappa opioid agonist-induced water diuresis in the rat","volume":"270","author":"Wang","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2000.0832_RF39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-4835(78)90083-0","article-title":"A fluorophotometric study of the effect of topical timolol on aqueous humor dynamics","volume":"27","author":"Yablonski","year":"1978","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0832_RF40","first-page":"2076","article-title":"Fluorophotometric study of intravenous carbonic anhydrase inhibitors in rabbits","volume":"28","author":"Yablonski","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0832_RF41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00045391-199705000-00003","article-title":"Sustained antihypertensive effects of chronic administration of two \u03ba-opioid agonists in spontaneously hypertensive rats","volume":"4","author":"Zhai","year":"1997","journal-title":"Amer. J. Ther."},{"key":"10.1006\/exer.2000.0832_RF42","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/00005344-199806000-00002","article-title":"Comparative hypotensive actions of three nonpeptide kappa opioid agonists on hippocampus of SHRs and normotensive WKY rats","volume":"31","author":"Zhai","year":"1998","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1006\/exer.2000.0832_RF43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/jop.1998.14.217","article-title":"Bunazosin reduces intraocular pressure in rabbits by increasing uveoscleral outflow","volume":"14","author":"Zhan","year":"1998","journal-title":"J. Ocular Pharmacol. Ther."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483500908327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483500908327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T02:55:52Z","timestamp":1557370552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483500908327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0014483500908327"],"URL":"https:\/\/doi.org\/10.1006\/exer.2000.0832","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}