{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:44:39Z","timestamp":1762159479530},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1006\/exer.2000.0853","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:46:56Z","timestamp":1032191216000},"page":"81-90","source":"Crossref","is-referenced-by-count":23,"title":["Expression and Characterization of SPARC in Human Lens and in the Aqueous and Vitreous Humors"],"prefix":"10.1006","volume":"71","author":[{"given":"Qi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John I","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Helene","family":"Sage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.2000.0853_RF1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.129.3.881","article-title":"Transglutaminase-catalysed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate","volume":"129","author":"Aeschlimann","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1006\/exer.2000.0853_RF2","series-title":"Ocular Pathology","author":"Apple","year":"1998"},{"key":"10.1006\/exer.2000.0853_RF3","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1242\/jcs.112.13.2155","article-title":"Molecular architecture of the lens fiber cell basal membrane complex","volume":"112","author":"Bassnett","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1006\/exer.2000.0853_RF4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/exer.1998.0608","article-title":"Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation","volume":"68","author":"Bassuk","year":"1999","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0853_RF5","series-title":"Perspective in Vision Research","article-title":"Biochemistry of the eye","author":"Berman","year":"1990"},{"key":"10.1006\/exer.2000.0853_RF6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1083\/jcb.130.3.503","article-title":"Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1","volume":"130","author":"Bornstein","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1006\/exer.2000.0853_RF7","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1091\/mbc.10.5.1569","article-title":"Primary mesenchymal cells isolated from SPARC-null animals display accelerated rates of proliferation","volume":"10","author":"Bradshaw","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1006\/exer.2000.0853_RF8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF01921736","article-title":"Tenascins, a growing family of extracellular matrix proteins","volume":"51","author":"Chiquet-Ehrismann","year":"1995","journal-title":"Experientia"},{"key":"10.1006\/exer.2000.0853_RF9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1432-1033.1986.tb10466.x","article-title":"Purification and tissue distribution of a small protein (BM-40) extracted from a basement membrane tumor","volume":"161","author":"Dziadek","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/exer.2000.0853_RF10","doi-asserted-by":"crossref","first-page":"32145","DOI":"10.1074\/jbc.274.45.32145","article-title":"SPARC regulates the expression of collagen type I and transforming growth factor-beta 1 in mesangial cells","volume":"274","author":"Francki","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.2000.0853_RF11","first-page":"109","article-title":"Large-scale sequencing of the rabbit corneal endothelial cDNA library","volume":"18","author":"Fujimaki","year":"1999","journal-title":"Cornea"},{"key":"10.1006\/exer.2000.0853_RF12","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1073\/pnas.88.7.2648","article-title":"SPARC modulates cell cycle progression in bovine aortic endothelial cells","volume":"88","author":"Funk","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1006\/exer.2000.0853_RF13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jcp.1041540108","article-title":"Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts","volume":"154","author":"Funk","year":"1993","journal-title":"J. Cell Physiol."},{"key":"10.1006\/exer.2000.0853_RF14","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/emboj\/17.7.1860","article-title":"Mice deficient for the secreted glycoprotein SPARC\/osteonectin\/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens","volume":"17","author":"Gilmour","year":"1998","journal-title":"EMBO J."},{"key":"10.1006\/exer.2000.0853_RF15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/(SICI)1097-4644(19990801)74:2<152::AID-JCB2>3.0.CO;2-4","article-title":"Cell cycle-dependent nuclear location of the matricellular protein SPARC: association with the nuclear matrix","volume":"74","author":"Gooden","year":"1999","journal-title":"J. Cell Biochem."},{"key":"10.1006\/exer.2000.0853_RF16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1440-169x.1999.00443.x","article-title":"A calcium-binding motif in SPARC\/osteonectin inhibits chordomesoderm cell migration during Xenopus laevis gastrulation: evidence of counter-adhesive activity in vivo","volume":"41","author":"Huynh","year":"1999","journal-title":"Dev. Growth Differ."},{"key":"10.1006\/exer.2000.0853_RF17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1242\/dev.117.2.701","article-title":"Regulation of lens cell growth and polarity by an embryo-specific growth factor and by inhibitors of lens cell proliferation and differentiation","volume":"117","author":"Hyatt","year":"1993","journal-title":"Development"},{"key":"10.1006\/exer.2000.0853_RF18","first-page":"1","article-title":"Quantitative determination of human aqueous proteins by crossed immunoelectrophoresis","volume":"28","author":"Inada","year":"1984","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1006\/exer.2000.0853_RF19","first-page":"4","article-title":"Up-regulation of osteonectin\/SPARC in age-related cataractous human lens epithelia","volume":"17","author":"Kantorow","year":"1998","journal-title":"Mol. Vis."},{"key":"10.1006\/exer.2000.0853_RF20","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V75.5.1105.1105","article-title":"Human platelet osteonectin: release, surface expression and partial characterization","volume":"75","author":"Kelm","year":"1990","journal-title":"Blood"},{"key":"10.1006\/exer.2000.0853_RF21","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1182\/blood.V80.12.3112.3112","article-title":"Characterization of human osteoblast and megakaryocyte-derived osteonectin (SPARC)","volume":"80","author":"Kelm","year":"1992","journal-title":"Blood"},{"key":"10.1006\/exer.2000.0853_RF22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1006\/exer.1997.0377","article-title":"Spatiotemporal distribution of SPARC\/osteonectin in developing and mature chicken retina","volume":"65","author":"Kim","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0853_RF23","doi-asserted-by":"crossref","first-page":"29635","DOI":"10.1074\/jbc.273.45.29635","article-title":"SPARC inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells","volume":"273","author":"Kupprion","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.2000.0853_RF52","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"277","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1006\/exer.2000.0853_RF24","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1083\/jcb.111.6.3065","article-title":"Functional mapping of SPARC: peptides from two distinct Ca++-binding sites modulate cell shape","volume":"111","author":"Lane","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1006\/exer.2000.0853_RF25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1096\/fasebj.8.2.8119487","article-title":"The biology of SPARC, a protein that modulates cell-matrix interactions","volume":"8","author":"Lane","year":"1994","journal-title":"FASEB J."},{"key":"10.1006\/exer.2000.0853_RF26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1006\/exer.1996.0148","article-title":"Distribution of SPARC protein (osteonectin) in normal and wounded feline cornea","volume":"63","author":"Latvala","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0853_RF27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/8756-3282(92)90206-C","article-title":"Immunological screening of SPARC\/osteonectin in nonmineralized tissues","volume":"13","author":"Maillard","year":"1992","journal-title":"Bone"},{"key":"10.1006\/exer.2000.0853_RF28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-5793(87)81040-2","article-title":"Solubilization of protein BM-40 from a basement membrane tumor with chelating agents and evidence for its identity with osteonectin and SPARC","volume":"218","author":"Mann","year":"1987","journal-title":"FASEB J."},{"key":"10.1006\/exer.2000.0853_RF29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/jmbi.1995.0557","article-title":"The C-terminal portion of BM-40 (SPARC\/osteonectin) is an autonomously-folding and crystallisable domain that binds calcium and collagen IV","volume":"253","author":"Maurer","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1006\/exer.2000.0853_RF30","first-page":"2547","article-title":"SPARC from corneal epithelial cells modulates collagen contraction by keratocytes","volume":"39","author":"Mishima","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0853_RF31","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/(SICI)1097-4644(19980915)70:4<543::AID-JCB10>3.0.CO;2-I","article-title":"SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway","volume":"70","author":"Motamed","year":"1998","journal-title":"J. Cell Biochem."},{"key":"10.1006\/exer.2000.0853_RF32","first-page":"A704","article-title":"Fibroblast growth factor receptor (FGFR)-1 mediates the inhibition of endothelial cell proliferation and promotion of skeletal myoblast differentiation by SPARC","volume":"13","author":"Motamed","year":"1999","journal-title":"FASEB J."},{"key":"10.1006\/exer.2000.0853_RF33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcb.240570218","article-title":"SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the calcium-binding EF-Hand","volume":"57","author":"Murphy-Ullrich","year":"1995","journal-title":"J. Cell Biochem."},{"key":"10.1006\/exer.2000.0853_RF34","series-title":"Principles and Concepts","article-title":"Ophthalmology","author":"Newell","year":"1996"},{"key":"10.1006\/exer.2000.0853_RF35","first-page":"2674","article-title":"SPARC deficiency leads to early-onset cataractogenesis","volume":"39","author":"Norose","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0853_RF36","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1073\/pnas.89.4.1281","article-title":"The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors","volume":"89","author":"Raines","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1006\/exer.2000.0853_RF37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jcp.1041270305","article-title":"Endothelial cell injury in vitro is associated with increased secretion of an Mr 43000 glycoprotein ligand","volume":"127","author":"Sage","year":"1986","journal-title":"J Cell Physiol"},{"key":"10.1006\/exer.2000.0853_RF38","doi-asserted-by":"crossref","first-page":"14831","DOI":"10.1016\/S0021-9258(18)98545-5","article-title":"Extracellular proteins that modulate cell-matrix interactions: SPARC, tenascin, and thrombospondin","volume":"266","author":"Sage","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.2000.0853_RF39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcb.240570113","article-title":"Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca+2-binding E-F hand sequence","volume":"57","author":"Sage","year":"1995","journal-title":"J Cell Biochem"},{"key":"10.1006\/exer.2000.0853_RF40","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1074\/jbc.272.14.9237","article-title":"Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens","volume":"272","author":"Sasaki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exer.2000.0853_RF41","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/emboj\/17.6.1625","article-title":"Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40\/SPARC\/osteonectin","volume":"17","author":"Sasaki","year":"1998","journal-title":"EMBO J."},{"key":"10.1006\/exer.2000.0853_RF42","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0014-4835(05)80060-0","article-title":"Identification of SPARC in the anterior lens capsule and its expression by lens epithelial cells","volume":"61","author":"Sawhney","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0853_RF43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1242\/dev.118.1.117","article-title":"Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns","volume":"118","author":"Schulz","year":"1993","journal-title":"Development"},{"key":"10.1006\/exer.2000.0853_RF44","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1073\/pnas.81.9.2868","article-title":"Monoclonal antibodies to native non-collagenous bone-specific proteins","volume":"81","author":"Stenner","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1006\/exer.2000.0853_RF45","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1073\/pnas.83.18.6892","article-title":"Human platelets contain and secrete osteonectin, a major protein of mineralized bone","volume":"83","author":"Stenner","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1006\/exer.2000.0853_RF46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-4835(89)90025-0","article-title":"Protein composition of human aqueous humor: SDS\u2013PAGE analysis of surgical and post-mortem samples","volume":"48","author":"Tripathi","year":"1989","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0853_RF47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1432-0436.1996.6120077.x","article-title":"Cellular and molecular features of lens differentiation: a review of recent advances","volume":"61","author":"Wride","year":"1996","journal-title":"Differentiation"},{"key":"10.1006\/exer.2000.0853_RF48","first-page":"2185","article-title":"Primary culture and characterization of microvascular endothelial cells from Macaca monkey retina","volume":"37","author":"Yan","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0853_RF49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/002215549804600102","article-title":"SPARC is expressed by ganglion cells and astrocytes in bovine retina","volume":"46","author":"Yan","year":"1998","journal-title":"J Histochem. Cytochem."},{"key":"10.1006\/exer.2000.0853_RF50","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1177\/002215549904701201","article-title":"SPARC, a matricellular glycoprotein with important biological functions","volume":"47","author":"Yan","year":"1999","journal-title":"J. Histochem. Cytochem."},{"key":"10.1006\/exer.2000.0853_RF51","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1350-9462(96)00024-9","article-title":"Cell cycle regulation in the lens: proliferation, quiescence, apoptosis and differentiation","volume":"16","author":"Zelenka","year":"1997","journal-title":"Prog. Retinal Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483500908534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483500908534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T03:36:05Z","timestamp":1620012965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483500908534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0014483500908534"],"URL":"https:\/\/doi.org\/10.1006\/exer.2000.0853","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}