{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:36:36Z","timestamp":1772516196026,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1006\/exer.2000.0873","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:46:56Z","timestamp":1032191216000},"page":"209-213","source":"Crossref","is-referenced-by-count":79,"title":["Bax -dependent and Independent Pathways of Retinal Ganglion Cell Death Induced by Different Damaging Stimuli"],"prefix":"10.1006","volume":"71","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra L.","family":"Schlamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith P.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Nickells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.2000.0873_RF1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1006\/exer.2000.0873_RF2","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","article-title":"Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats","volume":"14","author":"Berkelaar","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1006\/exer.2000.0873_RF3","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1523\/JNEUROSCI.16-13-04186.1996","article-title":"Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2","volume":"16","author":"Bonfanti","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exer.2000.0873_RF4","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/j.1460-9568.1996.tb01317.x","article-title":"Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice","volume":"8","author":"Cenni","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exer.2000.0873_RF5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0169-328X(99)00032-7","article-title":"Caspase inhibitors block the retinal ganglion cell death following optic nerve transection","volume":"67","author":"Chaudhary","year":"1999","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exer.2000.0873_RF6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80173-7","article-title":"BAX is required for neuronal death after trophic factor deprivation and during development","volume":"17","author":"Deckwerth","year":"1996","journal-title":"Neuron"},{"key":"10.1006\/exer.2000.0873_RF7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/neu.480250408","article-title":"Apoptosis in adult retinal ganglion cells after axotomy","volume":"25","author":"Garcia-Valenzuela","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1006\/exer.2000.0873_RF8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-4835(95)80056-5","article-title":"Programmed cell death of retinal ganglion cells during experimental glaucoma","volume":"61","author":"Garcia-Valenzuela","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1006\/exer.2000.0873_RF9","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0006-291X(05)80297-9","article-title":"Fragmentation of DNA in the retina of chicken embryos coincides with retinal ganglion cell death","volume":"183","author":"Ilschner","year":"1992","journal-title":"Biochem. Biophys. Res. Com."},{"key":"10.1006\/exer.2000.0873_RF10","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1460-9568.1997.tb01534.x","article-title":"Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat","volume":"9","author":"Isenmann","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exer.2000.0873_RF11","first-page":"713","article-title":"Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53","volume":"40","author":"Joo","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF12","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle glaucoma","volume":"115","author":"Kerrigan","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"10.1006\/exer.2000.0873_RF13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.270.5233.96","article-title":"Bax-deficient mice with lymphoid hyperplasia and male germ cell death","volume":"270","author":"Knudson","year":"1995","journal-title":"Science"},{"key":"10.1006\/exer.2000.0873_RF14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/archopht.1996.01100130484027","article-title":"Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy","volume":"114","author":"Levin","year":"1996","journal-title":"Arch. Ophthalmol."},{"key":"10.1006\/exer.2000.0873_RF15","first-page":"2545","article-title":"Identification of bcl-2 family genes in the rat retina","volume":"38","author":"Levin","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF16","first-page":"1004","article-title":"Experimental induction of retinal ganglion cell death in adult mice","volume":"40","author":"Li","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF17","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0896-6273(94)90266-6","article-title":"Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia","volume":"13","author":"Martinou","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/exer.2000.0873_RF18","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1126\/science.281.5385.2027","article-title":"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis","volume":"281","author":"Marzo","year":"1998","journal-title":"Science"},{"key":"10.1006\/exer.2000.0873_RF19","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.187.8.1261","article-title":"The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins","volume":"187","author":"Marzo","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1006\/exer.2000.0873_RF20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.139.1.205","article-title":"Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death","volume":"139","author":"Miller","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1006\/exer.2000.0873_RF21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor supressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1006\/exer.2000.0873_RF22","first-page":"1713","article-title":"Suppression of developmental retinal cell death but not photoreceptor degeneration in Bax-deficient mice","volume":"39","author":"Mosinger Ogilvie","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF23","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.7878471","article-title":"Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice","volume":"267","author":"Motoyama","year":"1995","journal-title":"Science"},{"key":"10.1006\/exer.2000.0873_RF24","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF25","first-page":"2132","article-title":"The role of the p53 protein in the selective vulnerability of the inner retina to transient ischemia","volume":"39","author":"Rosenbaum","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2000.0873_RF26","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1001\/archopht.117.11.1540","article-title":"Is neuroprotection a viable therapy for glaucoma?","volume":"117","author":"Weinreb","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"10.1006\/exer.2000.0873_RF27","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.281.5381.1355","article-title":"Essential role of CED-4 oligomerization in CED-3 activation and apoptosis","volume":"281","author":"Yang","year":"1998","journal-title":"Science"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448350090873X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448350090873X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T19:25:46Z","timestamp":1576524346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448350090873X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S001448350090873X"],"URL":"https:\/\/doi.org\/10.1006\/exer.2000.0873","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}