{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:50:18Z","timestamp":1762159818884},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1006\/exer.2002.1173","type":"journal-article","created":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T14:13:08Z","timestamp":1036419188000},"page":"747-752","source":"Crossref","is-referenced-by-count":13,"title":["Phenytoin Blocks Retinal Ganglion Cell Death After Partial Optic Nerve Crush"],"prefix":"10.1006","volume":"74","author":[{"given":"Rita","family":"Naskar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Quinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Romann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schuettauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exer.2002.1173_RF1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0168-0102(96)01165-0","article-title":"Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells","volume":"27","author":"Agostinho","year":"1997","journal-title":"Neurosci. Res."},{"key":"10.1006\/exer.2002.1173_RF2","first-page":"413","article-title":"Effect of diphenylhydantoin on glaucomatous field loss: a preliminary report","volume":"76","author":"Becker","year":"1972","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1006\/exer.2002.1173_RF3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0304-3940(94)91106-1","article-title":"Phenytoin protects against hypoxia-induced death of cultured hippocampal neurons","volume":"175","author":"Boehm","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exer.2002.1173_RF4","first-page":"1549","article-title":"Pharmacologic protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam","volume":"266","author":"Fern","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exer.2002.1173_RF5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1476-5381.1980.tb10890.x","article-title":"Presynaptic and postsynaptic depressant effect on phenytoin sodium at the neuromuscular junction","volume":"69","author":"Gage","year":"1980","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/exer.2002.1173_RF6","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0003-4975(00)01354-0","article-title":"Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection","volume":"69","author":"Gangemi","year":"2000","journal-title":"Ann. Thorac. Surg."},{"key":"10.1006\/exer.2002.1173_RF7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0014-4886(75)90170-3","article-title":"The nerve cell body response to axotomy","volume":"48","author":"Grafstein","year":"1975","journal-title":"Exp. Neurol."},{"key":"10.1006\/exer.2002.1173_RF8","first-page":"190","article-title":"Ethambutol is toxic to retinal ganglion cell through an excitotoxic pathway","volume":"40","author":"Heng","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2002.1173_RF9","first-page":"113","article-title":"Effect of diphenylhydantoin in ischemic optic neuritis","volume":"70","author":"Keltner","year":"1972","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1006\/exer.2002.1173_RF10","first-page":"451","article-title":"The effect of diphenylhydantoin on ocal cerebral blood flow","volume":"22","author":"Kennedy","year":"1972","journal-title":"Neurology"},{"key":"10.1006\/exer.2002.1173_RF11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1212\/WNL.37.2.319","article-title":"Effect of anticonvulsant drugs on glutamate neurotoxicity in cortical cell culture","volume":"36","author":"Koh","year":"1987","journal-title":"Neurology"},{"key":"10.1006\/exer.2002.1173_RF12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/08820539909061468","article-title":"Saving the nerve from glaucoma: memantine to caspases","volume":"14","author":"Naskar","year":"1999","journal-title":"Semin. Ophthalmol."},{"key":"10.1006\/exer.2002.1173_RF13","first-page":"393","article-title":"Diphenylhydantoin and sodium influx","volume":"20","author":"Pincus","year":"1970","journal-title":"Neurology"},{"key":"10.1006\/exer.2002.1173_RF14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1001\/archneur.1972.00490070022003","article-title":"Diphenylhydantoin and ion flux in lobster nerve","volume":"26","author":"Pincus","year":"1972","journal-title":"Arch. Neurol."},{"key":"10.1006\/exer.2002.1173_RF15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1001\/archneur.1973.00490280051007","article-title":"Diphenylhydantoin and calcium. Relation to norepinephrine release from brain slices","volume":"29","author":"Pincus","year":"1973","journal-title":"Arch. Neurol."},{"key":"10.1006\/exer.2002.1173_RF29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0014-4886(86)90255-4","article-title":"Phenytoin, tetrodoxin, and acetylcholine release","volume":"94","author":"Pincus","year":"1986","journal-title":"Exp. Neurol."},{"key":"10.1006\/exer.2002.1173_RF16","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1046\/j.1471-4159.1996.66062506.x","article-title":"Oxidative stress, hypoxia and ischemia-like conditons increase the release of endogenous amino acids by distinct mechanisms of cultured retinal cells","volume":"66","author":"Rego","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1006\/exer.2002.1173_RF17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0166-2236(87)90177-9","article-title":"Excitotoxicity and the NMDA receptor","volume":"10","author":"Rothman","year":"1987","journal-title":"Trends Neurosci."},{"key":"10.1006\/exer.2002.1173_RF18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1460-9568.1993.tb00533.x","article-title":"Recovery of brightness discrimination in adult rats despite progressive loss of retrogradely labelled retinal ganglion cells after controlled optic nerve crush","volume":"5","author":"Sautter","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exer.2002.1173_RF19","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1089\/10430349950017716","article-title":"Bcl-2 gene therapy exacerbates excitotoxicity","volume":"10","author":"Simon","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1006\/exer.2002.1173_RF20","series-title":"Biometry","author":"Sokal","year":"1995"},{"key":"10.1006\/exer.2002.1173_RF21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-8993(89)90045-0","article-title":"Phenytoin protects against ischemia-produced neuronal cell death","volume":"483","author":"Taft","year":"1989","journal-title":"Brain Res."},{"key":"10.1006\/exer.2002.1173_RF22","first-page":"1618","article-title":"Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine","volume":"37","author":"Vorwerk","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1006\/exer.2002.1173_RF23","first-page":"208","article-title":"Chelating drugs and zinc","volume":"33","author":"Weismann","year":"1986","journal-title":"Danish Med. Bull."},{"key":"10.1006\/exer.2002.1173_RF24","first-page":"195","article-title":"Inhibition of synaptic transmission by diphenylhydantoin","volume":"101","author":"Yaari","year":"1976","journal-title":"Trans. Am. Neurol. Assoc."},{"key":"10.1006\/exer.2002.1173_RF25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ana.410010405","article-title":"Depression of synaptic transmission by diphenylhydantoin","volume":"1","author":"Yaari","year":"1977","journal-title":"Ann. Neurol."},{"key":"10.1006\/exer.2002.1173_RF26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ana.410200202","article-title":"Phenytoin: mechanisms of its anticonvulsant action","volume":"20","author":"Yaari","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1006\/exer.2002.1173_RF27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1089\/neu.1997.14.665","article-title":"NMDA-receptor antagonist protects neurons from secondary degeneration after partial optic nerve crush","volume":"14","author":"Yoles","year":"1997","journal-title":"J. Neurotrauma"},{"key":"10.1006\/exer.2002.1173_RF28","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archopht.116.7.906","article-title":"Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve","volume":"116","author":"Yoles","year":"1998","journal-title":"Arch. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483502911735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483502911735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T10:20:38Z","timestamp":1554978038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483502911735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["S0014483502911735"],"URL":"https:\/\/doi.org\/10.1006\/exer.2002.1173","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}