{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:48:47Z","timestamp":1791906527579,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1006\/exnr.1997.6688","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T23:00:46Z","timestamp":1033945246000},"page":"193-202","source":"Crossref","is-referenced-by-count":97,"title":["A Neuronal Correlate of Secondary Hyperalgesia in the Rat Spinal Dorsal Horn Is Submodality Selective and Facilitated by Supraspinal Influence"],"prefix":"10.1006","volume":"149","author":[{"given":"Antti","family":"Pertovaara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.1997.6688_EN976688RF1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0304-3959(96)03199-5","article-title":"Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin","volume":"68","author":"Ali","year":"1996","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0361-9230(95)02027-6","article-title":"The medullary dorsal reticular nucleus facilitates acute nociception in the rat","volume":"39","author":"Almeida","year":"1996","journal-title":"Brain Res. Bull."},{"key":"10.1006\/exnr.1997.6688_EN976688RF3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.ne.07.030184.001521","article-title":"Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry","volume":"7","author":"Basbaum","year":"1984","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3959(96)03165-X","article-title":"Mechanisms of touch-evoked pain (allodynia): A new model","volume":"68","author":"Cervero","year":"1996","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3959(94)90181-3","article-title":"A psychophysical study of secondary hyperalgesia: Evidence for increased pain to input from nociceptors","volume":"58","author":"Cervero","year":"1994","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0304-3959(84)90094-0","article-title":"A positive feedback loop between spinal cord nociceptive pathways and antinociceptive areas of the cat's brain stem","volume":"20","author":"Cervero","year":"1984","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0304-3959(94)90105-8","article-title":"Pentobarbital prevents the development of C-fiber-induced hyperalgesia in the rat","volume":"57","author":"Cleland","year":"1994","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00234321","article-title":"The blockade of bulbospinal inhibition by 5-hydroxytryptamine antagonists","volume":"11","author":"Clineschmidt","year":"1970","journal-title":"Exp. Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(93)90161-H","article-title":"Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence","volume":"52","author":"Coderre","year":"1993","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0304-3959(87)90071-6","article-title":"WDR response profiles of spinal dorsal horn neurons may be unmasked by barbiturate anesthesia","volume":"28","author":"Collins","year":"1987","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1523\/JNEUROSCI.12-03-00883.1992","article-title":"Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey","volume":"12","author":"Dougherty","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3940(93)90837-B","article-title":"Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans","volume":"159","author":"Gr\u00f6nroos","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6688_EN976688RF13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3940(94)90788-9","article-title":"Capsaicin-induced central facilitation of a sympathetic vasoconstrictor response to painful stimulation in humans","volume":"182","author":"Gr\u00f6nroos","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6688_EN976688RF14","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1152\/jn.1980.43.6.1578","article-title":"Inhibition and excitation of primate spinothalamic tract neurons by stimulation in region of nucleus reticularis gigantocellularis","volume":"43","author":"Haber","year":"1980","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(96)12588-X","article-title":"Supraspinal influence on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis","volume":"209","author":"Herrero","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6688_EN976688RF16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(83)90111-7","article-title":"Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy","volume":"288","author":"Hodge","year":"1983","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF17","series-title":"Principles of Neural Science","author":"Kandel","year":"1991"},{"key":"10.1006\/exnr.1997.6688_EN976688RF18","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1523\/JNEUROSCI.11-05-01433.1991","article-title":"Hyperalgesia during acute opioid abstinence: Evidence for a nociceptive facilitating function of the rostroventromedial medulla","volume":"11","author":"Kaplan","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3959(92)90262-A","article-title":"Dynamic and static components of mechanical hyperalgesia in human hairy skin","volume":"51","author":"Koltzenburg","year":"1992","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/brain\/117.3.579","article-title":"Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain","volume":"117","author":"Koltzenburg","year":"1994","journal-title":"Brain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF21","first-page":"190","article-title":"Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms","volume":"66","author":"Lamotte","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0304-3959(79)90049-6","article-title":"Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat","volume":"6","author":"Lebars","year":"1979","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/jn.1996.76.2.1005","article-title":"Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is reduced during central sensitization","volume":"76","author":"Lin","year":"1996","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF24","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1523\/JNEUROSCI.16-09-03026.1996","article-title":"Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons","volume":"16","author":"Lin","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0361-9230(96)00313-9","article-title":"Supraspinal influence on hindlimb withdrawal thresholds and mustard oil-induced secondary allodynia in rats","volume":"42","author":"Mansikka","year":"1997","journal-title":"Brain Res. Bull."},{"key":"10.1006\/exnr.1997.6688_EN976688RF26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0014-2999(95)00725-3","article-title":"Different roles of \u03b12","volume":"297","author":"Mansikka","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0304-3940(91)90784-Q","article-title":"Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat","volume":"127","author":"Martin","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6688_EN976688RF28","first-page":"1161","article-title":"Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuli","volume":"72","author":"Morgan","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF29","first-page":"337","article-title":"Receptor and cellular mechanisms involved in mustard oil-induced activation of dorsal horn neurones","volume":"2","author":"Munro","year":"1994","journal-title":"Prog. Pain Res. Manag."},{"key":"10.1006\/exnr.1997.6688_EN976688RF30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0031-9384(66)90064-3","article-title":"Injection of solutions into cerebral tissue: Relation between volume and diffusion","volume":"1","author":"Myers","year":"1966","journal-title":"Physiol. Behav."},{"key":"10.1006\/exnr.1997.6688_EN976688RF31","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1006\/exnr.1997.6688_EN976688RF32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(96)13136-0","article-title":"Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats","volume":"218","author":"Pertovaara","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6688_EN976688RF33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1006\/exnr.1997.6555","article-title":"Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat","volume":"147","author":"Pertovaara","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0006-8993(86)91217-5","article-title":"Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat","volume":"384","author":"Reeh","year":"1986","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF35","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1152\/jn.1996.76.5.3025","article-title":"Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation","volume":"76","author":"Ren","year":"1996","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/BF00255242","article-title":"The use of local anesthetic microinjections to identify central neural pathways: A quantitative evaluation of the time course and extent of the neuronal block","volume":"68","author":"Sandk\u00fchler","year":"1987","journal-title":"Exp. Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(93)90183-P","article-title":"Afferent and spinal mechanisms of joint pain","volume":"55","author":"Schaible","year":"1993","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF38","first-page":"21","article-title":"Presynaptic inhibition in the vertebrate central nervous system","volume":"57","author":"Schmidt","year":"1973","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1523\/JNEUROSCI.15-01-00333.1995","article-title":"Novel classes of responsive and unresponsive C nociceptors in human skin","volume":"15","author":"Schmidt","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-8993(89)91293-6","article-title":"Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin","volume":"486","author":"Simone","year":"1989","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1152\/jn.1991.66.1.228","article-title":"Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons","volume":"66","author":"Simone","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0006-8993(93)91492-B","article-title":"Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injection","volume":"607","author":"Sorkin","year":"1993","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF43","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1152\/jn.1986.56.5.1411","article-title":"Viscerosomatic neurons in the lower thoracic spinal cord of the cat: Excitations and inhibitions evoked by splanchnic and somatic nerve volleys and by stimulation of brain stem nuclei","volume":"56","author":"Tattersal","year":"1986","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.1992.sp019069","article-title":"Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans","volume":"448","author":"Torebj\u00f6rk","year":"1992","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/exnr.1997.6688_EN976688RF45","first-page":"216","article-title":"Modern concepts of pain and hyperalgesia: Beyond the polymodal C-nociceptor","volume":"10","author":"Treede","year":"1995","journal-title":"News Physiol. Sci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia","volume":"38","author":"Treede","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"10.1006\/exnr.1997.6688_EN976688RF47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(96)00631-2","article-title":"Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia","volume":"737","author":"Urban","year":"1996","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0304-3959(92)90150-A","article-title":"Temporal processing of formalin pain: Differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation","volume":"49","author":"Vaccarino","year":"1992","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1958.sp005997","article-title":"Excitability changes in afferent fibre terminations and their relation to slow potentials","volume":"142","author":"Wall","year":"1958","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/exnr.1997.6688_EN976688RF50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(94)91044-8","article-title":"Subcutaneous formalin produces centrifugal hyperalgesia at a noninjected site via the NMDA-nitric oxide cascade","volume":"649","author":"Wiertelak","year":"1994","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1997.6688_EN976688RF51","first-page":"301","article-title":"Central plastic responses to pain","volume":"2","author":"Willis","year":"1994","journal-title":"Prog. Pain Res. Manag."},{"key":"10.1006\/exnr.1997.6688_EN976688RF52","series-title":"Sensory Mechanisms of the Spinal Cord","author":"Willis","year":"1991"},{"key":"10.1006\/exnr.1997.6688_EN976688RF53","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0304-3959(84)90045-9","article-title":"Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat","volume":"18","author":"Woolf","year":"1984","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF54","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1523\/JNEUROSCI.10-08-02717.1990","article-title":"Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord","volume":"10","author":"Woolf","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1997.6688_EN976688RF55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0304-3959(94)90195-3","article-title":"Sensitization of high mechanothreshold superficial dorsal horn and flexor motoneurones following chemosensitive primary afferent activation","volume":"58","author":"Woolf","year":"1994","journal-title":"Pain"},{"key":"10.1006\/exnr.1997.6688_EN976688RF56","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0304-3959(90)91147-B","article-title":"Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat","volume":"42","author":"Zhuo","year":"1990","journal-title":"Pain"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488697966887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488697966887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T15:43:49Z","timestamp":1576597429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488697966887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["S0014488697966887"],"URL":"https:\/\/doi.org\/10.1006\/exnr.1997.6688","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}