{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:04:49Z","timestamp":1790154289181,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1006\/exnr.1997.6772","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:57:12Z","timestamp":1033930632000},"page":"235-239","source":"Crossref","is-referenced-by-count":45,"title":["Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia"],"prefix":"10.1006","volume":"150","author":[{"given":"Josephine M.","family":"Heffernan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Eastwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice W.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.1997.6772_EN976772RF1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3940(92)90385-K","article-title":"Cholinergic fiber loss occurs in the absence of synaptophysin depletion in Alzheimer's disease primary visual cortex","volume":"142","author":"Beach","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6772_EN976772RF2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0197-4580(95)00013-5","article-title":"Correlations of synaptic and pathological markers with cognition of the elderly","volume":"16","author":"Dickson","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1006\/exnr.1997.6772_EN976772RF4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0306-4522(94)90292-5","article-title":"Synaptophysin gene expression in human brain: a quantitativein situ","volume":"59","author":"Eastwood","year":"1994","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.1997.6772_EN976772RF5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0306-4522(94)00586-T","article-title":"Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia","volume":"66","author":"Eastwood","year":"1995","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.1997.6772_EN976772RF6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr.Res."},{"key":"10.1006\/exnr.1997.6772_EN976772RF7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1001\/archpsyc.1997.01830180077010","article-title":"Increased concentrations of presynaptic proteins in the cingulate cortex of subjects with schizophrenia","volume":"54","author":"Gabriel","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1006\/exnr.1997.6772_EN976772RF8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease","volume":"41","author":"G\u00f3mez-Isla","year":"1997","journal-title":"Ann. Neurol"},{"key":"10.1006\/exnr.1997.6772_EN976772RF9","series-title":"Neurobiology and Psychiatry","article-title":"In vitro","author":"Harrison","year":"1995"},{"key":"10.1006\/exnr.1997.6772_EN976772RF10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1017\/S0033291700029858","article-title":"Regional and neuronal reductions of polyadenylated mRNA in Alzheimer's disease","volume":"21","author":"Harrison","year":"1991","journal-title":"Psychol. Med."},{"key":"10.1006\/exnr.1997.6772_EN976772RF11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0169-328X(91)90125-H","article-title":"Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated byin situ","volume":"9","author":"Harrison","year":"1991","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exnr.1997.6772_EN976772RF12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0169-328X(91)90058-6","article-title":"Alzheimer's disease: Specific increases in a G protein subunit (Gs","volume":"10","author":"Harrison","year":"1991","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exnr.1997.6772_EN976772RF13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3940(95)12102-A","article-title":"The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: Selective mRNA vulnerability and comparison with their encoded proteins","volume":"200","author":"Harrison","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6772_EN976772RF14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-9964(97)00048-0","article-title":"Gene expression and neuronal activity in schizophrenia: A study of polyadenylated mRNA in the hippocampal formation and cerebral cortex","volume":"26","author":"Harrison","year":"1997","journal-title":"Schizophr. Res."},{"key":"10.1006\/exnr.1997.6772_EN976772RF15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0197-4580(92)90111-A","article-title":"Regional synaptic pathology in Alzheimer's disease","volume":"13","author":"Honer","year":"1992","journal-title":"Neurobiol. Aging"},{"key":"10.1006\/exnr.1997.6772_EN976772RF16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-328X(94)00219-5","article-title":"Tissue pH as an indicator of mRNA preservation in human brain post-mortem","volume":"28","author":"Kingsbury","year":"1995","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exnr.1997.6772_EN976772RF17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(92)90003-K","article-title":"Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles","volume":"46","author":"Lassmann","year":"1992","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.1997.6772_EN976772RF18","series-title":"Regulation of Gene Expression and Brain Function","first-page":"31","article-title":"Chromatin structure, gene expression, and nuclear aluminum in Alzheimer's disease","author":"Lukiw","year":"1994"},{"key":"10.1006\/exnr.1997.6772_EN976772RF19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/neur.1996.0057","article-title":"Pyramidal nerve cell loss in Alzheimer's disease","volume":"5","author":"Mann","year":"1996","journal-title":"Neurodegeneration"},{"key":"10.1006\/exnr.1997.6772_EN976772RF20","first-page":"509","article-title":"Mechanisms of synaptic dysfunction in Alzheimer's disease","volume":"10","author":"Masliah","year":"1995","journal-title":"Histol. Histopathol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0304-3940(89)90582-X","article-title":"Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease","volume":"103","author":"Masliah","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1997.6772_EN976772RF22","first-page":"235","article-title":"Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease","volume":"138","author":"Masliah","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardisation of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1006\/exnr.1997.6772_EN976772RF24","first-page":"21","article-title":"Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria","volume":"6","author":"Nagy","year":"1995","journal-title":"Dementia"},{"key":"10.1006\/exnr.1997.6772_EN976772RF25","series-title":"CAMDEX: The Cambridge Examination for Mental Disorders in the Elderly","author":"Roth","year":"1988"},{"key":"10.1006\/exnr.1997.6772_EN976772RF26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00005072-199705000-00006","article-title":"Dementia with Lewy bodies versus pure Alzheimer disease: Differences in cognition, neuropathology, cholinergic dysfunction, and synapse density","volume":"56","author":"Samuel","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ana.410330209","article-title":"Synapse loss in the temporal lobe in Alzheimer's disease","volume":"33","author":"Scheff","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF28","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00005072-199708000-00011","article-title":"Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates cognitive decline in Alzheimer disease","volume":"56","author":"Sze","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF29","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1006\/exnr.1997.6772_EN976772RF30","first-page":"66","article-title":"Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia","volume":"4","author":"Zhan","year":"1993","journal-title":"Dementia"},{"key":"10.1006\/exnr.1997.6772_EN976772RF31","first-page":"79","article-title":"Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls","volume":"5","author":"Zhan","year":"1994","journal-title":"Dementia"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488697967728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488697967728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T20:26:12Z","timestamp":1557260772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488697967728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["S0014488697967728"],"URL":"https:\/\/doi.org\/10.1006\/exnr.1997.6772","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}