{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:31:03Z","timestamp":1772271063129,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1006\/exnr.1999.7167","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T22:54:06Z","timestamp":1033944846000},"page":"545-550","source":"Crossref","is-referenced-by-count":11,"title":["Role of Peripheral Adenosine A1 Receptors in the Regulation of Sleep Apneas in Rats"],"prefix":"10.1006","volume":"159","author":[{"given":"David W.","family":"Carley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miodrag","family":"Radulovacki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.1999.7167_RF1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1164\/ajrccm.150.2.8049848","article-title":"Treatment of refractory sleep apnea with supplemental carbon dioxide","volume":"150","author":"Badr","year":"1994","journal-title":"Am. Rev. Respir. Crit. Care Med."},{"key":"10.1006\/exnr.1999.7167_RF2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0006-8993(90)90277-I","article-title":"Cardiorespiratory function is altered by picomole injections of 5\u2032-N-ethyl-carboxamidoadenosine into the nucleus solitarius of rats","volume":"507","author":"Barraco","year":"1990","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7167_RF3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/sleep\/17.1.28","article-title":"Scoring transitions to REM sleep in rats based on the EEG phenomena of pre-REM sleep: An improved analysis of sleep structure","volume":"17","author":"Benington","year":"1994","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1164\/ajrccm\/143.2.245","article-title":"Effect of theophylline on sleep and sleep-disordered breathing in patients with chronic obstructive pulmonary disease","volume":"143","author":"Berry","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/exnr.1999.7167_RF5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.RES.61.6.779","article-title":"Cardiovascular and respiratory effects of adenosine in conscious man: Evidence of thermoreceptor activation","volume":"6","author":"Biaggioni","year":"1987","journal-title":"Circ. Res."},{"key":"10.1006\/exnr.1999.7167_RF6","first-page":"A325","article-title":"Systemic serotonin increases REM sleep apneas","volume":"17","author":"Carley","year":"1998","journal-title":"FASEB J."},{"key":"10.1006\/exnr.1999.7167_RF7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/sleep\/20.12.1093","article-title":"Adenosine A1 receptor agonist GR79236 suppresses apnea during all sleep stages in the rat","volume":"20","author":"Carley","year":"1997","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0031-9384(95)02205-8","article-title":"Effects of REM sleep deprivation on apnea in spontaneously hypertensive (SHR) and normotensive Wistar rats","volume":"59","author":"Carley","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.1006\/exnr.1999.7167_RF9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/sleep\/19.5.363","article-title":"Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar\u2013Kyoto rats","volume":"19","author":"Carley","year":"1996","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF10","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1152\/jappl.1996.80.6.2102","article-title":"Effects of inspired gas on sleep-related apneas in rats","volume":"80","author":"Christon","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/exnr.1999.7167_RF11","series-title":"Physiology of the Cerebrospinal Fluid","year":"1970"},{"key":"10.1006\/exnr.1999.7167_RF12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0006-8993(84)91096-5","article-title":"Respiratory effects of a long acting analog of adenosine","volume":"301","author":"Eldridge","year":"1984","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7167_RF13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1164\/ajrccm\/136.1.80","article-title":"The effects of aminophylline on sleep and sleep-disordered breathing in patients with obstructive apnea syndrome","volume":"136","author":"Espinoza","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/exnr.1999.7167_RF14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0165-0270(97)00118-0","article-title":"Detection of adenosine receptor antagonists in rat brain using a modified radioreceptor assay","volume":"77","author":"Finlayson","year":"1997","journal-title":"J. Neurosci. Methods"},{"key":"10.1006\/exnr.1999.7167_RF15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1542\/peds.62.5.801","article-title":"Aminophylline therapy for idiopathic apnea in premature infants: effects on lung function","volume":"62","author":"Gerhardt","year":"1978","journal-title":"Pediatrics"},{"key":"10.1006\/exnr.1999.7167_RF16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1164\/ajrccm\/145.2_Pt_1.453","article-title":"Adenosine stimulation, ventilation, and arousal from sleep","volume":"145","author":"Gleeson","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/exnr.1999.7167_RF17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(82)90242-7","article-title":"Regulation of breathing in the rat: Indication for a role of central adenosine mechanisms","volume":"33","author":"Hedner","year":"1982","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7167_RF18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/ajrccm\/138.1.16","article-title":"Alteration in obstructive apnea pattern induced by changes in oxygen and carbon-dioxide concentrations","volume":"138","author":"Hudgel","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/exnr.1999.7167_RF19","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1021\/jm00100a020","article-title":"Synthesis and biological activity of N6-sulfoalkyl derivatives of adenosine; water soluble and peripherally selective adenosine agonists","volume":"35","author":"Jacobson","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1006\/exnr.1999.7167_RF20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/thx.44.2.121","article-title":"Increase in ventilation caused by aminophylline in the absence of changes in ventral medullary extracellular fluid pH and carbon dioxide tension","volume":"44","author":"Javaheri","year":"1989","journal-title":"Thorax"},{"key":"10.1006\/exnr.1999.7167_RF21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJM199608223350805","article-title":"Effect of theophylline on sleep-disordered breathing in heart failure","volume":"335","author":"Javaheri","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/exnr.1999.7167_RF22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2362.1989.tb00197.x","article-title":"Adenosine receptor mediated stimulation of ventilation in man","volume":"19","author":"Jonzon","year":"1989","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1006\/exnr.1999.7167_RF23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-8993(98)00567-8","article-title":"Autoradiographic visualisation of axonal transport of adenosine A1 receptors along the rat vagus nerve and characterisation of adenosine A1 receptor binding in the dorsal vagal complex of hypertensive and normotensive rats","volume":"802","author":"Krstew","year":"1998","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7167_RF24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-2999(97)83032-4","article-title":"Complex interactions between nitric oxide and adenosine receptors in the rat isolated nodose ganglion","volume":"328","author":"Lawrence","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/PL00004947","article-title":"Adenosine\u2013dopamine receptor interactions in the isolated rat nodose ganglion but not in membranes of dorsal vagal complex","volume":"355","author":"Lawrence","year":"1997","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF26","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1152\/jappl.1986.61.5.1762","article-title":"Effects of adenosine on ventilatory responses to hypoxia and hypercapnia in humans","volume":"61","author":"Maxwell","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/exnr.1999.7167_RF27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1476-5381.1981.tb09964.x","article-title":"Effect of adenosine on carotid chemoreceptor activity in the cat","volume":"74","author":"McQueen","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF28","first-page":"H441","article-title":"Localization and functional effects of adenosine A1 receptors on cardiac vagal afferents in adult rats","volume":"274","author":"Middlekauff","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1006\/exnr.1999.7167_RF29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00177715","article-title":"Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat","volume":"335","author":"Monteiro","year":"1987","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0091-3057(94)00395-Y","article-title":"Adenosine analogs modulate the incidence of sleep apneas in rats","volume":"51","author":"Monti","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1006\/exnr.1999.7167_RF31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0091-3057(95)02032-2","article-title":"p-SPA, a peripheral adenosine A1 analogue, reduces sleep apneas in rats","volume":"53","author":"Monti","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1006\/exnr.1999.7167_RF32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1378\/chest.101.3.753","article-title":"Theophylline in obstructive sleep apnea. A double-blind evaluation","volume":"101","author":"Mulloy","year":"1992","journal-title":"Chest"},{"key":"10.1006\/exnr.1999.7167_RF33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0301-0082(81)90014-9","article-title":"The role of adenosine and its nucleotides in central synaptic transmission","volume":"16","author":"Phillis","year":"1981","journal-title":"Prog. Neurobiol."},{"key":"10.1006\/exnr.1999.7167_RF34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/sleep\/21.2.131","article-title":"Serotonin 5-HT3 receptor antagonist GR38032F suppresses sleep apneas in rats","volume":"21","author":"Radulovacki","year":"1998","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF35","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/sleep\/19.10.767","article-title":"Acute hypotension reduces sleep apneas in Zucker lean and Zucker obese rats","volume":"19","author":"Radulovacki","year":"1996","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF36","first-page":"268","article-title":"Adenosine analogs and sleep in rats","volume":"228","author":"Radulovacki","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exnr.1999.7167_RF37","series-title":"The Pharmacological Basis of Therapeutics","first-page":"589","article-title":"Central nervous system stimulants: The methylxanthines","author":"Rall","year":"1985"},{"key":"10.1006\/exnr.1999.7167_RF38","first-page":"346","article-title":"Adenosine and brain ischemia","volume":"4","author":"Rudolphi","year":"1992","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"10.1006\/exnr.1999.7167_RF39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1021\/jm00126a014","article-title":"Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7 positions","volume":"32","author":"Shamim","year":"1989","journal-title":"J. Med. Chem."},{"key":"10.1006\/exnr.1999.7167_RF40","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/jappl.1983.55.3.813","article-title":"Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation","volume":"55","author":"Skatrud","year":"1983","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/exnr.1999.7167_RF41","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1073\/pnas.78.5.3260","article-title":"Adenosine receptors and behavioral actions of methylxanthines","volume":"78","author":"Snyder","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.1999.7167_RF42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/sleep\/17.1.61","article-title":"Effect of inhaled 3% CO2 on Cheyne\u2013Stokes respiration in congestive heart failure","volume":"17","author":"Steens","year":"1994","journal-title":"Sleep"},{"key":"10.1006\/exnr.1999.7167_RF43","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/PL00005124","article-title":"Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: Comparison of pharmacokinetic, haemodynamic and EEG effects","volume":"356","author":"van Schaick","year":"1997","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF44","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2125.1985.tb05108.x","article-title":"Adenosine stimulates respiration in man","volume":"20","author":"Watt","year":"1985","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-2999(95)00533-1","article-title":"Changes in adenosine receptors mediating hypotension in morphine-dependent rats","volume":"294","author":"Whyte","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.1999.7167_RF46","first-page":"917","article-title":"Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat","volume":"260","author":"Yoshioka","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699971674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699971674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T10:28:20Z","timestamp":1680604100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488699971674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0014488699971674"],"URL":"https:\/\/doi.org\/10.1006\/exnr.1999.7167","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}