{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:44:00Z","timestamp":1791899040202,"version":"4.3.4"},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1006\/exnr.1999.7274","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:54:06Z","timestamp":1033930446000},"page":"392-396","source":"Crossref","is-referenced-by-count":55,"title":["Lesion-Induced Increase of BDNF Is Greater in the Striatum of Young versus Old Rat Brain"],"prefix":"10.1006","volume":"161","author":[{"given":"David M.","family":"Yurek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Fletcher-Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.1999.7274_RF1","first-page":"389","article-title":"The compensatory increase in striatal trophic activity is reduced in the aged rat brain","volume":"135","author":"Carvey","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.1999.7274_RF2","first-page":"1209","article-title":"28-month-old rats with a 16-month history of unilateral nigrostriatal lesion: Drug-induced behavior and response to grafted dopamine neurons and Schwann cells","volume":"22","author":"Collier","year":"1996","journal-title":"Soc. Neurosci."},{"key":"10.1006\/exnr.1999.7274_RF3","series-title":"Parkinson's Disease and Movement Disorders","first-page":"1065","article-title":"Neural transplantation for the treatment of Parkinson's disease: Present-day optimism and future challenges","author":"Collier","year":"1998"},{"key":"10.1006\/exnr.1999.7274_RF4","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1523\/JNEUROSCI.19-13-05563.1999","article-title":"Diminished viability, growth and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion. An argument for neurotrophic supplementation","volume":"19","author":"Collier","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1999.7274_RF5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(96)13146-3","article-title":"In vitro assessment of neurotrophic activity from the striatum of aging rats","volume":"218","author":"Kaseloo","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7274_RF6","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/j.1460-9568.1995.tb01148.x","article-title":"BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: Partial disagreement with mRNA levels","volume":"7","author":"Nawa","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.1999.7274_RF7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(93)90560-A","article-title":"Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts","volume":"626","author":"Sauer","year":"1993","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7274_RF8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/exnr.1993.1182","article-title":"Expression of neurotrophins by midbrain dopaminergic neurons","volume":"124","author":"Seroogy","year":"1993","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.1999.7274_RF9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/cne.903420302","article-title":"Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs","volume":"342","author":"Seroogy","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.1999.7274_RF10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00001756-199401120-00014","article-title":"6-hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra","volume":"5","author":"Venero","year":"1994","journal-title":"NeuroReport"},{"key":"10.1006\/exnr.1999.7274_RF11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/exnr.1996.0011","article-title":"BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons","volume":"137","author":"Yurek","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.1999.7274_RF12","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1523\/JNEUROSCI.18-15-06040.1998","article-title":"Optimal effect of BDNF on the development of fetal ventral mesencephalic tissue transplants coincides with the developmental expression of BDNF within the striatum","volume":"18","author":"Yurek","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.1999.7274_RF13","unstructured":"Yurek, D. M., and K. B. Seroogy. 1999. Neurotrophic factor protection of dopaminergic neurons. In Neurobiology of the NeurotrophinsI. Mocchetti, Ed., Sullburger & Graham, New York, in press."},{"key":"10.1006\/exnr.1999.7274_RF14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0165-3806(96)00159-9","article-title":"The BDNF content of postnatal and adult rat brain: The effects of 6-hydroxydopamine lesions in adult brain","volume":"97","author":"Zhou","year":"1996","journal-title":"Dev. Brain Res."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699972746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699972746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T04:05:53Z","timestamp":1576555553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488699972746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0014488699972746"],"URL":"https:\/\/doi.org\/10.1006\/exnr.1999.7274","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}