{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:33:06Z","timestamp":1791117186409,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1006\/exnr.1999.7302","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T22:25:04Z","timestamp":1033943104000},"page":"714-723","source":"Crossref","is-referenced-by-count":33,"title":["Selective Susceptibility to Inhibitors of GABA Synthesis and Antagonists of GABAA Receptor in Rats with Genetic Absence Epilepsy"],"prefix":"10.1006","volume":"161","author":[{"given":"Marguerite","family":"Vergnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Any","family":"Boehrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Reibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Simler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Marescaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.1999.7302_RF1","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"111","article-title":"Physiopathogenesis of feline generalized penicillin epilepsy: The role of thalamocortical mechanisms","author":"Avoli","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0165-6147(93)90056-P","article-title":"GABA B receptors","volume":"14","author":"Bittiger","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1006\/exnr.1999.7302_RF3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/0028-3908(83)90113-2","article-title":"Benzodiazepine receptor ligands with positive and negative efficacy","volume":"22","author":"Braestrup","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1006\/exnr.1999.7302_RF4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0306-4522(99)00227-4","article-title":"Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy","volume":"93","author":"Brailowsky","year":"1999","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.1999.7302_RF5","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"399","article-title":"Anatomy of generalized convulsive seizures","author":"Browning","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-1211(90)90002-D","article-title":"Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): Differences in threshold and pattern","volume":"6","author":"Browning","year":"1990","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF7","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/jn.1989.62.5.1149","article-title":"Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex","volume":"62","author":"Chagnac-Amitai","year":"1989","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/(SICI)1096-9861(19980518)394:4<520::AID-CNE9>3.0.CO;2-3","article-title":"Neocortex in the hippocampus: An anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats","volume":"394","author":"Chevassus-au-Louis","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.1999.7302_RF9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0920-1211(87)90005-2","article-title":"The WAG\/Rij rat model for absence epilepsy: Age and sex factors","volume":"1","author":"Coenen","year":"1987","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1152\/jn.1997.78.1.335","article-title":"Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo","volume":"78","author":"Contreras","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF11","first-page":"792","article-title":"Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: Antagonism by MK-801","volume":"262","author":"Corda","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exnr.1999.7302_RF12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-0082(97)00091-9","article-title":"Pathophysiological mechanisms of genetic absence epilepsy in the rat","volume":"55","author":"Danober","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1006\/exnr.1999.7302_RF13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1152\/jn.1997.77.2.621","article-title":"Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse stargazer","volume":"77","author":"Di Pasquale","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF14","first-page":"37","article-title":"Diminished GABA-A receptor-mediated inhibition in the inferior colliculus may subserve audiogenic seizure susceptibility","volume":"39","author":"Faingold","year":"1998","journal-title":"Epilepsia"},{"key":"10.1006\/exnr.1999.7302_RF15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1989.tb05273.x","article-title":"Developing genetically epilepsy-prone rats have an abnormal seizure response to Flurothyl","volume":"30","author":"Franck","year":"1989","journal-title":"Epilepsia"},{"key":"10.1006\/exnr.1999.7302_RF16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00004691-198610000-00002","article-title":"Role of inhibitory mechanisms in staring spells","volume":"3","author":"Fromm","year":"1986","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0166-2236(88)90166-X","article-title":"Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy","volume":"11","author":"Gloor","year":"1988","journal-title":"Trends Neurosci."},{"key":"10.1006\/exnr.1999.7302_RF18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0006-8993(96)00806-2","article-title":"Fos induction in subtypes of cerebrocortical neurons following single picrotoxin-induced seizures","volume":"738","author":"Hiscock","year":"1996","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7302_RF19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0361-9230(80)90099-4","article-title":"GABA and seizures induced by inhibitors of glutamic acid decarboxylase","volume":"5","author":"Horton","year":"1980","journal-title":"Brain Res. Bull."},{"key":"10.1006\/exnr.1999.7302_RF20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1126\/science.1321503","article-title":"The role of GABA B receptor activation in absence seizures of lethargic (lh\/lh) mice","volume":"257","author":"Hosford","year":"1992","journal-title":"Science"},{"key":"10.1006\/exnr.1999.7302_RF21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0920-1211(98)00028-X","article-title":"Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures","volume":"31","author":"Ikeda-Douglas","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0306-4522(94)00329-4","article-title":"Spike-and-wave epilepsy in rats: Sex differences and inheritance of physiological traits","volume":"64","author":"Jando","year":"1995","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.1999.7302_RF23","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"385","article-title":"The GEPR model of the epilepsies","author":"Jobe","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF24","first-page":"189","article-title":"GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy","volume":"35","author":"Knight","year":"1992","journal-title":"J. Neural Transm."},{"key":"10.1006\/exnr.1999.7302_RF25","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0896-6273(00)80407-9","article-title":"Kainate reveals its targets","volume":"19","author":"Lerma","year":"1997","journal-title":"Neuron"},{"key":"10.1006\/exnr.1999.7302_RF26","first-page":"1","article-title":"Human absence epilepsies","volume":"35","author":"Loiseau","year":"1992","journal-title":"J. Neural Transm."},{"key":"10.1006\/exnr.1999.7302_RF27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0920-1211(95)00032-6","article-title":"Impairment of intracortical GABAergic inhibition in a rat model of absence epilepsy","volume":"22","author":"Luhmann","year":"1995","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0165-3806(90)90152-O","article-title":"Control of NMDA receptor-mediated activity by GABAergic mechanisms in mature and developing rat neocortex","volume":"54","author":"Luhmann","year":"1990","journal-title":"Dev. Brain Res."},{"key":"10.1006\/exnr.1999.7302_RF29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(94)91472-9","article-title":"Potassium currents in epilepsy: Effects of the epileptogenic agent pentylenetetrazol on a cloned potassium channel","volume":"656","author":"Madeja","year":"1994","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7302_RF30","first-page":"37","article-title":"Genetic absence epilepsy in rats from Strasbourg\u2014A review","volume":"35","author":"Marescaux","year":"1992","journal-title":"J. Neural Transm."},{"key":"10.1006\/exnr.1999.7302_RF31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0013-4694(95)00225-1","article-title":"Frontal cortex leads other brain structures in generalised spike-and-wave spindles and seizure spikes induced by picrotoxin","volume":"98","author":"Medvedev","year":"1996","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0165-6147(91)90594-I","article-title":"Proto-oncogene transcription factors and epilepsy","volume":"12","author":"Morgan","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1006\/exnr.1999.7302_RF33","series-title":"Neurotransmitters, Seizures, and Epilepsy II","first-page":"337","article-title":"Petit mal epilepsy: Too little or too much GABA? In","author":"Myslobodsky","year":"1984"},{"key":"10.1006\/exnr.1999.7302_RF34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0304-3940(97)00241-3","article-title":"Inhibition of glutamate decarboxylase activity by 3-mercaptopropionic acid has different time course in the immature and adult rat brains","volume":"226","author":"Netopilova","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7302_RF35","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"215","article-title":"Genetic and phenotypic heterogeneity of inherited spike-and-wave epilepsies","author":"Noebels","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF36","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1046\/j.1471-4159.1995.65041674.x","article-title":"Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: A microdialysis study","volume":"65","author":"Richards","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1006\/exnr.1999.7302_RF37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/exnr.1996.6368","article-title":"Differential spatial patterns of fos induction following generalized clonic and generalized tonic seizures","volume":"143","author":"Samoriski","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.1999.7302_RF38","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"133","article-title":"Pathophysiological mechanisms of experimental generalized absence seizures in rats","author":"Snead","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3940(92)90669-X","article-title":"The GABAA receptor complex in experimental absence seizures in rat\u2014An autoradiographic study","volume":"140","author":"Snead","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7302_RF40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0920-1211(93)90060-K","article-title":"GABA-A receptor impairment in the genetic absence epilepsy rats from Strasbourg (GAERS): An immunocytochemical and receptor binding autoradiographic study","volume":"15","author":"Spreafico","year":"1993","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF41","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0024-3205(84)90159-0","article-title":"Convulsant potencies of tetrazoles are highly correlated with actions on GABA\/benzodiazepine\/picrotoxin receptor complexes in brain","volume":"35","author":"Squires","year":"1984","journal-title":"Life Sci."},{"key":"10.1006\/exnr.1999.7302_RF42","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1152\/jn.1998.80.3.1439","article-title":"Spike-wave complexes and fast components of cortically generated seizures. I. Role of neocortex and thalamus","volume":"80","author":"Steriade","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1006\/exnr.1999.7302_RF43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0920-1211(97)00058-2","article-title":"Aberrant expression of GABAA receptor subunits in the tottering mouse: An animal model for absence seizures","volume":"28","author":"Tehrani","year":"1997","journal-title":"Epilepsy Res."},{"key":"10.1006\/exnr.1999.7302_RF44","series-title":"Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects","first-page":"151","article-title":"Pathophysiological mechanisms underlying genetic absence epilepsy in rats","author":"Vergnes","year":"1994"},{"key":"10.1006\/exnr.1999.7302_RF45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(90)91638-W","article-title":"Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy","volume":"523","author":"Vergnes","year":"1990","journal-title":"Brain Res."},{"key":"10.1006\/exnr.1999.7302_RF46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0014-2999(97)01085-6","article-title":"Opposite effects of GABAB receptor antagonists on absences and convulsive seizures","volume":"332","author":"Vergnes","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.1999.7302_RF47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3940(84)90226-X","article-title":"Enhancement of spike and wave discharges by GABA mimetic drugs in rats with spontaneous petit-mal-like epilepsy","volume":"44","author":"Vergnes","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7302_RF48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0304-3940(82)90136-7","article-title":"Spontaneous paroxysmal electroclinical patterns in rat: A model of generalized non convulsive epilepsy","volume":"33","author":"Vergnes","year":"1982","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.1999.7302_RF49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0306-4522(96)00462-9","article-title":"Fos induction following systemic kainic acid: Early expression in hippocampus and later widespread expression correlated with seizure","volume":"77","author":"Willoughby","year":"1997","journal-title":"Neuroscience"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699973028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488699973028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T13:16:21Z","timestamp":1576588581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488699973028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0014488699973028"],"URL":"https:\/\/doi.org\/10.1006\/exnr.1999.7302","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}