{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:39:55Z","timestamp":1790008795495,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1006\/exnr.2000.7508","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T11:46:56Z","timestamp":1032176816000},"page":"392-402","source":"Crossref","is-referenced-by-count":152,"title":["Differential Patterns of ERK and STAT3 Phosphorylation after Sciatic Nerve Transection in the Rat"],"prefix":"10.1006","volume":"166","author":[{"given":"John Y.","family":"Sheu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris J.","family":"Kulhanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix P.","family":"Eckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.2000.7508_RF1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/exnr.1995.1095","article-title":"Differential macrophage responses in the peripheral and central nervous system during wallerian degeneration of axons","volume":"136","author":"Avellino","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2000.7508_RF2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1046\/j.1471-4159.1995.64020850.x","article-title":"Interleukin-6 production by Schwann cells and induction in sciatic nerve injury","volume":"64","author":"Bolin","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1006\/exnr.2000.7508_RF3","first-page":"135","article-title":"Quantification of interleukin-6 mRNA in wallerian degeneration by competitive reverse transcription polymerase chain reaction","volume":"69","author":"Bourde","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1006\/exnr.2000.7508_RF4","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1523\/JNEUROSCI.17-05-01642.1997","article-title":"Expression of neuregulins and their putative receptors, erbb2 and erbb3, is induced during wallerian degeneration","volume":"17","author":"Carroll","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF5","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1073\/pnas.94.13.7018","article-title":"Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons","volume":"94","author":"Creedon","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2000.7508_RF6","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1046\/j.1471-4159.1995.64041541.x","article-title":"Fibroblast growth factors stimulate protein tyrosine phosphorylation and mitogen-activated protein kinase activity in primary cultures of hippocampal neurons","volume":"64","author":"Creuzet","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1006\/exnr.2000.7508_RF7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0896-6273(94)90163-5","article-title":"Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve","volume":"12","author":"Curtis","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/exnr.2000.7508_RF8","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1006\/exnr.2000.7508_RF9","series-title":"Peripheral Neuropathy","first-page":"290","article-title":"Schwann cell proliferation","author":"De Vries","year":"1993"},{"key":"10.1006\/exnr.2000.7508_RF10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1523\/JNEUROSCI.11-02-00412.1991","article-title":"Acidic and basic fibroblast growth factors in the nervous system: Distribution and differential alteration of levels after injury of central versus peripheral nerve","volume":"11","author":"Eckenstein","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0896-6273(91)90288-B","article-title":"Prominent expression of acidic fibroblast growth factor in motor and sensory neurons","volume":"7","author":"Elde","year":"1991","journal-title":"Neuron"},{"key":"10.1006\/exnr.2000.7508_RF12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.ne.13.030190.000355","article-title":"Peripheral nerve regeneration","volume":"13","author":"Fawcett","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1083\/jcb.123.2.455","article-title":"Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve","volume":"123","author":"Funakoshi","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2990.1989.tb01251.x","article-title":"Regeneration in the peripheral nervous system","volume":"15","author":"Hall","year":"1989","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1006\/exnr.2000.7508_RF15","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1083\/jcb.104.6.1623","article-title":"Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection","volume":"104","author":"Heumann","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(95)90403-4","article-title":"Transcriptional regulation by extracellular signals: Mechanisms and specificity","volume":"80","author":"Hill","year":"1995","journal-title":"Cell"},{"key":"10.1006\/exnr.2000.7508_RF17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1998.tb11157.x","article-title":"Signaling by the cytokine receptor superfamily","volume":"865","author":"Ihle","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1006\/exnr.2000.7508_RF18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0006-8993(98)00242-X","article-title":"Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRalpha, LIFRbeta, IL-6R alpha and gp130) in injured peripheral nerves","volume":"793","author":"Ito","year":"1998","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2000.7508_RF19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(94)90333-6","article-title":"Cytokine signal transduction","volume":"76","author":"Kishimoto","year":"1994","journal-title":"Cell"},{"key":"10.1006\/exnr.2000.7508_RF20","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1523\/JNEUROSCI.17-21-08293.1997","article-title":"Activation of ErbB2 during Wallerian degeneration of sciatic nerve","volume":"17","author":"Kwon","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","article-title":"The stress-activated protein kinase subfamily of c-Jun kinases","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1006\/exnr.2000.7508_RF22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/330658a0","article-title":"Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve","volume":"330","author":"Lindholm","year":"1987","journal-title":"Nature"},{"key":"10.1006\/exnr.2000.7508_RF23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.119.1.45","article-title":"Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGF mRNA","volume":"119","author":"Meyer","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1460-9568.1995.tb01073.x","article-title":"Acidic FGF and FGF receptors are specifically expressed in neurons of developing and adult rat dorsal root ganglia","volume":"7","author":"Oellig","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0898-6568(97)00042-9","article-title":"Stress-activated protein kinases: Activation, regulation and function","volume":"9","author":"Paul","year":"1997","journal-title":"Cell Signal"},{"key":"10.1006\/exnr.2000.7508_RF26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF02057901","article-title":"Events in degenerating cat peripheral nerve: Induction of Schwann cell S phase and its relation to nerve fibre degeneration","volume":"15","author":"Pellegrino","year":"1986","journal-title":"J. Neurocytol."},{"key":"10.1006\/exnr.2000.7508_RF27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/bies.950140610","article-title":"Role of macrophages in peripheral nerve degeneration and repair","volume":"14","author":"Perry","year":"1992","journal-title":"BioEssays"},{"key":"10.1006\/exnr.2000.7508_RF28","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1084\/jem.165.4.1218","article-title":"The macrophage response to central and peripheral nerve injury: A possible role for macrophages in regeneration","volume":"165","author":"Perry","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1006\/exnr.2000.7508_RF29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1460-9568.1996.tb01237.x","article-title":"Interleukin 6 in intact and injured mouse peripheral nerves","volume":"8","author":"Reichert","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/glia.440050105","article-title":"Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve","volume":"5","author":"Rende","year":"1992","journal-title":"Glia"},{"key":"10.1006\/exnr.2000.7508_RF31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0165-5728(92)90176-L","article-title":"Interleukin-1 activity in lesioned peripheral nerve","volume":"39","author":"Rotshenker","year":"1992","journal-title":"J. Neuroimmunol."},{"key":"10.1006\/exnr.2000.7508_RF32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1083\/jcb.84.3.739","article-title":"Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury","volume":"84","author":"Salzer","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.ne.19.030196.002335","article-title":"Intracellular signaling pathways activated by neurotrophic factors","volume":"19","author":"Segal","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF34","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1523\/JNEUROSCI.19-21-09160.1999","article-title":"Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons","volume":"19","author":"Soler","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2000.7508_RF35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/exnr.1994.1091","article-title":"Expression of GDNF mRNA in rat and human nervous tissue","volume":"127","author":"Springer","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2000.7508_RF36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1083\/jcb.115.2.447","article-title":"Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain","volume":"115","author":"Stockli","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1083\/jcb.130.1.137","article-title":"Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons","volume":"130","author":"Trupp","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2000.7508_RF38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/MCB.14.1.181","article-title":"Fibroblast growth factor receptors have different signaling and mitogenic potentials","volume":"14","author":"Wang","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/exnr.2000.7508_RF39","doi-asserted-by":"crossref","first-page":"23619","DOI":"10.1074\/jbc.271.39.23619","article-title":"Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase","volume":"271","author":"Worby","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/exnr.2000.7508_RF40","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1523\/JNEUROSCI.11-10-03257.1991","article-title":"Membrane resealing in cultured rat septal neurons after neurite transection: Evidence for enhancement by Ca(2+)-triggered protease activity and cytoskeletal disassembly","volume":"11","author":"Xie","year":"1991","journal-title":"J. Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488600975083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488600975083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T07:48:21Z","timestamp":1576482501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488600975083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S0014488600975083"],"URL":"https:\/\/doi.org\/10.1006\/exnr.2000.7508","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}