{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:49:17Z","timestamp":1791121757862,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1006\/exnr.2001.7790","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T11:46:56Z","timestamp":1032176816000},"page":"29-46","source":"Crossref","is-referenced-by-count":70,"title":["Characterization of Human Cleaved N-CAM and Association with Schizophrenia"],"prefix":"10.1006","volume":"172","author":[{"given":"Marquis P.","family":"Vawter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nsima","family":"Usen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Thatcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Ladenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale M.","family":"VanderPutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Conant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"van Kammen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Sedvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Garver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Freed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.2001.7790_RF1","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1073\/pnas.92.7.2785","article-title":"Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains","volume":"92","author":"Barbeau","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2001.7790_RF2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/mcne.1999.0804","article-title":"Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin","volume":"14","author":"Berger","year":"1999","journal-title":"Mol. Cell Neurosci."},{"key":"10.1006\/exnr.2001.7790_RF3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0006-8993(94)01384-T","article-title":"Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers","volume":"674","author":"Breese","year":"1995","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7790_RF4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/syn.1058","article-title":"Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: Evidence from cDNA array","volume":"41","author":"Cadet","year":"2001","journal-title":"Synapse"},{"key":"10.1006\/exnr.2001.7790_RF5","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1073\/pnas.95.6.3117","article-title":"Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia","volume":"95","author":"Conant","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2001.7790_RF6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/schbul\/13.4.577","article-title":"Schizophrenia and the hippocampus: The embryological hypothesis extended","volume":"13","author":"Conrad","year":"1987","journal-title":"Schizophr. Bull."},{"key":"10.1006\/exnr.2001.7790_RF7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/43894","article-title":"Familial dementia caused by polymerization of mutant neuroserpin","volume":"401","author":"Davis","year":"1999","journal-title":"Nature"},{"key":"10.1006\/exnr.2001.7790_RF8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0165-3806(88)90211-8","article-title":"Early appearance of type II astrocytes in developing human fetal brain","volume":"470","author":"Elder","year":"1988","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7790_RF9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(98)00204-3","article-title":"Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats","volume":"246","author":"Endo","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.2001.7790_RF10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-0102(98)00105-9","article-title":"Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator\u2013plasmin system after kainate injection in the mouse hippocampus","volume":"33","author":"Endo","year":"1999","journal-title":"Neurosci. Res."},{"key":"10.1006\/exnr.2001.7790_RF11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/elps.1150190619","article-title":"Routine identification of proteins from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels or polyvinyl difluoride membranes using matrix assisted laser desorption\/ionization-time of flight-mass spectrometry (MALDI-TOF-MS)","volume":"19","author":"Fernandez","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1006\/exnr.2001.7790_RF12","first-page":"1973","article-title":"A peptide ligand of N-CAM IgI domain prevents N-CAM internalization and disrupts passive avoidance learning","volume":"25","author":"Gallagher","year":"1999","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1006\/exnr.2001.7790_RF13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0920-9964(00)00015-3","article-title":"Brain and ventricle instability during psychotic episodes of the schizophrenias","volume":"44","author":"Garver","year":"2000","journal-title":"Schizophr. Res."},{"key":"10.1006\/exnr.2001.7790_RF14","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1523\/JNEUROSCI.16-07-02220.1996","article-title":"Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator","volume":"16","author":"Gualandris","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2001.7790_RF15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/brain\/122.4.593","article-title":"The neuropathology of schizophrenia. A critical review of the data and their interpretation","volume":"122","author":"Harrison","year":"1999","journal-title":"Brain"},{"key":"10.1006\/exnr.2001.7790_RF16","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1073\/pnas.83.9.3037","article-title":"Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM","volume":"83","author":"Hemperly","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2001.7790_RF17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0003-2697(88)90209-6","article-title":"Methods for increasing the resolution of two-dimensional protein electrophoresis","volume":"173","author":"Hochstrasser","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1006\/exnr.2001.7790_RF18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0006-8993(98)00907-X","article-title":"Activation of NMDA receptors stimulates extracellular proteolysis of cell adhesion molecules in hippocampus","volume":"811","author":"Hoffman","year":"1998","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7790_RF19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0006-8993(98)00906-8","article-title":"Proteolysis of cell adhesion molecules by serine proteases: A role in long term potentiation?","volume":"811","author":"Hoffman","year":"1998","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7790_RF20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0306-4522(96)00489-7","article-title":"Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia","volume":"78","author":"Honer","year":"1997","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.2001.7790_RF21","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1523\/JNEUROSCI.17-23-08984.1997","article-title":"Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse","volume":"17","author":"Krueger","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2001.7790_RF22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0006-3223(88)90065-0","article-title":"The expression of an N-CAM serum fragment is positively correlated with severity of negative features in type II schizophrenia","volume":"23","author":"Lyons","year":"1988","journal-title":"Biol. Psychiatry"},{"key":"10.1006\/exnr.2001.7790_RF23","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.1585176","article-title":"Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia","volume":"256","author":"Mayford","year":"1992","journal-title":"Science"},{"key":"10.1006\/exnr.2001.7790_RF24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0006-3223(99)00018-9","article-title":"MRI anatomy of schizophrenia","volume":"45","author":"McCarley","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1006\/exnr.2001.7790_RF25","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1073\/pnas.79.20.6380","article-title":"A neural cell adhesion molecule from human brain","volume":"79","author":"McClain","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2001.7790_RF26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1046\/j.1471-4159.1996.67031268.x","article-title":"Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multitrial spatial training","volume":"67","author":"Murphy","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1006\/exnr.2001.7790_RF27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0925-4927(97)00013-9","article-title":"Progression of cerebroventricular enlargement and the subtyping of schizophrenia","volume":"74","author":"Nair","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1006\/exnr.2001.7790_RF28","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1002\/j.1460-2075.1996.tb00657.x","article-title":"Neuroserpin, an axonally secreted serine protease inhibitor","volume":"15","author":"Osterwalder","year":"1996","journal-title":"EMBO J."},{"key":"10.1006\/exnr.2001.7790_RF29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cne.902880108","article-title":"Immunoelectron-microscopic localization of the 180 kD component of the neural cell adhesion molecule N-CAM in postsynaptic membranes","volume":"288","author":"Persohn","year":"1989","journal-title":"J. Comp Neurol."},{"key":"10.1006\/exnr.2001.7790_RF30","first-page":"2006","article-title":"Isolation of intact CNS synaptic junctions: The maintenance of synaptic adhesion","volume":"25","author":"Phillips","year":"1999","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1006\/exnr.2001.7790_RF31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1176\/jnp.2.4.413","article-title":"Expression of a neural cell adhesion molecule serum fragment is depressed in autism","volume":"2","author":"Plioplys","year":"1990","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1006\/exnr.2001.7790_RF32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0014-4886(95)90048-9","article-title":"Disturbances in cell recognition molecules (N-CAM and L1 antigen) in the CSF of patients with schizophrenia","volume":"131","author":"Poltorak","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7790_RF33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0006-8993(97)00023-1","article-title":"Monozygotic twins discordant for schizophrenia are discordant for N-CAM and L1 in CSF","volume":"751","author":"Poltorak","year":"1997","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7790_RF34","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1073\/pnas.93.13.6421","article-title":"Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality","volume":"93","author":"Rabinowitz","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2001.7790_RF35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0736-5748(99)00088-X","article-title":"The neural cell adhesion molecule in synaptic plasticity and ageing","volume":"18","author":"Ronn","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1006\/exnr.2001.7790_RF36","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0531-5565(98)00040-0","article-title":"The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system","volume":"33","author":"Ronn","year":"1998","journal-title":"Exp. Gerontol."},{"key":"10.1006\/exnr.2001.7790_RF37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0928-4257(97)87926-0","article-title":"Cell adhesion molecules and the transition from short- to long-term memory","volume":"90","author":"Rose","year":"1996","journal-title":"J. Physiol Paris"},{"key":"10.1006\/exnr.2001.7790_RF38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0167-4838(91)90234-Q","article-title":"Proteolytic modification of neural cell adhesion molecule (NCAM) by the intracellular proteinase calpain","volume":"1076","author":"Sheppard","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/exnr.2001.7790_RF39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0896-6273(00)80874-0","article-title":"Molecular modification of N-cadherin in response to synaptic activity","volume":"25","author":"Tanaka","year":"2000","journal-title":"Neuron"},{"key":"10.1006\/exnr.2001.7790_RF40","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0006-3223(97)00324-7","article-title":"Further studies of elevated cerebrospinal fluid neuronal cell adhesion molecule in schizophrenia","volume":"43","author":"van Kammen","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1006\/exnr.2001.7790_RF41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-2999(00)00568-9","article-title":"Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders","volume":"405","author":"Vawter","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.2001.7790_RF42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/exnr.1997.6721","article-title":"Abnormal expression of cell recognition molecules in schizophrenia","volume":"149","author":"Vawter","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7790_RF43","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0361-9230(01)00522-6","article-title":"Examining functional genomic expression in schizophrenia with cDNA microarrays","volume":"55","author":"Vawter","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1006\/exnr.2001.7790_RF44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(98)00103-0","article-title":"CSF N-CAM in neuroleptic-naive first-episode patients with schizophrenia","volume":"34","author":"Vawter","year":"1998","journal-title":"Schizophr. Res."},{"key":"10.1006\/exnr.2001.7790_RF45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1998.6889","article-title":"VASE-containing N-CAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia","volume":"154","author":"Vawter","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7790_RF46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.mp.4000547","article-title":"Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia","volume":"4","author":"Vawter","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"10.1006\/exnr.2001.7790_RF47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1101\/SQB.1992.057.01.048","article-title":"Second messengers underlying cell-contact-dependent axonal growth stimulated by transfected N-CAM, N-cadherin, or L1","volume":"57","author":"Walsh","year":"1992","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1006\/exnr.2001.7790_RF48","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00001756-199802160-00019","article-title":"NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle","volume":"9","author":"Wood","year":"1998","journal-title":"NeuroReport"},{"key":"10.1006\/exnr.2001.7790_RF49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1176\/ajp.157.1.16","article-title":"Meta-analysis of regional brain volumes in schizophrenia","volume":"157","author":"Wright","year":"2000","journal-title":"Am. J. Psychiatry"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488601977908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488601977908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:55:08Z","timestamp":1576457708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488601977908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0014488601977908"],"URL":"https:\/\/doi.org\/10.1006\/exnr.2001.7790","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}