{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:22:06Z","timestamp":1791271326852,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1006\/exnr.2001.7823","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:48:37Z","timestamp":1033933717000},"page":"363-376","source":"Crossref","is-referenced-by-count":23,"title":["Parkinsonian Motor Deficits Are Reflected by Proportional A9\/A10 Dopamine Neuron Degeneration in the Rat"],"prefix":"10.1006","volume":"172","author":[{"given":"A.E.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cicchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Isacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.2001.7823_RF1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"Abercrombie","year":"1946","journal-title":"Anat. Rec."},{"key":"10.1006\/exnr.2001.7823_RF2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0773.1966.tb00389.x","article-title":"Functional role of the nigro-neostriatal dopamine neurons","volume":"24","author":"Anden","year":"1966","journal-title":"Acta Pharmacol. Toxicol. (Copenhagen)"},{"key":"10.1006\/exnr.2001.7823_RF3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.2042-7158.1967.tb09604.x","article-title":"Evidence for dopamine receptor stimulation by apomorphine","volume":"19","author":"Anden","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1006\/exnr.2001.7823_RF4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/exnr.1994.1026","article-title":"Behavioral assessment of the effects of embryonic nigral grafts in marmosets with unilateral 6-OHDA lesions of the nigrostriatal pathway","volume":"125","author":"Annett","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/brain\/115.3.825","article-title":"Behavioural analysis of unilateral monoamine depletion in the marmoset","volume":"115","author":"Annett","year":"1992","journal-title":"Brain"},{"key":"10.1006\/exnr.2001.7823_RF6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(86)90399-X","article-title":"The neurotoxic actions of 6-hydroxydopamine infused into the rat substantia nigra","volume":"67","author":"Bradbury","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.2001.7823_RF7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00247041","article-title":"Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion","volume":"69","author":"Brundin","year":"1987","journal-title":"Exp. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-2999(86)90072-5","article-title":"D-1 receptor supersensitivity in the rat striatum after unilateral 6- hydroxydopamine lesions","volume":"126","author":"Buonamici","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.2001.7823_RF9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-4328(90)90027-C","article-title":"Injections of 6-hydroxydopamine in the substantia nigra of the rat brain: Morphological and biochemical effects","volume":"38","author":"Buonamici","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(76)90843-X","article-title":"The relationship between striatal and mesolimbic dopamine dysfunction and the nature of circling responses following 6-hydroxydopamine and electrolytic lesions of the ascending dopamine systems of rat brain","volume":"118","author":"Costall","year":"1976","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nbdi.1998.0185","article-title":"A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease","volume":"5","author":"Costantini","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/exnr.2001.7823_RF12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0306-4522(98)00287-5","article-title":"Compartmental expression of trkB receptor protein in the developing striatum","volume":"89","author":"Costantini","year":"1999","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.2001.7823_RF13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/exnr.2000.7417","article-title":"Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture","volume":"164","author":"Costantini","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0306-4522(88)90069-3","article-title":"Striatal grafts in rats with unilateral neostriatal lesions\u2014III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching","volume":"24","author":"Dunnett","year":"1988","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.2001.7823_RF15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(77)90865-4","article-title":"Behavioral effects of lesions in the A10 dopaminergic area of the rat","volume":"124","author":"Galey","year":"1977","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1996.0109","article-title":"Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: Functional recovery and graft morphology","volume":"140","author":"Galpern","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0963-6897(95)00027-U","article-title":"Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex","volume":"4","author":"Garcia","year":"1995","journal-title":"Cell Transplant."},{"key":"10.1006\/exnr.2001.7823_RF18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-7091-6842-4_7","article-title":"Mechanism of 6-hydroxydopamine neurotoxicity","volume":"50","author":"Glinka","year":"1997","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1006\/exnr.2001.7823_RF19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-8993(80)90871-9","article-title":"Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization","volume":"195","author":"Hefti","year":"1980","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF20","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1046\/j.1460-9568.1999.00692.x","article-title":"Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat","volume":"11","author":"Henderson","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2001.7823_RF21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1460-9568.1998.00077.x","article-title":"Behavioural effects of subthalamic nucleus lesions in the hemiparkinsonian marmoset (Callithrix jacchus)","volume":"10","author":"Henderson","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2001.7823_RF22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0166-4328(88)90054-X","article-title":"Effects of intra-accumbens dopaminergic grafts on behavioral deficits induced by 6-OHDA lesions of the nucleus accumbens or A10 dopaminergic neurons: A comparison","volume":"29","author":"Herman","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(93)90576-9","article-title":"Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats","volume":"626","author":"Hudson","year":"1993","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3940(79)96149-4","article-title":"The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat","volume":"14","author":"Joyce","year":"1979","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.2001.7823_RF25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0028-3908(83)90051-5","article-title":"Effect of injections of 6-OHDA into either nucleus accumbens septi or frontal cortex on spontaneous and drug-induced activity","volume":"22","author":"Joyce","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1006\/exnr.2001.7823_RF26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/263695a0","article-title":"Mesolimbic dopaminergic neurones in the rotational model of nigrostriatal function","volume":"263","author":"Kelly","year":"1976","journal-title":"Nature"},{"key":"10.1006\/exnr.2001.7823_RF27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00432814","article-title":"Mesolimbic dopamine neurons: Effects of 6-hydroxydopamine-induced destruction and receptor blockade on drug-induced rotation of rats","volume":"55","author":"Kelly","year":"1977","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1006\/exnr.2001.7823_RF28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0006-8993(75)90233-4","article-title":"Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum","volume":"94","author":"Kelly","year":"1975","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/exnr.1998.6848","article-title":"Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat","volume":"152","author":"Kirik","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0166-4328(81)90004-8","article-title":"Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system","volume":"3","author":"Koob","year":"1981","journal-title":"Behav. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0166-4328(90)90178-H","article-title":"Nigral D1 and striatal D2 receptors mediate the behavioral effects of dopamine agonists","volume":"38","author":"LaHoste","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0306-4522(95)00571-4","article-title":"Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat","volume":"72","author":"Lee","year":"1996","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.2001.7823_RF33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0301-0082(80)90018-0","article-title":"From motivation to action: Functional interface between the limbic system and the motor system","volume":"14","author":"Mogenson","year":"1980","journal-title":"Prog. Neurobiol."},{"key":"10.1006\/exnr.2001.7823_RF34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-0270(91)90048-5","article-title":"The \u201cstaircase test\u201d: A measure of independent forelimb reaching and grasping abilities in rats","volume":"36","author":"Montoya","year":"1991","journal-title":"J. Neurosci. Methods"},{"key":"10.1006\/exnr.2001.7823_RF35","unstructured":"Moore, A. E, F. Ciccetti, L. Bjorklund, and, O. Isacson, 2000, Comparative motor test methodologies in the 6-OHDA rat model of Parkinson's disease. 27th Annual Society for Neuroscience, New Orleans."},{"key":"10.1006\/exnr.2001.7823_RF36","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0031-9384(86)90042-9","article-title":"Motivational versus motor impairment after haloperidol injection or 6-OHDA lesions in the ventral tegmental area or substantia nigra in rats","volume":"38","author":"Papp","year":"1986","journal-title":"Physiol. Behav."},{"key":"10.1006\/exnr.2001.7823_RF37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-4328(87)90022-2","article-title":"Separation of the motivational and motor consequences of 6-hydroxydopamine lesions of the mesolimbic or nigrostriatal system in rats","volume":"23","author":"Papp","year":"1987","journal-title":"Behav. Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF38","series-title":"The Rat Brain in Stereotaxic Co-ordinates","author":"Paxinos","year":"1986"},{"key":"10.1006\/exnr.2001.7823_RF39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/16060","article-title":"Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient [see comments]","volume":"2","author":"Piccini","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1006\/exnr.2001.7823_RF40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-2999(76)90299-5","article-title":"Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity","volume":"35","author":"Pijnenburg","year":"1976","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.2001.7823_RF41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0006-8993(94)91533-4","article-title":"Effect of bilateral 6-OHDA lesions of the substantia nigra on locomotor activity in the rat","volume":"633","author":"Sakai","year":"1994","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00426628","article-title":"Behavioural effects of amphetamine in a small primate: Relative potencies of the d- and l-isomers","volume":"59","author":"Scraggs","year":"1978","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1006\/exnr.2001.7823_RF43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00536990","article-title":"Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine","volume":"261","author":"Thoenen","year":"1968","journal-title":"Naunyn Schmiedeberg's Arch .Exp. Pathol. Pharmacol."},{"key":"10.1006\/exnr.2001.7823_RF44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/exnr.1994.1054","article-title":"A 6-hydroxydopamine-induced selective parkinsonian rat model: Further biochemical and behavioral characterization","volume":"126","author":"Thomas","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF45","first-page":"42","article-title":"Supersensitivity to dopamine agonists following unilateral, 6-hydroxydopamine-induced striatal lesions in mice","volume":"192","author":"Thornburg","year":"1975","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/exnr.2001.7823_RF46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(68)90164-7","article-title":"6-Hydroxy-dopamine induced degeneration of central monoamine neurons","volume":"5","author":"Ungerstedt","year":"1968","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/exnr.2001.7823_RF47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-201X.1971.tb11000.x","article-title":"Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system","volume":"367","author":"Ungerstedt","year":"1971","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1006\/exnr.2001.7823_RF48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-201X.1971.tb10999.x","article-title":"Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour","volume":"367","author":"Ungerstedt","year":"1971","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1006\/exnr.2001.7823_RF49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-8993(70)90187-3","article-title":"Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system","volume":"24","author":"Ungerstedt","year":"1970","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2001.7823_RF50","first-page":"57","article-title":"Dopaminergic supersensitivity in the striatum","volume":"9","author":"Ungerstedt","year":"1975","journal-title":"Adv. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF51","first-page":"421","article-title":"Behavioral, physiological, and neurochemical changes after 6- hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons","volume":"5","author":"Ungerstedt","year":"1974","journal-title":"Adv. Neurol."},{"key":"10.1006\/exnr.2001.7823_RF52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-75846-1_1","article-title":"The human substantia nigra and ventral tegmental area. A neuroanatomical study with notes on aging and aging diseases","volume":"121","author":"van Domburg","year":"1991","journal-title":"Adv. Anat. Embryol. Cell Biol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488601978239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488601978239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:23:57Z","timestamp":1554992637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488601978239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0014488601978239"],"URL":"https:\/\/doi.org\/10.1006\/exnr.2001.7823","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}