{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:01:37Z","timestamp":1791266497550,"version":"4.1.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1006\/exnr.2002.7901","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T11:46:56Z","timestamp":1032176816000},"page":"282-296","source":"Crossref","is-referenced-by-count":69,"title":["Neurotrophins Reduce Degeneration of Injured Ascending Sensory and Corticospinal Motor Axons in Adult Rat Spinal Cord"],"prefix":"10.1006","volume":"175","author":[{"given":"Faisal T.","family":"Sayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Oudega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Hagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/exnr.2002.7901_RF1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1248\/bpb.23.1051","article-title":"Involvement of Na+-K+ pump in l-glutamate clearance by cultured rat cortical astrocytes","volume":"23","author":"Abe","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"10.1006\/exnr.2002.7901_RF2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1523\/JNEUROSCI.16-02-00545.1996","article-title":"Mechanisms of secondary injury to spinal cord axons in vitro: Role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger","volume":"16","author":"Agrawal","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-1136(200010)32:1<1::AID-GLIA10>3.0.CO;2-W","article-title":"Astrocyte glutamate transport: Review of properties, regulation, and physiological functions","volume":"32","author":"Anderson","year":"2000","journal-title":"Glia"},{"key":"10.1006\/exnr.2002.7901_RF4","first-page":"257","article-title":"Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels","volume":"13","author":"Bamber","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-1136(20000115)29:2<175::AID-GLIA11>3.0.CO;2-F","article-title":"NI-35\/250\/nogo-a: A neurite growth inhibitor restricting structural plasticity and regeneration of nerve fibers in the adult vertebrate CNS","volume":"29","author":"Bandtlow","year":"2000","journal-title":"Glia"},{"key":"10.1006\/exnr.2002.7901_RF6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.8418499","article-title":"Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones","volume":"259","author":"Bandtlow","year":"1993","journal-title":"Science"},{"key":"10.1006\/exnr.2002.7901_RF7","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1523\/JNEUROSCI.19-05-01708.1999","article-title":"Activated macrohages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neutotrophic factor","volume":"19","author":"Batchelor","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0006-8993(00)02779-7","article-title":"Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia","volume":"883","author":"Bowes","year":"2000","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3171\/jns.1998.89.5.0699","article-title":"Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial","volume":"89","author":"Bracken","year":"1998","journal-title":"J. Neurosurg."},{"key":"10.1006\/exnr.2002.7901_RF10","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1046\/j.1460-9568.1999.00809.x","article-title":"NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord","volume":"11","author":"Bradbury","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0012-1606(82)90232-9","article-title":"Development of sympathetic neurons in compartmentalized cultures. I. Local control of neurite growth by nerve growth factor","volume":"93","author":"Campenot","year":"1982","journal-title":"Dev. Biol."},{"key":"10.1006\/exnr.2002.7901_RF12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0012-1606(82)90233-0","article-title":"Development of sympathetic neurons in compartmentalized cultures. II. Local control of neurite survival by nerve growth factor","volume":"93","author":"Campenot","year":"1982","journal-title":"Dev. Biol."},{"key":"10.1006\/exnr.2002.7901_RF13","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1523\/JNEUROSCI.16-20-06433.1996","article-title":"Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes","volume":"16","author":"Cohen","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF02736783","article-title":"Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system","volume":"6","author":"Condorelli","year":"1995","journal-title":"J. Mol. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF15","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1523\/JNEUROSCI.19-14-05810.1999","article-title":"Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord","volume":"19","author":"Davies","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.19-18-j0002.1999","article-title":"Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons","volume":"19","author":"Delcroix","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF17","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1006\/nbdi.2000.0318","article-title":"Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia\/macrophages after spinal cord injury","volume":"7","author":"Dougherty","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/exnr.2002.7901_RF18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3171\/jns.1971.35.6.0700","article-title":"Pathological findings in acute experimental spinal cord trauma","volume":"35","author":"Ducker","year":"1971","journal-title":"J. Neurosurg."},{"key":"10.1006\/exnr.2002.7901_RF19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1460-9568.1994.tb00983.x","article-title":"Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord","volume":"6","author":"Dusart","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF20","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1073\/pnas.90.23.10984","article-title":"Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones","volume":"90","author":"Ehrhard","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2002.7901_RF21","article-title":"Expression of functional trk protooncogene in human monocytes","volume":"91","author":"Ehrhard","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2002.7901_RF22","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1523\/JNEUROSCI.16-10-03123.1996","article-title":"Naturally occuring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling","volume":"16","author":"Eide","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1097-4547(19981001)54:1<117::AID-JNR12>3.0.CO;2-4","article-title":"Lipopolysaccharide differentially regulated microglial trk receptor and neurotrophin expression","volume":"54","author":"Elkabes","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/exnr.2002.7901_RF24","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1227\/00006123-199311000-00017","article-title":"Spinal cord transection in adult rats: effects of local infusion of nerve growth factor on the corticospinal tract axons","volume":"33","author":"Fernandez","year":"1993","journal-title":"Neurosurgery"},{"key":"10.1006\/exnr.2002.7901_RF25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-8993(88)90370-8","article-title":"Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds","volume":"460","author":"Finkelstein","year":"1988","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF26","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1523\/JNEUROSCI.20-04-01333.2000","article-title":"Evidence that wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases","volume":"20","author":"Finn","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0006-8993(84)91131-4","article-title":"Identified central axons differ in their response to spinal cord transection","volume":"305","author":"Fishman","year":"1984","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(94)90347-6","article-title":"The up-regulation of trkA and trkB in dorsal column astrocytes following dorzal rhizotomy","volume":"169","author":"Foschini","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.2002.7901_RF29","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.89.23.11282","article-title":"Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord","volume":"89","author":"Frisen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2002.7901_RF30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00001756-199312000-00043","article-title":"trkC expression in the injured rat spinal cord","volume":"5","author":"Frisen","year":"1993","journal-title":"Neuroreport"},{"key":"10.1006\/exnr.2002.7901_RF31","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1073\/pnas.90.11.4971","article-title":"Characterization of glial trkB receptors: Differential response to injury in the central and peripheral nervous systems","volume":"90","author":"Frisen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2002.7901_RF32","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1006\/exnr.1997.6699","article-title":"Truncated trkB receptors on nonneuronal cells inhibit BDNF-induced neurite outgrowth in vitro","volume":"148","author":"Fryer","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1083\/jcb.123.2.455","article-title":"Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve","volume":"123","author":"Funakoshi","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2002.7901_RF34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2567.1998.00505.x","article-title":"Expression of the TrkB neurotrophin receptor by thymic macrophages","volume":"94","author":"Garcia-Suarez","year":"1998","journal-title":"Immunology"},{"key":"10.1006\/exnr.2002.7901_RF35","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1523\/JNEUROSCI.15-10-06445.1995","article-title":"Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels","volume":"15","author":"George","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF36","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1460-9568.1996.tb01284.x","article-title":"BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo","volume":"8","author":"Giehl","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00209047","article-title":"Early axonal changes following lesions of the dorsal columns in rats","volume":"149","author":"Gilson","year":"1974","journal-title":"Cell Tissue Res."},{"key":"10.1006\/exnr.2002.7901_RF38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sc.1981.19","article-title":"Post-traumatic syringomyelia (cystic myelopathy","volume":"19","author":"Griffiths","year":"1981","journal-title":"Paraplegia"},{"key":"10.1006\/exnr.2002.7901_RF39","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1523\/JNEUROSCI.17-14-05560.1997","article-title":"Cellular delivery of neurotrophin-3 promotes corticospinal axonal growht and partial functional recovery after spinal cord injury","volume":"17","author":"Grill","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF40","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<888::AID-JNR24>3.0.CO;2-W","article-title":"Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts","volume":"50","author":"Guest","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/exnr.2002.7901_RF41","doi-asserted-by":"crossref","unstructured":"Hagg, T.1994. Continuous CNS infusions using mini-osmotic pumps. In Providing Therapeutic Access to the Brain: Alternate Approaches (T. R. Flanagan, D. F. Emerich, and S. Winn, Eds.), Series: Methods in Neurosciences (P. M. Conn, Ed.), pp. 201\u2013213. Academic Press, San Diego, California.","DOI":"10.1016\/B978-0-12-185291-7.50018-7"},{"key":"10.1006\/exnr.2002.7901_RF42","series-title":"Pharmacological Strategies in the Treatment of CNS Injuries","first-page":"169","article-title":"Neurotrophic factors","author":"Hagg","year":"1999"},{"key":"10.1006\/exnr.2002.7901_RF43","series-title":"Spinal Cord Monitoring: Basic and Clinical Aspects","first-page":"129","article-title":"Neurotrophic factors and regeneration","author":"Hagg","year":"1999"},{"key":"10.1006\/exnr.2002.7901_RF44","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1083\/jcb.104.6.1623","article-title":"Changes in NGF synthesis in non-neuronal cells in response to sciatic nerve transection","volume":"104","author":"Heumann","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2002.7901_RF45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-4886(92)90030-T","article-title":"Regeneration of dorsal root axons is related to specific non-neuronal cells lining NGF-treated intraspinal nitrocellulose implants","volume":"118","author":"Houle","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/exnr.2001.7645","article-title":"Chronically injured supraspinal neurons exhibit only modest axonal dieback in response to a cervical hemisection lesion","volume":"169","author":"Houle","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/exnr.1998.6867","article-title":"Collagen containing neurotrophin-3 (NT-3) attracts regrowing injured corticospinal axons in the adult rat spinal cord and promotes partial functional recovery","volume":"153","author":"Houweling","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jnr.490320309","article-title":"Expression of p75, trkA and trkB in rat C6 glioma and type I astrocyte cultures","volume":"32","author":"Hutton","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/exnr.2002.7901_RF49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1460-9568.1993.tb00201.x","article-title":"Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain","volume":"5","author":"Ip","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF50","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.ne.19.030196.002423","article-title":"The neurotrophins and CNTF: Two families of collaborative neurotrophic factors","volume":"19","author":"Ip","year":"1996","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0169-328X(94)90138-4","article-title":"Target-deprived CNS neurons express the NGF gene while reactive glia around their axons terminals contain low and high affinity NGF receptors","volume":"24","author":"Junier","year":"1994","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF52","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sc.1987.37","article-title":"The clinical neuropathology of spinal cord injury. A guide to the future","volume":"25","author":"Kakulas","year":"1987","journal-title":"Paraplegia"},{"key":"10.1006\/exnr.2002.7901_RF53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0006-8993(75)90130-4","article-title":"Retrograde cortical and axonal changes following lesions of the pyramidal tract","volume":"89","author":"Kalil","year":"1975","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00005072-197701000-00012","article-title":"Electron microscopic observations of the mechanisms of terminal club formation in transected spinal cord axons","volume":"36","author":"Kao","year":"1977","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF55","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3171\/jns.1977.46.6.0745","article-title":"The mechanism of spinal cord cavitation following spinal cord transection. Part 2. Electron microscopic observations","volume":"46","author":"Kao","year":"1977","journal-title":"J. Neurosurg."},{"key":"10.1006\/exnr.2002.7901_RF56","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/sc.1988.46","article-title":"Spinal cord regeneration: New experimental approach","volume":"26","author":"Khalili","year":"1988","journal-title":"Paraplegia"},{"key":"10.1006\/exnr.2002.7901_RF57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1471-4159.2000.740730.x","article-title":"Nerve growth factor in glia and inflammatory cells of the injured rat spinal cord","volume":"74","author":"Krenz","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1006\/exnr.2002.7901_RF58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0169-328X(93)90086-5","article-title":"CNS glial cells express neurotrophin receptors whose levels are regulated by NGF","volume":"17","author":"Kumar","year":"1993","journal-title":"Mol. Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF59","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cne.902930305","article-title":"Anatomical studies of dorsal column axons and dorsal root ganglion cells after spinal cord injury in the newborn rat","volume":"293","author":"Lahr","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF60","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00005072-196707000-00001","article-title":"A comparative electronmicroscopic study of reactive, degenerating, regenerating and dystrophic axons","volume":"26","author":"Lampert","year":"1967","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF61","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0166-2236(96)10058-8","article-title":"Nerve growth factor: From neurotrophin to neurokine","volume":"19","author":"Levi-Montalcini","year":"1996","journal-title":"Trends. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF63","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cne.903110306","article-title":"Corticomotoneuronal connections in the rat: Evidence from double-labeling of motoneurons and corticospinal axon arborizations","volume":"311","author":"Liang","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF64","first-page":"337","article-title":"Transforming growht factor-beta 1 and basic fibroblast growth factor in the injured CNS","volume":"14","author":"Logan","year":"1993","journal-title":"Trends Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF65","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0361-9230(93)90285-J","article-title":"Syngeneic grafting of adult rat DRG-derived Schwann cells to the injured spinal cord","volume":"30","author":"Martin","year":"1993","journal-title":"Brain Res. Bull."},{"key":"10.1006\/exnr.2002.7901_RF66","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1073\/pnas.85.17.6508","article-title":"Nerve growth factor promotes human hemopoietic colony growth and differentiation","volume":"85","author":"Matsuda","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/exnr.2002.7901_RF67","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1006\/exnr.1997.6698","article-title":"Expression of full-length trkB receptors by reactive astrocytes after chronic CNS injury","volume":"148","author":"McKeon","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF68","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","article-title":"Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth","volume":"13","author":"McKerracher","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/exnr.2002.7901_RF69","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0896-6273(94)90323-9","article-title":"Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets","volume":"12","author":"McMahon","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/exnr.2002.7901_RF70","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/exnr.2000.7372","article-title":"Localization of transforming growth factor-betal and receptor mRNA after experimental spinal cord injury","volume":"163","author":"McTigue","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF71","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/eji.1830260903","article-title":"Nerve growth factor signal transduction in human B lymphocytes is mediated by gp145trk","volume":"26","author":"Melamed","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/exnr.2002.7901_RF72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.119.1.45","article-title":"Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGF mRNA","volume":"119","author":"Meyer","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2002.7901_RF73","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1460-9568.1994.tb00302.x","article-title":"Morphological and molecular characterization of the response of differentiated PC12 cells to calcium stress","volume":"6","author":"Michel","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/exnr.1996.0149","article-title":"Increased basic fibroblast growth factor expression following contusive spinal cord injury","volume":"141","author":"Mocchetti","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/exnr.1996.6318","article-title":"Fetal spinal cord transplants rescue some axotomized rubrospinal neurons from retrograde cell death in adult rats","volume":"143","author":"Mori","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF76","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0896-6273(94)90042-6","article-title":"A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration","volume":"13","author":"Mukhopadhyay","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/exnr.2002.7901_RF77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0963-6897(95)02028-4","article-title":"Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3 or basic FGF elicit differential responses in adult spinal cord","volume":"5","author":"Nakahara","year":"1996","journal-title":"Cell Trans."},{"key":"10.1006\/exnr.2002.7901_RF78","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/(SICI)1098-1136(199811)24:3<272::AID-GLIA2>3.0.CO;2-4","article-title":"Neurotropinbs regulate the function of cultured microglia","volume":"24","author":"Nakajima","year":"1998","journal-title":"Glia"},{"key":"10.1006\/exnr.2002.7901_RF79","first-page":"2295","article-title":"Human mast cells express functional Trk receptor and are source of nerve growth factor","volume":"27","author":"Nilsson","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF80","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-3940(96)13267-5","article-title":"Brain-derived neurotrophic factor reduces necrotic zone and supports neuronal survival after spinal cord hemisection in adult rats","volume":"20","author":"Novikova","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1006\/exnr.2002.7901_RF81","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/nm1297-1329","article-title":"Regeneration in the adult central nervous system: Experimental repair strategies","volume":"3","author":"Olson","year":"1997","journal-title":"Nat. Med."},{"key":"10.1006\/exnr.2002.7901_RF82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0079-6123(08)62590-X","article-title":"Grafts, growth factors and grafts that make growth factors","volume":"82","author":"Olson","year":"1990","journal-title":"Prog. Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF83","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/exnr.1994.1161","article-title":"Regeneration of adult rat sensory axons into intraspinal nerve grafts: Promoting effects of conditioning lesion and graft predegeneration","volume":"129","author":"Oudega","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF84","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/exnr.1996.0131","article-title":"Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord","volume":"140","author":"Oudega","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF85","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0006-8993(98)01314-6","article-title":"Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord","volume":"818","author":"Oudega","year":"1999","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF86","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1046\/j.1460-9568.1999.00666.x","article-title":"Long-term effects of methylprednisolone following transection of adult rat spinal cord","volume":"11","author":"Oudega","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF87","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/(SICI)1097-4695(199703)32:3<251::AID-NEU1>3.0.CO;2-6","article-title":"Changes in expression of neurotrophic factor (CNTF and CNTF-receptor alpha after spinal cord injury","volume":"32","author":"Oyesiku","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1006\/exnr.2002.7901_RF88","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3171\/jns.1988.68.1.0124","article-title":"Retrograde degeneration of corticospinal axons following transection of the spinal cord in rats. A quantitative study with anterogradely transported horseradish peroxidase","volume":"68","author":"Pallini","year":"1988","journal-title":"J. Neurosurg."},{"key":"10.1006\/exnr.2002.7901_RF89","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cne.902900307","article-title":"Ascending unmyelinated primary afferent fibers in the dorsal funiculus","volume":"290","author":"Patterson","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF90","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S","article-title":"Cellular inflammatory response after spinal cord injury in Sprague\u2013Dawley and Lewis rats","volume":"377","author":"Popovich","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4886(77)90155-8","article-title":"The possibility of structural and functional restitution after spinal cord injury. A review","volume":"55","author":"Puchala","year":"1977","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF92","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1089\/neu.1999.16.817","article-title":"Basic fibroblast growth factor (bFGF) enhances tissue sparing and functional recovery following moderate spinal cord injury","volume":"16","author":"Rabchevsky","year":"1999","journal-title":"J. Neurotrauma"},{"key":"10.1006\/exnr.2002.7901_RF93","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/35002084","article-title":"Functional regeneration of sensory axons into the adult spinal cord","volume":"403","author":"Ramer","year":"2000","journal-title":"Nature"},{"key":"10.1006\/exnr.2002.7901_RF94","series-title":"Degeneration and Regeneration of the Nervous System","author":"Ramon","year":"1928"},{"key":"10.1006\/exnr.2002.7901_RF95","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/309791a0","article-title":"Peripheral injury enhances central regeneration of primary sensory neurons","volume":"309","author":"Richardson","year":"1984","journal-title":"Nature"},{"key":"10.1006\/exnr.2002.7901_RF96","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1523\/JNEUROSCI.18-03-01132.1998","article-title":"Differential effects of neurotrophic factors on motoneuron retrograde labeling in a murine model of motoneuron disease","volume":"18","author":"Sagot","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF97","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1097\/00001756-200011270-00054","article-title":"Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury","volume":"11","author":"Satake","year":"2000","journal-title":"Neuroreport"},{"key":"10.1006\/exnr.2002.7901_RF98","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/367170a0","article-title":"Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion","volume":"367","author":"Schnell","year":"1994","journal-title":"Nature"},{"key":"10.1006\/exnr.2002.7901_RF99","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1046\/j.1460-9568.1999.00792.x","article-title":"Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord","volume":"11","author":"Schnell","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/exnr.2002.7901_RF100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physrev.1996.76.2.319","article-title":"Degeneration and regeneration of axons in the lesioned spinal cord","volume":"76","author":"Schwab","year":"1996","journal-title":"Physiol. Rev."},{"key":"10.1006\/exnr.2002.7901_RF101","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.138.2.411","article-title":"Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmentalized cultures","volume":"138","author":"Senger","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1006\/exnr.2002.7901_RF102","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0006-8993(86)90149-6","article-title":"Control of Na+, K+-pump activity in dorsal root ganglionic neurons by different neuronotrophic agents","volume":"386","author":"Skaper","year":"1986","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF103","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/exnr.1998.6835","article-title":"Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis","volume":"152","author":"Streit","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF104","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0006-8993(89)91225-0","article-title":"Calcitonin gene-related peptide and Substance P containing primary afferents in the dorsal column of the rat","volume":"495","author":"Tamatani","year":"1989","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1750-3639.1995.tb00619.x","article-title":"Update on the pathophysiology and pathology of acute spinal cord injury","volume":"5","author":"Tator","year":"1995","journal-title":"Brain Pathol."},{"key":"10.1006\/exnr.2002.7901_RF106","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0079-6123(08)61142-5","article-title":"Response of rubrospinal and corticospinal neurons to injury and neurotrophins","volume":"103","author":"Tetzlaff","year":"1994","journal-title":"Prog. Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF107","first-page":"1176","article-title":"Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury","volume":"38","author":"Tymianski","year":"1996","journal-title":"Neurosurgery"},{"key":"10.1006\/exnr.2002.7901_RF108","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(95)00238-L","article-title":"Brain-derived neurotrophic factor (BDNF) prevents lesion-induced axonal die-back in young rat optic nerve","volume":"679","author":"Weibel","year":"1995","journal-title":"Brain Res."},{"key":"10.1006\/exnr.2002.7901_RF109","series-title":"Sensory Mechanisms of Spinal Cord","author":"Willis","year":"1991"},{"key":"10.1006\/exnr.2002.7901_RF110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s004410050020","article-title":"Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp","volume":"299","author":"Woodnutt","year":"2000","journal-title":"Cell Tissue Res."},{"key":"10.1006\/exnr.2002.7901_RF111","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0306-4522(98)00685-X","article-title":"Dexamethasone selectively suppresses microglial trophic responses to hippocampal deafferentation","volume":"91","author":"Woods","year":"1999","journal-title":"Neuroscience"},{"key":"10.1006\/exnr.2002.7901_RF112","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.903510302","article-title":"Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia","volume":"351","author":"Wright","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/exnr.2002.7901_RF113","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/(SICI)1097-4547(19981115)54:4<554::AID-JNR12>3.0.CO;2-M","article-title":"NT-3 delivered by adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats","volume":"54","author":"Zhang","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/exnr.2002.7901_RF114","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0006-8993(93)90802-T","article-title":"Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system","volume":"622","author":"Zhou","year":"1993","journal-title":"Brain Res."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860297901X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860297901X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T02:04:48Z","timestamp":1576548288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448860297901X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S001448860297901X"],"URL":"https:\/\/doi.org\/10.1006\/exnr.2002.7901","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}