{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:44:01Z","timestamp":1760852641164},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1006\/expr.2000.4555","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T22:30:52Z","timestamp":1032301852000},"page":"97-107","source":"Crossref","is-referenced-by-count":8,"title":["Trypanosoma cruzi: Acute Infection Affects Expression of \u03b1-2-Macroglobulin and A2MR\/LRP Receptor Differently in C3H and C57BL\/6 Mice"],"prefix":"10.1006","volume":"96","author":[{"given":"Maria de Nazar\u00e9 C.","family":"Soeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio M.","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana C.","family":"Waghabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Nazareth L.","family":"Meirelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Lorent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Henriques-Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia M.L.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred Van","family":"Leuven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania C.","family":"Ara\u00fajo-Jorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/expr.2000.4555_RF1","first-page":"39","article-title":"Morphological and behavioral characterization of Trypanosoma cruzi strains","volume":"18","author":"Andrade","year":"1985","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1006\/expr.2000.4555_RF2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00928742","article-title":"Inhibition of host cell uptake of infective bloodstream forms by alpha-2-macro-globulin","volume":"72","author":"Ara\u00fajo-Jorge","year":"1986","journal-title":"Zeitung Parasitenkund"},{"key":"10.1006\/expr.2000.4555_RF3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00931729","article-title":"Trypanosoma cruzi: Enhanced alpha-macroglobulin levels correlate with the resistance of Balb\/cj mice to acute infection","volume":"78","author":"Ara\u00fajo-Jorge","year":"1992","journal-title":"Parasitology Research"},{"key":"10.1006\/expr.2000.4555_RF4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1749-6632.1994.tb44338.x","article-title":"\u03b12-Macroglobulin in experimental and human Chaga's disease","volume":"10","author":"Ara\u00fajo-Jorge","year":"1994","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1006\/expr.2000.4555_RF5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000237653","article-title":"Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease","volume":"114","author":"Brener","year":"1997","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1006\/expr.2000.4555_RF6","first-page":"792","article-title":"Biology of disease. \u03b12-Macroglobulin, complement, and biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation","volume":"71","author":"Chu","year":"1994","journal-title":"Laboratory Investigation"},{"key":"10.1006\/expr.2000.4555_RF7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s004360050224","article-title":"Alpha-2-macroglobulin binds to the surface of Trypanosoma cruzi","volume":"83","author":"Coutinho","year":"1997","journal-title":"Parasitology Research"},{"key":"10.1006\/expr.2000.4555_RF8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0040-8166(98)80055-4","article-title":"Alpha-2-macroglobulin receptor is differently expressed in peritoneal macrophages from C3H and C57\/Bl6 mice and up regulated during Trypanosoma cruzi infection","volume":"30","author":"Coutinho","year":"1998","journal-title":"Tissue and Cell"},{"key":"10.1006\/expr.2000.4555_RF9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s004360050543","article-title":"Detection of alpha-macroglobulin in the heart of mice infected with Trypanosoma cruzi","volume":"85","author":"Coutinho","year":"1999","journal-title":"Parasitology Research"},{"key":"10.1006\/expr.2000.4555_RF10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0012-1606(86)90211-3","article-title":"Endocytosis of \u03b12-macroglobulin is developmentally regulated during myogenesis","volume":"114","author":"Haye","year":"1986","journal-title":"Developmental Biology"},{"key":"10.1006\/expr.2000.4555_RF11","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.4049\/jimmunol.151.12.7038","article-title":"Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi","volume":"151","author":"Hoft","year":"1993","journal-title":"The Journal of Immunology"},{"key":"10.1006\/expr.2000.4555_RF12","doi-asserted-by":"crossref","first-page":"19441","DOI":"10.1016\/S0021-9258(17)45392-0","article-title":"Colony stimulating factor-1 modulates \u03b12-macroglobulin receptor expression in murine bone marrow macrophages","volume":"264","author":"Hussaini","year":"1990","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1006\/expr.2000.4555_RF13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/BF00931096","article-title":"Trypanosoma cruzi: Plasma levels of alpha-2-macroglobulin during experimental murine infections with reticulotropic and myotropic strains","volume":"76","author":"Isaac","year":"1990","journal-title":"Parasitology Research"},{"key":"10.1006\/expr.2000.4555_RF14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s000110050485","article-title":"Murine alpha-2-macroglobulin increase during inflammatory responses and tumor growth","volume":"48","author":"Isaac","year":"1999","journal-title":"Inflammation Research"},{"key":"10.1006\/expr.2000.4555_RF15","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI116283","article-title":"Regulation of macrophage \u03b12-macroglobulin receptor\/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-\u03b3","volume":"91","author":"La Marre","year":"1993","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1006\/expr.2000.4555_RF16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1749-6632.1994.tb44334.x","article-title":"Human \u03b12-macroglobulin as cytokine-binding plasma protein","volume":"737","author":"Legr\u00e8s","year":"1994","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1006\/expr.2000.4555_RF17","doi-asserted-by":"crossref","first-page":"8381","DOI":"10.1074\/jbc.270.15.8381","article-title":"Evidence for the binding of a biologically active Interleukin-2 to human \u03b12-macroglobulin","volume":"270","author":"Legr\u00e8s","year":"1995","journal-title":"The Journal of Biology and Chemistry"},{"key":"10.1006\/expr.2000.4555_RF18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1432-0436.1994.5530213.x","article-title":"Study of the distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macro-globulin receptor associated protein during mouse embryogenesis and in adult tissues","volume":"55","author":"Lorent","year":"1994","journal-title":"Differentiation"},{"key":"10.1006\/expr.2000.4555_RF19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0306-4522(94)00555-J","volume":"65","author":"Lorent","year":"1995","journal-title":"Neuroscience"},{"key":"10.1006\/expr.2000.4555_RF20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00932384","article-title":"Heterogeneity in the plasma levels of two acute-phase proteins in mice from inbred strains infected with Trypanosoma cruzi","volume":"80","author":"Luz","year":"1994","journal-title":"Parasitology Research"},{"key":"10.1006\/expr.2000.4555_RF21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1128\/IAI.67.1.308-318.1999","article-title":"Influence of acute-phase parasite load on pathology, parasitism, and activation of the immune system at the late chronic phase of Chagas' disease","volume":"67","author":"Marinho","year":"1999","journal-title":"Infection and Immunity"},{"key":"10.1006\/expr.2000.4555_RF22","first-page":"189","article-title":"Quadro histopatol\u00f3gico em camundongos isog\u00eanicos C3H\/HeJ e C57BL\/10 na fase aguda da infec\u00e7\u00e3o com cepas de Trypanosoma cruzi isoladas nas regi\u00f5es central (Goi\u00e1s) e sul (Rio Grande do Sul) do Brasil","volume":"26","author":"Martins","year":"1997","journal-title":"Revista de Patologia Tropical"},{"key":"10.1006\/expr.2000.4555_RF23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/tropej\/42.2.68","article-title":"Acute Chagas' disease: Plasma levels of alpha-2-macroglobulin and C-reactive protein in children under 13 years in a highly endemic area of Bolivia","volume":"42","author":"Medrano-Mercado","year":"1995","journal-title":"Journal of Tropical Pediatrics"},{"key":"10.1006\/expr.2000.4555_RF24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00926652","article-title":"Interaction of T. cruzi with macrophages \u201cin vitro\u201d: Dissociation of the attachment and internalization phases by low temperature and cytochalasins B","volume":"68","author":"Meirelles","year":"1982","journal-title":"Zeitung Parasitenkund"},{"key":"10.1006\/expr.2000.4555_RF25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2307\/3279787","article-title":"Tissue tropism of different Trypanosoma cruzi strains","volume":"64","author":"Melo","year":"1978","journal-title":"The Journal of Parasitology"},{"key":"10.1006\/expr.2000.4555_RF26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/intimm\/9.6.825","article-title":"Human T cell response against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: Role of the multifunctional \u03b1;i2-macroglobulin receptor in antigen presentation by monocytes","volume":"9","author":"Morrot","year":"1997","journal-title":"International Immunity"},{"key":"10.1006\/expr.2000.4555_RF27","doi-asserted-by":"crossref","first-page":"16903","DOI":"10.1016\/S0021-9258(18)55388-6","article-title":"Molecular characterization of the murinoglobulins","volume":"266","author":"Overbergh","year":"1991","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1006\/expr.2000.4555_RF28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1550-7408.2000.tb00047.x","article-title":"Trypanosoma cruzi infection affects actin mRNA regulation in heart muscle cells","volume":"47","author":"Pereira","year":"2000","journal-title":"Journal of Eukaryotic Microbiology"},{"key":"10.1006\/expr.2000.4555_RF29","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1093\/nar\/12.18.6951","article-title":"Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues","volume":"12","author":"Piechaczyk","year":"1984","journal-title":"Nucleic Acids Research"},{"key":"10.1006\/expr.2000.4555_RF30","first-page":"43","article-title":"Influencia de la constitucion genetica en la resistencia de la laucha a la infeccion experimental por Trypanosoma cruzi","volume":"8","author":"Pizzi","year":"1948","journal-title":"Biologica"},{"key":"10.1006\/expr.2000.4555_RF31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0769-2625(87)80051-X","article-title":"Immune resistance to Trypanosoma cruzi: Synergy of specific antibodies and recombinant interferon gamma in vivo","volume":"138","author":"Plata","year":"1987","journal-title":"Annals of the Institute Pasteur\/Immunology"},{"key":"10.1006\/expr.2000.4555_RF32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4269\/ajtmh.1983.32.497","article-title":"Studies of Trypanosoma cruzi clones in inbred mice. I. A comparison of the course of infection of C3H\/HEN mice with two clones isolated from a common source","volume":"32","author":"Postan","year":"1983","journal-title":"The American Society of Tropical Medicine and Hygiene"},{"key":"10.1006\/expr.2000.4555_RF33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4269\/ajtmh.1984.33.236","article-title":"Studies of Trypanosoma cruzi clones in inbred mice. II. Course of infection of C57BL\/6 mice with single-cell-isolated stocks","volume":"33","author":"Postan","year":"1984","journal-title":"The American Society of Tropical Medicine and Hygiene"},{"key":"10.1006\/expr.2000.4555_RF34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0035-9203(86)90193-8","article-title":"A histopathological analysis of the course of myocarditis in C3H\/ He mice infected with Trypanosoma cruzi clone Sylvio-X10\/4","volume":"80","author":"Postan","year":"1986","journal-title":"The American Society of Tropical Medicine and Hygiene"},{"key":"10.1006\/expr.2000.4555_RF35","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000058703","article-title":"Immunology of Trypanosoma cruzi infections","volume":"70","author":"Reed","year":"1998","journal-title":"Chem. Immunol."},{"key":"10.1006\/expr.2000.4555_RF36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/bj2900085","article-title":"Identification of monomeric \u03b1-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric \u03b1-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbiana","volume":"290","author":"Rubenstein","year":"1993","journal-title":"The Biochemistry Journal"},{"key":"10.1006\/expr.2000.4555_RF37","doi-asserted-by":"crossref","unstructured":"Soeiro, M. N. C, Paiva, M, Waghabi, M, Meirelles, M. N. L, Lorent, K, Ara\u00fajo-Jorge, T, and, Van Leuven, F. 2000, Differential expression of mRNA coding for the Alpha-2-Macroglobulin family and the A2MR\/LRP receptor scavenger system in C57BL\/6 and C3H mice. Submitted for publication.","DOI":"10.1247\/csf.26.161"},{"key":"10.1006\/expr.2000.4555_RF38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0923-2494(91)90019-F","article-title":"Is TNF involved in early susceptibility of Trypanosoma cruzi-infected C3H\/He mice?","volume":"142","author":"Starobinas","year":"1991","journal-title":"Research Immunology"},{"key":"10.1006\/expr.2000.4555_RF39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0268-9499(94)90718-8","article-title":"LDL receptor-related protein (A2MR\/LRP): A multiligand receptor","volume":"8","author":"Strickland","year":"1994","journal-title":"Fibrinolysis"},{"key":"10.1006\/expr.2000.4555_RF40","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4894(78)90055-3","article-title":"Trypanosoma cruzi: Role of the immune system in the natural resistance of inbred strains of mice","volume":"45","author":"Trischmann","year":"1978","journal-title":"Experimental Parasitology"},{"key":"10.1006\/expr.2000.4555_RF41","doi-asserted-by":"crossref","first-page":"19778","DOI":"10.1074\/jbc.270.34.19778","article-title":"Targeted inactivation of the mouse \u03b12-macroglobulin gene","volume":"270","author":"Umans","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1006\/expr.2000.4555_RF42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0002-9440(10)65198-X","article-title":"Alpha-2-Macroglobulin and Murinoglobulin-1 deficient mice: A mouse model for acute pancreatitis","volume":"155","author":"Umans","year":"1999","journal-title":"The American Journal of Pathology"},{"key":"10.1006\/expr.2000.4555_RF43","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1016\/S0021-9258(18)50573-1","article-title":"Demonstration of an \u03b12-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines","volume":"254","author":"Van Leuven","year":"1979","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1006\/expr.2000.4555_RF44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0968-0004(82)90135-9","article-title":"Human alpha-2-macroglobulin: Structure and function","volume":"7","author":"Van Leuven","year":"1982","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1006\/expr.2000.4555_RF45","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/oxfordjournals.jbchem.a121982","article-title":"A mouse monoclonal antibody to human \u03b12-macroglobulin (\u03b12-M) crossreacts with \u03b12-M from mouse: Epitope mapping and characterization of subunit structure of murine \u03b12-M","volume":"101","author":"Van Leuven","year":"1987","journal-title":"The Journal of Biochemistry"},{"key":"10.1006\/expr.2000.4555_RF46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1432-1033.1992.tb17424.x","article-title":"The primary sequence and the subunit structure of mouse \u03b1-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of cDNA","volume":"210","author":"Van Leuven","year":"1992","journal-title":"The European Journal of Biochemistry"},{"key":"10.1006\/expr.2000.4555_RF47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0167-4781(93)90244-8","article-title":"Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA","volume":"1173","author":"Van Leuven","year":"1993","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1006\/expr.2000.4555_RF48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/01.ATV.14.6.1000","article-title":"Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages: Possible involvement in the atherosclerotic process","volume":"14","author":"Watanabe","year":"1994","journal-title":"Arteriosclerosis and Thrombosis"},{"key":"10.1006\/expr.2000.4555_RF49","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/bj3200551","article-title":"Proteinases are isoform-specific regulators of the binding of transforming growth factor \u03b2 to \u03b12-macroglobulin","volume":"320","author":"Webb","year":"1996","journal-title":"The Biochemistry Journal"},{"key":"10.1006\/expr.2000.4555_RF50","first-page":"265","article-title":"Binding of tumor necrosis factor alpha to activated forms of human plasma alpha-2-macroglobulin","volume":"138","author":"Wollenberg","year":"1991","journal-title":"The American Journal of Pathology"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489400945557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489400945557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T20:40:06Z","timestamp":1680554406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489400945557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0014489400945557"],"URL":"https:\/\/doi.org\/10.1006\/expr.2000.4555","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}