{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:03:39Z","timestamp":1789733019980,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genomics"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1006\/geno.1999.5915","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T11:41:44Z","timestamp":1033990904000},"page":"188-198","source":"Crossref","is-referenced-by-count":33,"title":["Characterization of the Human Aldehyde Reductase Gene and Promoter"],"prefix":"10.1006","volume":"60","author":[{"given":"Oleg A.","family":"Barski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"Gabbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt M.","family":"Bohren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/geno.1999.5915_RF1","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1073\/pnas.84.6.1718","article-title":"Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl","volume":"84","author":"Bagnasco","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/geno.1999.5915_RF2","series-title":"Enzymology and Molecular Biology of Carbonyl Metabolism 6","first-page":"443","article-title":"Aldehyde reductase: Catalytic mechanism and substrate recognition","author":"Barski","year":"1996"},{"key":"10.1006\/geno.1999.5915_RF3","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/bi9619740","article-title":"The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity","volume":"35","author":"Barski","year":"1996","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF4","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1021\/bi00035a036","article-title":"Mechanism of human aldehyde reductase: Characterization of the active site pocket","volume":"34","author":"Barski","year":"1995","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF5","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1021\/bi9604688","article-title":"Structure of 3 alpha-hydroxysteroid\/dihydrodiol dehydrogenase complexed with NADP+","volume":"35","author":"Bennett","year":"1996","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF6","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.1016\/S0021-9258(18)60566-6","article-title":"The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases","volume":"264","author":"Bohren","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF7","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1021\/bi00174a007","article-title":"Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: Enzyme kinetics and crystal structure of the Y48H mutant enzyme","volume":"33","author":"Bohren","year":"1994","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1042\/bj2990805","article-title":"Bacterial morphine dehydrogenase further defines a distinct superfamily of oxidoreductases with diverse functional activities","volume":"299","author":"Bruce","year":"1994","journal-title":"Biochem. J."},{"key":"10.1006\/geno.1999.5915_RF9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0168-9525(96)10037-8","article-title":"Directing alternative splicing: Cast and scenarios","volume":"12","author":"Chabot","year":"1996","journal-title":"Trends Genet."},{"key":"10.1006\/geno.1999.5915_RF10","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/363640a0","article-title":"Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma","volume":"363","author":"Crozat","year":"1993","journal-title":"Nature"},{"key":"10.1006\/geno.1999.5915_RF11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nsb0895-687","article-title":"Structure of porcine aldehyde reductase holoenzyme","volume":"2","author":"el-Kabbani","year":"1995","journal-title":"Nat. Struct. Biol."},{"key":"10.1006\/geno.1999.5915_RF12","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1128\/MCB.9.10.4196","article-title":"Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents","volume":"9","author":"Fornace","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/geno.1999.5915_RF13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/diab.23.5.460","article-title":"Purification and immunologic identification of aldose reductases","volume":"23","author":"Gabbay","year":"1974","journal-title":"Diabetes"},{"key":"10.1006\/geno.1999.5915_RF14","unstructured":"Genetics Computer Group, 1998. Wisconsin Package (9.1), Oxford Molecular Group, Inc. Madison, WI."},{"key":"10.1006\/geno.1999.5915_RF15","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.1016\/S0021-9258(20)89582-9","article-title":"Structure of the human aldose reductase gene","volume":"266","author":"Graham","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF16","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1021\/bi00174a006","article-title":"An anion binding site in human aldose reductase: Mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate","volume":"33","author":"Harrison","year":"1994","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-1119(90)90033-N","article-title":"Limited bidirectional activity of two housekeeping gene promoters: Human HPRT and PGK","volume":"88","author":"Johnson","year":"1990","journal-title":"Gene"},{"key":"10.1006\/geno.1999.5915_RF18","doi-asserted-by":"crossref","first-page":"20162","DOI":"10.1074\/jbc.270.34.20162","article-title":"Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases","volume":"270","author":"Khanna","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF19","doi-asserted-by":"crossref","first-page":"16431","DOI":"10.1074\/jbc.272.26.16431","article-title":"Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene","volume":"272","author":"Ko","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/nar\/19.3.485","article-title":"The promoter of the chicken alpha 2(VI) collagen gene has features characteristic of house-keeping genes and of proto-oncogenes","volume":"19","author":"Koller","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/geno.1999.5915_RF21","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.1016\/S0021-9258(17)37210-1","article-title":"Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding","volume":"269","author":"Lou","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/oxfordjournals.jbchem.a127352","article-title":"Enzymatic studies on TPN-L-hexonate dehydrogenase from rat liver","volume":"49","author":"Mano","year":"1961","journal-title":"J. Biochem."},{"key":"10.1006\/geno.1999.5915_RF23","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1016\/S0021-9258(18)67136-4","article-title":"Purification and characterization of chlordecone reductase from human liver","volume":"261","author":"Molowa","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/15287398609530832","article-title":"Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man","volume":"17","author":"Molowa","year":"1986","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1006\/geno.1999.5915_RF25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0378-1119(94)90176-7","article-title":"Structure of a gene coding for human dihydrodiol dehydrogenase\/bile acid-binding protein","volume":"149","author":"Qin","year":"1994","journal-title":"Gene"},{"key":"10.1006\/geno.1999.5915_RF26","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1093\/nar\/23.23.4878","article-title":"MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data","volume":"23","author":"Quandt","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/geno.1999.5915_RF27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ng0693-175","article-title":"Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma","volume":"4","author":"Rabbitts","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1006\/geno.1999.5915_RF28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription","volume":"6","author":"Ron","year":"1992","journal-title":"Genes Dev."},{"key":"10.1006\/geno.1999.5915_RF29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/355469a0","article-title":"Novel NADPH-binding domain revealed by the crystal structure of aldose reductase","volume":"355","author":"Rondeau","year":"1992","journal-title":"Nature"},{"key":"10.1006\/geno.1999.5915_RF30","unstructured":"Smit, A. F. A. G. P. 1998, RepeatMasker, (unpublished)."},{"key":"10.1006\/geno.1999.5915_RF31","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1093\/nar\/21.10.2465","article-title":"Cell type-specific interactions of transcription factors with a housekeeping promoter in vivo","volume":"21","author":"Stapleton","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/geno.1999.5915_RF32","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1128\/MCB.17.12.7353","article-title":"CCAAT\/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice","volume":"17","author":"Timchenko","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/geno.1999.5915_RF33","first-page":"103","article-title":"Metabolism of aldehydes in brain","volume":"1","author":"Tipton","year":"1977","journal-title":"Essays Neurochem. Neuropharmacol."},{"key":"10.1006\/geno.1999.5915_RF34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/bj1440353","article-title":"Simulation of biogenic amine metabolism in the brain","volume":"144","author":"Turner","year":"1974","journal-title":"Biochem. J."},{"key":"10.1006\/geno.1999.5915_RF35","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1128\/MCB.16.4.1479","article-title":"Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element","volume":"16","author":"Ubeda","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/geno.1999.5915_RF36","doi-asserted-by":"crossref","first-page":"16052","DOI":"10.1016\/S0021-9258(18)82356-0","article-title":"Characterization of the human aldose reductase gene promoter","volume":"268","author":"Wang","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1432-1033.1983.tb07280.x","article-title":"Aldose and aldehyde reductase exhibit isocorticosteroid reductase activity","volume":"131","author":"Wermuth","year":"1983","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/geno.1999.5915_RF38","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1016\/S0021-9258(17)40325-5","article-title":"Purification and properties of NADPH-dependent aldehyde reductase from human liver","volume":"252","author":"Wermuth","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.1621098","article-title":"An unlikely sugar substrate site in the 1.65 \u00c5 structure of the human aldose reductase holoenzyme implicated in diabetic complications","volume":"257","author":"Wilson","year":"1992","journal-title":"Science"},{"key":"10.1006\/geno.1999.5915_RF40","doi-asserted-by":"crossref","first-page":"14323","DOI":"10.1021\/bi00044a009","article-title":"1.7 \u00c5 structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor","volume":"34","author":"Wilson","year":"1995","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.5915_RF41","first-page":"231","article-title":"Immunohistochemical localisation of aldehyde and aldose reductase in human tissues","volume":"174","author":"Wirth","year":"1985","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1006\/geno.1999.5915_RF42","doi-asserted-by":"crossref","first-page":"20994","DOI":"10.1074\/jbc.272.34.20994","article-title":"Complex regulation of the BRCA1 gene","volume":"272","author":"Xu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.5915_RF43","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754399959153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754399959153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T10:20:15Z","timestamp":1620037215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754399959153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["S0888754399959153"],"URL":"https:\/\/doi.org\/10.1006\/geno.1999.5915","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}