{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:13:10Z","timestamp":1790896390768,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genomics"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1006\/geno.1999.6012","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T18:31:03Z","timestamp":1032287463000},"page":"251-259","source":"Crossref","is-referenced-by-count":90,"title":["Molecular Characterization of Zyme\/Protease M\/Neurosin (PRSS9), A Hormonally Regulated Kallikrein-like Serine Protease"],"prefix":"10.1006","volume":"62","author":[{"given":"George M.","family":"Yousef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Sotiropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios P.","family":"Diamandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/geno.1999.6012_RF1","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/geno.1999.6012_RF2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/BF03401646","article-title":"A novel protease homolog differentially expressed in breast and ovarian cancer","volume":"2","author":"Anisowicz","year":"1996","journal-title":"Mol. Med."},{"key":"10.1006\/geno.1999.6012_RF3","first-page":"225","article-title":"Stable transfection of human prostate cancer cell line PC-3 with prostate specific antigen induces apoptosis both in vivo and in vitro","author":"Balbay","year":"1999","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"10.1006\/geno.1999.6012_RF4","series-title":"Genome Analysis: A Laboratory Manual","author":"Birren","year":"1998"},{"key":"10.1006\/geno.1999.6012_RF5","series-title":"The Kinin System","first-page":"71","article-title":"The molecular biology of the kallikreins and their roles in inflammation","author":"Clements","year":"1997"},{"key":"10.1006\/geno.1999.6012_RF6","first-page":"79","article-title":"Atlas of protein sequence and structure","volume":"5","author":"Dayhoff","year":"1978","journal-title":"Natl. Biomed. Res. Found."},{"key":"10.1006\/geno.1999.6012_RF7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00666007","article-title":"Detection of prostate-specific antigen immunoreactivity in breast tumours","volume":"32","author":"Diamandis","year":"1994","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1006\/geno.1999.6012_RF8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/j.1460-2075.1985.tb02327.x","article-title":"Genes for the \u03b1 and \u03b3 subunits of mouse nerve growth factor","volume":"4","author":"Evans","year":"1985","journal-title":"EMBO J."},{"key":"10.1006\/geno.1999.6012_RF9","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1016\/S0021-9258(18)47521-7","article-title":"Mouse glandular kallikrein genes: Structure and partial sequence analysis of the kallikrein gene locus","volume":"262","author":"Evans","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.6012_RF10","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1021\/bi00409a003","article-title":"Structure and chromosomal localization of the human renal kallikrein gene","volume":"27","author":"Evans","year":"1988","journal-title":"Biochemistry"},{"key":"10.1006\/geno.1999.6012_RF11","first-page":"1","article-title":"Immunological identification of rat tissue kallikrein cDNA and characterization of the kallikrein gene family","volume":"866","author":"Gerald","year":"1986","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1006\/geno.1999.6012_RF12","first-page":"4782","article-title":"The role of NES1 serine protease as a novel tumor suppressor","volume":"58","author":"Goyal","year":"1998","journal-title":"Cancer Res."},{"key":"10.1006\/geno.1999.6012_RF13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0022-2836(88)90331-2","article-title":"Structure and evolution of the bovine prothrombin gene","volume":"212","author":"Irwin","year":"1988","journal-title":"Mol. Biol."},{"key":"10.1006\/geno.1999.6012_RF14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/ajcp\/106.2.242","article-title":"Salivary duct carcinoma secreting prostate specific antigen","volume":"106","author":"James","year":"1996","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1006\/geno.1999.6012_RF15","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/(SICI)1097-0215(19960611)66:6<743::AID-IJC6>3.0.CO;2-#","article-title":"Prostate-specific antigen in breast cyst fluid: Possible role of prostate specific antigen in hormone-dependent breast cancer","volume":"66","author":"Lai","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1006\/geno.1999.6012_RF16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0022-5193(05)80486-2","article-title":"Quantification analysis of 5\u2032 splice signal sequences in mRNA precursors","volume":"145","author":"Lida","year":"1990","journal-title":"J. Theor. Biol."},{"key":"10.1006\/geno.1999.6012_RF17","doi-asserted-by":"crossref","first-page":"25135","DOI":"10.1074\/jbc.272.40.25135","article-title":"Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain","volume":"272","author":"Little","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.6012_RF18","first-page":"3371","article-title":"Identification of a novel serine protease-like gene, the expression of which is down regulated during breast cancer progression","volume":"56","author":"Liu","year":"1996","journal-title":"Cancer Res."},{"key":"10.1006\/geno.1999.6012_RF19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1006\/bbrc.1997.7333","article-title":"Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2","volume":"238","author":"Lovgren","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/geno.1999.6012_RF20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1006\/bbrc.1998.8793","article-title":"Structural characterization and mapping of the normal epithelial cell-specific 1 gene","volume":"247","author":"Luo","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/geno.1999.6012_RF21","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/clinchem\/45.10.1774","article-title":"Human glandular kallikrein (hK2) in breast milk, amniotic fluid and breast cyst fluid","volume":"45","author":"Magklara","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1006\/geno.1999.6012_RF22","series-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman","year":"1994"},{"key":"10.1006\/geno.1999.6012_RF23","doi-asserted-by":"crossref","first-page":"351s","DOI":"10.1042\/cs061351s","article-title":"Kallikrein and renin: Molecular biology and biosynthesis","volume":"61","author":"Morris","year":"1981","journal-title":"Clin. Sci."},{"key":"10.1006\/geno.1999.6012_RF24","first-page":"1034","article-title":"Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage","volume":"48","author":"Pericak-Vance","year":"1991","journal-title":"Am. J. Hum. Genet."},{"key":"10.1006\/geno.1999.6012_RF25","first-page":"1175","article-title":"Molecular genetic analysis of oligodendroglial tumours shows preferential allelic deletions on 19q and 1p","volume":"145","author":"Reifenberger","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1006\/geno.1999.6012_RF26","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1016\/S0021-9258(19)81027-X","article-title":"Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl estero-peptidase group of serine proteases","volume":"257","author":"Richards","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.6012_RF27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0888-7543(05)80275-7","article-title":"Characterization of the human kallikrein locus","volume":"14","author":"Riegman","year":"1992","journal-title":"Genomics"},{"key":"10.1006\/geno.1999.6012_RF28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-291X(89)92409-1","article-title":"Characterization of the prostate-specific antigen gene: A novel human kallikrein-like gene","volume":"159","author":"Riegman","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/geno.1999.6012_RF29","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1006\/geno.1999.6012_RF30","first-page":"967","article-title":"Prostate specific antigen levels in nipple aspirate fluid correlate with breast cancer risk","volume":"5","author":"Sauter","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1006\/geno.1999.6012_RF31","first-page":"1","article-title":"Kallikreins (kininogenases)\u2014A group of serine proteases with bioregulatory actions","volume":"31","author":"Schachter","year":"1980","journal-title":"Pharmac. Rev."},{"key":"10.1006\/geno.1999.6012_RF32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/dna.1987.6.429","article-title":"Primary structure of a human glandular kallikrein gene","volume":"6","author":"Schedlich","year":"1987","journal-title":"DNA"},{"key":"10.1006\/geno.1999.6012_RF33","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1016\/S0021-9258(19)57247-7","article-title":"Mouse glandular kallikrein genes. Identification, structure and expression of the renal kallikrein gene","volume":"261","author":"Van Leeuwen","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1006\/geno.1999.6012_RF34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1073\/pnas.76.2.615","article-title":"Preparative and analytical purification of DNA from agarose","volume":"76","author":"Vogelstein","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/geno.1999.6012_RF35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-4781(96)00187-X","article-title":"Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain","volume":"1350","author":"Yamashiro","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/geno.1999.6012_RF36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1119(98)00232-7","article-title":"Sequence analysis and expression of human neuropsin cDNA and gene","volume":"213","author":"Yoshida","year":"1998","journal-title":"Gene"},{"key":"10.1006\/geno.1999.6012_RF37","first-page":"2842","article-title":"Identification of novel human kallikrein-like genes on chromosome 19q13.3\u2013q13.4","volume":"79","author":"Yousef","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1006\/geno.1999.6012_RF38","first-page":"2104","article-title":"Prostate specific antigen is a new favourable prognostic indicator for women with breast cancer","volume":"55","author":"Yu","year":"1995","journal-title":"Cancer Res."},{"key":"10.1006\/geno.1999.6012_RF39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF01806212","article-title":"Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue","volume":"40","author":"Yu","year":"1996","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1006\/geno.1999.6012_RF40","first-page":"1489","article-title":"Prognostic value of prostate-specific antigen for women with breast cancer: A large U.S. cohort study","volume":"4","author":"Yu","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"10.1006\/geno.1999.6012_RF41","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/clinchem\/42.3.361","article-title":"Detection of prostate specific antigen mRNA and protein in breast tumors","volume":"42","author":"Zarghami","year":"1996","journal-title":"Clin. Chem."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754399960123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754399960123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T21:08:42Z","timestamp":1619989722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754399960123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0888754399960123"],"URL":"https:\/\/doi.org\/10.1006\/geno.1999.6012","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}