{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:52:29Z","timestamp":1784803949955,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecologic Oncology"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1006\/gyno.1996.4609","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T18:28:34Z","timestamp":1034015314000},"page":"130-137","source":"Crossref","is-referenced-by-count":45,"title":["Expression of Genes of Potential Importance in the Response to Chemotherapy and DNA Repair in Patients with Ovarian Cancer"],"prefix":"10.1006","volume":"65","author":[{"given":"A.M.","family":"Codegoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Broggini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Pitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pantarotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Torri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mangioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"D'Incalci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/gyno.1996.4609_GO964609C1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1056\/NEJM199311183292108","article-title":"Cancer of the ovary","volume":"329","author":"Cannistra","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1006\/gyno.1996.4609_GO964609C2","first-page":"1","volume":"12","year":"1994","journal-title":"NIH Consensus Statement"},{"key":"10.1006\/gyno.1996.4609_GO964609C3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","article-title":"Biochemistry of multidrug resistance mediated by the multidrug transporter","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annu Rev Biochem"},{"key":"10.1006\/gyno.1996.4609_GO964609C4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0305-7372(90)90081-P","article-title":"The role of detoxifying systems in resistance of tumor cells to cisplatin and Adriamycin","volume":"17","author":"Meijer","year":"1990","journal-title":"Cancer Treat Rev"},{"key":"10.1006\/gyno.1996.4609_GO964609C5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0277-5379(88)90284-2","article-title":"Current status of chemotherapy for ovarian carcinoma","volume":"24","author":"Ten Bokkel Huinink","year":"1988","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C6","first-page":"5062","article-title":"Expression of a human multidrug resistance gene in ovarian cancer carcinomas","volume":"49","author":"Bourhis","year":"1989","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C7","first-page":"1355","article-title":"Expression of multidrug resistance gene and localization of P-glycoprotein in human primary ovarian cancer","volume":"54","author":"Arao","year":"1994","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C8","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1073\/pnas.89.7.3070","article-title":"High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis","volume":"89","author":"Godwin","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/gyno.1996.4609_GO964609C9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/bjc.1992.388","article-title":"Glutathione S-transferase activity and isoenzyme composition in benign ovarian tumours, untreated malignant ovarian tumours, and malignant ovarian tumours after platinum\/cyclophosphamide chemotherapy","volume":"66","author":"van der Zee","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/bjc.1993.321","article-title":"Glutathione S-transferase expression in benign and malignant ovarian tumours","volume":"68","author":"Green","year":"1993","journal-title":"Br J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1200\/JCO.1995.13.1.70","article-title":"Value of P-glycoprotein, glutathione S-transferase pi, c-erbB-2, and p53 as prognostic factors in ovarian carcinomas","volume":"13","author":"van der Zee","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C12","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/bjc.1992.389","article-title":"Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy","volume":"66","author":"Murphy","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1054-3589(08)60342-7","article-title":"DNA topoisomerases as anticancer drug targets","volume":"21","author":"Schneider","year":"1990","journal-title":"Adv Pharmacol"},{"key":"10.1006\/gyno.1996.4609_GO964609C14","first-page":"307","article-title":"DNA topoisomerase II as the primary target of antitumor anthracyclines","volume":"5","author":"Zunino","year":"1990","journal-title":"Anticancer Drug Des"},{"key":"10.1006\/gyno.1996.4609_GO964609C15","first-page":"6592","article-title":"Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines","volume":"51","author":"Fry","year":"1991","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C16","first-page":"3537","article-title":"Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II","volume":"48","author":"Potmesil","year":"1988","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/oxfordjournals.annonc.a058700","article-title":"Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer","volume":"5","author":"van der Zee","year":"1994","journal-title":"Ann Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C18","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/0959-8049(93)90079-U","article-title":"Expression of O6-alkylguanine-DNA-alkyltransferase in situ in ovarian and Hodgkin's tumours","volume":"29A","author":"Lee","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/gyno.1994.1026","article-title":"O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy","volume":"52","author":"Chen","year":"1994","journal-title":"Gynecol Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C20","doi-asserted-by":"crossref","first-page":"11855","DOI":"10.1073\/pnas.90.24.11855","article-title":"Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase","volume":"90","author":"Matijasevic","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/gyno.1996.4609_GO964609C21","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1002\/j.1460-2075.1992.tb05544.x","article-title":"Expression of the E. coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents","volume":"11","author":"Klungland","year":"1992","journal-title":"EMBO J"},{"key":"10.1006\/gyno.1996.4609_GO964609C22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0168-9525(93)90121-W","article-title":"Nucleotide excision repair. II. From yeast to mammals","volume":"9","author":"Hoeijmakers","year":"1993","journal-title":"Trends Genet"},{"key":"10.1006\/gyno.1996.4609_GO964609C23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI117388","article-title":"Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy","volume":"94","author":"Dabholkar","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1006\/gyno.1996.4609_GO964609C24","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/jnci\/84.19.1512","article-title":"ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients","volume":"84","author":"Dabholkar","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1006\/gyno.1996.4609_GO964609C25","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","article-title":"Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease","volume":"18","author":"Chirgwin","year":"1979","journal-title":"Biochemistry"},{"key":"10.1006\/gyno.1996.4609_GO964609C26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/bjc.1989.217","article-title":"Flow cytometric analysis of DNA content in human ovarian cancers","volume":"60","author":"Erba","year":"1989","journal-title":"Br J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C27","series-title":"Analysis of Binary Data","author":"Cox","year":"1970"},{"key":"10.1006\/gyno.1996.4609_GO964609C28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1006\/gyno.1996.4609_GO964609C29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1996","journal-title":"J R Stat Soc B"},{"key":"10.1006\/gyno.1996.4609_GO964609C30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1200\/JCO.1995.13.3.726","article-title":"Impact of doxorubicin on survival in advanced ovarian cancer","volume":"13","author":"A'Hern","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C31","first-page":"222","article-title":"Chemotherapy of ovarian cancer","volume":"18","author":"Ozols","year":"1991","journal-title":"Semin Oncol"},{"key":"10.1006\/gyno.1996.4609_GO964609C32","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJM199504133321507","article-title":"Paclitaxel (Taxol)","volume":"332","author":"Rowinsky","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1006\/gyno.1996.4609_GO964609C33","first-page":"1741","article-title":"Second-line chemotherapy in epithelial ovarian carcinoma: Platinum again? Taxanes? How to choose?","volume":"30A","author":"Guastalla","year":"1994","journal-title":"Eur J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nm0695-578","article-title":"The drug resistance-related protein LRP is the human majour vault protein","volume":"1","author":"Scheffer","year":"1995","journal-title":"Nat Med"},{"key":"10.1006\/gyno.1996.4609_GO964609C35","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1360704","article-title":"Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line","volume":"258","author":"Cole","year":"1992","journal-title":"Science"},{"key":"10.1006\/gyno.1996.4609_GO964609C36","first-page":"2123","article-title":"Tumour levels of O6-alkylguanine-DNA-alkyltransferase and sensitivity to BCNU of human xenografts","volume":"12","author":"Tagliabue","year":"1992","journal-title":"Anticancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/jnci\/84.5.337","article-title":"Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues","volume":"84","author":"Citron","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1006\/gyno.1996.4609_GO964609C38","first-page":"4131","article-title":"O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary","volume":"51","author":"Citron","year":"1991","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C39","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1096\/fasebj.6.6.1544541","article-title":"Repair of DNA containing O6-alkylguanine","volume":"6","author":"Pegg","year":"1992","journal-title":"FASEB J"},{"key":"10.1006\/gyno.1996.4609_GO964609C40","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/bjc.1992.370","article-title":"O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines","volume":"66","author":"Walker","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1006\/gyno.1996.4609_GO964609C41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0921-8777(93)90069-S","article-title":"Increased resistance of the Chinese hamster mutant irs1 cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes","volume":"293","author":"Habraken","year":"1993","journal-title":"Mutat Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C42","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/carcin\/13.11.1989","article-title":"Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells","volume":"13","author":"Ibeanu","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1006\/gyno.1996.4609_GO964609C43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/carcin\/15.3.533","article-title":"3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents","volume":"15","author":"Imperatori","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1006\/gyno.1996.4609_GO964609C44","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/nar\/22.15.3005","article-title":"Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage","volume":"22","author":"Larminat","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C45","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/carcin\/14.10.2177","article-title":"Cisplatin sensitivity\/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3","volume":"14","author":"Lee","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1006\/gyno.1996.4609_GO964609C46","first-page":"3237","article-title":"Effect of ERCC-1 overexpression on sensitivity of Chinese hamster ovary cells to DNA damaging agents","volume":"53","author":"Bramson","year":"1993","journal-title":"Cancer Res"},{"key":"10.1006\/gyno.1996.4609_GO964609C47","first-page":"209","article-title":"Expression of an alternatively spliced ERCC1 mRNA species is related to reduced DNA repair efficiency in human T lymphocytes","volume":"2","author":"Dabholkar","year":"1995","journal-title":"Oncol Rep"},{"key":"10.1006\/gyno.1996.4609_GO964609C48","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/ijc.2910530526","article-title":"Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro","volume":"53","author":"Pantazis","year":"1993","journal-title":"Int J Cancer"}],"container-title":["Gynecologic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825896946090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090825896946090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T23:46:33Z","timestamp":1733183193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090825896946090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0090825896946090"],"URL":"https:\/\/doi.org\/10.1006\/gyno.1996.4609","relation":{},"ISSN":["0090-8258"],"issn-type":[{"value":"0090-8258","type":"print"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}