{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:07:23Z","timestamp":1788188843141,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hormones and Behavior"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1006\/hbeh.2000.1580","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T18:50:18Z","timestamp":1032288618000},"page":"377-387","source":"Crossref","is-referenced-by-count":27,"title":["Effects of Intracerebroventricular Leptin Administration on Feeding and Sexual Behaviors in Lean and Obese Female Zucker Rats"],"prefix":"10.1006","volume":"37","author":[{"given":"Adam S.","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Foorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah H.","family":"Olster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/hbeh.2000.1580_RF1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1172\/JCI119172","article-title":"Leptin accelerates the onset of puberty in normal female mice","volume":"99","author":"Ahima","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1006\/hbeh.2000.1580_RF2","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1210\/endo.137.7.8770941","article-title":"Leptin is a metabolic signal to the reproductive system","volume":"137","author":"Barash","year":"1996","journal-title":"Endocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0031-9384(90)90107-F","article-title":"Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: Implications in feeding and sexual behaviors","volume":"47","author":"Beck","year":"1990","journal-title":"Physiol. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF4","first-page":"148","article-title":"The Zucker-fatty rat: A review","volume":"36","author":"Bray","year":"1977","journal-title":"Fed. Proc."},{"key":"10.1006\/hbeh.2000.1580_RF5","series-title":"Mammalian Reproductive Biology.","author":"Bronson","year":"1989"},{"key":"10.1006\/hbeh.2000.1580_RF6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1055\/s-2007-979867","article-title":"The OB protein (leptin) pathway-A link between adipose tissue mass and central neural networks","volume":"28","author":"Campfield","year":"1996","journal-title":"Horm. Metab. Res."},{"key":"10.1006\/hbeh.2000.1580_RF7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"key":"10.1006\/hbeh.2000.1580_RF8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0396-318","article-title":"Correction of sterility defect in homozygous obese female mice by treatment with human recombinant leptin","volume":"12","author":"Chehab","year":"1996","journal-title":"Nature Genet."},{"key":"10.1006\/hbeh.2000.1580_RF9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.275.5296.88","article-title":"Early onset of reproductive function in normal female mice treated with human recombinant leptin","volume":"275","author":"Chehab","year":"1997","journal-title":"Science"},{"key":"10.1006\/hbeh.2000.1580_RF10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0031-9384(81)90276-6","article-title":"Copulatory behavior and reproductive capacity of the genetically obese female Zucker rat","volume":"27","author":"Chelich","year":"1981","journal-title":"Physiol. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1210\/endo.138.2.5054","article-title":"Leptin is a metabolic gate for the onset of puberty in the female rat","volume":"138","author":"Cheung","year":"1997","journal-title":"Endocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2337\/diab.45.8.1141","article-title":"Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr)","volume":"45","author":"Chua","year":"1996","journal-title":"Diabetes"},{"key":"10.1006\/hbeh.2000.1580_RF13","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/endo-117-6-2435","article-title":"Neuropeptide Y stimulates feeding but inhibits sex behavior in rats","volume":"117","author":"Clark","year":"1985","journal-title":"Endocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF14","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/diab.45.10.1446","article-title":"The weight reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa\/fa rats","volume":"45","author":"Cusin","year":"1996","journal-title":"Diabetes"},{"key":"10.1006\/hbeh.2000.1580_RF15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"Halaas","year":"1995","journal-title":"Science"},{"key":"10.1006\/hbeh.2000.1580_RF16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0031-9384(71)90120-X","article-title":"Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat","volume":"7","author":"Hardy","year":"1971","journal-title":"Physiol. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF17","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Statist."},{"key":"10.1006\/hbeh.2000.1580_RF18","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2527\/1998.7651405x","article-title":"The biology of leptin: A review","volume":"76","author":"Houseknecht","year":"1998","journal-title":"J. Anim. Sci."},{"key":"10.1006\/hbeh.2000.1580_RF19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/bbrc.1996.0691","article-title":"Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa\/fa) rat","volume":"222","author":"Iida","year":"1996","journal-title":"Biochem. Res. Commun."},{"key":"10.1006\/hbeh.2000.1580_RF20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/bbrc.1996.1070","article-title":"Substitution at codon 269 (Glutamine-Proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa\/fa) rat","volume":"224","author":"Iida","year":"1996","journal-title":"Biochem. Res. Commun."},{"key":"10.1006\/hbeh.2000.1580_RF21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev.nu.11.070191.001545","article-title":"Animal models of obesity: Genetic aspects","volume":"11","author":"Johnson","year":"1991","journal-title":"Annu. Rev. Nutr."},{"key":"10.1006\/hbeh.2000.1580_RF22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(97)00896-3","article-title":"Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: Role of neuropeptide Y","volume":"240","author":"Kalra","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1006\/hbeh.2000.1580_RF23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0167-0115(98)00085-8","article-title":"Intracerebroventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats","volume":"75\u201376","author":"Mar\u00edn-Bivens","year":"1998","journal-title":"Regul. Pept."},{"key":"10.1006\/hbeh.2000.1580_RF24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/endo.138.1.4849","article-title":"Abnormal estrous cyclicity and behavioral hyporesponsiveness to ovarian hormones in genetically obese female Zucker rats","volume":"138","author":"Mar\u00edn-Bivens","year":"1997","journal-title":"Endocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF25","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0031-9384(99)00006-2","article-title":"Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats","volume":"66","author":"Mar\u00edn-Bivens","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0091-3057(99)00042-8","article-title":"Opioid receptor blockade promotes weight loss and improves the display of sexual behaviors in obese Zucker rats","volume":"63","author":"Mar\u00edn-Bivens","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000054335","article-title":"Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting","volume":"67","author":"Nagatani","year":"1998","journal-title":"Neuroendocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF28","unstructured":"Olster, D. H., and Auerbach, I. D.1999. Sexual behaviors and neural steroid receptors in female Zucker rats. Prgm. 5th IBRO World Congr. Neurosci., p. 112, Jerusalem, Israel, 1999."},{"key":"10.1006\/hbeh.2000.1580_RF29","series-title":"A Stereotaxic Atlas of the Rat Brain","author":"Pellegrino","year":"1979"},{"key":"10.1006\/hbeh.2000.1580_RF30","first-page":"E955","article-title":"Does estradiol mediate leptin's effects on adiposity and body weight?","volume":"276","author":"Pelleymounter","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1006\/hbeh.2000.1580_RF31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science"},{"key":"10.1006\/hbeh.2000.1580_RF32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0149-7634(87)80002-7","article-title":"Opioids and sexual behavior","volume":"11","author":"Pfaus","year":"1987","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1006\/hbeh.2000.1580_RF33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng0596-18","article-title":"Leptin receptor missense mutation in the fatty Zucker rat","volume":"13","author":"Phillips","year":"1996","journal-title":"Nature Genet."},{"key":"10.1006\/hbeh.2000.1580_RF34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/hbeh.1998.1453","article-title":"Leptin indirectly affects estrous cycles by increasing metabolic fuel oxidation","volume":"33","author":"Schneider","year":"1998","journal-title":"Horm. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF35","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1055\/s-2007-979874","article-title":"Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats","volume":"28","author":"Seeley","year":"1996","journal-title":"Horm. Metab. Res."},{"key":"10.1006\/hbeh.2000.1580_RF36","series-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel","year":"1988"},{"key":"10.1006\/hbeh.2000.1580_RF37","first-page":"R1770","article-title":"Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure","volume":"271","author":"Stehling","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1006\/hbeh.2000.1580_RF38","first-page":"R726","article-title":"Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats","volume":"272","author":"Thiele","year":"1997","journal-title":"Am. J. Phyisol."},{"key":"10.1006\/hbeh.2000.1580_RF39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00350889","article-title":"Genetic map of rat chromosome 5 including the fatty (fa) locus","volume":"6","author":"Truett","year":"1995","journal-title":"Mamm. Genome"},{"key":"10.1006\/hbeh.2000.1580_RF40","first-page":"449","article-title":"Resistance to the feeding and body weight inhibitory effects of peripherally-injected leptin (rMuLep) in Zucker obese and lean rats","volume":"28","author":"Vasselli","year":"1998","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1006\/hbeh.2000.1580_RF41","first-page":"R1354","article-title":"Leptin facilitates and inhibits sexual behavior in female hamsters","volume":"272","author":"Wade","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1006\/hbeh.2000.1580_RF42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0031-9384(98)00173-5","article-title":"Responses of lean and obese Zucker rats to centrally administered leptin","volume":"65","author":"Wang","year":"1998","journal-title":"Physiol. Behav."},{"key":"10.1006\/hbeh.2000.1580_RF43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/bbrc.1999.0718","article-title":"A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats","volume":"259","author":"Watanobe","year":"1999","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1006\/hbeh.2000.1580_RF44","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/bbrc.1999.1331","article-title":"Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats","volume":"263","author":"Watanobe","year":"1999","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1006\/hbeh.2000.1580_RF45","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2337\/diab.46.6.1077","article-title":"Leptin receptor of Zucker fatty rat performs reduced signal transduction","volume":"46","author":"Yamashita","year":"1997","journal-title":"Diabetes"},{"key":"10.1006\/hbeh.2000.1580_RF46","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1998.8689","article-title":"Leptin receptor signal transduction: OBRa and OBRb of fa type","volume":"246","author":"Yamashita","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/hbeh.2000.1580_RF47","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1210\/endo-111-3-977","article-title":"Serum testosterone and gonadotropins in the genetically obese male Zucker rat","volume":"111","author":"Young","year":"1982","journal-title":"Endocrinology"},{"key":"10.1006\/hbeh.2000.1580_RF48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/oxfordjournals.jhered.a107093","article-title":"Fatty, a new mutation in the rat","volume":"52","author":"Zucker","year":"1961","journal-title":"J. Hered."}],"container-title":["Hormones and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X00915800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0018506X00915800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T04:44:31Z","timestamp":1576471471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0018506X00915800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0018506X00915800"],"URL":"https:\/\/doi.org\/10.1006\/hbeh.2000.1580","relation":{},"ISSN":["0018-506X"],"issn-type":[{"value":"0018-506X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}