{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:26:13Z","timestamp":1784291173777,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1006\/jmbi.1996.0778","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:24:54Z","timestamp":1032377094000},"page":"160-172","source":"Crossref","is-referenced-by-count":21,"title":["X-ray structure at 1.76 \u00c5 resolution of a polypeptide phospholipase A2 Inhibitor 1 1 Edited by R. Huber"],"prefix":"10.1006","volume":"266","author":[{"given":"Yancho","family":"Devedjiev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Atanasov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Bartunik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/jmbi.1996.0778_BIB1","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1016\/S0021-9258(17)39377-8","article-title":"Crystals of crotoxin suitable for high resolution X-ray diffraction analysis","volume":"260","author":"Achari","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB2","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1021\/bi00346a005","article-title":"Rattlesnake presynaptic neurotoxins","volume":"24","author":"Aird","year":"1985","journal-title":"Biochemistry"},{"key":"10.1006\/jmbi.1996.0778_BIB3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0041-0101(76)90065-9","article-title":"Action on phosphatidylcholine of the toxic phospholipase A2 from the venom of Bulgarian viper (Vipera ammodytes ammodytes)","volume":"14","author":"Aleksiev","year":"1976","journal-title":"Toxicon"},{"key":"10.1006\/jmbi.1996.0778_BIB4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","article-title":"The Protein Data Bank","volume":"112","author":"Bernstein","year":"1977","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB5","series-title":"PhD thesis","author":"Beshkov","year":"1973"},{"key":"10.1006\/jmbi.1996.0778_BIB6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/jmbi.1993.1297","article-title":"Crystallization and preliminary X-ray analysis of vipoxin, a complex between a toxic phospholipase A2 and its natural polypeptide inhibitor","volume":"231","author":"Betzel","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB7","first-page":"663","article-title":"Neurotoxic action of a protein complex from the venom of the Bulgarian viper (Vipera ammodytes ammodytes)","volume":"32","author":"Blinov","year":"1979","journal-title":"C.R.Acad. Bull. Sci."},{"key":"10.1006\/jmbi.1996.0778_BIB8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/pro.5560010402","article-title":"The refined 1.9 \u00c5 X-ray structure of d-Phe-Pro-Arg chlormethylketone-inhibited human alpha-thrombin","volume":"1","author":"Bode","year":"1992","journal-title":"Protein Sci"},{"key":"10.1006\/jmbi.1996.0778_BIB9","first-page":"471","article-title":"Postsynaptic effects of crotoxin and its isolated subunits","volume":"99","author":"Bon","year":"1979","journal-title":"J. Biochem"},{"key":"10.1006\/jmbi.1996.0778_BIB10","series-title":"XV Version 3.0","author":"Bradley","year":"1993"},{"key":"10.1006\/jmbi.1996.0778_BIB11","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1016\/S0021-9258(17)39301-8","article-title":"The refined structure of dimeric phospholipase A2 at 2.5 \u00c5","volume":"260","author":"Brunie","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB12","series-title":"X-PLOR (Version 3.1) Manual","author":"Br\u00fc","year":"1992"},{"key":"10.1006\/jmbi.1996.0778_BIB13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0005-2795(79)90006-0","article-title":"Study of some properties of the neurotoxic complex and its componenets from the venom of Bulgarian sand viper, Vipera ammodytes ammodyres I. Luminescence of tryptophan residues","volume":"577","author":"Bukolova-Orlova","year":"1979","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1006\/jmbi.1996.0778_BIB14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0003-9861(80)90348-3","article-title":"Study of the neurotoxic complex and its components from the venom of the Bulgarian sand viper (Vipera ammodytes ammodytes)","volume":"200","author":"Bukolova-Orlova","year":"1980","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1006\/jmbi.1996.0778_BIB15","series-title":"The Bulletin of Tzar\u2032s Institutes of Natural History in Sofia","first-page":"106","article-title":"Studies on distribition of the reptiles and amphibia in Bulgaria and over the Balkan peninsula. P.II. Snakes","author":"Buresh","year":"1934"},{"key":"10.1006\/jmbi.1996.0778_BIB16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00508469","article-title":"Crotoxin, the neurotoxin of south american rattlesnake venom, is a presynaptic toxin acting like \u03b2-bungarotoxin","volume":"296","author":"Chang","year":"1977","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol"},{"key":"10.1006\/jmbi.1996.0778_BIB17","first-page":"91","article-title":"Solubility and phase states of vipoxin from the venom of Bulgarian viper (Vipera ammodytes ammodytes)","volume":"42","author":"Devedjiev","year":"1989","journal-title":"C.R.Acad. Bull. Sci."},{"key":"10.1006\/jmbi.1996.0778_BIB18","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1006\/jmbi.1993.1109","article-title":"Crystals of phospholipase A2 inhibitor. The non-toxic component of vipoxin from the venom of Bulgarian viper (Vipera ammodytes)","volume":"229","author":"Devedjiev","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/289604a0","article-title":"Active site and catalytic mechanism of phospholipase A2","volume":"289","author":"Dijkstra","year":"1981","journal-title":"Nature"},{"key":"10.1006\/jmbi.1996.0778_BIB20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-2836(81)90081-4","article-title":"Structure of bovine pancreatic phospholipase A2 at 1.7 \u00c5 resolution","volume":"147","author":"Dijkstra","year":"1981","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0006-291X(78)90622-8","article-title":"Crotoxin effects on Torpedo californica cholinergic excitable vesicles and the role of its phospholipase A activity","volume":"82","author":"Hanley","year":"1978","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/jmbi.1996.0778_BIB22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1476-5381.1977.tb07553.x","article-title":"The mode of action at the mouse neuromuscular junction of the phospholipase A-crotapotin complex isolated from the venom of the South American rattlesnake","volume":"61","author":"Hawgood","year":"1977","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/jmbi.1996.0778_BIB23","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1073\/pnas.68.7.1560","article-title":"Biological role of the two components of crotoxin","volume":"68","author":"Hendon","year":"1971","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1006\/jmbi.1996.0778_BIB24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0022-2836(88)90606-7","article-title":"Surfaces, subunit interfaces and interior of oligomeric proteins","volume":"204","author":"Janin","year":"1988","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallog. sect. A"},{"key":"10.1006\/jmbi.1996.0778_BIB26","doi-asserted-by":"crossref","DOI":"10.1002\/bip.360221211","article-title":"Dictionary of protein secondary structure","volume":"22","author":"Kabsch","year":"1983","journal-title":"Biopolymers"},{"key":"10.1006\/jmbi.1996.0778_BIB27","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1016\/S0021-9258(19)68887-3","article-title":"The 2.5 \u00c5 crystal structure of a dimeric phospholipase A2 from the venom of Crotalus artrox","volume":"256","author":"Keith","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB28","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"MOLSCRIPT","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Crystallog."},{"key":"10.1006\/jmbi.1996.0778_BIB29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0167-4838(89)90218-5","article-title":"Primary structure of ammodytoxin C further reveals the toxic site of ammodytoxin","volume":"999","author":"Krizaj","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/jmbi.1996.0778_BIB30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"Procheck","volume":"26","author":"Laskovski","year":"1993","journal-title":"J. Appl. Crystallog."},{"key":"10.1006\/jmbi.1996.0778_BIB31","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1107\/S0365110X52002161","article-title":"Traitement statistique des erreurs dans la determination des structures cristallines","volume":"5","author":"Luzzati","year":"1952","journal-title":"Acta Cystallog"},{"key":"10.1006\/jmbi.1996.0778_BIB32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1515\/bchm2.1984.365.2.885","article-title":"Sequence homology between phospholipase and its inhibitor in snake venom. The primary structure of the inhibitor of vipoxin from the venom of the Bulgarian viper (Vipera ammodytes ammodytes)","volume":"356","author":"Mancheva","year":"1984","journal-title":"Hoppe-Seyler Z. Physiol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB33","first-page":"343","article-title":"Sequence homology between phospholipase and its inhibitor in snake venom. The primary structure of phospholipase A2 of vipoxin from the venom of Bulgarian viper (Vipera ammodytes ammodytes)","volume":"368","author":"Mancheva","year":"1987","journal-title":"Hoppe-Seyler Z. Physiol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB34","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(68)90205-2","article-title":"Solvent content of protein crystals","volume":"33","author":"Matthews","year":"1968","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.1996.0778_BIB35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1107\/S002188988708662X","article-title":"Crystal orientation and X-ray pattern prediction routines for area detector diffractometer system in macromolecular crystallography","volume":"20","author":"Messerchmidt","year":"1987","journal-title":"J. Appl. Crystallog."},{"key":"10.1006\/jmbi.1996.0778_BIB36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","article-title":"AMoRe","volume":"A,50","author":"Navaza","year":"1994","journal-title":"Acta Crystallog. Sect."},{"key":"10.1006\/jmbi.1996.0778_BIB37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1107\/S0567739468000707","article-title":"A semi-empirical method of absorption correction","volume":"24","author":"North","year":"1968","journal-title":"Acta Crystallog. sect. A"},{"key":"10.1006\/jmbi.1996.0778_BIB38","first-page":"415","article-title":"A method for data collection for macromolecular crystals on KARD-6 X-ray diffractometer, supplied with two-dimensional multiwire detector","volume":"39","author":"Popov","year":"1994","journal-title":"Kristallografiya"},{"key":"10.1006\/jmbi.1996.0778_BIB39","doi-asserted-by":"crossref","first-page":"11627","DOI":"10.1016\/S0021-9258(17)39077-4","article-title":"A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom","volume":"260","author":"Renetseder","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.1996.0778_BIB40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0167-4838(85)90312-7","article-title":"Ammodytoxin A, a highly lethal phospholipase A2 from Vipera ammodytes ammodytes venom","volume":"828","author":"Ritonja","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/jmbi.1996.0778_BIB41","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1515\/bchm3.1986.367.2.919","article-title":"Amino acid sequence of ammodytoxin B partially reveals the location of the site of toxicity of ammodytoxins","volume":"367","author":"Ritonja","year":"1986","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"10.1006\/jmbi.1996.0778_BIB42","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.2274785","article-title":"Interfacial catalysis","volume":"250","author":"Scott","year":"1990","journal-title":"Science"},{"key":"10.1006\/jmbi.1996.0778_BIB43","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.2274788","article-title":"Crystal structure of bee venom phospholipase A2 in a complex with a transition state analog","volume":"250","author":"Scott","year":"1990","journal-title":"Science"},{"key":"10.1006\/jmbi.1996.0778_BIB44","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1948070","article-title":"Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate","volume":"254","author":"Scott","year":"1991","journal-title":"Science"},{"key":"10.1006\/jmbi.1996.0778_BIB45","first-page":"558","article-title":"A simple procedure for the isolation of vipoxin - a neurotoxin with weak phospholipase activity from the venom of the Bulgarian viper (Vipera ammodytes ammodytes)","volume":"3","author":"Tchorbanov","year":"1981","journal-title":"J. Appl. Biochem."},{"key":"10.1006\/jmbi.1996.0778_BIB46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0041-0101(78)90058-2","article-title":"A neurotoxic complex from the venom of the Bilgarian viper (Vipera ammodytes ammodytes) and a partial amino acid sequence of the toxic phospholipase A2","volume":"16","author":"Tchorbanov","year":"1978","journal-title":"Toxicon"},{"key":"10.1006\/jmbi.1996.0778_BIB47","series-title":"Use of the non-crystallographic symmetry in structural protein crystallography","author":"Vagin","year":"1983"},{"key":"10.1006\/jmbi.1996.0778_BIB48","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1432-1033.1992.tb17330.x","article-title":"Characterization and molecular cloning of neurotoxic phospholipases A2 from Taiwan viper (Vipera russeli formosensis)","volume":"209","author":"Wang","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1006\/jmbi.1996.0778_BIB49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/352079a0","article-title":"Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 \u00c5 resolution","volume":"352","author":"Wery","year":"1991","journal-title":"Nature"},{"key":"10.1006\/jmbi.1996.0778_BIB50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-5793(92)81238-H","article-title":"The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 \u00c5 resolution","volume":"301","author":"Westerlund","year":"1992","journal-title":"FEBS Letters"},{"key":"10.1006\/jmbi.1996.0778_BIB51","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1126\/science.2274787","article-title":"Crystal structure of cobra-venom phospholopase A2 in a complex with a transition state analog","volume":"250","author":"White","year":"1990","journal-title":"Science"},{"key":"10.1006\/jmbi.1996.0778_BIB52","first-page":"284","article-title":"Two-dimensional multiwire detector of high resolution for X-ray diffractometer","volume":"38","author":"Zanevsky","year":"1993","journal-title":"Kristallografiya"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283696907780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283696907780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:48:20Z","timestamp":1620010100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283696907780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0022283696907780"],"URL":"https:\/\/doi.org\/10.1006\/jmbi.1996.0778","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}