{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:56:49Z","timestamp":1790794609857,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/jmbi.2000.4388","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:24:54Z","timestamp":1032377094000},"page":"145-157","source":"Crossref","is-referenced-by-count":39,"title":["Dissection of the promoter region of the inositol 1,4,5-trisphosphate receptor gene, itr-1, in C. elegans: a molecular basis for cell-specific expression of IP3R isoforms11Edited by J. Karn"],"prefix":"10.1006","volume":"306","author":[{"given":"Nicholas J.D","family":"Gower","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian R","family":"Temple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline E","family":"Schein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise S","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A","family":"Baylis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/jmbi.2000.4388_BIB1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"key":"10.1006\/jmbi.2000.4388_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000169064","article-title":"Inositol trisphosphate and calcium","volume":"17","author":"Berridge","year":"1997","journal-title":"Am. J. Nephrol."},{"key":"10.1006\/jmbi.2000.4388_BIB3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0092-8674(95)90408-5","article-title":"Calcium signalling","volume":"80","author":"Clapham","year":"1995","journal-title":"Cell"},{"key":"10.1006\/jmbi.2000.4388_BIB4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1054\/ceca.1999.0021","article-title":"Molecular properties of inositol 1,4,5-trisphosphate receptors","volume":"25","author":"Patel","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1006\/jmbi.2000.4388_BIB5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1054\/ceca.1999.0090","article-title":"Expression of inositol trisphosphate receptors","volume":"26","author":"Taylor","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1006\/jmbi.2000.4388_BIB6","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1074\/jbc.270.19.11678","article-title":"Type I, II and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down regulation and are expressed in markedly different proportions in different cell types","volume":"270","author":"Wojcikiewicz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB7","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.96.10.5797","article-title":"Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons","volume":"96","author":"Genazzani","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1006\/jmbi.2000.4388_BIB8","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1046\/j.1471-4159.1999.721717.x","article-title":"Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor","volume":"72","author":"Konishi","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1006\/jmbi.2000.4388_BIB9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(99)00048-7","article-title":"Activation of the mouse inositol 1,4,5-trisphosphate receptor type 1 promoter by AP-2","volume":"229","author":"Ohkawa","year":"1999","journal-title":"Gene"},{"key":"10.1006\/jmbi.2000.4388_BIB10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0092-8674(00)80945-9","article-title":"Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans","volume":"92","author":"Clandinin","year":"1998","journal-title":"Cell"},{"key":"10.1006\/jmbi.2000.4388_BIB11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1006\/jmbi.1999.3229","article-title":"Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1)","volume":"294","author":"Baylis","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)81510-X","article-title":"The inositol 1,4,5-trisphosphate receptor regulates a 50-second behavioural rhythm in C. elegans","volume":"98","author":"Dal Santo","year":"1999","journal-title":"Cell"},{"key":"10.1006\/jmbi.2000.4388_BIB13","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/nar\/22.21.4414","article-title":"Cloning by synteny","volume":"22","author":"Kuwabara","year":"1994","journal-title":"Nucl. Acids Res."},{"key":"10.1006\/jmbi.2000.4388_BIB14","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1073\/pnas.83.20.7821","article-title":"Toward a physical map of the genome of the nematode Caenorhabditis elegans","volume":"83","author":"Coulson","year":"1986","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1006\/jmbi.2000.4388_BIB15","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1101\/gr.7.11.1072","article-title":"High throughput fingerprint analysis of large-insert clones","volume":"11","author":"Marra","year":"1997","journal-title":"Genome Res."},{"key":"10.1006\/jmbi.2000.4388_BIB16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/nar\/28.1.231","article-title":"SMART","volume":"28","author":"Schultz","year":"2000","journal-title":"Nucl. Acids Res."},{"key":"10.1006\/jmbi.2000.4388_BIB17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/28.1.263","article-title":"The Pfam Protein Families Database","volume":"28","author":"Bateman","year":"2000","journal-title":"Nucl. Acids Res."},{"key":"10.1006\/jmbi.2000.4388_BIB18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0169-328X(98)00106-5","article-title":"FMRFamide-related gene family in the nematode, Caenorhabditis elegans","volume":"58","author":"Nelson","year":"1998","journal-title":"Mol. Brain Res"},{"key":"10.1006\/jmbi.2000.4388_BIB19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/nar\/28.1.316","article-title":"TRANSFAC","volume":"28","author":"Wingender","year":"2000","journal-title":"Nucl. Acids Res."},{"key":"10.1006\/jmbi.2000.4388_BIB20","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1242\/dev.120.8.2175","article-title":"The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle","volume":"120","author":"Okkema","year":"1994","journal-title":"Development"},{"key":"10.1006\/jmbi.2000.4388_BIB21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1242\/dev.125.3.421","article-title":"Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans","volume":"125","author":"Harfe","year":"1998","journal-title":"Development"},{"key":"10.1006\/jmbi.2000.4388_BIB22","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1242\/dev.124.20.3965","article-title":"The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development","volume":"124","author":"Okkema","year":"1997","journal-title":"Development"},{"key":"10.1006\/jmbi.2000.4388_BIB23","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1242\/dev.120.10.3019","article-title":"The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans","volume":"120","author":"Mango","year":"1994","journal-title":"Development"},{"key":"10.1006\/jmbi.2000.4388_BIB24","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1242\/dev.125.12.2171","article-title":"pha-4 is Ce-fkh-1, a fork head\/HNF-3\u03b1,\u03b2,\u03b3 homolog that functions in organogenesis of the C. elegans pharynx","volume":"125","author":"Kalb","year":"1998","journal-title":"Development"},{"key":"10.1006\/jmbi.2000.4388_BIB25","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0092-8674(92)90078-Q","article-title":"Skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo","volume":"68","author":"Bowerman","year":"1992","journal-title":"Cell"},{"key":"10.1006\/jmbi.2000.4388_BIB26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0092-8674(93)80046-H","article-title":"The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos","volume":"74","author":"Bowerman","year":"1993","journal-title":"Cell"},{"key":"10.1006\/jmbi.2000.4388_BIB27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1101\/gad.11.13.1651","article-title":"ELT-1, a GATA-like transcription factor, is required for epidermal call fates in Caenorhabditis elegans embryos","volume":"11","author":"Page","year":"1997","journal-title":"Genes Dev."},{"key":"10.1006\/jmbi.2000.4388_BIB28","doi-asserted-by":"crossref","first-page":"14666","DOI":"10.1074\/jbc.270.24.14666","article-title":"elt-2, a second GATA factor from the nematode Caenorhabditis elegans","volume":"270","author":"Hawkins","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/dbio.1999.9202","article-title":"ELT-3","volume":"208","author":"Gilleard","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB30","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1101\/gad.11.21.2883","article-title":"end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos","volume":"11","author":"Zhu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1006\/jmbi.2000.4388_BIB31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/dbio.1995.1225","article-title":"A Gut-to-Pharynx\/Tail switch in embryonic expression of the Caenorhabditis elegans ges-1 gene centers on two GATA sequences","volume":"170","author":"Egan","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB32","first-page":"286","article-title":"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine","volume":"198","author":"Fukushige","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0166-6851(92)90074-T","article-title":"Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene","volume":"51","author":"Ray","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1006\/jmbi.2000.4388_BIB34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/dna.1996.15.75","article-title":"Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans","volume":"15","author":"Larminie","year":"1996","journal-title":"DNA Cell Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB35","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/S0021-9258(18)53810-2","article-title":"The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression","volume":"268","author":"Freedman","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB36","doi-asserted-by":"crossref","first-page":"29655","DOI":"10.1074\/jbc.274.42.29655","article-title":"Regulation of metallothionein gene transcription","volume":"274","author":"Moilanen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB37","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1128\/MCB.12.4.1652","article-title":"Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans","volume":"12","author":"MacMorris","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/MCB.14.1.484","article-title":"Analysis of the VPE sequences in the Caenorhabditis elegans vit-2 promoter with extrachromosomal tandem array-containing transgenic strains","volume":"14","author":"MacMorris","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB39","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1074\/jbc.271.30.18277","article-title":"Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor","volume":"271","author":"Yoshikawa","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB40","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1074\/jbc.274.1.328","article-title":"Cooperative formation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains","volume":"274","author":"Yoshikawa","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jmbi.2000.4388_BIB41","first-page":"4","article-title":"Basic cell culture methods","volume":"48","author":"Lewis","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1006\/jmbi.2000.4388_BIB42","first-page":"149","article-title":"ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit","volume":"5","author":"Baylis","year":"1997","journal-title":"Receptors Channels"},{"key":"10.1006\/jmbi.2000.4388_BIB43","doi-asserted-by":"crossref","first-page":"12098","DOI":"10.1073\/pnas.93.22.12098","article-title":"Multiple DNA and protein sequence alignment based on segment-to-segment comparison","volume":"93","author":"Morgenstern","year":"1996","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1006\/jmbi.2000.4388_BIB44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bioinformatics\/15.3.211","article-title":"DIALIGN 2","volume":"15","author":"Morgenstern","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1006\/jmbi.2000.4388_BIB45","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1093\/nar\/23.23.4878","article-title":"MatInd and MatInspector - new fast and versatile tools for detection of consensus matches in nucleotide sequence data","volume":"23","author":"Quandt","year":"1995","journal-title":"Nucl. Acids Res."},{"key":"10.1006\/jmbi.2000.4388_BIB46","series-title":"TESS","author":"Schug","year":"1997"},{"key":"10.1006\/jmbi.2000.4388_BIB47","first-page":"452","article-title":"DNA transformation","volume":"48","author":"Mello","year":"1995","journal-title":"Methods Cell Biol."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283600943882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283600943882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:13:07Z","timestamp":1620018787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283600943882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0022283600943882"],"URL":"https:\/\/doi.org\/10.1006\/jmbi.2000.4388","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}