{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:07:13Z","timestamp":1751483233681},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1006\/jmcc.2000.1133","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:06:17Z","timestamp":1032372377000},"page":"925-936","source":"Crossref","is-referenced-by-count":14,"title":["Calcium and Osmotic Regulation of the Na+\/H+Exchanger in Neonatal Ventricular Myocytes"],"prefix":"10.1016","volume":"32","author":[{"given":"Andrea N","family":"Moor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakhilya","family":"Murtazina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Fliegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/jmcc.2000.1133_RF1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(89)90901-X","article-title":"Molecular cloning, primary structure, and expression of the human growth factor-activatable Na\/H antiporter","volume":"56","author":"Sardet","year":"1989","journal-title":"Cell"},{"key":"10.1006\/jmcc.2000.1133_RF2","unstructured":"Orlowski, J, Shull, G, Characteristics of the plasma membrane Na+\/H+exchanger gene family. In The Na+\/H+Exchanger, Edited by L. Fliegel, R. G. Landes Company, 1996, 123, 148"},{"key":"10.1006\/jmcc.2000.1133_RF3","unstructured":"Fliegel, L, Dibrov, P, Biochemistry and molecular biology of the Na+\/H+exchanger: An overview. In The Na+\/H+Exchanger, Edited by L. Fliegel, Springer\/R. G. Landes Company, 317, 1996"},{"key":"10.1006\/jmcc.2000.1133_RF4","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.1074\/jbc.272.36.22373","article-title":"Na+\/H+exchangers of mammalian cells","volume":"272","author":"Orlowski","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-5793(91)80241-T","article-title":"Identification of the protein and cDNA of the cardiac Na\/H exchanger","volume":"279","author":"Fliegel","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1006\/jmcc.2000.1133_RF6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00936442","article-title":"Cloning and analysis of the human myocardial Na+\/H+exchanger","volume":"125","author":"Fliegel","year":"1993","journal-title":"Mol Cell Biochem"},{"key":"10.1006\/jmcc.2000.1133_RF7","doi-asserted-by":"crossref","first-page":"11917","DOI":"10.1016\/S0021-9258(19)50287-3","article-title":"Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+\/H+exchanger isoform (NHE-2)","volume":"268","author":"Tse","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF8","doi-asserted-by":"crossref","first-page":"9331","DOI":"10.1016\/S0021-9258(19)50428-8","article-title":"Molecular cloning of putative members of the Na\/H exchanger gene family","volume":"267","author":"Orlowski","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF9","doi-asserted-by":"crossref","first-page":"C198","DOI":"10.1152\/ajpcell.1995.269.1.C198","article-title":"Cloning, tissue distribution, and functional analysis of the human Na+\/H+exchanger isoform, NHE3","volume":"269","author":"Brant","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0888-7543(95)80002-4","article-title":"Molecular cloning and physical and genetic mapping of a novel human Na+\/H+exchanger (NHE5\/SLC9A5) to chromosome 16q22.1","volume":"25","author":"Klanke","year":"1995","journal-title":"Genomics"},{"key":"10.1006\/jmcc.2000.1133_RF11","first-page":"H709","article-title":"Subcellular localization of the Na+\/H+exchanger NHE1 in rat myocardium","volume":"276","author":"Petrecca","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF12","doi-asserted-by":"crossref","first-page":"C489","DOI":"10.1152\/ajpcell.1994.266.2.C489","article-title":"Intracellular pH recovery during respiratory acidosis in perfused hearts","volume":"266","author":"Vandenberg","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1113\/jphysiol.1992.sp019169","article-title":"Na+-HCO3-symport in the sheep cardiac purkinje fibre","volume":"451","author":"Dart","year":"1992","journal-title":"J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.1992.sp019423","article-title":"Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte","volume":"458","author":"Lagadic-Gossmann","year":"1992","journal-title":"J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF15","unstructured":"Avkiran, M, Yasutake, M, Role of the Sarcolemmal Na+\/H+Exchanger in Arrhythmogenesis During Reperfusion of Ischemic Myocardium. Pp 173\u2013187. In The Na+\/H+Exchanger, Edited by L. Fliegel Springer\/R. G. Landes Company, Austin, Texas, 317, 1996"},{"key":"10.1006\/jmcc.2000.1133_RF16","unstructured":"Karmazyn, M, Role of sodium-hydrogen exchange in mediating myocardial ischemic and reperfusion injury. Mechanisms and therapeutic implications. In The Na+\/H+Exchanger, 1996; Edited by L. Fliegel, R. G. Landes Company, Austin, Tx USA"},{"key":"10.1006\/jmcc.2000.1133_RF17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0022-5223(96)70064-8","article-title":"Sodium-hydrogen exchange inhibition\u2014A superior cardioprotective strategy","volume":"112","author":"Karmazyn","year":"1996","journal-title":"J Thoracic Cardiovasc Surg"},{"key":"10.1006\/jmcc.2000.1133_RF18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.85.9.777","article-title":"The myocardial Na+-H+exchange. Structure, regulation, and its role in heart disease","volume":"85","author":"Karmazyn","year":"1999","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1133_RF19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1126\/science.2154036","article-title":"Growth factors induce phosphorylation of the Na+\/H+antiporter, glycoprotein of 110 kD","volume":"247","author":"Sardet","year":"1990","journal-title":"Science"},{"key":"10.1006\/jmcc.2000.1133_RF20","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1021\/bi970802f","article-title":"Phosphorylation and regulation of the Na+\/H+exchanger through mitogen-activated protein kinase","volume":"36","author":"Wang","year":"1997","journal-title":"Biochemistry"},{"key":"10.1006\/jmcc.2000.1133_RF21","doi-asserted-by":"crossref","first-page":"22985","DOI":"10.1074\/jbc.274.33.22985","article-title":"Protein kinase mediated regulation of the Na+\/H+exchanger in the rat myocardium by MAP-kinase-dependent pathways","volume":"274","author":"Moor","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/bj2820139","article-title":"Phosphorylation of the carboxyl-terminal domain of the Na+\/H+exchanger by Ca2+\/calmodulin-dependent protein kinase II","volume":"282","author":"Fliegel","year":"1992","journal-title":"Biochem J"},{"key":"10.1006\/jmcc.2000.1133_RF23","doi-asserted-by":"crossref","first-page":"C998","DOI":"10.1152\/ajpcell.1995.269.4.C998","article-title":"Reponsiveness of mutant s of NHE1 isoform of Na+\/H+antiport to osmotic stress","volume":"269","author":"Bianchini","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF24","doi-asserted-by":"crossref","first-page":"C283","DOI":"10.1152\/ajpcell.1995.268.2.C283","article-title":"Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+\/H+exchanger isoforms","volume":"268","author":"Noel","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF25","doi-asserted-by":"crossref","first-page":"13710","DOI":"10.1016\/S0021-9258(17)36888-6","article-title":"Mutation of calmodulin-binding site renders the Na+\/H+exchanger (NHE1) highly H+-sensitive and Ca2+regulation-defective","volume":"269","author":"Wakabayashi","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF26","unstructured":"Schmitt, BM, Ikeda, T, Shigekawa, M, Wakabayashi, S, The regulatory cytoplasmic domain of the Na+\/H+exchanger. In The Na+\/H+Exchanger, Edited by L. Fliegel, R. G. Landes Company, 1996, 170"},{"key":"10.1006\/jmcc.2000.1133_RF27","doi-asserted-by":"crossref","first-page":"12854","DOI":"10.1021\/bi9715472","article-title":"Calmodulin-Binding autoinhibitory domain controls \u201cpH-Sensing\u201d in the Na+\/H+exchanger NHE1 through sequence specific interaction","volume":"36","author":"Wakabayashi","year":"1997","journal-title":"Biochem"},{"key":"10.1006\/jmcc.2000.1133_RF28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1006\/jmcc.1997.0636","article-title":"Ischemic preconditioning: effects on pH, Na and Ca in newborn rabbit hearts during Ischemia\/Reperfusion","volume":"30","author":"Liu","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF29","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1006\/jmcc.1997.0442","article-title":"Ethylisopropylamiloride diminishes changes in intracellular Na, Ca and pH in ischemic newborn myocardium","volume":"29","author":"Liu","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF30","first-page":"V146","article-title":"Why are newborn heart vulnerable to global ischemia?","volume":"76","author":"Chiu","year":"1987","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1133_RF31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.RES.61.5.609","article-title":"Global myocardial ischemia in the newborn, juvenile, and adult isolated isovolumic rabbit heart","volume":"61","author":"Parrish","year":"1987","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1133_RF32","first-page":"156","article-title":"Relative vulnerability of neonatal and adult hearts to ischemic injury","volume":"76","author":"Wittnich","year":"1987","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1133_RF33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/jmcc.1996.0277","article-title":"Cardiac Na+\/H+exchanger during post-natal development in the rat: Changes in mRNA expression and sarcolemmal activity","volume":"29","author":"Haworth","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF34","first-page":"H259","article-title":"Regulation of the NHE-1 promoter in the mammalian myocardium","volume":"270","author":"Yang","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF35","first-page":"205","article-title":"Requirement of the Na+\/H+exchanger for tumor growth","volume":"49 (1)","author":"Rotin","year":"1989","journal-title":"Cancer Res"},{"key":"10.1006\/jmcc.2000.1133_RF36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/abbi.1998.0833","article-title":"Functional Role of Cysteine Residues in the Na+\/H+Exchanger","volume":"358","author":"Wang","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1006\/jmcc.2000.1133_RF37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0008-6363(96)88571-3","article-title":"Induction of expression of the sodium-hydrogen exchanger in rat myocardium","volume":"29","author":"Dyck","year":"1995","journal-title":"Cardiovascular Res"},{"key":"10.1006\/jmcc.2000.1133_RF38","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1085\/jgp.86.6.765","article-title":"Intracellular calibration of a pH-sensitive dye in isolated perfused salamander proximal tubules","volume":"86","author":"Chaillet","year":"1985","journal-title":"J Gen Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF39","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1074\/jbc.270.18.10420","article-title":"Specific activation of the Na+\/H+exchanger during neuronal differentiation of embryonal carcinoma cells","volume":"270","author":"Dyck","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF40","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s004240050347","article-title":"Characterization of the Na+\/H+Exchanger in Human Choriocarcinoma (BeWo) Cells","volume":"433","author":"Silva","year":"1997","journal-title":"Eur J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF41","unstructured":"Shrode, L, Cabado, A, Goss, G, Grinstein, S, Role of the Na+\/H+antiporter isoforms in cell volume regulation. In The Na+\/H+Exchanger, Edited by L. Fliegel, R. G. Landes Company, 1996, 101, 122"},{"key":"10.1006\/jmcc.2000.1133_RF42","doi-asserted-by":"crossref","first-page":"13703","DOI":"10.1016\/S0021-9258(17)36887-4","article-title":"The Na+\/H+exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins","volume":"269","author":"Bertrand","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0163-7258(98)00025-4","article-title":"Cardiac cell volume: crystal clear or murky waters? A comparison with other cell types","volume":"80","author":"Wright","year":"1998","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1006\/jmcc.2000.1133_RF44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000241064","article-title":"Perinatal changes in glycolytic function in response to hypoxia in the incubated or perfused rat heart","volume":"33","author":"Hoerter","year":"1978","journal-title":"Biol Neonate"},{"key":"10.1006\/jmcc.2000.1133_RF45","first-page":"H469","article-title":"Effect of hypoxia on mechanical function in the neonatal mammalian heart","volume":"235","author":"Jarmakani","year":"1978","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF46","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.RES.63.4.779","article-title":"Effects of acidosis on ventricular muscle from adult and neonatal rats","volume":"63","author":"Solaro","year":"1988","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1133_RF47","doi-asserted-by":"crossref","first-page":"S-60","DOI":"10.1016\/S0022-2828(87)80804-0","article-title":"Comparison of the responses of neonatal and adult rat ventricular muscles to acidosis: Role of the myofibrillar proteins","volume":"19 (suppl. IV)","author":"Solaro","year":"1987","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF48","first-page":"338","article-title":"Type (AT1) and (AT2) angiotensin receptors mediate opposing effects on sarcolemmal Na+\/H+exchanger activity","volume":"30","author":"Gunasegaram","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF49","first-page":"S225","article-title":"Angiotensin II stimulates macula densa basolateral Sodium\/hydrogen exchange via type 1 angiotensin II receptors","volume":"10","author":"Bell","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1006\/jmcc.2000.1133_RF50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1085\/jgp.85.5.765","article-title":"Mechanism of osmotic activation of Na+\/H+exchange in rat thymic lymphocytes","volume":"85","author":"Grinstein","year":"1985","journal-title":"J Gen Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF51","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1006\/jmcc.1999.0993","article-title":"Na(+)influx via Na(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes","volume":"31","author":"Hayasaki-Kajiwara","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1133_RF52","first-page":"H658","article-title":"Regulation of intracellular pH in cardiac muscle during cell shrinkage and swelling in anisosmolar solutions","volume":"266","author":"Whalley","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.1991.sp018873","article-title":"Sodium-hydrogen exchange in guinea-pig ventricular muscle during exposure to hyperosmolar solutions","volume":"444","author":"Whalley","year":"1991","journal-title":"J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.RES.64.4.676","article-title":"The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+\/H+antiport","volume":"64","author":"Weissberg","year":"1989","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1133_RF55","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0701936","article-title":"Activation of a nonspecific cation current in rat cultured retinal pigment epithelial cells: involvement of a G(alpha i) subunit protein and the mitogen-activated protein kinase signalling pathway","volume":"124","author":"Ryan","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1006\/jmcc.2000.1133_RF56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000054309","article-title":"Calcium\/calmodulin-dependent protein kinase II involvement in release of gonadotropin-releasing hormone","volume":"67","author":"Waters","year":"1998","journal-title":"Neuroendocrinol"},{"key":"10.1006\/jmcc.2000.1133_RF57","doi-asserted-by":"crossref","first-page":"29754","DOI":"10.1074\/jbc.273.45.29754","article-title":"Pyrimidion receptor-mediated potentiation of inducible nitric-oxide synthase induction in J774 macrophages","volume":"273","author":"Chen","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF58","doi-asserted-by":"crossref","first-page":"C257","DOI":"10.1152\/ajpcell.1995.269.1.C257","article-title":"Shrinkage-induced activation of Na+\/H+exchanges in primary rat astrocytes: role of myosin light-chain kinase","volume":"269","author":"Shrode","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1133_RF59","doi-asserted-by":"crossref","first-page":"23823","DOI":"10.1016\/S0021-9258(18)35911-8","article-title":"Activation of the Na+H+antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism","volume":"267","author":"Grinstein","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1133_RF60","doi-asserted-by":"crossref","first-page":"17A","DOI":"10.1016\/S0002-9149(97)00454-2","article-title":"Lactate transport in heart in relation to myocardial ischemia","volume":"80","author":"Halestrap","year":"1997","journal-title":"Am J Cardiol"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282800911337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282800911337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T01:58:46Z","timestamp":1620007126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282800911337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0022282800911337"],"URL":"https:\/\/doi.org\/10.1006\/jmcc.2000.1133","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}