{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:03:28Z","timestamp":1791263008938,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/jmcc.2000.1308","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:06:17Z","timestamp":1032372377000},"page":"359-371","source":"Crossref","is-referenced-by-count":262,"title":["Altered Connexin Expression in Human Congestive Heart Failure"],"prefix":"10.1016","volume":"33","author":[{"given":"Emmanuel","family":"Dupont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyaz A.","family":"Kaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Coppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Kaprielian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi H.","family":"Yacoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Severs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/jmcc.2000.1308_RF1","first-page":"492","article-title":"Management of heart failure","author":"Smith","year":"1997","journal-title":"In: Braunwald E (ed.), Heart disease: a textbook of cardiovascular medicine. London: WB Saunders Company"},{"key":"10.1006\/jmcc.2000.1308_RF2","first-page":"687","article-title":"Pathophysiology of heart failure","author":"Schlant","year":"1998","journal-title":"In: Alexander RW, Schlant RC, Fuster V (eds), Hurst's the heart. London: McGraw-Hill"},{"key":"10.1006\/jmcc.2000.1308_RF3","first-page":"825","article-title":"Mechanisms of cardiac arrhyth\u00cdmias and conduction disturbances","author":"Waldo","year":"1998","journal-title":"In: Alexander RW, Schlant RC, Fuster V (eds), Hurst's the heart. London: McGraw-Hill"},{"key":"10.1006\/jmcc.2000.1308_RF4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.CIR.72.3.596","article-title":"Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts","volume":"72","author":"Gardner","year":"1985","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1308_RF5","first-page":"571","article-title":"Recording of transmembrane action potentials in chronic ischemic heart disease and dilated cardiomyopathy and the effects of the new class III antiarrhythmic agents D-sotalol and dofetilide","volume":"27","author":"Montero","year":"1996","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1006\/jmcc.2000.1308_RF6","first-page":"73","article-title":"The importance of the electro\u00cdphysiologic substrates in the development of ventricular tachyarrhythmias","volume":"4","author":"Spear","year":"1985","journal-title":"P R Health Sci J"},{"key":"10.1006\/jmcc.2000.1308_RF7","first-page":"5","article-title":"Discontinuous cardiac conduction: its origin in cellular connectivity with long-term adaptative changes that causes arrhythmias","author":"Spach","year":"1997","journal-title":"In: Spooner PM, Joyner RW, Jalife J (eds), Discontinuous conduction in the heart. New York: Futura Publishing Company, Inc"},{"key":"10.1006\/jmcc.2000.1308_RF8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1540-8159.1997.tb06199.x","article-title":"Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias","volume":"20","author":"Spach","year":"1997","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1006\/jmcc.2000.1308_RF9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.RES.81.5.727","article-title":"Ionic mechanisms of propagation in cardiac tissue\u2014roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling","volume":"81","author":"Shaw","year":"1997","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.275.5301.841","article-title":"Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling","volume":"275","author":"Rohr","year":"1997","journal-title":"Science"},{"key":"10.1006\/jmcc.2000.1308_RF11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur J Biochem"},{"key":"10.1006\/jmcc.2000.1308_RF12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1006\/jmcc.1999.0937","article-title":"Chamber-related differences in connexin expression in the human heart","volume":"31","author":"Vozzi","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1308_RF13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/bies.950180907","article-title":"Connexins in mammalian heart function","volume":"18","author":"Gros","year":"1996","journal-title":"BioEssays"},{"key":"10.1006\/jmcc.2000.1308_RF14","first-page":"188","article-title":"Cardiovascular disease","author":"Severs","year":"1999","journal-title":"In: Cardew, G (ed), Gap Junction-Mediated Intercellular Signalling in Health and Disease. New York: John Wiley & Sons Ltd"},{"key":"10.1006\/jmcc.2000.1308_RF15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02110109","article-title":"Size and selectivity of gap junction channels formed from different connexins","volume":"28","author":"Veenstra","year":"1996","journal-title":"J Bioenerg Biomembr"},{"key":"10.1006\/jmcc.2000.1308_RF16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.CIR.88.3.864","article-title":"Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischaemic human hearts","volume":"88","author":"Peters","year":"1993","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1308_RF17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/01.RES.86.8.871","article-title":"Remodelling of gap-junctional coupling in hypertrophied right ventricules of rats with monocrotaline-induced pulmonary hypertension","volume":"86","author":"Uzzaman","year":"2000","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF18","first-page":"801","article-title":"Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy","volume":"139","author":"Smith","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1006\/jmcc.2000.1308_RF19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/hrt.76.5.412","article-title":"Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy","volume":"76","author":"Sepp","year":"1996","journal-title":"Heart"},{"key":"10.1006\/jmcc.2000.1308_RF20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.CIR.97.7.651","article-title":"Down-regulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle","volume":"97","author":"Kaprielian","year":"1998","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1308_RF21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0171-9335(98)80040-X","article-title":"Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term","volume":"75","author":"Kilarski","year":"1998","journal-title":"Eur J Cell Biol"},{"key":"10.1006\/jmcc.2000.1308_RF22","first-page":"H1449","article-title":"Atrial natriuretic peptide transcription, storage and release in rats with myocardial infarction","volume":"253","author":"Mendez","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1308_RF23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2362.1987.tb01235.x","article-title":"Messenger RNA content and complexity in normal and overload rat heart","volume":"17","author":"De la Bastie","year":"1987","journal-title":"Eur J Clin Invest"},{"key":"10.1006\/jmcc.2000.1308_RF24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF01870924","article-title":"Immunological characterization of rat cardiac gap junctions: presence of common antigenic determinants in heart of other vertebrate species and in various organs","volume":"104","author":"Dupont","year":"1988","journal-title":"J Membr Biol"},{"key":"10.1006\/jmcc.2000.1308_RF25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/01.RES.82.2.232","article-title":"Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart","volume":"82","author":"Coppen","year":"1998","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF26","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.103.6.842","article-title":"The gap-junctional protein, connexin40, is elevated in patients susceptible to post-operative atrial fibrillation","author":"Dupont","year":"2001","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1308_RF27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1469-7580.1999.19530341.x","article-title":"Local- isation and quantitation of autonomic innervation in the porcine heart","volume":"195","author":"Crick","year":"1999","journal-title":"J Anat"},{"key":"10.1006\/jmcc.2000.1308_RF28","article-title":"Cellular mechanisms of left ventricular remodelling in heart failure","author":"Kaprielian","year":"1997","journal-title":"(MD Thesis). University of London"},{"key":"10.1006\/jmcc.2000.1308_RF29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/002215549704500406","article-title":"Gap junction localisation and connexin expression in cytochemically identified endothelial cells from arterial tissue","volume":"45","author":"Yeh","year":"1997","journal-title":"J Histochem Cytochem"},{"key":"10.1006\/jmcc.2000.1308_RF30","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1083\/jcb.111.5.2077","article-title":"Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines","volume":"111","author":"Musil","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1006\/jmcc.2000.1308_RF31","article-title":"Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system","volume":"52: in press.","author":"Severs","year":"2001","journal-title":"Microsc Res Tech"},{"key":"10.1006\/jmcc.2000.1308_RF32","doi-asserted-by":"crossref","first-page":"C356","DOI":"10.1152\/ajpcell.1995.268.2.C356","article-title":"Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells","volume":"268","author":"Moreno","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2000.1308_RF33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0960-9822(98)70113-7","article-title":"Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block","volume":"8","author":"Simon","year":"1998","journal-title":"Curr Biol"},{"key":"10.1006\/jmcc.2000.1308_RF34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jemt.1070310511","article-title":"Differential connexin distribution accommodates cardiac function in different species","volume":"31","author":"Van Kempen","year":"1995","journal-title":"Microsc Res Tech"},{"key":"10.1006\/jmcc.2000.1308_RF35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/01.RES.74.5.839","article-title":"Restricted distribution of connexin40, a gap junctional protein, in mammalian heart","volume":"74","author":"Gros","year":"1994","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF36","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/01.RES.73.6.1138","article-title":"Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions","volume":"73","author":"Bastide","year":"1993","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1242\/jcs.105.4.985","article-title":"The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of the cardiac atrioventricular conduction system","volume":"105","author":"Gourdie","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1006\/jmcc.2000.1308_RF38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0960-9822(98)70114-9","article-title":"Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice","volume":"8","author":"Kirchhoff","year":"1998","journal-title":"Curr Biol"},{"key":"10.1006\/jmcc.2000.1308_RF39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.83.1.1","article-title":"Ventricular myocytes are not terminally differentiated in the adult mammalian heart","volume":"83","author":"Anversa","year":"1998","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1023\/A:1009719926882","article-title":"Changes in cardiac phenotype in hypertrophy and failure: from receptor to gene","volume":"2","author":"Van Heugten","year":"1997","journal-title":"Heart Failure Reviews"},{"key":"10.1006\/jmcc.2000.1308_RF41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.RES.79.2.174","article-title":"Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes","volume":"79","author":"Darrow","year":"1996","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/excr.1995.1337","article-title":"TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels","volume":"220","author":"Kwak","year":"1995","journal-title":"Exp Cell Res"},{"key":"10.1006\/jmcc.2000.1308_RF43","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1074\/jbc.273.15.9188","article-title":"Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase","volume":"273","author":"Warn-Cramer","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2000.1308_RF44","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0022-2828(95)90623-1","article-title":"Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells","volume":"27","author":"Firek","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2000.1308_RF45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.1987.sp016363","article-title":"Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of Guinea pig","volume":"382","author":"Noma","year":"1986","journal-title":"J Physiol"},{"key":"10.1006\/jmcc.2000.1308_RF46","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.CIR.101.5.547","article-title":"Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice","volume":"101","author":"Lerner","year":"2000","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2000.1308_RF47","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/01.RES.65.5.1426","article-title":"Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium","volume":"65","author":"Lesh","year":"1989","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2000.1308_RF48","first-page":"223","article-title":"The site of healing over after a local injury in the heart","volume":"5","author":"Deleze","year":"1975","journal-title":"Recent Adv Stud Cardiac Struct Metab"},{"key":"10.1006\/jmcc.2000.1308_RF49","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1161\/01.CIR.96.10.3579","article-title":"Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion","volume":"96","author":"Garcia-Dorado","year":"1997","journal-title":"Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282800913087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282800913087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:01:40Z","timestamp":1620018100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282800913087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0022282800913087"],"URL":"https:\/\/doi.org\/10.1006\/jmcc.2000.1308","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}