{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:03:00Z","timestamp":1780084980314,"version":"3.54.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1006\/jmcc.2001.1379","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:06:17Z","timestamp":1032372377000},"page":"1153-1163","source":"Crossref","is-referenced-by-count":55,"title":["Autoantibodies from Mothers of Children with Congenital Heart Block Downregulate Cardiac L-type Ca Channels"],"prefix":"10.1016","volume":"33","author":[{"given":"Yongxia","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boutjdir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/jmcc.2001.1379_RF1","first-page":"544","article-title":"Autoantibody-associated congenital heart block: outcome in mothers and children","volume":"20","author":"Waltuck","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1006\/jmcc.2001.1379_RF2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/01.CIR.56.1.82","article-title":"Congenital heart block in newborns of mothers with connective tissue disease","volume":"56","author":"McCue","year":"1977","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1379_RF3","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1056\/NEJM197712012972203","article-title":"Association of maternal systemic lupus erythematosus with congenital complete heart block","volume":"297","author":"Chameides","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1006\/jmcc.2001.1379_RF4","first-page":"835","article-title":"Direct fetal therapy for hydrops secondary to congenital atrioventricular heart block","volume":"87","author":"Anandakumar","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1006\/jmcc.2001.1379_RF5","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.RES.80.3.354","article-title":"Arrhythmogenicity of IgG and anti-52-kDa SSA\/Ro affinity-purified antibodies from mothers of children with congenital heart block","volume":"80","author":"Boutjdir","year":"1997","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1379_RF6","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.161.11.5886","article-title":"Induction of antibodies reactive with SSA\/Ro-SSB\/La and development of congenital heart block in a murine model","volume":"161","author":"Miranda-Carus","year":"1998","journal-title":"J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF7","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1161\/01.CIR.99.14.1914","article-title":"Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block","volume":"99","author":"Mazel","year":"1999","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1379_RF8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1203\/00006450-199807000-00002","article-title":"Serum and immunoglobulin G from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model","volume":"44","author":"Boutjdir","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1006\/jmcc.2001.1379_RF9","first-page":"1943","article-title":"Relationship between maternal and neonatal levels of antibodies to 48-kDa SSB(La), 52-kDa SSA(Ro), and 60-kDa SSA(Ro) in pregnancies complicated by congenital heart block","volume":"21","author":"Buyon","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1006\/jmcc.2001.1379_RF10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0008-6363(99)00402-2","article-title":"Gene expression of Na+\/Ca2+exchanger during development in human heart","volume":"45","author":"Qu","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1006\/jmcc.2001.1379_RF11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1203\/00006450-199902000-00018","article-title":"mRNA and protein expression of SSA\/Ro and SSB\/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure","volume":"45","author":"Tseng","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1006\/jmcc.2001.1379_RF12","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1540-8167.1999.tb00246.x","article-title":"Unitary current analysis of L-type Ca2+ channels in human fetal ventricular myocytes","volume":"10","author":"Chen","year":"1999","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1006\/jmcc.2001.1379_RF13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.RES.53.4.544","article-title":"Isolation and characterization of single canine cardiac Purkinje cells","volume":"53","author":"Sheets","year":"1983","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1379_RF14","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.RES.65.4.955","article-title":"Electrophysiological and ultrastructure of canine subendocardial purkinje cells isolated from control and 24-hour infracted hearts","volume":"65","author":"Boyden","year":"1989","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1379_RF15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-291X(85)90563-7","article-title":"Purification of the cardiac 1,4-dihydropyridine receptor\/calcium channel complex","volume":"126","author":"Rengasamy","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/jmcc.2001.1379_RF16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1139\/y96-108","article-title":"Okadaic acid enhances prepulse facilitation of cardiac alpha 1-subunit but not endogenous calcium channel currents in Xenopus laevis oocytes","volume":"74","author":"Chahine","year":"1996","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1006\/jmcc.2001.1379_RF17","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1172\/JCI114013","article-title":"Isolation and characterization of a cDNA clone encoding the 60-kDa component of the human SS-A\/Ro ribonucleoprotein autoantigen","volume":"83","author":"Ben-Chetrit","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1379_RF18","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1084\/jem.167.5.1560","article-title":"A 52-kDa protein is a novel component of the SS-A\/Ro antigenic particle","volume":"167","author":"Ben-Chetrit","year":"1988","journal-title":"J Exp Med"},{"key":"10.1006\/jmcc.2001.1379_RF19","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.4049\/jimmunol.136.10.3744","article-title":"Epitopes, structural domains, and asymmetry of amino acid residues in SS-B\/La nuclear protein","volume":"136","author":"Chan","year":"1986","journal-title":"J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0896-8411(92)90007-D","article-title":"Cross-reactive maternal autoantibodies and congenital heart block","volume":"5","author":"Horsfall","year":"1992","journal-title":"J Autoimmun"},{"key":"10.1006\/jmcc.2001.1379_RF21","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/1521-4141(200010)30:10<2782::AID-IMMU2782>3.0.CO;2-9","article-title":"Anti-SSA\/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block","volume":"30","author":"Eftekhari","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF22","first-page":"454","article-title":"Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity","volume":"78","author":"Baboonian","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF23","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1172\/JCI111569","article-title":"Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes","volume":"74","author":"LeFeber","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1379_RF24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4049\/jimmunol.141.5.1480","article-title":"Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A\/Ro and SS-B\/La. Another possible mechanism for estradiol influence of lupus erythematosus","volume":"141","author":"Furukawa","year":"1988","journal-title":"J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0896-8411(91)90015-5","article-title":"Ro and La antigens and maternal anti-La idiotype on the surface of myocardial fibres in congenital heart block","volume":"4","author":"Horsfall","year":"1991","journal-title":"J Autoimmun"},{"key":"10.1006\/jmcc.2001.1379_RF26","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.4049\/jimmunol.161.9.5061","article-title":"Accessibility of SSA\/Ro and SSB\/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes","volume":"161","author":"Miranda","year":"1998","journal-title":"J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0896-8411(89)90176-5","article-title":"Anti-SS-A\/Ro SS-B\/La antibodies bind to neonatal rabbit cardiac cells and preferentially inhibit in vitro cardiac repolarization","volume":"2","author":"Alexander","year":"1989","journal-title":"J Autoimmun"},{"key":"10.1006\/jmcc.2001.1379_RF28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1172\/JCI117025","article-title":"Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro\/SSA-positive patients in rabbit hearts","volume":"93","author":"Garcia","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1379_RF29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00001573-199501000-00009","article-title":"Recent insights into the regulation of cardiac Ca2+ flux during perinatal development and in cardiac failure","volume":"10","author":"Fisher","year":"1995","journal-title":"Curr Opin Cardiol"},{"key":"10.1006\/jmcc.2001.1379_RF30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/BF00210230","article-title":"Investigations into Ro-specific antibody-associated congenital cardiac conduction defects","volume":"70","author":"Dorner","year":"1992","journal-title":"Clin Invest"},{"key":"10.1006\/jmcc.2001.1379_RF31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/hrt.62.4.320","article-title":"Family studies of congenital heart block associated with Ro antibody","volume":"62","author":"Behan","year":"1989","journal-title":"Br Heart J"},{"key":"10.1006\/jmcc.2001.1379_RF32","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/art.1780281202","article-title":"Ro (SS-A) antibody and antigen in a patient with congenital complete heart block","volume":"28","author":"Harley","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1006\/jmcc.2001.1379_RF33","first-page":"311","article-title":"Sex hormone involvement in induction of experimental SLE by a pathogenic anti-DNA idiotype in native mice","volume":"17","author":"Blank","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1006\/jmcc.2001.1379_RF34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1203\/00006450-199902000-00018","article-title":"mRNA and expression of SSA\/Ro and SSB\/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure","volume":"45","author":"Tseng","year":"1999","journal-title":"Pediatric Res"},{"key":"10.1006\/jmcc.2001.1379_RF35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/1521-4141(200102)31:2<573::AID-IMMU573>3.0.CO;2-9","article-title":"Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor","volume":"31","author":"Eftekhari","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1006\/jmcc.2001.1379_RF36","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/cvr\/20.12.869","article-title":"Electrical properties and response to noradrenaline of individual heart cells isolate from human ventricular tissue","volume":"20","author":"Mitchell","year":"1986","journal-title":"Cardiovasc Res"},{"key":"10.1006\/jmcc.2001.1379_RF37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1540-8167.1993.tb01281.x","article-title":"Calcium current in single human cardiac myocytes","volume":"4","author":"Cohen","year":"1993","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1006\/jmcc.2001.1379_RF38","first-page":"H463","article-title":"Apamin, a highly potent fetal L-type Ca current blocker in single heart cells","volume":"262","author":"Bkaily","year":"1992","journal-title":"Am J Physoiol"},{"key":"10.1006\/jmcc.2001.1379_RF39","doi-asserted-by":"crossref","DOI":"10.1203\/00006450-200111000-00006","article-title":"Gene expression of SERCA2a, L- and T-type Ca2+channels during human heart development","author":"Qu","year":"2001","journal-title":"Pediatric Res"},{"key":"10.1006\/jmcc.2001.1379_RF40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.75.3.503","article-title":"Developmental and tissue-specific regulation of rabbit skeletal and cardiac muscle calcium channels involved in excitation-contraction coupling","volume":"75","author":"Brillantes","year":"1994","journal-title":"Circ Res"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282801913793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282801913793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T02:21:35Z","timestamp":1680574895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282801913793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S0022282801913793"],"URL":"https:\/\/doi.org\/10.1006\/jmcc.2001.1379","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}