{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:27:54Z","timestamp":1762954074394},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1006\/jmcc.2001.1408","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:06:17Z","timestamp":1032372377000},"page":"1455-1465","source":"Crossref","is-referenced-by-count":46,"title":["BW373U86, a \u03b4 Opioid Agonist, Partially Mediates Delayed Cardioprotection via a Free Radical Mechanism that is Independent of Opioid Receptor Stimulation"],"prefix":"10.1016","volume":"33","author":[{"given":"Hemal H.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannine","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett J.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/jmcc.2001.1408_RF1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1161\/01.RES.72.6.1293","article-title":"Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia","volume":"72","author":"Kuzuya","year":"1993","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1408_RF3","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1161\/01.CIR.88.3.1264","article-title":"Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction","volume":"88","author":"Marber","year":"1993","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00788633","article-title":"Characterisation of the infarct-limiting effect of delayed preconditioning: time course and dose-dependency studies in rabbit myocardium","volume":"92","author":"Baxter","year":"1997","journal-title":"Basic Res Cardiol"},{"key":"10.1006\/jmcc.2001.1408_RF5","first-page":"H1375","article-title":"Demonstration of an early and late phase of preconditioning in mice","volume":"275","author":"Guo","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF6","first-page":"H874","article-title":"Increased protein synthesis is necessary for development of late preconditioning against myocardial stunning","volume":"277","author":"Rizvi","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0022-2828(08)80006-5","article-title":"Heat shock proteins and protection against myocardial ischemia","volume":"27","author":"Mestril","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2001.1408_RF8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.85.2.769","article-title":"Heat shock protein induction in rat hearts: a role for improved myocardial salvage after ischemia and reperfusion?","volume":"85","author":"Donnelley","year":"1992","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.CIR.89.1.355","article-title":"Heat shock protein induction in rat hearts: A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection","volume":"89","author":"Hutter","year":"1994","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF10","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/01.CIR.98.14.1414","article-title":"Whole-body hyperthermia provides biphasic cardioprotection against ischemia\/reperfusion injury in the rat","volume":"98","author":"Yamashita","year":"1998","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF11","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1161\/01.CIR.101.24.2841","article-title":"Adenosine A1receptor activation induces delayed preconditioning in rats mediated by manganese superoxide dismutase","volume":"101","author":"Dana","year":"2000","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF12","first-page":"H33","article-title":"Sublethal ischemia alters myocardial antioxidant activity in canine heart","volume":"264","author":"Hoshida","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF13","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1172\/JCI117580","article-title":"Induction of manganese superoxide dismutase in rat cardiac myocytes increases tolerance to hypoxia 24 hours after preconditioning","volume":"94","author":"Yamashita","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1408_RF14","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1006\/jmcc.1998.0682","article-title":"A \u201csecond window of protection\u201d occurs 24 h after ischemic preconditioning in the rat heart","volume":"30","author":"Yamashita","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2001.1408_RF15","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1161\/01.CIR.92.11.3318","article-title":"Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats","volume":"92","author":"Auyeung","year":"1995","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.RES.81.1.42","article-title":"Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by generation of nitric oxide","volume":"81","author":"Bolli","year":"1997","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1408_RF17","first-page":"H2418","article-title":"Glycolipid RC-552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice","volume":"277","author":"Xi","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF18","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.CIR.102.8.902","article-title":"Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A1receptors: evidence from gene-knockout mice","volume":"102","author":"Zhao","year":"2000","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF19","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1073\/pnas.96.20.11507","article-title":"The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene","volume":"96","author":"Guo","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/jmcc.2001.1408_RF20","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1006\/jmcc.1999.0983","article-title":"Ischemic preconditioning increases iNOS transcript levels in conscious rabbits via a nitric oxide-dependent mechanism","volume":"31","author":"Jones","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1006\/jmcc.2001.1408_RF21","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/01.RES.81.6.1094","article-title":"The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase: evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning","volume":"81","author":"Bolli","year":"1997","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1408_RF22","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1074\/jbc.273.29.18092","article-title":"Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes","volume":"273","author":"Hoek","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2001.1408_RF23","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/01.CIR.97.13.1282","article-title":"Ischemic preconditioning in the intact rat heart is mediated by \u03b41- but not \u03bc- or \u03ba-opioid receptors","volume":"97","author":"Schultz","year":"1998","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF24","first-page":"H909","article-title":"TAN-67, a \u03b41-opioid receptor agonist, reduces infarct size via activation of Gi\/oproteins and KATPchannels","volume":"274","author":"Schultz","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF25","first-page":"II.357","article-title":"Opiate drugs and \u03b4-receptor-mediated myocardial protection","volume":"100 (Suppl. II)","author":"Benedict","year":"1999","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF26","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/01.RES.84.7.846","article-title":"Opioid induced second window of cardioprotection: potential role of mitochondrial KATPchannels","volume":"84","author":"Fryer","year":"1999","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1408_RF27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0014-5793(97)00264-0","article-title":"Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin","volume":"406","author":"Paradies","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1006\/jmcc.2001.1408_RF28","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/bi00181a003","article-title":"Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content","volume":"33","author":"Wagner","year":"1994","journal-title":"Biochemistry"},{"key":"10.1006\/jmcc.2001.1408_RF29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3240001","article-title":"Biochemistry and pathology of radical-mediated protein oxidation","volume":"324","author":"Dean","year":"1997","journal-title":"Biochem J"},{"key":"10.1006\/jmcc.2001.1408_RF30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1096\/fasebj.1.1.2886388","article-title":"Modification of hepatic proteins in rats exposed to high oxygen concentration","volume":"1","author":"Starke","year":"1987","journal-title":"FASEB J"},{"key":"10.1006\/jmcc.2001.1408_RF31","doi-asserted-by":"crossref","first-page":"14742","DOI":"10.1074\/jbc.270.24.14742","article-title":"Carbonic anhydrase III: oxidative modification in vivo and loss of phosphatase activity during aging","volume":"270","author":"Cabiscol","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1006\/jmcc.2001.1408_RF32","first-page":"317","article-title":"Oxidant injury of cells","volume":"9","author":"Schraufstatter","year":"1987","journal-title":"Int J Tiss Res"},{"key":"10.1006\/jmcc.2001.1408_RF33","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI113165","article-title":"Role of oxidants in DNA damage: hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke","volume":"80","author":"Jackson","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1408_RF34","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1172\/JCI119473","article-title":"Perspective series: host\/pathogen interactions-mechanisms of nitric oxide-related antimicrobial activity","volume":"99","author":"Fang","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1408_RF35","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1096\/fasebj.9.13.7557022","article-title":"Molecular mechanisms and therapeutic strategies related to nitric oxide","volume":"9","author":"Moncada","year":"1995","journal-title":"FASEB J"},{"key":"10.1006\/jmcc.2001.1408_RF36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0896-6273(00)80859-4","article-title":"Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO\u2212","volume":"24","author":"Kim","year":"1999","journal-title":"Neuron"},{"key":"10.1006\/jmcc.2001.1408_RF37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0896-6273(00)80310-4","article-title":"(S)NO signals: translocation, regulation, and a consensus motif","volume":"18","author":"Stamler","year":"1997","journal-title":"Neuron"},{"key":"10.1006\/jmcc.2001.1408_RF38","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1172\/JCI118449","article-title":"Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs","volume":"97","author":"Sun","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1006\/jmcc.2001.1408_RF39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0921-8734(89)90004-0","article-title":"Chromosomal instability and progressive loss of chromosomes in HeLa cells during adaptation to hyperoxic growth conditions","volume":"219","author":"Gille","year":"1989","journal-title":"Mutation Res"},{"key":"10.1006\/jmcc.2001.1408_RF40","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/01.CIR.93.6.1177","article-title":"Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes","volume":"93","author":"Zhou","year":"1996","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF41","first-page":"H2240","article-title":"Generation of superoxide in cardiomyocytes during ischemia before reperfusion","volume":"277","author":"Becker","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.RES.86.5.541","article-title":"Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion","volume":"86","author":"Hoek","year":"2000","journal-title":"Circ Res"},{"key":"10.1006\/jmcc.2001.1408_RF43","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1093\/cvr\/27.11.2016","article-title":"Ischemic preconditioning is not mediated by oxygen derived free radicals in rats","volume":"27","author":"Richard","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1006\/jmcc.2001.1408_RF44","first-page":"H1208","article-title":"Cardioprotection is strain dependent in rat in response to whole body hyperthermia","volume":"280","author":"Patel","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1006\/jmcc.2001.1408_RF45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.CIR.103.2.290","article-title":"Morphine mimics preconditioning via free radical signal and mitochondrial KATPchannels in myocytes","volume":"103","author":"McPherson","year":"2001","journal-title":"Circulation"},{"key":"10.1006\/jmcc.2001.1408_RF46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(00)80836-3","article-title":"Retention of supraspinal delta-like analgesia and loss of morphine tolerance in \u03b4 opioid receptor knockout mice","volume":"24","author":"Zhu","year":"1999","journal-title":"Neuron"},{"key":"10.1006\/jmcc.2001.1408_RF47","first-page":"451","article-title":"Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels","volume":"294","author":"Fryer","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/jmcc.2001.1408_RF48","first-page":"888","article-title":"Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice","volume":"267","author":"Comer","year":"1993","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282801914087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282801914087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T15:21:37Z","timestamp":1576509697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282801914087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0022282801914087"],"URL":"https:\/\/doi.org\/10.1006\/jmcc.2001.1408","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}