{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:04Z","timestamp":1791288904318,"version":"4.3.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2002,11]]},"DOI":"10.1006\/jsre.2002.6451","type":"journal-article","created":{"date-parts":[[2003,1,9]],"date-time":"2003-01-09T07:12:55Z","timestamp":1042096375000},"page":"44-50","source":"Crossref","is-referenced-by-count":13,"title":["Differential Heparanase-1 Expression in Malignant and Benign Pheochromocytomas"],"prefix":"10.1006","volume":"108","author":[{"given":"Roderick M.","family":"Quiros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Maxhimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Prinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/jsre.2002.6451_RF1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/edrv-15-3-356","article-title":"Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma","volume":"15","author":"Bravo","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1006\/jsre.2002.6451_RF2","first-page":"1061","article-title":"Oncologic aspects of pheochromocytoma: The importance of follow-up","volume":"96","author":"Scott","year":"1984","journal-title":"Surgery"},{"key":"10.1006\/jsre.2002.6451_RF3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0046-8177(85)80107-6","article-title":"Adrenal pheochromocytoma: A clinicopathologic review of 60 cases","volume":"16","author":"Medeiros","year":"1985","journal-title":"Hum. Pathol."},{"key":"10.1006\/jsre.2002.6451_RF4","series-title":"Sabiston Textbook of Surgery, the Biological Basis of Modern Surgical Practice","first-page":"662","article-title":"Pituitary and adrenal glands","author":"Moley","year":"2001"},{"key":"10.1006\/jsre.2002.6451_RF5","doi-asserted-by":"crossref","first-page":"24153","DOI":"10.1074\/jbc.274.34.24153","article-title":"Human heparanase: Purification, characterization, cloning, and expression","volume":"274","author":"Toyoshima","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/jsre.2002.6451_RF6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/10525","article-title":"Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis","volume":"5","author":"Hulett","year":"1999","journal-title":"Nature Med."},{"key":"10.1006\/jsre.2002.6451_RF7","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1042\/bj3301341","article-title":"Human platelet heparanase: Purification, characterization, and catalytic activity","volume":"330","author":"Freeman","year":"1998","journal-title":"Biochem. J."},{"key":"10.1006\/jsre.2002.6451_RF8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/bbrc.1999.0962","article-title":"Cloning and functional expression of a human heparanase gene","volume":"261","author":"Kussie","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/jsre.2002.6451_RF9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/10455","article-title":"Heparanase: Breaking down barriers in tumors","volume":"5","author":"Eccles","year":"1999","journal-title":"Nature Med."},{"key":"10.1006\/jsre.2002.6451_RF10","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/10518","article-title":"Mammalian heparanase: Gene cloning, expression, and function in tumor progression and metastasis","volume":"5","author":"Vlodavsky","year":"1999","journal-title":"Nature Med."},{"key":"10.1006\/jsre.2002.6451_RF11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1097-0215(19990702)82:1<112::AID-IJC19>3.0.CO;2-9","article-title":"Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells","volume":"82","author":"Walch","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1006\/jsre.2002.6451_RF12","first-page":"4655","article-title":"Heparanase expression in primary and metastatic pancreatic cancer","volume":"61","author":"Koliopanos","year":"2001","journal-title":"Cancer Res."},{"key":"10.1006\/jsre.2002.6451_RF13","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0002-9440(10)64632-9","article-title":"Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma: Evidence for its role in colonic tumorigenesis","volume":"157","author":"Friedmann","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1006\/jsre.2002.6451_RF14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0090-4295(98)00612-8","article-title":"Pheochromocytomas: Can malignant potential be predicted?","volume":"53","author":"John","year":"1999","journal-title":"Urology"},{"key":"10.1006\/jsre.2002.6451_RF15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/01.HYP.36.6.1045","article-title":"Malignant pheochromocytoma: Chromaffin granule transmitter and response to treatment","author":"Rao","year":"2000","journal-title":"Hypertension"},{"key":"10.1006\/jsre.2002.6451_RF16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2265.1996.624448.x","article-title":"Flow cytometric analysis does not reliably differentiate benign from malignant phaeochromocytoma","volume":"44","author":"Heaney","year":"1996","journal-title":"Clin. Endocrinol."},{"key":"10.1006\/jsre.2002.6451_RF17","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1200\/JCO.1989.7.11.1720","article-title":"Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma","volume":"7","author":"Helman","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1006\/jsre.2002.6451_RF18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1096-9896(199905)188:1<51::AID-PATH310>3.0.CO;2-R","article-title":"Prognostic value of p53, bcl-2, and c-erb B2 protein expression in phaeochromocytomas","volume":"188","author":"Krijger","year":"1999","journal-title":"J. Pathol."},{"key":"10.1006\/jsre.2002.6451_RF19","first-page":"922","article-title":"Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing","volume":"145","author":"Komminoth","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1006\/jsre.2002.6451_RF20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1096-9896(200006)191:2<175::AID-PATH615>3.0.CO;2-Z","article-title":"Proliferative index in pheochromocytomas: Does it predict the occurrence of metastases?","volume":"191","author":"Van Der Harst","year":"2000","journal-title":"J. Pathol."},{"key":"10.1006\/jsre.2002.6451_RF21","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1583::AID-CNCR28>3.3.CO;2-R","article-title":"Predicting metastasis of pheochromocytomas using DNA flow cytometry and immunohistochemical markers of cell proliferation: A positive correlation between MIB-1 staining and malignant tumor behavior","volume":"86","author":"Brown","year":"1999","journal-title":"Cancer"},{"key":"10.1006\/jsre.2002.6451_RF22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<176::AID-CNCR22>3.0.CO;2-Z","article-title":"Elevated levels of telomerase activity in malignant pheochromocytoma","volume":"82","author":"Kubota","year":"1998","journal-title":"Cancer"},{"key":"10.1006\/jsre.2002.6451_RF23","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1096\/fj.00-0895fje","article-title":"Heparanase as mediator of angiogenesis: Mode of action","volume":"15","author":"Elkin","year":"2001","journal-title":"FASEB J."},{"key":"10.1006\/jsre.2002.6451_RF24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0039-6060(96)80037-7","article-title":"Tumor angiogenesis in pheochromocytomas and paragangliomas","volume":"120","author":"Liu","year":"1996","journal-title":"Surgery"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480402964516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480402964516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T12:25:57Z","timestamp":1554207957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480402964516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["S0022480402964516"],"URL":"https:\/\/doi.org\/10.1006\/jsre.2002.6451","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}