{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:32:58Z","timestamp":1791397978882,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1006\/mcne.2001.1042","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T15:46:43Z","timestamp":1032364003000},"page":"512-524","source":"Crossref","is-referenced-by-count":85,"title":["M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices"],"prefix":"10.1006","volume":"18","author":[{"given":"Jennifer L.","family":"Berkeley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Gomeza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Wess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Nathanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/mcne.2001.1042_RF1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/MCB.19.2.1301","article-title":"Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth","volume":"19","author":"Abe","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/mcne.2001.1042_RF2","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1152\/jn.1994.72.4.2034","article-title":"A novel cholinergic induction of long-term potentiation in rat hippocampus","volume":"72","author":"Auerbach","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1006\/mcne.2001.1042_RF3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.1996.sp021323","article-title":"Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus","volume":"492","author":"Auerbach","year":"1996","journal-title":"J. Physiol."},{"key":"10.1006\/mcne.2001.1042_RF4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1471-4159.2000.0750487.x","article-title":"Muscarinic activation of mitogen-activated protein kinase in PC12 cells","volume":"75","author":"Berkeley","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2001.1042_RF5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1046\/j.1471-4159.1998.70020558.x","article-title":"Region-specific targets of p42\/p44MAPK signaling in rat brain","volume":"70","author":"Bhat","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2001.1042_RF6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3940(90)90835-W","article-title":"Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus","volume":"119","author":"Blitzer","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1006\/mcne.2001.1042_RF7","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/80624","article-title":"Dual MAP kinase pathways mediate opposing forms of long-tem plasticity at CA3-CA1 synapses","volume":"3","author":"Bolshakov","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF8","first-page":"469","article-title":"Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells","volume":"35","author":"Buckley","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"10.1006\/mcne.2001.1042_RF9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0165-3806(84)90167-6","article-title":"MAP2 is localized to the dendrites of hippocampal neurons which develop in culture","volume":"315","author":"Caceres","year":"1984","journal-title":"Brain Res."},{"key":"10.1006\/mcne.2001.1042_RF10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1006\/mcne.2001.1042_RF11","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/369418a0","article-title":"Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits","volume":"369","author":"Crespo","year":"1994","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1042_RF12","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1073\/pnas.95.5.2313","article-title":"Presence and phosphorylation of transcription factors in developing dendrites","volume":"95","author":"Crino","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/0264-6021:3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"10.1006\/mcne.2001.1042_RF14","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1074\/jbc.274.20.13978","article-title":"Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases","volume":"274","author":"Della Rocca","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF15","doi-asserted-by":"crossref","first-page":"19103","DOI":"10.1074\/jbc.272.31.19103","article-title":"A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation","volume":"272","author":"English","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF16","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1093\/emboj\/19.12.2911","article-title":"Active ERK\/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src","volume":"19","author":"Fincham","year":"2000","journal-title":"Embo J."},{"key":"10.1006\/mcne.2001.1042_RF17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02740604","article-title":"Role of MAP kinase in neurons","volume":"16","author":"Fukunaga","year":"1998","journal-title":"Mol. Neurobiol."},{"key":"10.1006\/mcne.2001.1042_RF18","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1073\/pnas.96.4.1692","article-title":"Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice","volume":"96","author":"Gomeza","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF19","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.96.18.10483","article-title":"Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice","volume":"96","author":"Gomeza","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF20","doi-asserted-by":"crossref","first-page":"13311","DOI":"10.1073\/pnas.94.24.13311","article-title":"Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice","volume":"94","author":"Hamilton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF21","doi-asserted-by":"crossref","first-page":"15850","DOI":"10.1074\/jbc.M011563200","article-title":"The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons","volume":"276","author":"Hamilton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF22","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1046\/j.1471-4159.1998.71052094.x","article-title":"Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion","volume":"71","author":"Haring","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2001.1042_RF23","doi-asserted-by":"crossref","first-page":"17148","DOI":"10.1074\/jbc.270.29.17148","article-title":"Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation","volume":"270","author":"Hawes","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF24","first-page":"F366","article-title":"Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells","volume":"267","author":"Heasley","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mcne.2001.1042_RF25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)80747-3","article-title":"Making New Connection: Role of ERK\/MAP kinase signaling in neuronal plasticity","volume":"23","author":"Impey","year":"1999","journal-title":"Neuron"},{"key":"10.1006\/mcne.2001.1042_RF26","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1523\/JNEUROSCI.15-05-04077.1995","article-title":"Expression of m1\u2013m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation","volume":"15","author":"Levey","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF27","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1523\/JNEUROSCI.11-10-03218.1991","article-title":"Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies","volume":"11","author":"Levey","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2174\/0929867003374589","article-title":"Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: Lessons from bradykinin signaling","volume":"7","author":"Liebmann","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"10.1006\/mcne.2001.1042_RF29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/7243","article-title":"G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors","volume":"2","author":"Lu","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF30","doi-asserted-by":"crossref","unstructured":"Marino, M. J., Rouse, S. T., Levey, A. I., Potter, L. T., and Conn, P. J.1998. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-d-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. 95: 11465\u201311470.","DOI":"10.1073\/pnas.95.19.11465"},{"key":"10.1006\/mcne.2001.1042_RF31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0304-3940(90)90495-U","article-title":"Acetylcholine potentiates responses to N-methyl-d-aspartate in the rat hippocampus","volume":"113","author":"Markram","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1006\/mcne.2001.1042_RF32","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1523\/JNEUROSCI.13-10-04293.1993","article-title":"Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors","volume":"13","author":"Max","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF33","first-page":"480","article-title":"Use of m1-toxin as a selective antagonist of m1 muscarinic receptors","volume":"267","author":"Max","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/mcne.2001.1042_RF34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00250251","article-title":"Carbachol effects on hippocampal neurons in vitro: Dependence on the rate of rise of carbachol tissue concentration","volume":"72","author":"Muller","year":"1988","journal-title":"Exp. Brain Res."},{"key":"10.1006\/mcne.2001.1042_RF35","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1073\/pnas.97.12.6245","article-title":"A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away","volume":"97","author":"Nathanson","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1471-4159.1998.71020603.x","article-title":"Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors","volume":"71","author":"Peavy","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2001.1042_RF37","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1523\/JNEUROSCI.19-11-04337.1999","article-title":"The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus","volume":"19","author":"Roberson","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1523\/JNEUROSCI.20-03-00977.2000","article-title":"ERKI\/II regulation by the muscarinic acetylcholine receptors in neurons","volume":"20","author":"Rosenblum","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF39","doi-asserted-by":"crossref","first-page":"24935","DOI":"10.1074\/jbc.274.35.24935","article-title":"Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis","volume":"274","author":"Schramm","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF40","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1523\/JNEUROSCI.18-01-00214.1998","article-title":"In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain","volume":"18","author":"Sgambato","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF41","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.1073\/pnas.96.19.10899","article-title":"Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice","volume":"96","author":"Shapiro","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1042_RF42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/mol.54.1.59","article-title":"A crucial role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells","volume":"54","author":"Tang","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1006\/mcne.2001.1042_RF43","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/MCB.19.1.136","article-title":"Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices","volume":"19","author":"Vanhoutte","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/mcne.2001.1042_RF44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0169-328X(00)00003-6","article-title":"Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain","volume":"76","author":"Veeranna","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1006\/mcne.2001.1042_RF45","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1523\/JNEUROSCI.20-16-05924.2000","article-title":"Coactivation of \u03b2-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region","volume":"20","author":"Watabe","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF46","doi-asserted-by":"crossref","first-page":"24624","DOI":"10.1074\/jbc.273.38.24624","article-title":"Differential coupling of \u03b11-, \u03b12-, and \u03b2-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells","volume":"273","author":"Williams","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2001.1042_RF47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000028196","article-title":"M1, M3 and M5 muscarinic receptors stimulate mitogen-activated protein kinase","volume":"56","author":"Wotta","year":"1998","journal-title":"Pharmacology"},{"key":"10.1006\/mcne.2001.1042_RF48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/83976","article-title":"Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology","volume":"4","author":"Wu","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35065604","article-title":"Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean","volume":"410","author":"Yamada","year":"2001","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1042_RF50","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1523\/JNEUROSCI.18-11-04042.1998","article-title":"Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway","volume":"18","author":"Yan","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1042_RF51","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.96.20.11607","article-title":"D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons","volume":"96","author":"Yan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743101910425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743101910425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T23:08:16Z","timestamp":1576451296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743101910425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S1044743101910425"],"URL":"https:\/\/doi.org\/10.1006\/mcne.2001.1042","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}