{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:00:34Z","timestamp":1791165634531,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1006\/mcne.2001.1086","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:40:07Z","timestamp":1033929607000},"page":"389-401","source":"Crossref","is-referenced-by-count":45,"title":["Long-Term Expression of \u03b2-Glucuronidase by Genetically Modified Human Neural Progenitor Cells Grafted into the Mouse Central Nervous System"],"prefix":"10.1006","volume":"19","author":[{"given":"Delphine","family":"Buchet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ch\u00e9","family":"Serguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Zennou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Charneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/mcne.2001.1086_RF1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(78)90102-2","article-title":"Human beta-glucuronidase: In vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells","volume":"15","author":"Achord","year":"1978","journal-title":"Cell"},{"key":"10.1006\/mcne.2001.1086_RF2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI114010","article-title":"Murine mucopolysaccharidosis type VII: Characterization of a mouse with beta-glucuronidase deficiency","volume":"83","author":"Birkenmeier","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mcne.2001.1086_RF3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/mthe.1999.0005","article-title":"Long-term and significant correction of brain lesions in adult mucopolysaccharidosis type VII mice using recombinant AAV vectors","volume":"1","author":"Bosch","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1006\/mcne.2001.1086_RF4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1089\/10430340050015194","article-title":"Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer","volume":"11","author":"Bosch","year":"2000","journal-title":"Hum. Gene Ther."},{"key":"10.1006\/mcne.2001.1086_RF5","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/3481","article-title":"Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats","volume":"16","author":"Brustle","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1006\/mcne.2001.1086_RF6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/nbdi.1995.0004","article-title":"Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiate in vitro","volume":"2","author":"Buc-Caron","year":"1995","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/mcne.2001.1086_RF7","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.10183","article-title":"Long-term fate of human telencephalic progenitor cells grafted into the adult mouse brain: Effects of previous amplification in vitro","author":"Buchet","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/mcne.2001.1086_RF8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/exnr.1999.7098","article-title":"In vitro expansion of a multipotent population of human neural progenitor cells","volume":"158","author":"Carpenter","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1006\/mcne.2001.1086_RF9","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0306-4522(96)00386-7","article-title":"In vitro propagation and inducible differentiation of multipotential progenitor cells from human fetal brain","volume":"76","author":"Chalmers-Redman","year":"1997","journal-title":"Neuroscience"},{"key":"10.1006\/mcne.2001.1086_RF10","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.275.5301.838","article-title":"Dopaminergic neurons protected from degeneration by GDNF gene therapy","volume":"275","author":"Choi-Lundberg","year":"1997","journal-title":"Science"},{"key":"10.1006\/mcne.2001.1086_RF11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/7901","article-title":"A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors","volume":"17","author":"Corti","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1006\/mcne.2001.1086_RF12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/10430349950019219","article-title":"Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice","volume":"10","author":"Daly","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1006\/mcne.2001.1086_RF13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1357-4310(98)01370-7","article-title":"Towards gene therapy for the central nervous system","volume":"4","author":"During","year":"1998","journal-title":"Mol. Med. Today"},{"key":"10.1006\/mcne.2001.1086_RF14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.gt.3300931","article-title":"Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector","volume":"6","author":"Elliger","year":"1999","journal-title":"Gene Ther."},{"key":"10.1006\/mcne.2001.1086_RF15","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1097\/00001756-200012180-00014","article-title":"The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS","volume":"11","author":"Englund","year":"2000","journal-title":"NeuroReport"},{"key":"10.1006\/mcne.2001.1086_RF16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/3473","article-title":"Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes","volume":"16","author":"Flax","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1006\/mcne.2001.1086_RF17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1203\/00006450-197707000-00007","article-title":"Human beta-glucuronidase. I. Recognition and uptake by animal fibroblasts suggests animal models for enzyme replacement studies","volume":"11","author":"Frankel","year":"1977","journal-title":"Pediatr. Res."},{"key":"10.1006\/mcne.2001.1086_RF18","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1523\/JNEUROSCI.19-14-05990.1999","article-title":"Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain","volume":"19","author":"Fricker","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2001.1086_RF19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.80.3.775","article-title":"Identification and characterization of cells deficient in the mannose 6-phosphate receptor: Evidence for an alternate pathway for lysosomal enzyme targeting","volume":"80","author":"Gabel","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1086_RF20","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1089\/hum.1998.9.16-2331","article-title":"Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain","volume":"9","author":"Ghodsi","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1006\/mcne.2001.1086_RF21","first-page":"980","article-title":"Beta-glucuronidase deficiency in a dog: A model of human mucopolysaccharidosis VII","volume":"18","author":"Haskins","year":"1984","journal-title":"Pediatr. Res."},{"key":"10.1006\/mcne.2001.1086_RF22","first-page":"133","article-title":"Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system","volume":"47","author":"Hughes","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1006\/mcne.2001.1086_RF23","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1182\/blood.V82.4.1358.1358","article-title":"Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells","volume":"82","author":"Marechal","year":"1993","journal-title":"Blood"},{"key":"10.1006\/mcne.2001.1086_RF24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nm0495-353","article-title":"Long term delivery of lysosomal enzyme by genetically-modified fibroblasts in dogs","volume":"1","author":"Moullier","year":"1995","journal-title":"Nat. Med."},{"key":"10.1006\/mcne.2001.1086_RF25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng0693-154","article-title":"Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically-modified skin fibroblasts","volume":"4","author":"Moullier","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1006\/mcne.2001.1086_RF26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.bi.60.070191.001353","article-title":"Lysosomal storage diseases","volume":"60","author":"Neufeld","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"10.1006\/mcne.2001.1086_RF27","series-title":"Metabolic Basis of Inherited Disease","first-page":"2465","article-title":"The mucopolysaccharidoses","author":"Neufeld","year":"1995"},{"key":"10.1006\/mcne.2001.1086_RF28","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1172\/JCI1773","article-title":"Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function","volume":"101","author":"O'Connor","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mcne.2001.1086_RF29","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1073\/pnas.94.4.1287","article-title":"Adenovirus-mediated gene transfer and expression of human \u03b2-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice","volume":"94","author":"Ohashi","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1086_RF30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1073\/pnas.88.4.1330","article-title":"Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes","volume":"88","author":"Palmer","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1086_RF31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/35075141","article-title":"Progenitor cells from human brain after death","volume":"411","author":"Palmer","year":"2001","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1086_RF32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1203\/00006450-199408000-00009","article-title":"Bone marrow transplantation has a significant effect on enzyme levels and storage of glycosaminoglycans in tissues and in isolated hepatocytes of mucopolysaccharidosis type VII mice","volume":"36","author":"Poorthuis","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1006\/mcne.2001.1086_RF33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0963-6897(97)00048-1","article-title":"Organization and histochemical phenotype of human fetal cerebellar cells following transplantation into the cerebellum of nude mice","volume":"6","author":"Pundt","year":"1997","journal-title":"Cell Transplant."},{"key":"10.1006\/mcne.2001.1086_RF34","first-page":"317","article-title":"Adenovirus for neurodegenerative diseases: In vivo strategies and ex vivo gene therapy using human neural progenitors","volume":"3","author":"Sabat\u00e9","year":"1995","journal-title":"Clin. Neurosci."},{"key":"10.1006\/mcne.2001.1086_RF35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng0395-256","article-title":"Transplantation to the rat brain of human neural progenitors that were genetically modified using adenovirus","volume":"9","author":"Sabat\u00e9","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1006\/mcne.2001.1086_RF36","first-page":"676","article-title":"Treatment of murine mucopolysaccharidosis type VII by syngeneic bone marrow transplantation in neonates","volume":"68","author":"Sands","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1006\/mcne.2001.1086_RF37","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI119322","article-title":"Murine mucopolysaccharidosis type VII: Long term therapeutic effects of enzyme replacement and enzyme replacement followed by bone marrow transplantation","volume":"99","author":"Sands","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mcne.2001.1086_RF38","doi-asserted-by":"crossref","first-page":"14638","DOI":"10.1073\/pnas.260472897","article-title":"Efficient transduction of neural cells in vitro and in vivo by a baculovirus-derived vector","volume":"97","author":"Sarkis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2001.1086_RF39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1354\/vp.37-5-502","article-title":"Mucopolysaccharidosis VII in a cat","volume":"37","author":"Schultheiss","year":"2000","journal-title":"Vet. Pathol."},{"key":"10.1006\/mcne.2001.1086_RF40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1006\/mthe.2001.0319","article-title":"Primary adult human astrocytes as an ex vivo vehicle for \u03b2-glucuronidase delivery in the brain","volume":"3","author":"Serguera","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1006\/mcne.2001.1086_RF41","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1006\/mthe.2001.0282","article-title":"Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD\/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors","volume":"3","author":"Sirven","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1006\/mcne.2001.1086_RF42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3476(73)80162-3","article-title":"Beta glucuronidase deficiency: Report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis","volume":"82","author":"Sly","year":"1973","journal-title":"J. Pediatr."},{"key":"10.1006\/mcne.2001.1086_RF43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/374367a0","article-title":"Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain","volume":"374","author":"Snyder","year":"1995","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1086_RF44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nm0797-771","article-title":"Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector corrected fibroblasts secreting high levels of \u03b2-glucuronidase","volume":"3","author":"Taylor","year":"1997","journal-title":"Nat. Med."},{"key":"10.1006\/mcne.2001.1086_RF45","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/38410","article-title":"Gene therapy\u2014Promises, problems and prospects","volume":"389","author":"Verma","year":"1997","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1086_RF46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/exnr.1998.6998","article-title":"Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation","volume":"156","author":"Vescovi","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1006\/mcne.2001.1086_RF47","first-page":"207","article-title":"A murine model of mucopolysaccharidosis VII. Gross and microscopic findings in beta-glucuronidase-deficient mice","volume":"136","author":"Vogler","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1006\/mcne.2001.1086_RF48","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/sj.gt.3300775","article-title":"Treatment of lysosomal storage disease in MPS VII mice using a recombinant adeno-associated virus","volume":"5","author":"Watson","year":"1998","journal-title":"Gene Ther."},{"key":"10.1006\/mcne.2001.1086_RF49","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/360749a0","article-title":"Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer","volume":"360","author":"Wolfe","year":"1992","journal-title":"Nature"},{"key":"10.1006\/mcne.2001.1086_RF50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0092-8674(00)80828-4","article-title":"HIV-1 genome nuclear import is mediated by a central DNA flap","volume":"101","author":"Zennou","year":"2000","journal-title":"Cell"},{"key":"10.1006\/mcne.2001.1086_RF51","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/88115","article-title":"The HIV DNA flap strongly stimulates HIV vector mediated cell transduction in the brain","volume":"19","author":"Zennou","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1006\/mcne.2001.1086_RF52","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nbt0997-871","article-title":"Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo","volume":"15","author":"Zufferey","year":"1997","journal-title":"Nat. Biotechnol."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743101910863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743101910863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T13:28:28Z","timestamp":1583414908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743101910863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S1044743101910863"],"URL":"https:\/\/doi.org\/10.1006\/mcne.2001.1086","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}