{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:57:41Z","timestamp":1791158261421,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Neuroscience"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1006\/mcne.2002.1166","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T15:22:53Z","timestamp":1034004173000},"page":"51-62","source":"Crossref","is-referenced-by-count":89,"title":["BDNF Modulates Sensory Neuron Synaptic Activity by a Facilitation of GABA Transmission in the Dorsal Horn"],"prefix":"10.1006","volume":"21","author":[{"given":"Sophie","family":"Pezet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaykumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Grist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Gavazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel J.","family":"Lever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Malcangio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/mcne.2002.1166_RF1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cne.903570209","article-title":"Differential distribution of exogenous BDNF, NGF and NT-3 in the brain corresponds to the relative abundance and distribution of the high affinity and low affinity neurotrophin receptors","volume":"357","author":"Anderson","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/mcne.2002.1166_RF2","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1046\/j.1460-9568.1998.00307.x","article-title":"NT-3 but not BDNF prevents atrophy and death of axotomised spinal cord projection neurons","volume":"10","author":"Bradbury","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/242","article-title":"A role for BDNF in mechanosensation","volume":"1","author":"Carroll","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3959(00)00245-1","article-title":"Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction","volume":"86","author":"Cejas","year":"2000","journal-title":"Pain"},{"key":"10.1006\/mcne.2002.1166_RF5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1471-4159.2001.00430.x","article-title":"Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord","volume":"78","author":"Charbel-Issa","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2002.1166_RF6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1152\/jn.2000.84.2.1006","article-title":"GABA-B receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord","volume":"84","author":"Chery","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1006\/mcne.2002.1166_RF7","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1152\/jn.1998.80.6.3383","article-title":"Brain derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of hippocampus","volume":"80","author":"Frerking","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1006\/mcne.2002.1166_RF8","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1523\/JNEUROSCI.21-13-04891.2001","article-title":"Brain-derived neurotrophic factor increases uninjured dorsal roots ganglion neurons in selective spinal nerve ligation model","volume":"21","author":"Fukuoka","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF9","doi-asserted-by":"crossref","first-page":"8107","DOI":"10.1073\/pnas.141015098","article-title":"BDNF but not NT-4 is required for normal flexion reflex plasticity and function","volume":"98","author":"Heppenstall","year":"2001","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1006\/mcne.2002.1166_RF10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.0954-6820.2000.00773.x","article-title":"Substance P: A pioneer amongst peptides","volume":"249","author":"H\u00f6kfelt","year":"2001","journal-title":"J. Int. Med."},{"key":"10.1006\/mcne.2002.1166_RF11","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/0306-4522(81)90029-4","article-title":"An immunohistochemical study of neuronal populations containing neuropeptides or \u03b3-aminobutyrate within the superficial layers of the rat dorsal horn","volume":"6","author":"Hunt","year":"1981","journal-title":"Neuroscience"},{"key":"10.1006\/mcne.2002.1166_RF12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/268549a0","article-title":"Opiate analgesics inhibit substance P release from rat trigeminal nucleus","volume":"268","author":"Jessell","year":"1977","journal-title":"Nature"},{"key":"10.1006\/mcne.2002.1166_RF13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/73888","article-title":"Synapsin as mediators of BDNF-enhanced neurotransmitter release","volume":"3","author":"Jovanovic","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0955-0674(97)80065-8","article-title":"Signal transduction by the neurotrophin receptors","volume":"9","author":"Kaplan","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/mcne.2002.1166_RF15","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/neu.480251108","article-title":"Neurotrophin signal transduction by the Trk receptor","volume":"25","author":"Kaplan","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1006\/mcne.2002.1166_RF16","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1523\/JNEUROSCI.19-12-05138.1999","article-title":"Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord","volume":"19","author":"Kerr","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF17","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1111\/j.1471-4159.1992.tb10085.x","article-title":"K-252 compounds: modulators of neurotrophin signal transduction","volume":"59","author":"Knusel","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2002.1166_RF18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/341149a0","article-title":"Molecular cloning and expression of brain-derived neurotrophic factor","volume":"341","author":"Leibrock","year":"1989","journal-title":"Nature"},{"key":"10.1006\/mcne.2002.1166_RF19","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1523\/JNEUROSCI.21-12-04469.2001","article-title":"Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation","volume":"21","author":"Lever","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF20","doi-asserted-by":"crossref","first-page":"10231","DOI":"10.1523\/JNEUROSCI.18-24-10231.1998","article-title":"Enhancement of neurotransmitter reelase induced by brain-derived neurotrophic factor in cultured hippocampal neurons","volume":"18","author":"Li","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF21","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/j.1476-5381.1994.tb17174.x","article-title":"Spinal cord release and hyperalgesia in monoarthritic rats: Involvement of the GABAB receptor system","volume":"113","author":"Malcangio","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/mcne.2002.1166_RF22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0165-6147(96)01013-9","article-title":"GABA and its receptors in the spinal cord","volume":"17","author":"Malcangio","year":"1996","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1006\/mcne.2002.1166_RF23","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1523\/JNEUROSCI.17-21-08459.1997","article-title":"Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord","volume":"17","author":"Malcangio","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1460-9568.2000.00890.x","article-title":"Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord","volume":"12","author":"Malcangio","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF25","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1073\/pnas.96.16.9385","article-title":"Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity","volume":"96","author":"Mannion","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mcne.2002.1166_RF26","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1126\/science.7539937","article-title":"Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation","volume":"268","author":"Mantyh","year":"1995","journal-title":"Science"},{"key":"10.1006\/mcne.2002.1166_RF27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1460-9568.1999.00445.x","article-title":"Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABAB receptors","volume":"11","author":"Marviz\u00f3n","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF28","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0896-6273(94)90323-9","article-title":"Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets","volume":"12","author":"McMahon","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/mcne.2002.1166_RF29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00001756-200101220-00012","article-title":"Effect of brain-derived neurotrophic factor on the reelase of substance P from rat spinal cord","volume":"12","author":"Meyer-Tuve","year":"2001","journal-title":"NeuroReport"},{"key":"10.1006\/mcne.2002.1166_RF30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","article-title":"The induction of pain: An integrative review","volume":"57","author":"Millan","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1006\/mcne.2002.1166_RF31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-0102(00)00103-6","article-title":"BDNF rapidly induces aspartate release from cultured CNS neurons","volume":"37","author":"Numakawa","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1006\/mcne.2002.1166_RF32","first-page":"510.5","article-title":"Nociceptive stimulation induces trkB receptor phosphorylation in the spinal dorsal horn","author":"Pezet","year":"2001","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1006\/mcne.2002.1166_RF33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0006-8993(99)01500-0","article-title":"The types of neurons which contain protein kinase C gamma in rat spinal cord","volume":"833","author":"Polgar","year":"1999","journal-title":"Brain Res."},{"key":"10.1006\/mcne.2002.1166_RF34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1046\/j.1471-4159.2001.00485.x","article-title":"Presynaptic autoreceptors","volume":"78","author":"Raiteri","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1006\/mcne.2002.1166_RF35","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1046\/j.1460-9568.1998.00227.x","article-title":"Nerve growth factor and brain-derived neurotrophic factor increase neurotransmitter release in the rat visual cortex","volume":"10","author":"Sala","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0166-2236(00)01672-6","article-title":"The neurotrophin hypothesis for synaptic plasticity","volume":"23","author":"Schinder","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF37","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0006-8993(94)91556-3","article-title":"Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3","volume":"633","author":"Siuciak","year":"1994","journal-title":"Brain Res."},{"key":"10.1006\/mcne.2002.1166_RF38","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1460-9568.1995.tb00670.x","article-title":"BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociception","volume":"7","author":"Siuciak","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF39","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0896-6273(00)81003-X","article-title":"Tackling pain at the source: New ideas about nociceptors","volume":"20","author":"Snider","year":"1998","journal-title":"Neuron"},{"key":"10.1006\/mcne.2002.1166_RF40","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(91)90396-G","article-title":"The neurotrophic factors brain-derived neurotrotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor","volume":"65","author":"Soppet","year":"1991","journal-title":"Cell"},{"key":"10.1006\/mcne.2002.1166_RF41","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1074\/jbc.273.42.27620","article-title":"Brain-derived neurotrophic factor induces rapid and transient release of glutamate through the non-exocytotic pathway from cortical neurons","volume":"273","author":"Takei","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mcne.2002.1166_RF42","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1523\/JNEUROSCI.17-09-02959.1997","article-title":"Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus","volume":"17","author":"Tanaka","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF43","first-page":"371","article-title":"K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors","volume":"2","author":"Tapley","year":"1992","journal-title":"Oncogene"},{"key":"10.1006\/mcne.2002.1166_RF44","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1476-5381.1996.tb15518.x","article-title":"GABA, glutamate and substance-P like immunoreactivity release: Effects of novel GABAB antagonists","volume":"118","author":"Teoh","year":"1996","journal-title":"Br. J. Pharmacol"},{"key":"10.1006\/mcne.2002.1166_RF45","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1111\/j.1460-9568.1996.tb01543.x","article-title":"GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn","volume":"8","author":"Todd","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF46","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/cne.902960312","article-title":"Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat","volume":"296","author":"Todd","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1006\/mcne.2002.1166_RF47","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1046\/j.1460-9568.2000.00237.x","article-title":"GABA-B receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia","volume":"12","author":"Towers","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF48","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1523\/JNEUROSCI.21-10-03457.2001","article-title":"Neurotrophic fcators and receptors in the immature and adult spinal cord after mechanical injury or kainic acid","volume":"21","author":"Widenfalk","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1006\/mcne.2002.1166_RF49","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: Increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1006\/mcne.2002.1166_RF50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0006-8993(93)90802-T","article-title":"Distribution of TrkB tyrosine kinase immunoreactivity in the rat central nervous system","volume":"622","author":"Zhou","year":"1993","journal-title":"Brain Res."}],"container-title":["Molecular and Cellular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743102911668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044743102911668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T12:54:21Z","timestamp":1548420861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044743102911668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S1044743102911668"],"URL":"https:\/\/doi.org\/10.1006\/mcne.2002.1166","relation":{},"ISSN":["1044-7431"],"issn-type":[{"value":"1044-7431","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}