{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:03:41Z","timestamp":1770217421200,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/mgme.2000.3126","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:46:30Z","timestamp":1032378390000},"page":"168-174","source":"Crossref","is-referenced-by-count":61,"title":["Association between Total Serum Calcium and the A986S Polymorphism of the Calcium-Sensing Receptor Gene"],"prefix":"10.1006","volume":"72","author":[{"given":"David E.C.","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang M.","family":"Trang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty Y.-L.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey N.","family":"Hendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence A.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/mgme.2000.3126_RF1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/000456328402100303","article-title":"The effects of inheritance on constituents of plasma: A twin study on some biochemical variables","volume":"21","author":"Whitfield","year":"1984","journal-title":"Ann Clin Biochem"},{"key":"10.1006\/mgme.2000.3126_RF2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/cs0820493","article-title":"Platelet cytosolic free calcium concentration, total plasma calcium concentration and blood pressure in human twins: A genetic analysis","volume":"82","author":"Williams","year":"1992","journal-title":"Clin Sci"},{"key":"10.1006\/mgme.2000.3126_RF3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gepi.1370040102","article-title":"Heritability of clinical chemistries in an older twin cohort: The NHLBI twin study","volume":"4","author":"Kalousdian","year":"1987","journal-title":"Genet Epidemiol"},{"key":"10.1006\/mgme.2000.3126_RF4","first-page":"659","article-title":"Genetic variability of clinical chemical values","volume":"23","author":"Havlik","year":"1997","journal-title":"Clin Chem"},{"key":"10.1006\/mgme.2000.3126_RF5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S8756-3282(97)00002-1","article-title":"Calcium-receptor-regulated parathyroid and renal function","volume":"20","author":"Brown","year":"1997","journal-title":"Bone"},{"key":"10.1006\/mgme.2000.3126_RF6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1677\/joe.0.1540371","article-title":"The calcium-sensing receptor: Insights into extracellular calcium homeostasis in health and disease","volume":"154","author":"Pearce","year":"1997","journal-title":"J Endocrinol"},{"key":"10.1006\/mgme.2000.3126_RF7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/1098-1004(200010)16:4<281::AID-HUMU1>3.0.CO;2-A","article-title":"Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia","volume":"16","author":"Hendy","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1006\/mgme.2000.3126_RF8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1172\/JCI119137","volume":"99","author":"Bai","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1006\/mgme.2000.3126_RF9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1096-8628(19970808)71:2<202::AID-AJMG16>3.0.CO;2-I","article-title":"Neonatal severe hyperparathyroidism, secondary hyperparathyroidism, and familial hypocalciuric hypercalcemia: Multiple different phenotypes associated with an inactivating Alu insertion mutation of the calcium-sensing receptor gene","volume":"71","author":"Cole","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1006\/mgme.2000.3126_RF10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM199610103351505","article-title":"A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor","volume":"335","author":"Pearce","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1006\/mgme.2000.3126_RF11","doi-asserted-by":"crossref","first-page":"19537","DOI":"10.1074\/jbc.271.32.19537","article-title":"Expression and characterization of inactivating and activating mutations in the human Ca2+0-sensing receptor","volume":"271","author":"Bai","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1006\/mgme.2000.3126_RF12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(98)06434-4","article-title":"A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations","volume":"353","author":"Cole","year":"1999","journal-title":"Lancet"},{"key":"10.1006\/mgme.2000.3126_RF13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1359\/jbmr.1999.14.4.633","article-title":"Determinants of peak bone mass: Clinical and genetic analyses in a young female Canadian cohort","volume":"14","author":"Rubin","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1006\/mgme.2000.3126_RF14","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1093\/nar\/21.16.3623","article-title":"Mutagenically separated PCR (MS-PCR): A highly specific one step procedure for easy mutation detection","volume":"21","author":"Rust","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1006\/mgme.2000.3126_RF15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1210\/jcem.81.4.8636323","article-title":"Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains","volume":"81","author":"Heath","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1006\/mgme.2000.3126_RF16","first-page":"880","article-title":"Insertion of an Alu sequence in the Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism","volume":"56","author":"Janicic","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1006\/mgme.2000.3126_RF17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/00365519709168318","article-title":"Calcium sensing receptor gene: Analysis of polymorphism frequency","volume":"57","author":"Rubin","year":"1997","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1006\/mgme.2000.3126_RF18","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/clinchem\/41.12.1751","article-title":"Cobas Integra: Clinical laboratory instrument with continuous and random-access capabilities","volume":"41","author":"Palmer","year":"1995","journal-title":"Clin Chem"},{"key":"10.1006\/mgme.2000.3126_RF19","unstructured":"Weir, B, S, Genetic Data Analysis II, Sinauer Associates, Inc. Sunderland, MA, 1996."},{"key":"10.1006\/mgme.2000.3126_RF20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0272-6386(98)70074-5","article-title":"Serum creatinine levels in the US population: Third National Health and Nutrition Examination Survey","volume":"32","author":"Jones","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1006\/mgme.2000.3126_RF21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloningand characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid","volume":"366","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"10.1006\/mgme.2000.3126_RF22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/clinchem\/35.1.14","article-title":"Improved method for calculating calcium fractions in plasma: Reference values and effect of menopause","volume":"35","author":"Nordin","year":"1989","journal-title":"Clin Chem"},{"key":"10.1006\/mgme.2000.3126_RF23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0009-8981(86)90226-3","article-title":"Serum calcium status in health and disease: A comparison of measured and derived parameters","volume":"157","author":"White","year":"1986","journal-title":"Clin Chim Acta"},{"key":"10.1006\/mgme.2000.3126_RF24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/00365518909089086","article-title":"Comparison of serum total calcium, albumin-corrected total calcium, and ionized calcium in 1213 patients with suspected calcium disorders","volume":"49","author":"Thode","year":"1989","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1006\/mgme.2000.3126_RF25","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0140-6736(05)66921-8","article-title":"A986S polymorphism of calcium-sensing receptor","volume":"353","author":"Kanazawa","year":"1999","journal-title":"Lancet"},{"key":"10.1006\/mgme.2000.3126_RF26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1507\/endocrj.47.29","article-title":"The effect of calcium-sensing receptor gene polymorphisms on serum calcium levels: A familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing receptor gene","volume":"47","author":"Kanazawa","year":"2000","journal-title":"Endocr J"},{"key":"10.1006\/mgme.2000.3126_RF27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0002-9343(98)00418-5","article-title":"Physiology and pathophysiology of the extracellular calcium-sensing receptor","volume":"106","author":"Brown","year":"1999","journal-title":"Am J Med"},{"key":"10.1006\/mgme.2000.3126_RF28","first-page":"S248","article-title":"Calcium excretion is independently associated with the vitamin D receptor (VDR) and calcium-sensing receptor (CASR) polymorphisms in a nephrolithiasis population","volume":"23","author":"Cole","year":"1998","journal-title":"Bone"},{"key":"10.1006\/mgme.2000.3126_RF29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/PL00005835","article-title":"Association of bone mineral density with polymorphism of the human calcium-sensing receptor locus","volume":"66","author":"Tsukamoto","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"10.1006\/mgme.2000.3126_RF30","first-page":"S252","article-title":"Calcium-sensing receptor gene polymorphism (A986S) in primary hyperparathyroidism","volume":"15","author":"Cetani","year":"2000","journal-title":"J Bone Miner Res"}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719200931263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719200931263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:01:34Z","timestamp":1620018094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719200931263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S1096719200931263"],"URL":"https:\/\/doi.org\/10.1006\/mgme.2000.3126","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}