{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:33:19Z","timestamp":1774693999894,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/mpat.2000.0413","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:46:30Z","timestamp":1032378390000},"page":"91-99","source":"Crossref","is-referenced-by-count":31,"title":["Structure\u2013activity relationship of mycoloyl glycolipids derived from Rhodococcus sp. 4306"],"prefix":"10.1006","volume":"30","author":[{"given":"Sadao","family":"Ueda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagatoshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Naka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuyo","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuya","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kasama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/mpat.2000.0413_RF1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1084\/jem.91.2.197","article-title":"Studies on the virulence of tubercle bacilli. Isolation and biological properties of a constituent of virulent organisms","volume":"91","author":"Bloch","year":"1950","journal-title":"J Exp Med"},{"key":"10.1006\/mpat.2000.0413_RF2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0006-3002(56)90289-X","article-title":"The chemical structure of the cord factor of Mycobacterium tuberculosis","volume":"20","author":"Noll","year":"1956","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/mpat.2000.0413_RF3","unstructured":"Lederer, E, Chemistry of mycobacterial cord factor and related natural and synthetic trehalose esters, In Kubica GP, Wayne LG, Eds. The mycobacteria: a sourcebook part A New York: Marcel Dekker, 1984: 361\u201377"},{"key":"10.1006\/mpat.2000.0413_RF4","first-page":"1","article-title":"Mycobacterium tuberculosis cell envelope","volume":"215","author":"Lee","year":"1996","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1006\/mpat.2000.0413_RF5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.bi.64.070195.000333","article-title":"The envelope of mycobacteria","volume":"64","author":"Brennan","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1006\/mpat.2000.0413_RF6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/bms.1200050104","article-title":"Separation and analysis of molecular species of mycolic acids in Nocardia and related taxa by gas chromatography mass spectrometry","volume":"5","author":"Yano","year":"1978","journal-title":"Biomed Mass Spectrom"},{"key":"10.1006\/mpat.2000.0413_RF7","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1128\/JB.96.4.958-961.1968","article-title":"Acute granulomatous response produced in mice by trehalose-6,6-dimycolate","volume":"96","author":"Bekierkunst","year":"1968","journal-title":"J Bacteriol"},{"key":"10.1006\/mpat.2000.0413_RF8","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1128\/IAI.68.6.3704-3709.2000","article-title":"In vivo administration of mycobacterial cord factor (trehalose 6, 6-dimycolate) can induce lung and liver granulomas and thymic atrophy in rabbits","volume":"68","author":"Hamasaki","year":"2000","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF9","unstructured":"Bekierkunst, A, Adjuvanticity of mycobacteria and their glycolipid components, wax D and cord factors, In Kubica GP, Wayne LG, Eds. The mycobacteria: a sourcebook part B New York: Marcel Dekker, 1984: 761\u201386"},{"key":"10.1006\/mpat.2000.0413_RF10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01792076","article-title":"Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties","volume":"7","author":"Lederer","year":"1975","journal-title":"Mol Cell Biochem"},{"key":"10.1006\/mpat.2000.0413_RF11","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/IAI.65.5.1793-1799.1997","article-title":"In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6-dimycolate)","volume":"65","author":"Ozeki","year":"1997","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF12","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1128\/IAI.56.12.3067-3071.1988","article-title":"Tumor necrosis factor (cachectin) mediates induction of cachexia by cord factor from mycobacteria","volume":"56","author":"Silva","year":"1988","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1073\/pnas.88.3.737","article-title":"Cord factor (\u03b1,\u03b1-trehalose 6,6-dimycolate) inhibits fusion between phospholipid vesicles","volume":"88","author":"Spargo","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/mpat.2000.0413_RF14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4049\/jimmunol.129.2.860","article-title":"Antitumor activity and hydrogen peroxide release by macrophages elicited by trehalose diesters","volume":"129","author":"Lepoivre","year":"1982","journal-title":"J Immunol"},{"key":"10.1006\/mpat.2000.0413_RF15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/IAI.54.3.869-875.1986","article-title":"Granuloma formation and hemopoiesis induced by C36-48-mycolic acid-containing glycolipids from Nocardia rubra","volume":"54","author":"Kaneda","year":"1986","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01742373","article-title":"Parallel antitumor, granuloma-forming and tumor-necrosis-factor-priming activities of mycoloyl glycolipids fromNocardia rubra that differ in carbohydrate moiety: structure-activity relationships","volume":"31","author":"Natsuhara","year":"1990","journal-title":"Cancer Immunol Immunother"},{"key":"10.1006\/mpat.2000.0413_RF17","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1128\/IAI.68.4.2043-2052.2000","article-title":"Trehalose 6,6-dimycolate (cord factor) enhances neovascularization through vascular endothelial growth factor production by neutrophils and macrophages","volume":"68","author":"Sakaguchi","year":"2000","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF18","first-page":"2213","article-title":"Structure and molecular species composition of three homologous series of \u03b1-mycolic acids fromMycobacterium spp","volume":"134","author":"Kaneda","year":"1988","journal-title":"J Gen Microbiol"},{"key":"10.1006\/mpat.2000.0413_RF19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1348-0421.1995.tb02243.x","article-title":"Distribution of C22-, C24- and C26-\u03b1-unit-containing mycolic acid homologues in mycobacteria","volume":"39","author":"Kaneda","year":"1995","journal-title":"Microbiol Immunol"},{"key":"10.1006\/mpat.2000.0413_RF20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/oxfordjournals.jbchem.a021463","article-title":"Relationship between induction of macrophage chemotactic factors and formation of granulomas caused by mycoloyl glyco\u00cdlipids from Rhodococcus ruber (Nocardia rubra)","volume":"120","author":"Matsunaga","year":"1996","journal-title":"J Biochem (Tokyo)"},{"key":"10.1006\/mpat.2000.0413_RF21","unstructured":"Yano, I, Oka, S, Natsuhara, Y, Kato, Y, Tomiyasu, I, Kaneda, K, Molecular structure and immunopharmacological activities of the new glycolipids containing mycolic acids in actinomycetales, In Y. Okami, T. Beppu, H. Ogawara, Eds. Biology of actinomycetes Tokyo: Japan Scientific Societies Press, 1988: 469\u201377"},{"key":"10.1006\/mpat.2000.0413_RF22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/infdis\/174.3.564","article-title":"Interleukin (IL)-12 deficiency in susceptible mice infected with Mycobacterium avium and amelioration of established infection by IL-12 replacement therapy","volume":"174","author":"Kobayashi","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1006\/mpat.2000.0413_RF23","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1128\/IAI.58.5.1210-1216.1990","article-title":"Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene","volume":"58","author":"Sato","year":"1990","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/meth.1996.0027","article-title":"The Immunopathogenesis of Granulomatous Inflammation Induced by Mycobacterium tuberculosis","volume":"9","author":"Kobayashi","year":"1996","journal-title":"Methods"},{"key":"10.1006\/mpat.2000.0413_RF25","first-page":"466","article-title":"Anergy-like immunosuppression in mice bearing pulmonary foreign-body granulomatous inflammation","volume":"121","author":"Allred","year":"1985","journal-title":"Am J Pathol"},{"key":"10.1006\/mpat.2000.0413_RF26","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/IAI.67.7.3571-3579.1999","article-title":"Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium","volume":"67","author":"Ehlers","year":"1999","journal-title":"Infect Immun"},{"key":"10.1006\/mpat.2000.0413_RF27","first-page":"364","article-title":"Rhodococcus sputi sp. novnom. rev., and Rhodococcus aurantiacus sp. nov., nom. rev","volume":"35","author":"Tsukamura","year":"1985","journal-title":"I J S B"},{"key":"10.1006\/mpat.2000.0413_RF28","first-page":"141","article-title":"Production and partial characterization of anti-cord factor (trehalose-6,6-dimycolate) IgG antibody in rabbits recognizing mycolic acid subclasses of Mycobacterium tuberculosis or Mycobacterium avium","volume":"24","author":"Fujiwara","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1006\/mpat.2000.0413_RF29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/bms.1200230611","article-title":"Fast atom bombardment mass spectrometry of mycobacterial phenolic glycolipids","volume":"23","author":"Hartmann","year":"1994","journal-title":"Biol Mass Spectrom"},{"key":"10.1006\/mpat.2000.0413_RF30","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1128\/JCM.24.6.1060-1070.1986","article-title":"Determination of molecular species composition of C80 or longer-chain \u03b1-mycolic acids in Mycobacterium spp. by gas chromatography-mass spectrometry and mass chromatography","volume":"24","author":"Kaneda","year":"1986","journal-title":"J Clin Microbiol"},{"key":"10.1006\/mpat.2000.0413_RF31","first-page":"557","article-title":"Relationship of anti-tuberculous protection to lung granuloma produced by intravenous injection of synthetic 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with or without specific antigens","volume":"40","author":"Yamamoto","year":"1980","journal-title":"Immunology"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401000904133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401000904133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T03:55:56Z","timestamp":1680580556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401000904133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0882401000904133"],"URL":"https:\/\/doi.org\/10.1006\/mpat.2000.0413","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}