{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:22:21Z","timestamp":1771881741817,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":5120,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1006\/mthe.2002.0693","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T12:53:15Z","timestamp":1034772795000},"page":"455-463","source":"Crossref","is-referenced-by-count":15,"title":["HSV Amplicon-Mediated Delivery of LIGHT Enhances the Antigen-Presenting Capacity of Chronic Lymphocytic Leukemia"],"prefix":"10.1016","volume":"6","author":[{"given":"Khaled A.","family":"Tolba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Eling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Kipps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Federoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Rosenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/mthe.2002.0693_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1182\/blood.V88.1.41.41","article-title":"Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen","volume":"88","author":"Cardoso","year":"1996","journal-title":"Blood"},{"key":"10.1006\/mthe.2002.0693_bib2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1126\/science.169.3950.1042","article-title":"A theory of self-nonself discrimination","volume":"169","author":"Bretscher","year":"1970","journal-title":"Science"},{"key":"10.1006\/mthe.2002.0693_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0092-8674(05)80055-8","article-title":"Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7\/BB1 in interleukin-2 production and immunotherapy","volume":"71","author":"Schwartz","year":"1992","journal-title":"Cell"},{"key":"10.1006\/mthe.2002.0693_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/icb.1993.23","article-title":"The maintenance of self-tolerance","volume":"71","author":"Lafferty","year":"1993","journal-title":"Immunol. Cell Biol."},{"key":"10.1006\/mthe.2002.0693_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1074-7613(00)80455-0","article-title":"LIGHT, a new member of the TNF superfamily, and lymphotoxin \u03b1 are ligands for herpesvirus entry mediator","volume":"8","author":"Mauri","year":"1998","journal-title":"Immunity"},{"key":"10.1006\/mthe.2002.0693_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81363-X","article-title":"Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF\/NGF receptor family","volume":"87","author":"Montgomery","year":"1996","journal-title":"Cell"},{"key":"10.1006\/mthe.2002.0693_bib7","doi-asserted-by":"crossref","first-page":"13733","DOI":"10.1074\/jbc.274.20.13733","article-title":"A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis","volume":"274","author":"Yu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib8","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.4049\/jimmunol.164.8.4105","article-title":"LIGHT, a TNF-like molecule, costimulates T-cell proliferation and is required for dendritic cell-mediated allogeneic T-cell response","volume":"164","author":"Tamada","year":"2000","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib9","doi-asserted-by":"crossref","first-page":"27548","DOI":"10.1074\/jbc.273.42.27548","article-title":"Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM\/TR2, stimulates proliferation of T-cells and inhibits HT29 cell growth","volume":"273","author":"Harrop","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/73136","article-title":"Modulation of T-cell-mediated immunity in tumor and graftversus-host disease models through the LIGHT co-stimulatory pathway","volume":"6","author":"Tamada","year":"2000","journal-title":"Nat. Med."},{"key":"10.1006\/mthe.2002.0693_bib11","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1172\/JCI200113827","article-title":"The regulation of T-cell homeostasis and autoimmunity by Tcell-derived LIGHT","volume":"108","author":"Wang","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mthe.2002.0693_bib12","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.4049\/jimmunol.167.5.2479","article-title":"The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity","volume":"167","author":"Morel","year":"2001","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1182\/blood.V98.2.287","article-title":"Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia","volume":"98","author":"Tolba","year":"2001","journal-title":"Blood"},{"key":"10.1006\/mthe.2002.0693_bib14","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.90.23.11059","article-title":"Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation","volume":"90","author":"Boussiotis","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mthe.2002.0693_bib15","doi-asserted-by":"crossref","first-page":"14272","DOI":"10.1074\/jbc.272.22.14272","article-title":"A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation","volume":"272","author":"Kwon","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib16","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.4049\/jimmunol.165.8.4397","article-title":"Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T-cells: LIGHT down-regulates its own receptor","volume":"165","author":"Morel","year":"2000","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI1472","article-title":"Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells","volume":"101","author":"Kato","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mthe.2002.0693_bib18","doi-asserted-by":"crossref","first-page":"14307","DOI":"10.1074\/jbc.275.19.14307","article-title":"The lymphotoxin-\u03b2 receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells","volume":"275","author":"Rooney","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib19","doi-asserted-by":"crossref","first-page":"13471","DOI":"10.1074\/jbc.272.21.13471","article-title":"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5","volume":"272","author":"Hsu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib20","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1006\/mthe.2002.0693_bib21","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth","volume":"189","author":"Schneider","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1006\/mthe.2002.0693_bib22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1084\/jem.191.3.495","article-title":"TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo","volume":"191","author":"Josien","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1006\/mthe.2002.0693_bib23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/jlb.65.6.715","article-title":"TRANCE is a TNF family member that regulates dendritic cell and osteoclast function","volume":"65","author":"Wong","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"10.1006\/mthe.2002.0693_bib24","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1074\/jbc.274.11.6911","article-title":"Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G","volume":"274","author":"Chapman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/JVI.56.2.489-494.1985","article-title":"Specificity of Fc receptors induced by herpes simplex virus type 1: comparison of immunoglobulin G from different animal species","volume":"56","author":"Johansson","year":"1985","journal-title":"J. Virol."},{"key":"10.1006\/mthe.2002.0693_bib26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1128\/JVI.34.2.512-520.1980","article-title":"Immunoglobulin G(Fc)-binding receptors on virions of herpes simplex virus type 1 and transfer of these receptors to the cell surface by infection","volume":"34","author":"Para","year":"1980","journal-title":"J. Virol."},{"key":"10.1006\/mthe.2002.0693_bib27","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1074\/jbc.272.22.14029","article-title":"Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-\u03baB and AP-1","volume":"272","author":"Marsters","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib28","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1073\/pnas.032665099","article-title":"Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes","volume":"99","author":"Dadgostar","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mthe.2002.0693_bib29","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1074\/jbc.274.20.14246","article-title":"CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs","volume":"274","author":"Pullen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/mthe.2002.0693_bib30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1073\/pnas.96.4.1234","article-title":"Two differently regulated nuclear factor \u03baB activation pathways triggered by the cytoplasmic tail of CD40","volume":"96","author":"Tsukamoto","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mthe.2002.0693_bib31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.183.3.777","article-title":"A cell type-specific enhancer in the human B7.1 gene regulated by NF-\u03baB","volume":"183","author":"Zhao","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1006\/mthe.2002.0693_bib32","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.4049\/jimmunol.163.12.6386","article-title":"T suppressor lymphocytes inhibit NF-\u03baB-mediated transcription of CD86 gene in APC","volume":"163","author":"Li","year":"1999","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib33","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.4049\/jimmunol.162.5.2804","article-title":"Requirement for nuclear factor-\u03baB activation by a distinct subset of CD40-mediated effector functions in B lymphocytes","volume":"162","author":"Hsing","year":"1999","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1074-7613(00)80281-2","article-title":"Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells","volume":"6","author":"Hanissian","year":"1997","journal-title":"Immunity"},{"key":"10.1006\/mthe.2002.0693_bib35","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.4049\/jimmunol.159.9.4350","article-title":"Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement","volume":"159","author":"Karras","year":"1997","journal-title":"J. Immunol."},{"key":"10.1006\/mthe.2002.0693_bib36","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1182\/blood.V96.9.2917","article-title":"CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia","volume":"96","author":"Wierda","year":"2000","journal-title":"Blood"},{"key":"10.1006\/mthe.2002.0693_bib37","first-page":"752","article-title":"Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector","volume":"21","author":"Lu","year":"1995","journal-title":"Hepatology"},{"key":"10.1006\/mthe.2002.0693_bib38","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1073\/pnas.87.22.8950","article-title":"An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology","volume":"87","author":"Geller","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/mthe.2002.0693_bib39","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1128\/JVI.72.9.7137-7143.1998","article-title":"An enhanced packaging system for helper-dependent herpes simplex virus vectors","volume":"72","author":"Stavropoulos","year":"1998","journal-title":"J. Virol."},{"key":"10.1006\/mthe.2002.0693_bib40","doi-asserted-by":"crossref","unstructured":"Bowers, W. J., Howard, D. F., and Federoff, H. J.2000. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Mol. Ther.1: 294\u2013299,","DOI":"10.1006\/mthe.2000.0039"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001602906933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001602906933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T22:12:15Z","timestamp":1682374335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001602906933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S1525001602906933"],"URL":"https:\/\/doi.org\/10.1006\/mthe.2002.0693","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}