{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:01:09Z","timestamp":1788296469071,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1006\/mvre.1999.2146","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T10:37:12Z","timestamp":1033987032000},"page":"227-243","source":"Crossref","is-referenced-by-count":13,"title":["The Glomerular Barrier Fits a Two-Pore-and-Fiber-Matrix Model: Derivation and Physiologic Test"],"prefix":"10.1006","volume":"57","author":[{"given":"Murray A.","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard C.","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Gratrix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"C\u00e1rbajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/mvre.1999.2146_RF1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0006-3495(74)85962-X","article-title":"Mechanism of osmotic flow in porous membranes","volume":"14","author":"Anderson","year":"1974","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.163.3870.944","article-title":"Diffusive and convective flow across membranes: Irreversible thermodynamic approach","volume":"163","author":"Bresler","year":"1969","journal-title":"Science"},{"key":"10.1006\/mvre.1999.2146_RF3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0026-2862(78)90050-X","article-title":"A model to study the dynamics of glomerular ultrafiltration and glomerular capillary permselectivity characteristics","volume":"16","author":"Chang","year":"1978","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0006-3495(75)85862-0","article-title":"Permselectivity of the glomerular capillary wall to macromolecules. I. Theoretical considerations","volume":"15","author":"Chang","year":"1975","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0006-3495(75)85863-2","article-title":"Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran","volume":"15","author":"Chang","year":"1975","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/03008209009006984","article-title":"Water transport in extracellular matrices","volume":"25","author":"Comper","year":"1990","journal-title":"Connect. Tissue Res."},{"key":"10.1006\/mvre.1999.2146_RF7","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/ki.1995.178","article-title":"Charge selectivity in kidney ultrafiltration","volume":"47","author":"Comper","year":"1995","journal-title":"Kidney Int."},{"key":"10.1006\/mvre.1999.2146_RF8","series-title":"Handbook of Physiology","article-title":"Mechanisms and thermodynamics of transcapillary exchange","author":"Curry","year":"1984"},{"key":"10.1006\/mvre.1999.2146_RF9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI116668","article-title":"Glomerular permeability barrier in the rat. Functional assessment by in vitro methods","volume":"92","author":"Daniels","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mvre.1999.2146_RF10","first-page":"232","article-title":"Urinary proteins and glomerular morphology in protein overload proteinuria","volume":"38","author":"Davies","year":"1978","journal-title":"Lab. Invest."},{"key":"10.1006\/mvre.1999.2146_RF11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1152\/ajplegacy.1972.223.5.1178","article-title":"A model of glomerular ultrafiltration in the rat","volume":"223","author":"Deen","year":"1972","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF12","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1172\/JCI107324","article-title":"Dynamics of glomerular ultrafiltration in the rat. IV. Determination of the ultrafiltration coefficient","volume":"52","author":"Deen","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1006\/mvre.1999.2146_RF13","first-page":"F374","article-title":"Heteroporous model of glomerular size selectivity: Application to normal and nephrotic humans","volume":"249","author":"Deen","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF14","series-title":"Applied Regression Analysis","author":"Draper","year":"1981"},{"key":"10.1006\/mvre.1999.2146_RF15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0006-3495(97)78659-4","article-title":"Hindered transport of macromolecules in isolated glomeruli. I. Diffusion across intact and cell-free capillaries","volume":"72","author":"Edwards","year":"1997","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF16","series-title":"Biology and Chemistry of Basement Membranes","first-page":"43","article-title":"Structure and function in glomerular capillaries: Role of the basement membrane in glomerular filtration","author":"Farquhar","year":"1982"},{"key":"10.1006\/mvre.1999.2146_RF17","first-page":"433","article-title":"Ein neues Verfahren zur Trennung von Gasgemischen durch Diffusion","volume":"23","author":"Hertz","year":"1922","journal-title":"Phys. Z."},{"key":"10.1006\/mvre.1999.2146_RF18","first-page":"43","article-title":"Nonequilibrium thermodynamics","author":"Katchalsky","year":"1963","journal-title":"Int. Sci. Tech."},{"key":"10.1006\/mvre.1999.2146_RF19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0026-2862(80)90008-4","article-title":"Dependency of permeability-surface area product upon solute concentration, and its significance in the interpretation of lymph flux data","volume":"20","author":"Katz","year":"1980","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0026-2862(81)90097-2","article-title":"Changes in transcapillary protein flux by permeative and convective mechanisms as functions of increasing transcapillary water flux","volume":"22","author":"Katz","year":"1981","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0026-2862(85)90051-2","article-title":"Comparison of crosspoint and least squares regression methods in computation of membrane protein flux parameters from lymph flux analysis","volume":"30","author":"Katz","year":"1985","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF22","series-title":"Edema","first-page":"39","article-title":"Osmosis","author":"Katz","year":"1984"},{"key":"10.1006\/mvre.1999.2146_RF23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/10739689409148266","article-title":"Fiber matrix descriptors from permeability data without requiring membrane thickness: Theory, results, and optimization","volume":"1","author":"Katz","year":"1994","journal-title":"Microcirculation"},{"key":"10.1006\/mvre.1999.2146_RF24","first-page":"H1514","article-title":"Albumin reduces basement membrane hydraulic conductance in part due to arginyl side groups","volume":"269","author":"Katz","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mvre.1996.0013","article-title":"Basement membrane (Matrigel) compresses greatly, even at low pressures","volume":"51","author":"Katz","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF26","first-page":"150","article-title":"Thermodynamic properties of the glomerular filtration barrier","volume":"4","author":"Katz","year":"1997","journal-title":"Microcirculation"},{"key":"10.1006\/mvre.1999.2146_RF27","first-page":"A40","article-title":"The glomerular filtration barrier fits a two pore plus matrix barrier","volume":"11","author":"Katz","year":"1997","journal-title":"FASEB J."},{"key":"10.1006\/mvre.1999.2146_RF28","first-page":"F1046","article-title":"Glomerular size selectivity during protein overload in the rat","volume":"264","author":"Lemley","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/expphysiol.1987.sp003085","article-title":"Flow through interstitium and other fibrous matrices","volume":"72","author":"Levick","year":"1987","journal-title":"Q. J. Exp. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/ajplegacy.1948.154.3.532","article-title":"Mechanism of proteinuria. Effect of parenteral bovine albumin injections on hemoglobin excretion in rats","volume":"154","author":"Lippman","year":"1948","journal-title":"Am. J. Physiol."},{"key":"10.1006\/mvre.1999.2146_RF31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1039\/tf9545001303","article-title":"Methods of describing unidimensional diffusion in binary systems","volume":"50","author":"Ogston","year":"1954","journal-title":"Trans. Faraday Soc."},{"key":"10.1006\/mvre.1999.2146_RF32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0079-6107(79)90018-X","article-title":"General descriptions of passive transport of neutral solute and solvent through membranes","volume":"34","author":"Ogston","year":"1978","journal-title":"Progr. Biophys. Mol. Biol."},{"key":"10.1006\/mvre.1999.2146_RF33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1098\/rspa.1973.0064","article-title":"On the transport of compact particles through solutions of chain-polymers","volume":"333","author":"Ogston","year":"1973","journal-title":"Proc. R. Soc. London Ser. A"},{"key":"10.1006\/mvre.1999.2146_RF34","first-page":"1","article-title":"The molecular compression of dextran","volume":"183","author":"Ogston","year":"1979","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0022-5193(63)90088-2","article-title":"The flow of solute and solvent across a two membrane system","volume":"5","author":"Patlak","year":"1963","journal-title":"J. Theor. Biol."},{"key":"10.1006\/mvre.1999.2146_RF36","series-title":"F\u00fchrer durch die Str\u00f6mungslehre","author":"Prandtl","year":"1960"},{"key":"10.1006\/mvre.1999.2146_RF37","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/01.RES.41.6.735","article-title":"Multiple pathways of capillary permeability","volume":"41","author":"Renkin","year":"1977","journal-title":"Circ. Res."},{"key":"10.1006\/mvre.1999.2146_RF38","first-page":"1481","article-title":"Distribution of endogenous albumin in the glomerular wall of proteinuric patients","volume":"137","author":"Russo","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1006\/mvre.1999.2146_RF39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0026-2862(86)90057-9","article-title":"Preparation and high-performance size-exclusion chromatographic (HPSEC) analysis of fluorescein isothiocyanate\u2013hydroxyethyl starch: Macromolecular probes of the blood\u2013lymph barrier","volume":"32","author":"Schaeffer","year":"1986","journal-title":"Microvasc. Res."},{"key":"10.1006\/mvre.1999.2146_RF40","first-page":"181","article-title":"Macromolecular transport across endothelial monolayers","volume":"11","author":"Schaeffer","year":"1992","journal-title":"Int. J. Microcirc."},{"key":"10.1006\/mvre.1999.2146_RF41","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0006-3495(88)83043-1","article-title":"Analysis of steric partition behavior of molecules in membranes using statistical physics: Application to gel chromatography and electrophoresis","volume":"54","author":"Schnitzer","year":"1988","journal-title":"Biophys. J."},{"key":"10.1006\/mvre.1999.2146_RF42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0022-5193(66)90121-4","article-title":"Onsager reciprocal relations in complex membranes","volume":"10","author":"Snell","year":"1966","journal-title":"J. Theor. Biol."},{"key":"10.1006\/mvre.1999.2146_RF43","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0011-9164(00)80018-1","article-title":"Thermodynamics of hyperfiltration (reverse osmosis): Criteria for efficient membranes","volume":"1","author":"Spiegler","year":"1966","journal-title":"Desalination"},{"key":"10.1006\/mvre.1999.2146_RF44","first-page":"H293","article-title":"Transport parameter estimation from lymph measurements and the Patlak equation","volume":"262","author":"Watson","year":"1992","journal-title":"Am. J. Physiol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286299921465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286299921465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T06:28:37Z","timestamp":1576564117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286299921465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0026286299921465"],"URL":"https:\/\/doi.org\/10.1006\/mvre.1999.2146","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}